Publications

March 2021 (Revised April 2021)
Technical Note

Tales of Life-changing Innovations: Too Simple to be Safe? | Note on the Development of Fecal Transplants

By: Amar Bhidé and Srikant M. Datar

December 2020 (Revised May 2021)
Case

Dame Cicely Saunders and the Modern Hospice Movement: A Brother's View

By: Amar Bhidé and Srikant M. Datar

December 2020 (Revised May 2021)
Background Note

Tales of Life-changing Innovations: Living Drugs | Note on the Development of CAR-T Therapies (through 2019)

By: Amar Bhidé and Srikant M. Datar

2024
Working Paper

Chimeric Antigen Receptor T-Cell Therapy—Living Drugs: Case Histories of Transformational Advances

By: Amar Bhidé and Srikant M. Datar

In 2017, the US Food and Drug Administration (FDA) approved an immunotherapeutic treatment, called CAR-T therapy, for two kinds of blood cancers—acute leukemia (ALL) and a lymphoma. We describe 1) how CAR-T works, 2) the foundational advances and discoveries, 3) the... View Details

Keywords: Immunotherapy; Health Care and Treatment; Innovation and Invention; Research and Development; Governing Rules, Regulations, and Reforms

2024
Working Paper

Cephalosporins—Fighting Hospital Infections: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant Datar and Katherine Stebbins

This case history describes the development of three generations of cephalosporins – antibiotics that have significantly reduced hospital infections. Specifically, we chronicle how: 1) Early (pre-cephalosporin) antibiotics were developed in the first half of the 20th... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

2024
Working Paper

Gastrointestinal Endoscopy--Without Cutting In: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins

This case history describes how endoscopy transformed the diagnosis of ulcers, cancerous polyps, and other alimentary canal diseases and enabled “minimally invasive” surgeries to treat such diseases. Specifically, we chronicle how: 1) flexible glass fiber endoscopes... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

2024
Working Paper

Magnetic Resonance Imaging—High Quality and Radiation Free: Case Histories of Transformational Advances

By: Srikant M. Datar, Amar Bhidé and Katherine Stebbins

This case history describes how Magnetic Resource Imaging (MRI) came to complement – and partially replace -- computed tomography (CT) imaging of soft tissue. Specifically, we chronicle 1) the development of foundational techniques and prototypes (through the 1970s);... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

October 1990 (Revised August 1991)
Case

Peanut Butter Fantasies

By: Amar Bhide and Myra M. Hart

Addresses the interrelated challenges of marketing and finance faced by a small, struggling packaged foods company. View Details

Keywords: Business Ventures; Finance; Business or Company Management; Marketing; Distribution; Problems and Challenges; Food and Beverage Industry

July 1990
Background Note

Note on Acquiring Bank Credit

By: Amar Bhide and Howard H. Stevenson

Outlines the issues and alternatives faced by start-up businesses in attracting bank credit. The topics covered are how to lay the groundwork for establishing a banking relationship, selecting a bank, preparing an application, and negotiating a loan. View Details

Keywords: Business Startups; Credit; Financing and Loans; Management; Negotiation; Relationships