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- 12 Aug 2019
- Working Paper Summaries
Case Histories of Significant Medical Advances
- 2024
- Working Paper
Ultrasound Imaging--Cheap, Versatile, and Safe: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how efforts on multiple fronts, including advocacy, training, and technological development, made ultrasound the second most commonly used diagnostic imaging technology (after X-rays). Specifically, we chronicle 1) ultrasound’s development... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Ultrasound Imaging--Cheap, Versatile, and Safe: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-003, July 2019. (Revised May 2024.)
- 2024
- Working Paper
Magnetic Resonance Imaging—High Quality and Radiation Free: Case Histories of Transformational Advances
By: Srikant M. Datar, Amar Bhidé and Katherine Stebbins
This case history describes how Magnetic Resource Imaging (MRI) came to complement – and partially replace -- computed tomography (CT) imaging of soft tissue. Specifically, we chronicle 1) the development of foundational techniques and prototypes (through the 1970s);... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
Datar, Srikant M., Amar Bhidé, and Katherine Stebbins. "Magnetic Resonance Imaging—High Quality and Radiation Free: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-001, July 2019. (Revised May 2024.)
- 2024
- Working Paper
HIV Tests and AIDS Treatments—Containing a Fearsome Pandemic: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how a diverse cast of characters, including public health organizations, research laboratories, for-profit healthcare companies, activists, and regulators, rolled back the outbreak of HIV/AIDS in just fifteen years. Moreover, as the case... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "HIV Tests and AIDS Treatments—Containing a Fearsome Pandemic: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-007, July 2019. (Revised May 2024.)
- November 2020 (Revised May 2021)
- Technical Note
Tales of Life-changing Innovations: Safe and Cheap Diagnostics | Note on the Development of Ultrasound Scanning (through 2000)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Safe and Cheap Diagnostics | Note on the Development of Ultrasound Scanning (through 2000)." Harvard Business School Technical Note 321-054, November 2020. (Revised May 2021.)
- November 2020 (Revised April 2021)
- Technical Note
Tales of Life-changing Innovations: Containing a Fearsome Pandemic | Note on the Development of HIV/AIDS Controls, Tests, and Treatments (through 2000)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Containing a Fearsome Pandemic | Note on the Development of HIV/AIDS Controls, Tests, and Treatments (through 2000)." Harvard Business School Technical Note 321-052, November 2020. (Revised April 2021.)
- December 2020 (Revised May 2021)
- Technical Note
Tales of Life-changing Innovations: High Quality and Radiation Free | Note on the Development of Magnetic Resonance Imaging (through the 1990s)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: High Quality and Radiation Free | Note on the Development of Magnetic Resonance Imaging (through the 1990s)." Harvard Business School Technical Note 321-056, December 2020. (Revised May 2021.)
- 2024
- Working Paper
Gastrointestinal Endoscopy--Without Cutting In: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how endoscopy transformed the diagnosis of ulcers, cancerous polyps, and other alimentary canal diseases and enabled “minimally invasive” surgeries to treat such diseases. Specifically, we chronicle how: 1) flexible glass fiber endoscopes... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Gastrointestinal Endoscopy--Without Cutting In: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-005, July 2019. (Revised May 2024.)
- 2024
- Working Paper
Cephalosporins—Fighting Hospital Infections: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant Datar and Katherine Stebbins
This case history describes the development of three generations of cephalosporins – antibiotics that have significantly reduced hospital infections. Specifically, we chronicle how: 1) Early (pre-cephalosporin) antibiotics were developed in the first half of the 20th... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant Datar, and Katherine Stebbins. "Cephalosporins—Fighting Hospital Infections: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-133, July 2020. (Revised May 2024.)
- 2024
- Working Paper
Mammography - Early Detection, Precise Diagnoses: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how the development of x-ray-based techniques and equipment (“mammography”) led to widespread screening for breast cancer and enabled “minimally invasive” biopsies of breast tumors. Specifically, we chronicle how: 1) new protocols and... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Mammography - Early Detection, Precise Diagnoses: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-002, July 2019. (Revised May 2024.)
- 2024
- Working Paper
Antibiotic Treatments for Ulcers--Eradicating H-Pylori Infections: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how a chance discovery of bacteria that infect stomach linings completely changed how physicians treat ulcers. Specifically, we chronicle how: 1) two Australian physicians brought the bacterial infection to the world’s attention and... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Antibiotic Treatments for Ulcers--Eradicating H-Pylori Infections: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-006, July 2019. (Revised May 2024.)
- 2024
- Working Paper
Prozac—Controversial Blockbuster: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes the development of Prozac, a blockbuster drug that transformed
the treatment of depression – and became a cultural phenomenon in the United States. Specifically, we
chronicle the: 1) prior treatments for depression and the research that... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Prozac—Controversial Blockbuster: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-135, July 2020. (Revised May 2024.)
- 2024
- Working Paper
Computed Tomography (CT)--Beyond Traditional X-Rays: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how Computed Tomography (CT) scanners - that combine Xrays
and computers to image soft tissues of the brain and other organs -- have become a widely used
diagnostic tool. Specifically, we chronicle the 1) initial development of CT... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Computed Tomography (CT)--Beyond Traditional X-Rays: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-004, July 2019. (Revised May 2024.)
- November 2020 (Revised April 2021)
- Technical Note
Tales of Life-Changing Innovations: Fighting Hospital Infections | Note on the Development of Cephalosporins (through 2000)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-Changing Innovations: Fighting Hospital Infections | Note on the Development of Cephalosporins (through 2000)." Harvard Business School Technical Note 321-059, November 2020. (Revised April 2021.)
- December 2020 (Revised April 2021)
- Technical Note
Tales of Life-changing Innovations: Controversial Blockbuster | Note on the Development of Prozac (through 1999)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Controversial Blockbuster | Note on the Development of Prozac (through 1999)." Harvard Business School Technical Note 321-057, December 2020. (Revised April 2021.)
- December 2020 (Revised May 2021)
- Technical Note
Tales of Life-changing Innovations: Beyond Traditional X-rays | Note on the Development of Computed Tomography (through the 1990s)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Beyond Traditional X-rays | Note on the Development of Computed Tomography (through the 1990s)." Harvard Business School Technical Note 321-055, December 2020. (Revised May 2021.)
- November 2020 (Revised May 2021)
- Technical Note
Tales of Life-changing Innovations: Early Detection, Precise Diagnoses | Note on the Development of Mammography (though 2000)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Early Detection, Precise Diagnoses | Note on the Development of Mammography (though 2000)." Harvard Business School Technical Note 321-064, November 2020. (Revised May 2021.)
- November 2020 (Revised May 2021)
- Technical Note
Tales of Life-changing Innovations: Reducing Breast Cancer Risks | Note on the Development of Tamoxifen (through 1999)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Reducing Breast Cancer Risks | Note on the Development of Tamoxifen (through 1999)." Harvard Business School Technical Note 321-058, November 2020. (Revised May 2021.)
- November 2020 (Revised April 2021)
- Technical Note
Tales of Life-changing Innovations: Eradicating H-Pylori Infections | Note on the Development of Antibiotic Treatments for Ulcers
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Eradicating H-Pylori Infections | Note on the Development of Antibiotic Treatments for Ulcers." Harvard Business School Technical Note 321-053, November 2020. (Revised April 2021.)
- December 2020 (Revised April 2021)
- Technical Note
Tales of Life-changing Innovations: Without Cutting In | Note on the Development of Endoscopy (through the 1990s)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Without Cutting In | Note on the Development of Endoscopy (through the 1990s)." Harvard Business School Technical Note 321-061, December 2020. (Revised April 2021.)