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(3,240)
- People (2)
- News (504)
- Research (2,331)
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- Multimedia (31)
- Faculty Publications (1,896)
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- April 2025
- Background Note
Climate Change Adaptation with Artificial Intelligence and Machine Learning
By: Michael W. Toffel and Nabig Chaudhry
Artificial Intelligence (AI) and machine learning (ML) have emerged as powerful tools to address climate change. This note summarizes a wide range of the uses of AI/ML to drive climate change adaptation and resilience, the measures organizations and governments are... View Details
- September 2017 (Revised July 2023)
- Case
Adaptive Platform Trials: The Clinical Trial of the Future?
By: Ariel D. Stern and Sarah Mehta
In July 2017, Dr. Brian M. Alexander, president and CEO of the AGILE Research Foundation, was preparing to launch a new type of clinical trial—an adaptive platform trial—to study potential therapies for glioblastoma (GBM), an aggressive form of brain cancer.... View Details
Keywords: Clinical Trials; Cancer; Adaptive Platform Trials; Platform Trials; Adaptive Trials; Glioblastoma; Health; Health Care and Treatment; Health Testing and Trials; Business Strategy; Innovation Strategy; Health Industry; United States
Stern, Ariel D., and Sarah Mehta. "Adaptive Platform Trials: The Clinical Trial of the Future?" Harvard Business School Case 618-025, September 2017. (Revised July 2023.)
- October 2019
- Article
Adaptive Platform Trials: Definition, Design, Conduct and Reporting Considerations
By: Derek C. Angus, Brian M. Alexander, Scott Berry, Meredith Buxton, Roger Lewis, Melissa Paoloni, Steven A. R. Webb, Steven Arnold, Anna Barker, Donald A. Berry, Marc J. M. Bonten, Mary Brophy, Christopher Butler, Timothy F. Cloughesy, Lennie P. G. Derde, Laura J. Esserman, Ryan Ferguson, Louis Fiore, Sarah C. Gaffey, J. Michael Gaziano, Kathy Giusti, Herman Goossens, Stephane Heritier, Bradley Hyman, Michael Krams, Kay Larholt, Lisa M. LaVange, Philip Lavori, Andrew W. Lo, Alexander J. London, Victoria Manax, Colin McArthur, Genevieve O’Neill, Giovanni Parmigiani, Jane Perlmutter, Elizabeth A. Petzold, Craig Ritchie, Kathryn M. Rowan, Christopher W. Seymour, Nathan I. Shapiro, Diane M. Simeone, Bradley Smith, Bradley Spellberg, Ariel Dora Stern, Lorenzo Trippa, Mark Trusheim, Kert Viele, Patrick Y. Wen and Janet Woodcock
Researchers, clinicians, policymakers, and patients are increasingly interested in questions about therapeutic interventions that are difficult or costly to answer with traditional, free-standing, parallel-group randomized controlled trials (RCTs). Examples include... View Details
Angus, Derek C., Brian M. Alexander, Scott Berry, Meredith Buxton, Roger Lewis, Melissa Paoloni, Steven A. R. Webb, Steven Arnold, Anna Barker, Donald A. Berry, Marc J. M. Bonten, Mary Brophy, Christopher Butler, Timothy F. Cloughesy, Lennie P. G. Derde, Laura J. Esserman, Ryan Ferguson, Louis Fiore, Sarah C. Gaffey, J. Michael Gaziano, Kathy Giusti, Herman Goossens, Stephane Heritier, Bradley Hyman, Michael Krams, Kay Larholt, Lisa M. LaVange, Philip Lavori, Andrew W. Lo, Alexander J. London, Victoria Manax, Colin McArthur, Genevieve O’Neill, Giovanni Parmigiani, Jane Perlmutter, Elizabeth A. Petzold, Craig Ritchie, Kathryn M. Rowan, Christopher W. Seymour, Nathan I. Shapiro, Diane M. Simeone, Bradley Smith, Bradley Spellberg, Ariel Dora Stern, Lorenzo Trippa, Mark Trusheim, Kert Viele, Patrick Y. Wen, and Janet Woodcock. "Adaptive Platform Trials: Definition, Design, Conduct and Reporting Considerations." Nature Reviews: Drug Discovery 18, no. 10 (October 2019): 797–807.
- September 2019
- Supplement
Adaptive Platform Trials: The Clinical Trial of the Future? (B)
By: Ariel D. Stern and Sarah Mehta
This case provides an update to the (A) case, which introduces students to adaptive platform trials, an ambitious, more efficient type of clinical trial that increases access to therapies. The (A) case centers on Dr. Brian Alexander’s efforts to launch an adaptive... View Details
Keywords: Clinical Trials; Drug Trials; Drug Testing; Cancer Trials; Glioblastoma; Platform Trials; Adaptive Trials; Adaptive Platform Trials; Health Testing and Trials; Health Care and Treatment; Financing and Loans; Business Strategy; Health Industry; United States
Stern, Ariel D., and Sarah Mehta. "Adaptive Platform Trials: The Clinical Trial of the Future? (B)." Harvard Business School Supplement 620-001, September 2019.
- July 2021
- Supplement
Adaptive Platform Trials: The Clinical Trial of the Future? (C)
By: Ariel D. Stern and Sarah Mehta
This (C) case provides an update on the work of the Global Coalition for Adaptive Research (GCAR) and also illustrates how adaptive platform trials can nimbly respond to a global pandemic. View Details
Keywords: Clinical Trials; Drug Trials; Drug Testing; Cancer Trials; Glioblastoma; Platform Trials; Adaptive Trials; Adaptive Platform Trials; Health Testing and Trials; Health Care and Treatment; Business Strategy; Health Industry; United States
Stern, Ariel D., and Sarah Mehta. "Adaptive Platform Trials: The Clinical Trial of the Future? (C)." Harvard Business School Supplement 622-012, July 2021.
- Article
Adaptive Machine Unlearning
By: Varun Gupta, Christopher Jung, Seth Neel, Aaron Roth, Saeed Sharifi-Malvajerdi and Chris Waites
Data deletion algorithms aim to remove the influence of deleted data points from trained models at a cheaper computational cost than fully retraining those models. However, for sequences of deletions, most prior work in the non-convex setting gives valid guarantees... View Details
Gupta, Varun, Christopher Jung, Seth Neel, Aaron Roth, Saeed Sharifi-Malvajerdi, and Chris Waites. "Adaptive Machine Unlearning." Advances in Neural Information Processing Systems (NeurIPS) 34 (2021).
- October–December 2022
- Article
How Psychological Safety and Feeling Heard Relate to Burnout and Adaptation Amid Uncertainty
By: Michaela J. Kerrissey, Tuna Cem Hayirli, Aditi Bhanja, Nicholas Stark, James Hardy and Christopher Peabody
Background: Psychological safety—the belief that it is safe to speak up—is vital amid uncertainty, but its relationship to feeling heard is not well understood.
Purpose: The aims of this study were (a) to measure feeling heard and (b) to assess... View Details
Purpose: The aims of this study were (a) to measure feeling heard and (b) to assess... View Details
Keywords: Burnout; Crisis; Psychological Safety; Feeling Heard; Process Adaptation; Interpersonal Communication; Well-being; Health Care and Treatment; Adaptation
Kerrissey, Michaela J., Tuna Cem Hayirli, Aditi Bhanja, Nicholas Stark, James Hardy, and Christopher Peabody. "How Psychological Safety and Feeling Heard Relate to Burnout and Adaptation Amid Uncertainty." Health Care Management Review 47, no. 4 (October–December 2022): 308–316.
- August 2011 (Revised November 2017)
- Case
Adaptive Engineering, LLC
By: Richard S. Ruback and Royce Yudkoff
The owner and CEO of Adaptive Engineering was facing an important decision: should he focus on rebuilding its core professional services business which had generated significant revenue and cash flow over the past several years, or should he focus on developing and... View Details
Keywords: Leadership; Growth and Development Strategy; Decision Making; Service Industry; Technology Industry
Ruback, Richard S., and Royce Yudkoff. "Adaptive Engineering, LLC." Harvard Business School Case 212-010, August 2011. (Revised November 2017.)
- March 2018
- Teaching Note
Adaptive Platform Trials: The Clinical Trial of the Future?
By: Ariel D. Stern and Sarah Mehta
This teaching note provides guidance and recommendations for teaching HBS Case No. 618-025, entitled “Adaptive Platform Trials: The Clinical Trial of the Future?” View Details
- Research Summary
Climate Adaptation
By: John D. Macomber
It's clear that challenges like wildfires, river flooding, extreme heat, and storm surge are increasing. How will homeowners, businesses, instituations, goverments, and all of society decide what and whom to protect and what and whom to not protect? What is the timing?... View Details
- 06 Aug 2012
- Research & Ideas
Strategic Intelligence: Adapt or Die
corporate strategy, Wells has learned that the seeds of failure are often planted years before they sprout, and only by overcoming complacency and constantly adapting to the changing competitive environment can companies prosper in the... View Details
Keywords: by Michael Blanding
- January 2019
- Supplement
Adaptive Engineering, LLC
By: Richard S. Ruback and Royce Yudkoff
Ruback, Richard S., and Royce Yudkoff. "Adaptive Engineering, LLC." Harvard Business School Multimedia/Video Supplement 219-727, January 2019.
- Teaching Interest
Business Opportunties in Climate Adaptation
By: John D. Macomber
This is a Short Intensive Program or SIP at Harvard Business School. It’s an optional student offering prior to the formal start of the Spring semester the following week. SIPs tend to cover new material on current topics, to be less formal than the HBS Case Study... View Details
- May 2006
- Article
Survival of the Adaptive
By: Nitin Nohria
Keywords: Adaptation
Nohria, Nitin. "Survival of the Adaptive." Forethought. Harvard Business Review 84, no. 5 (May 2006): 23.
- 05 Dec 2023
- Cold Call Podcast
Tommy Hilfiger’s Adaptive Clothing Line: Making Fashion Inclusive
- 1974
- Chapter
Organizational Adaptation to Environmental Change
By: John J. Gabarro
Gabarro, John J. "Organizational Adaptation to Environmental Change." In Organizational Systems: General Systems Approaches to Complex Organizations, edited by Frank Baker. Homewood, IL: Richard D. Irwin, 1974.
- 2010
- Chapter
Happiness Adaptation to Income beyond 'Basic Needs'
By: Rafael Di Tella and Robert MacCulloch
We test for whether, once "basic needs" are satisfied, there is happiness adaptation to further gains in income using three data sets. Individual German Panel Data from 1985 to 2000, and data on the well-being of over 600,000 people in a panel of European countries... View Details
- January 1981
- Case
AT&T: Adaptation in Progress (B)
By: Paul R. Lawrence and Leonard A. Schlesinger
Lawrence, Paul R., and Leonard A. Schlesinger. "AT&T: Adaptation in Progress (B)." Harvard Business School Case 481-075, January 1981.
- January 1981
- Case
AT&T: Adaptation in Progress (D)
By: Paul R. Lawrence and Leonard A. Schlesinger
Lawrence, Paul R., and Leonard A. Schlesinger. "AT&T: Adaptation in Progress (D)." Harvard Business School Case 481-077, January 1981.
- January 1981
- Case
AT&T: Adaptation in Progress (A)
By: Paul R. Lawrence and Leonard A. Schlesinger
Lawrence, Paul R., and Leonard A. Schlesinger. "AT&T: Adaptation in Progress (A)." Harvard Business School Case 481-074, January 1981.