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- 2024
- Working Paper
Chimeric Antigen Receptor T-Cell Therapy—Living Drugs: Case Histories of Transformational Advances
By: Amar Bhidé and Srikant M. Datar
In 2017, the US Food and Drug Administration (FDA) approved an immunotherapeutic treatment, called CAR-T therapy, for two kinds of blood cancers—acute leukemia (ALL) and a lymphoma. We describe 1) how CAR-T works, 2) the foundational advances and discoveries, 3) the... View Details
Keywords: Immunotherapy; Health Care and Treatment; Innovation and Invention; Research and Development; Governing Rules, Regulations, and Reforms
Bhidé, Amar, and Srikant M. Datar. "Chimeric Antigen Receptor T-Cell Therapy—Living Drugs: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 21-035, August 2020. (Revised May 2024.)
- 28 Nov 2016
- News
One Obstacle to Curing Cancer: Patient Data Isn’t Shared
- Web
Faculty & Advisors | MBA
immunotherapy strategy which ultimately guided Celgene into the rapidly developing field of immuno-oncology (IO). Kareem started his career at Vertex Pharmaceuticals in formulation development. Mark Robinson MBA ‘93, Harvard University;... View Details
- 22 Feb 2024
- News
Combat-Tested Cancer Coaching
think I'll just rest on my laurels and see what happens now. I was equally as tenacious about finding the next immunotherapy drug that might come out. And so I think that balance was out of whack. I was so focused on that urgency. On the... View Details
- Web
Profiles - MBA
operators to overcome scientific and strategic challenges and break the boundaries of medicine. Moreover, I conduct research on improving immunotherapies for solid tumors in the translational Mitrogotri Lab at Harvard SEAS, and co-founded... View Details
- 15 Jan 2018
- Research & Ideas
A Better Business Model for Fighting Cancer
therapies has become a reality, as have immunotherapies that induce or suppress a body’s immune response to treat disease. Yet, this relatively swift progress has not been fast enough for millions of other patients who still lack... View Details