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  • December 2012
  • Teaching Note

Gene Patents (A) (TN)

By: Richard G. Hamermesh and Matthew Preble
This is the teaching note for case Gene Patents (A). In March 2010, U.S. District Court Judge Robert Sweet overturned 30 years of legal precedent and ruled that unaltered human genes could not be patented. This case reviews patent law and how it relates to our... View Details
Keywords: Biotech; Human Genome; Patents; Genetics; Biotechnology Industry; United States
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  • January 2014 (Revised December 2014)
  • Case

GenapSys: Business Models for the Genome

By: Richard G. Hamermesh, Joseph B. Fuller and Matthew Preble

GenapSys, a California-based startup, was soon to release a new DNA sequencer that the company's founder, Hesaam Esfandyarpour, believed was truly revolutionary. The sequencer would be substantially less expensive—potentially costing just a few thousand dollars—and... View Details

Keywords: DNA Sequencing; Life Sciences; Business Model; Innovation ＆ Entrepreneurship; Health Care and Treatment; Genetics; Business Strategy; Biotechnology Industry; Pharmaceutical Industry; Technology Industry; Health Industry; Medical Devices and Supplies Industry; United States
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  • March 2008 (Revised June 2008)
  • Case

The Broad Institute: Applying the Power of Genomics to Medicine

By: Vicki L. Sato and Rachel Gordon
In June 2003, Harvard University and MIT announced an unprecedented partnership to create a biomedical institute, The Broad Institute. The culture of the Broad centered on science, and those involved considered it to be at the edge of the scientific frontier. In just... View Details
Keywords: Education; Health Care and Treatment; Innovation Leadership; Growth and Development Strategy; Organizational Culture; Partners and Partnerships; Research and Development; Genetics
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  • February 2014
  • Case

BGI: Data-driven Research

By: Willy Shih and Sen Chai
BGI has the largest installed gene-sequencing capacity in the world, and to Zhang Gengyun, general manager of the Life Sciences Division, this represented an opportunity to apply his training as a plant breeder and his early career work as a biochemist to improving... View Details
Keywords: Genomics; Gene Sequencing; Life Sciences; Plant Breeding; Human Genome Program; Beijing Genomics Institute; BGI; Rice Genome; Technological Innovation; Innovation Strategy; Research; Research and Development; Science; Genetics; Science-Based Business; Strategy; Commercialization; Corporate Strategy; Information Technology; Applications and Software; Agriculture and Agribusiness Industry; Biotechnology Industry; Food and Beverage Industry; China; United States
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  • 2003
  • Case

Corning Microarray Technologies

By: Vijay Govindarajan, Chris Trimble and Gautam Bellur
In mid-2000, the scientific community reached a momentous milestone—the complete mapping of the human genome. Researchers in the field of genomics were anxious to dig into a tremendous array of newly possible scientific inquiries, and needed efficient experimental... View Details
Keywords: Expansion; Genetics; Manufacturing Industry; Industrial Products Industry
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  • Article

Beyond Magic Bullets: True Innovation in Health Care

By: Vaibhav A. Narayan, Marco Mohwinckel, Gary Pisano, Michael Yang and Husseini Manji
The molecular medicine revolution—based on advances in fields such as genomics and network modeling in the decade since the human genome sequence was completed—has changed the way we think about, study, and approach the development of novel therapies. However, these... View Details
Keywords: Integration; Business Model; Organizational Structure; Health Care and Treatment; Innovation and Invention; Pharmaceutical Industry
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  • October 2011
  • Case

Gene Sequencing: Staking a Position in an Expanding Industry

By: Richard G. Hamermesh, Mara Aspinall and Phillip Andrews
Towards the end of 2010, companies in the gene sequencing industry were pushing aggressive R&D programs to develop technologies and products in the race to sequence the entire human genome at a cost of $1,000. It remained to be seen when the "$1,000 genome" would... View Details
Keywords: Genetics; Business Growth and Maturation; Business Plan; Competition; Venture Capital; Biotechnology Industry
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  • 29 May 2001
  • Research & Ideas

Genomics: Can We Start Making Money Now?

Now that scientists have mapped the human gene, can drug makers map a road to unlimited riches? For John Lechleiter, Executive Vice President of Eli Lilly and Company's Pharmaceutical Products and Corporate Development, there remain more... View Details
Keywords: by Sean Silverthorne
  • 03 Dec 2001
  • Research & Ideas

Healthcare Conference Looks At Ailing Industry

proteins at work in the business of life. "The book of life" that made dramatic headlines last year—and was really a first draft of the human genome sequence—is destined to change and challenge... View Details
Keywords: by Martha Lagace; Health
  • 07 Aug 2000
  • Research & Ideas

The Business of Biotech

With the sequencing of the human genome running ahead of schedule, the American Stock Exchange's "BTK" biotech index registered an annual increase of 232 percent in February, prompting exuberant... View Details
Keywords: by Julia Hanna; Biotechnology; Health; Technology
  • 26 Jun 2000
  • Research & Ideas

Presentation Round-Up

their data for two years before publishing it. "Today," he said, "the standard is 24 hours to put information on the Web; that's the rule for participating in the Genome Project." (The U.S. Human View Details
Keywords: by Martha Lagace & Kenneth Liss; Technology; Communications; Telecommunications
  • 05 Jul 2017
  • What Do You Think?

Can Innovation Save Us From Ourselves?

Summing Up Do We Need to Give More Attention to the Dark Side of Innovation? Innovation may be able to help us deal with problems such as famine, pollution, and even global warming. But unless it can prove to be just as effective in combating destructive View Details
Keywords: by James Heskett; Technology
  • 20 May 2013
  • Op-Ed

Making America an Industrial Powerhouse Again

industries. Research funded by the Defense Advanced Research Projects Agency (DARPA) sowed the seeds for the internet and advanced computer graphics. And massive investments by the National Institutes of Health in biomedical research, including the View Details
Keywords: by Gary Pisano; Manufacturing
  • 02 Apr 2013
  • First Look

First Look: April 2

since the human genome sequence was completed-has changed the way we think about, study, and approach the development of novel therapies. However, these advances in knowledge have so far not been reflected... View Details
Keywords: Sean Silverthorne
  • 13 Jan 2009
  • First Look

First Look: January 13, 2009

structurally attractive for soft drink firms, and b) if so, how can Pepsi best "catch-up" with Coca-Cola in a given market. Purchase this case: http://harvardbusinessonline.hbsp.harvard.edu/ b01/en/common/item_detail.jhtml?id=709451 Diagnostic View Details
Keywords: Martha Lagace
  • 15 Jan 2018
  • Research & Ideas

A Better Business Model for Fighting Cancer

question—it’s clear.” Simply put, inefficiencies in the development of precision medicine can best be addressed by a business-analysis approach. With the mapping of the human genome completed 15 years ago,... View Details
Keywords: by Julia Hanna; Health; Pharmaceutical
  • 03 Mar 2015
  • First Look

First Look: March 3

generate large amounts of data, as it was capable of sequencing an entire human genome in less than eight hours. At this price, GenapSys' device would be attractive to customers that had been unable to... View Details
Keywords: Sean Silverthorne
  • 03 Jan 2017
  • First Look

January 3, 2017

November 28, 2016 Harvard Business Review One Obstacle to Curing Cancer: Patient Data Isn’t Shared By: Hamermesh, Richard G., and Kathy Giusti Abstract—Precision Medicine requires large datasets to identify the mutations that lead to various cancers. Currently, View Details
Keywords: Carmen Nobel
  • 19 May 2016
  • Research Event

Crowdsourcing, Patent Trolls, and Other Research Insights Highlighted at Harvard Business School Symposium

Lakhani said the question comes down to this: Do we have the right labor force? His research team recently held a three-weeklong contest that looked to improve the accuracy and processing speed of an algorithm designed to analyze genomic... View Details
Keywords: by Dina Gerdeman & Carmen Nobel
  • 10 Jan 2012
  • First Look

First Look: January 10

AndrewsHarvard Business School Case 812-004 Toward the end of 2010, companies in the gene sequencing industry were pushing aggressive R&D programs to develop technologies and products in the race to sequence the entire human View Details
Keywords: Sean Silverthorne

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