Publications

September 2012 (Revised September 2012)
Course Overview Note

Building Life Science Businesses Fall 2012: Course Outline and Syllabus

By: Richard G. Hamermesh and Richard G. Hamermesh

This Course Outline and Syllabus gives an overview of the Fall 2012 class Building Life Science Businesses View Details

Keywords: Healthcare Ventures; Entrepreneurial Management; Entrepreneurship; Entrepreneurs; Health Care and Treatment; Health Testing and Trials; Medical Specialties; Health Industry; Biotechnology Industry; Medical Devices and Supplies Industry; Asia; North America; Europe

2013
Article

Planning Prompts as a Means of Increasing Preventive Screening Rates

By: Katherine L Milkman, John Beshears, James J. Choi, David Laibson and Brigitte C. Madrian

Keywords: Reminder Systems; Communication; Economics; Behavioral; Primary Prevention; Colonoscopy; Memory; Behavior; Health Care and Treatment; Health Testing and Trials; Communication Strategy; Health Industry

15 Jan 2018
News

A Better Business Model for Fighting Cancer

Keywords: Scientific Research and Development Services

January 2018
Article

The Central and Unacknowledged Role of the U.S. Food and Drug Administration in the Design and Execution of Medical Device Pivotal Trials

By: Aaron V. Kaplan and Ariel D. Stern

The introduction of new medical devices has transformed cardiovascular care in recent decades. Devices, such as heart valves, pacemakers, stents, ventricular assist devices, and implantable defibrillators, have prolonged and improved the quality of life for millions of... View Details

Keywords: Health Testing and Trials; Business and Government Relations; Governing Rules, Regulations, and Reforms; Information Publishing; Medical Devices and Supplies Industry; United States

11 Nov 2015
Working Paper Summaries

Public R&D Investments and Private-sector Patenting: Evidence from NIH Funding Rules

Keywords: by Danielle Li; Health; Biotechnology; Pharmaceutical; Medical Devices & Supplies

January–February 2023
Article

Data-Driven COVID-19 Vaccine Development for Janssen

By: Dimitris Bertsimas, Michael Lingzhi Li, Xinggang Liu, Jennings Xu and Najat Khan

The COVID-19 pandemic has spurred extensive vaccine research worldwide. One crucial part of vaccine development is the phase III clinical trial that assesses the vaccine for safety and efficacy in the prevention of COVID-19. In this work, we enumerate the first... View Details

Keywords: COVID-19; Health Testing and Trials; Forecasting and Prediction; AI and Machine Learning; Research; Pharmaceutical Industry

May 2023 (Revised June 2023)
Supplement

Novartis (C): Reimagining Medicine

By: Ramon Casadesus-Masanell, Claudio Feser, Karolin Frankenberger and David Redaschi

This case unfolds around the first-ever approved personalized cancer treatment, how Novartis wrapped it into a new business model design, and how Novartis scaled it. Novartis — one of the largest pharmaceutical companies in the world — is, among other ventures,... View Details

Keywords: Health Testing and Trials; Health Care and Treatment; Business Model; Problems and Challenges; Pharmaceutical Industry; Switzerland

2010
Chapter

From Visible Harm to Relative Risk: Centralization and Fragmentation of Pharmacovigilance

By: Arthur A. Daemmrich

Adverse drug reactions pose distinct but potentially catastrophic risks to patients, physicians, pharmaceutical firms, and regulators. Between the early 1960s and the present, national systems were built to collect, standardize, and respond to individual reports of... View Details

Keywords: Governing Rules, Regulations, and Reforms; Health Testing and Trials; Business and Government Relations; Risk and Uncertainty; Safety; Pharmaceutical Industry; United States

15 Sep 2003
Research & Ideas

The Lessons of New-Market Disruption

Teradyne: Testing Opportunity In 1994, Teradyne, a leading provider of machines that test the quality of microprocessors and other integrated circuits as they come off the assembly line, saw an opportunity... View Details

Keywords: by Clark Gilbert; Technology

Mar 2012
Article

Rethinking School

Economists have found that the higher a country's academic test scores, the faster its GDP grows. That puts the United States' perennially mediocre test scores in a particularly ominous light. Progress is... View Details

23 Jul 2008
Sharpening Your Skills

Sharpening Your Skills: Balanced Scorecard in Action

reduce the gap between strategy and execution? Does the BSC work in testing strategy? How Can The Balanced Scorecard Improve Corporate Governance? Working Paper: Improving Corporate Governance with the Balanced Scorecard The authors... View Details

September 2020
Case

Minerva 2020: Clinical Trials

By: John R. Wells and Benjamin Weinstock

In March 2020, Dr. Cynthia Bamdad, founder and CEO of Minerva Biotechnologies Inc. (Minerva), was reviewing the first results of human clinical trials for the company’s novel CAR-T drug therapeutic, one of the first ever to target solid cancer tumors. The results... View Details

Keywords: Biotechnology; Strategic Decision Making; Entrepreneurship; Health Testing and Trials; Decision Choices and Conditions; Strategy

Educators

18 Feb 2016
News

Challenge Aims to Speed Drug Trials Process

The HBS Health Care Initiative is seeking innovative ideas from the science, patient, business, and medical communities on how to transform trials for precision medicine. Through the HBS Precision Trials Challenge, it aims to bring diagnostics and therapies to market... View Details

09 Oct 2019
News

Building a Tradition of Giving

Barry Sternlicht (MBA 1986) Barry Sternlicht (MBA 1986) Over time and experience, Barry Sternlicht (MBA 1986) has developed an approach to philanthropy that bridges both his professional and personal lives, delivering impact to both. He first started focusing on giving... View Details

12 Aug 2019
Working Paper Summaries

Case Histories of Significant Medical Advances

Keywords: by Amar Bhidé, Srikant M. Datar, and Katherine Stebbins

Article

Use of Connected Digital Products in Clinical Research Following the COVID-19 Pandemic: A Comprehensive Analysis of Clinical Trials

By: Caroline Marra, William J. Gordon and Ariel Dora Stern

Objectives: In an effort to mitigate COVID-19 related challenges for clinical research, the U.S. Food and Drug Administration (FDA) issued new guidance for the conduct of ‘virtual’ clinical trials in late March 2020. This study documents trends in the use of... View Details

Keywords: Connected Digital Products; Telehealth; Remote Monitoring; Health Testing and Trials; Research; Governing Rules, Regulations, and Reforms; Information Technology

Read Now

March 2015 (Revised January 2024)
Case

CV Ingenuity (A): How to Evaluate the Commercial Viability of New Health Care Technologies

By: Regina E. Herzlinger and Andrew Otazo

Duke Rohlen (HBS MBA ’01) hoped to win over a prominent venture capital investor for Series B financing of his firm CVI that was creating a drug-eluting balloon (DES) to treat peripheral arterial disease. As a second-mover, Duke felt he was more likely to acquire... View Details

Educators