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  • All HBS Web  (687)
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  • 2021
  • Book

Lead and Disrupt: How to Solve the Innovator's Dilemma

By: Charles A. O'Reilly III and Michael Tushman
Why do successful firms find it so difficult to adapt in the face of change—to innovate? In the past ten years, the importance of this question has increased as more industries and firms confront disruptive change. The pandemic has accelerated this crisis, collapsing... View Details
Keywords: Organization Change And Adaptation; Organizational Change and Adaptation; Disruptive Innovation; Innovation and Management; Leading Change
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O'Reilly, Charles A., III, and Michael Tushman. Lead and Disrupt: How to Solve the Innovator's Dilemma. Second ed. Stanford, CA: Stanford Business Books, 2021.
  • 27 May 2009
  • First Look

First Look: May 27, 2009

remain about Marquee's staying power, rising costs, and increased competition. When is the right time for Tepperberg to pull the plug on Marquee? Purchase this case: http://hbsp.harvard.edu/b01/en/common/item_detail.jhtml?id=509019 Merck: Global Health and Access to... View Details
Keywords: Martha Lagace
  • 15 Mar 2024
  • HBS Case

Let's Talk: Why It's Time to Stop Avoiding Taboo Topics at Work

for Ozempic, the costly medicine for diabetes that is often used off-label for weight loss. “We don’t have 1,000 people with diabetes all of a sudden, but we can’t go have that conversation with them because you’re not allowed to talk... View Details
Keywords: by Avery Forman
  • Research Summary

AIDS in Africa: Life, Death and Property Rights

By: Debora L. Spar
In the final years of the twentieth century, the world was hit by a plague of epidemic proportions--the plague of AIDS, a life-threatening disease that remained stubbornly immune to any cure or vaccine. In the developed nations of the West, AIDS was slowly brought... View Details
  • Article

A Feasibility Study Using Time-driven Activity-based Costing as a Management Tool for Provider Cost Estimation: Lessons from the National TB Control Program in Zimbabwe in 2018

By: J. Chirenda, B. Nhlema Simwaka, C. Sandy, K. Bodnar, S. Corbin, P. Desai, T. Mapako, S. Shamu, C. Timire, E. Antonio, A. Makone, A. Birikorang, T. Mapuranga, M. Ngwenya, T. Masunda, M. Dube, E. Wandwalo, L. Morrison and R. S. Kaplan
Background: This study used process maps and time-driven activity-based costing to document TB service delivery processes. The analysis identified the resources required to sustain TB services in Zimbabwe, as well as several opportunities for more effective and... View Details
Keywords: Time-Driven Activity-Based Costing; Provider Cost; Health Care and Treatment; Cost Management; Activity Based Costing and Management; Zimbabwe
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Chirenda, J., B. Nhlema Simwaka, C. Sandy, K. Bodnar, S. Corbin, P. Desai, T. Mapako, S. Shamu, C. Timire, E. Antonio, A. Makone, A. Birikorang, T. Mapuranga, M. Ngwenya, T. Masunda, M. Dube, E. Wandwalo, L. Morrison, and R. S. Kaplan. "A Feasibility Study Using Time-driven Activity-based Costing as a Management Tool for Provider Cost Estimation: Lessons from the National TB Control Program in Zimbabwe in 2018." BMC Health Services Research 21, no. 242 (2021).
  • March 1, 2022
  • Article

Widespread Use of National Academies Consensus Reports by the American Public

By: Diana Hicks, Matteo Zullo, Ameet Doshi and Omar Isaac Asensio
In seeking to understand how to protect the public information sphere from corruption, researchers understandably focus on dysfunction. However, parts of the public information ecosystem function very well, and understanding this as well will help in protecting and... View Details
Keywords: Reports; Surveys; AI and Machine Learning; Knowledge Dissemination; Knowledge Use and Leverage
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Hicks, Diana, Matteo Zullo, Ameet Doshi, and Omar Isaac Asensio. "Widespread Use of National Academies Consensus Reports by the American Public." e2107760119. Proceedings of the National Academy of Sciences 119, no. 9 (March 1, 2022).
  • 2021
  • Working Paper

The Health Costs of Cost-Sharing

By: Amitabh Chandra, Evan Flack and Ziad Obermeyer
We use the design of Medicare’s prescription drug benefit program to demonstrate three facts about the health consequences of cost-sharing. First, we show that an as-if-random increase of 33.6% in out-of-pocket price (11.0 percentage points (p.p.) change in... View Details
Keywords: Cost-sharing; Impact; Health Care and Treatment; Insurance; Health; Consumer Behavior
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Chandra, Amitabh, Evan Flack, and Ziad Obermeyer. "The Health Costs of Cost-Sharing." NBER Working Paper Series, No. 28439, February 2021.
  • 21 Apr 2009
  • First Look

First Look: April 21, 2009

  Working PapersHow Firms Respond to Being Rated (revised) Authors:Aaron K. Chatterji and Michael W. Toffel Abstract While many rating systems seek to help buyers overcome information asymmetries when making purchasing decisions, we investigate how these ratings also... View Details
Keywords: Martha Lagace
  • 25 Jan 2024
  • Research & Ideas

Being a Team Player: Why College Athletes Succeed in Business

degrees. 12 percent had law degrees. 5 percent were physicians. “Going into business, you're generally working with others as opposed to, say, a field like medicine or a field like academics; those tend to be a little more solitary,”... View Details
Keywords: by Rachel Layne
  • July–August 2018
  • Article

Using Time-Driven Activity-Based Costing to Model the Costs of Various Process-Improvement Strategies in Acute Pain Management

By: Keyuri Popat, Kelly Ann Gracia, Alexis B. Guzman and Thomas W. Feeley
Pain control for patients undergoing thoracic surgery is essential for their comfort and for improving their ability to function after surgery, but it can significantly increase costs. Here, we demonstrate how time-driven activity-based costing (TDABC) can be used to... View Details
Keywords: Time-Driven Activity-Based Costing; Health Care and Treatment; Cost Management; Performance Improvement
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Popat, Keyuri, Kelly Ann Gracia, Alexis B. Guzman, and Thomas W. Feeley. "Using Time-Driven Activity-Based Costing to Model the Costs of Various Process-Improvement Strategies in Acute Pain Management." Journal of Healthcare Management 63, no. 4 (July–August 2018): e76–e85.
  • June 2008 (Revised July 2008)
  • Case

The Miami Project to Cure Paralysis

By: Robert Steven Kaplan, Christopher Marquis and Brent Kazan
Marc Buoniconti is the co-founder of the Miami Project to Cure Paralysis, a nonprofit medical research organization. The project was founded in 1985 by Marc and his father Nick, a former Hall of Fame football player, when Marc suffered a spinal cord injury. In 2007,... View Details
Keywords: Investment; Philanthropy and Charitable Giving; Health Testing and Trials; Leadership; Growth and Development Strategy; Mission and Purpose; Research and Development; Nonprofit Organizations; Health Industry; Miami
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Kaplan, Robert Steven, Christopher Marquis, and Brent Kazan. "The Miami Project to Cure Paralysis." Harvard Business School Case 408-003, June 2008. (Revised July 2008.)
  • March 2014
  • Article

Delivering High-quality Cancer Care: The Critical Role of Quality Measurement

By: Tracy Spinks, Patricia Ganz, George Sledge, Laura Levit, James Hayman, Timothy Eberlein and Thomas W. Feeley

In 1999, the Institute of Medicine (IOM) published Ensuring Quality Cancer Care, an influential report that described an ideal cancer care system and issued ten recommendations to address pervasive gaps in the understanding and delivery of quality cancer... View Details

Keywords: Health Care Quality; Health Care and Treatment; Quality; Measurement and Metrics; Health Industry; North America
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Spinks, Tracy, Patricia Ganz, George Sledge, Laura Levit, James Hayman, Timothy Eberlein, and Thomas W. Feeley. "Delivering High-quality Cancer Care: The Critical Role of Quality Measurement." Healthcare: The Journal of Delivery Science and Innovation 2, no. 1 (March 2014): 53–62. (PMCID: PMC4021589.)
  • April 2024 (Revised November 2024)
  • Case

Moderna: Pioneering a People Platform to Accelerate Science Innovation

By: Tatiana Sandino, Emil Dy and Samuel Grad
Moderna was founded in 2010 to explore how messenger ribonucleic acid (mRNA) could be used to create breakthrough medicines by encoding instructions for the body to create antibodies. When Stéphane Bancel (HBS 2000) took over in 2011, he bet on the potential of this... View Details
Keywords: Disruptive Innovation; Talent and Talent Management; Selection and Staffing; AI and Machine Learning; Digital Strategy; Innovation and Management; Leadership Development; Management Practices and Processes; Management Systems; Organizational Culture; Performance Evaluation; Alignment; Employee Relationship Management; Science-Based Business; Expansion; Pharmaceutical Industry; Biotechnology Industry; United States
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Sandino, Tatiana, Emil Dy, and Samuel Grad. "Moderna: Pioneering a People Platform to Accelerate Science Innovation." Harvard Business School Case 124-091, April 2024. (Revised November 2024.)
  • October 2021 (Revised January 2022)
  • Supplement

Michael Ku and Global Clinical Supply at Pfizer Inc.: Bringing Hope to Patients (C)

By: Linda A. Hill and Emily Tedards
This case is the third installment in a series about the 10-year cultural and digital transformation of Pfizer’s Global Clinical Supply organization. In 2011, Michael Ku became Pfizer’s Vice President of Global Clinical Supply (GCS) after the company had undergone... View Details
Keywords: Clinical Supply Chain; COVID-19; Vaccine; Agile; Innovation and Invention; Change Management; Organizational Culture; Transformation; Leadership; Corporate Strategy; Health Pandemics; Crisis Management; Mission and Purpose; Health Care and Treatment; Supply Chain Management; Digital Transformation
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Hill, Linda A., and Emily Tedards. "Michael Ku and Global Clinical Supply at Pfizer Inc.: Bringing Hope to Patients (C)." Harvard Business School Supplement 422-041, October 2021. (Revised January 2022.)
  • May 15, 2012
  • Article

Ensuring Quality Cancer Care: A Follow-Up Review of the Institute of Medicine’s 10 Recommendations for Improving the Quality of Cancer Care in America

By: Tracy E. Spinks, Heidi W. Albright, Thomas W. Feeley, Ron Walters, Thomas W. Burke, Thomas Aloia, Eduardo Bruera, Aman Buzdar, Lewis Foxhall, David Hui, Barbara Summers, Alma Rodriguez, Raymond DuBois and Kenneth I. Shine
Responding to growing concerns regarding the safety, quality, and efficacy of cancer care in the United States, the Institute of Medicine (IOM) of the National Academy of Sciences commissioned a comprehensive review of cancer care delivery in the US health care system... View Details
Keywords: Cancer; Quality; Cancer Care In The U.S.; Quality Improvement; Health Care and Treatment; Health Industry; North and Central America
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Spinks, Tracy E., Heidi W. Albright, Thomas W. Feeley, Ron Walters, Thomas W. Burke, Thomas Aloia, Eduardo Bruera, Aman Buzdar, Lewis Foxhall, David Hui, Barbara Summers, Alma Rodriguez, Raymond DuBois, and Kenneth I. Shine. "Ensuring Quality Cancer Care: A Follow-Up Review of the Institute of Medicine’s 10 Recommendations for Improving the Quality of Cancer Care in America." Cancer 118, no. 10 (May 15, 2012): 2571–2582.
  • September 2023
  • Teaching Note

Roche: ESG and Access to Healthcare

By: George Serafeim
Teaching Note for HBS Case No. 123-075. In May 2022, Roche Group, one of the largest healthcare companies in the world, hosted its first ESG investor event focused exclusively on its efforts to impact access to healthcare. While Roche had recently set an ambitious goal... View Details
Keywords: ESG; Access To Care; Healthcare; Healthcare Access; Innovation; Social Impact; Affordable; Health Care and Treatment; Innovation and Invention; Product Development; Resource Allocation; Corporate Social Responsibility and Impact; Health Industry
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Serafeim, George. "Roche: ESG and Access to Healthcare." Harvard Business School Teaching Note 124-028, September 2023.
  • 19 Dec 2017
  • First Look

New Research and Ideas, December 19, 2017

Abstract—No abstract available. Publisher's link: https://www.hbs.edu/faculty/Pages/item.aspx?num=53633 Characterizing the Drug Development Pipeline for Precision Medicines By: Chandra, Amitabh, Craig Garthwaite, and Ariel Dora Stern... View Details
Keywords: Carmen Nobel
  • January–February 2023
  • Article

Data-Driven COVID-19 Vaccine Development for Janssen

By: Dimitris Bertsimas, Michael Lingzhi Li, Xinggang Liu, Jennings Xu and Najat Khan
The COVID-19 pandemic has spurred extensive vaccine research worldwide. One crucial part of vaccine development is the phase III clinical trial that assesses the vaccine for safety and efficacy in the prevention of COVID-19. In this work, we enumerate the first... View Details
Keywords: COVID-19; Health Testing and Trials; Forecasting and Prediction; AI and Machine Learning; Research; Pharmaceutical Industry
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Bertsimas, Dimitris, Michael Lingzhi Li, Xinggang Liu, Jennings Xu, and Najat Khan. "Data-Driven COVID-19 Vaccine Development for Janssen." INFORMS Journal on Applied Analytics 53, no. 1 (January–February 2023): 70–84.
  • May 2021
  • Article

Choice Architecture in Physician–patient Communication: A Mixed-methods Assessment of Physicians' Competency

By: J. Hart, K. Yadav, S. Szymanski, A. Summer, A. Tannenbaum, J. Zlatev, D. Daniels and S.D. Halpern
Background: Clinicians’ use of choice architecture, or how they present options, systematically influences the choices made by patients and their surrogate decision makers. However, clinicians may incompletely understand this influence.... View Details
Keywords: Choice Architecture; Health Care and Treatment; Interpersonal Communication; Decision Choices and Conditions; Competency and Skills
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Hart, J., K. Yadav, S. Szymanski, A. Summer, A. Tannenbaum, J. Zlatev, D. Daniels, and S.D. Halpern. "Choice Architecture in Physician–patient Communication: A Mixed-methods Assessment of Physicians' Competency." BMJ Quality & Safety 30, no. 5 (May 2021).
  • 25 Jul 2023
  • Research & Ideas

Could a Business Model Help Big Pharma Save Lives and Profit?

by harnessing a new business model. The bold approach worked. Gilead, one of the world’s leading antiviral makers, would sell its branded Hepatitis C medicines while offering local manufacturers voluntary licenses to produce generics,... View Details
Keywords: by Esther Schrader; Pharmaceutical; Health
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