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September 2013 (Revised August 2015)
Background Note

Leadership and Teaming

By: Ethan Bernstein

Small differences in the leadership of teams can have large consequences for the success of their efforts. Many initiatives fail not because of a fatal error in judgment or insufficient ideas, knowledge, motivation, or capabilities to deliver a solution. They fail... View Details

Keywords: Teams; Teaming; Leadership And Managing People; Leadership; Team Effectiveness; Team Performance; Team Design; Team Leadership; Teamwork; Team Process; Team Function; Team Launch; 60/30/10 Rule; Team Boundary; Distribution Of Leadership Authority; Self-Managed Teams; Virtual Teams; Unbounded Teams; Acts Of Leadership; Execution Teams; Decision Making Teams; Creativity Teams; Team Size; Task Design; Team Timeline; Team Roles; Team Representation; Diversity; Team Familiarity; Collective Intelligence; Team Stages Of Development; Team Coaching; Performance Pressure; X-Teams; Team Focus; Interaction; Management Teams; Managerial Roles; Management Systems; Management Style; Management Skills; Management Practices and Processes; Organizational Design; Organizational Structure; Performance Effectiveness; Performance Efficiency; Performance Productivity; Groups and Teams; Networks; Social Psychology; Behavior; Conflict and Resolution; Creativity; Social and Collaborative Networks; Satisfaction; Prejudice and Bias; Power and Influence; Personal Characteristics; Familiarity; Cognition and Thinking; Attitudes; Projects; Organizational Culture; Organizational Change and Adaptation; Leadership Development; Leadership Style; Leading Change; Knowledge Use and Leverage; Knowledge Sharing; Collaborative Innovation and Invention; Innovation and Management; Innovation Leadership; Design; Interpersonal Communication; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Accommodations Industry; Asia; North and Central America; South America; Atlantic Ocean; Central Asia; Europe; Latin America; Middle East; Oceania; West Indies

21 Apr 2009
First Look

First Look: April 21, 2009

institutional theory, and economic theory. Download the paper: http://www.hbs.edu/research/pdf/08-025.pdf Broadening Focus: Spillovers and the Benefits of Specialization in the Hospital Industry Authors:Jonathan R. Clark and Robert S.... View Details

Keywords: Martha Lagace

January 2001
Case

Abgenix and the XenoMouse

By: Robert J. Dolan

Abgenix has a unique method for generating antibodies useful in treating a number of diseases, including cancer. In early 2000, the company's cancer has performed very well in animal testing and is moving to early stage human testing. Abgenix must decide whether to... View Details

Keywords: Product Development; Marketing Strategy; Health Testing and Trials; Risk and Uncertainty; Technological Innovation; Innovation Strategy; Science-Based Business; Biotechnology Industry

October 2007 (Revised July 2013)
Case

Vertex Pharmaceuticals and the Cystic Fibrosis Foundation: Venture Philanthropy Funding for Biotech

By: Robert F. Higgins, Sophie LaMontagne and Brent Kazan

In 2001, Vertex Pharmaceuticals Incorporated acquired the San Diego-based biotech company, Aurora Biosciences. The combination of Vertex's and Aurora's technologies would improve the flow of novel drug candidates into development. However, several questions related to... View Details

Keywords: Philanthropy; Philanthropy Funding; Innovation; Funding Model; Venture Capital; Partners and Partnerships; Financing and Loans; Investment Funds; Acquisition; Philanthropy and Charitable Giving; Biotechnology Industry; Biotechnology Industry; San Diego

April 2023
Case

Drive Capital: A New Road for Venture

By: Paul A. Gompers and Alicia Dadlani

Founded by two former Sequoia Capital partners, Columbus-Ohio-based Drive Capital’s mission was to build a world-class venture capital firm in the middle of the U.S., an area historically overlooked by VCs. Drive faced early challenges of attracting investors, sourcing... View Details

Keywords: Venture Capital; Business Startups; Entrepreneurship; Investment; Business Strategy; Financial Services Industry; Financial Services Industry; United States; Ohio

December 2005 (Revised August 2006)
Case

Amgen Inc.'s Epogen--Commercializing the First Biotech Blockbuster Drug

By: Felix Oberholzer-Gee and Dennis A. Yao

Amgen Inc.'s Epogen was the first biotech blockbuster drug. Epogen helped prevent anemia, a condition that leads to severe fatigue, increased risk of cardiovascular disease, and even death. At the time, the market for Epogen, which included dialysis patients and... View Details

Keywords: Health Care and Treatment; Strategic Planning; Competition; Patents; Innovation and Invention; Pharmaceutical Industry; Pharmaceutical Industry; United States

November 2020
Case

Valuing Celgene's CVR

By: Benjamin C. Esty and Daniel Fisher

When Bristol-Myers Squibb (BMS) acquired Celgene Corporation in November 2019, Celgene shareholders received cash, BMS stock, and a contingent value right (CVRs) that would pay $9 if the U.S. Food and Drug Administration (FDA) approved three of Celgene’s late stage... View Details

Keywords: Mergers and Acquisitions; Value; Valuation; Judgments; Decision Making; Cash Flow; Financial Instruments; Cognition and Thinking; Pharmaceutical Industry; Pharmaceutical Industry; United States

January 2014 (Revised June 2015)
Case

Amgen Inc.: Pursuing Innovation and Imitation? (A)

By: Ian W. Mackenzie

Set in 2009, the (A) case explores whether Amgen, a leading innovator of biotech-based drugs, should enter the emerging business of biosimilars (BS), which are essentially 'me-too' products. There appear to be sound reasons to explore this related diversification:... View Details

Keywords: Corporate Strategy; Pharmaceutical Industry; Pharmaceutical Industry; United States

October 2004 (Revised March 2005)
Case

Langer Lab, The: Commercializing Science

By: H. Kent Bowen, Alex Kazaks, Ayr Muir-Harmony and Bryce LaPierre

Professor Robert Langer's laboratory at MIT is the source of an unusually large number of published papers, patents, and technology licenses to start-up and established companies in the biomedical industry. Explores Langer's leadership and other factors that create a... View Details

Keywords: Entrepreneurship; Technological Innovation; Business Startups; Research and Development; Patents; Innovation Leadership; Science-Based Business; Commercialization; Biotechnology Industry; Biotechnology Industry

January 2021 (Revised June 2023)
Case

Biobot Analytics

By: Raymond Kluender, Joshua Krieger and Mitchell Weiss

In 2017, Newsha Ghaeli and Mariana Matus were deciding whether to leave their labs at the Massachusetts Institute of Technology, put other job opportunities aside, and dive full-time into founding a wastewater analysis start-up, Biobot. Ghaeli, an architect, and Matus,... View Details

Keywords: Entrepreneurship; Information Technology; City; Analytics and Data Science; Personal Development and Career; Technology Industry; Technology Industry; Technology Industry; Technology Industry; Technology Industry; Technology Industry; United States; Kuwait; Korean Peninsula

December 2001 (Revised June 2002)
Case

Monsanto: Technology Cooperation and Small Holder Farmer Projects

By: James E. Austin, Diana Barrett and Stephanie Oestreich

As the leading plant technology company in the global food system, how can Monsanto share this technology with small-sale producers and not-for-profit researchers and institutions? View Details

Keywords: Food; Globalized Markets and Industries; Corporate Social Responsibility and Impact; Nonprofit Organizations; Society; Technology; Biotechnology Industry

15 May 2007
First Look

First Look: May 15, 2007

the industry and dominated it for nearly 20 years, the well-respected company faces a bevy of new entrants from the banking, mortgage finance, and insurance sectors. In particular, management must decide how to respond to an aggressive... View Details

Keywords: Martha Lagace

12 Sep 2006
First Look

First Look: September 12, 2006

Periodical:Journal of Law, Economics and Organization (forthcoming) Abstract Strategic alliances are commonplace in the biotechnology sector. We posit that the stock of prior alliances between participants in the biotech View Details

Keywords: Sean Silverthorne

27 Aug 2008
Research & Ideas

Creating Leaders for Science-Based Businesses

facing leaders in those businesses." Another industry veteran, Professor of Management Practice Vicki Sato, led a discussion on "Emerging Models of University Research," with cases that looked at the Harvard-affiliated... View Details

Keywords: by Garry Emmons; Biotechnology; Biotechnology

03 Feb 2009
First Look

First Look: February 3, 2009

Contractibility and Contract Design in Strategic Alliances Authors: Josh Lerner and Ulrike Malmendier Publication: American Economic Review (forthcoming) Abstract We analyze how variations in contractibility affect the design of contracts in the context of View Details

Keywords: Martha Lagace

May 1999
Teaching Note

Genset Initial Public Offering (A) & (B) TN

By: Paul A. Gompers

Teaching Note for (9-297-096) and (9-297-097). View Details

Keywords: Biotechnology Industry; United States; France

December 2023 (Revised March 2024)
Case

Manufacturing Moderna's Future

By: Satish Tadikonda and William Marks

In 2019, Moderna faced long odds of survival having failed to develop a successful clinical program out of the vast platform technology they had built around mRNA. Nearly overnight, the company skyrocketed to success with a vaccine for COVID-19, leading to an extremely... View Details

Keywords: Health Pandemics; Health Testing and Trials; Technological Innovation; Product Development; Production; Science-Based Business; Biotechnology Industry

January 2023
Case

Vertex and the Cure for Type 1 Diabetes

By: Amitabh Chandra, William J Anderson and Silvia Mare

Keywords: Biotechnology Industry

2016
Working Paper

Patent Publication and the Market for Ideas

By: Deepak Hegde and Hong Luo

In this paper, we study the effect of invention disclosure through patent publication on the market for ideas. We do so by analyzing the effects of the American Inventor's Protection Act of 1999 (AIPA)—which required US patent applications to be published 18 months... View Details

Keywords: Patents; Biotechnology Industry

January 2011 (Revised March 2011)
Case

Predictive Biosciences

By: Thomas R. Eisenmann, Jeffrey J. Bussgang and David Kiron

A small cancer diagnostics start-up is deciding whether to acquire a laboratory to make and sell its bladder cancer test or build its own manufacturing and sales team. View Details

Keywords: Mergers and Acquisitions; Factories, Labs, and Plants; Business Startups; Entrepreneurship; Health Testing and Trials; Growth and Development Strategy; Product Development; Biotechnology Industry

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