Publications

September 2019
Supplement

Adaptive Platform Trials: The Clinical Trial of the Future? (B)

By: Ariel D. Stern and Sarah Mehta

This case provides an update to the (A) case, which introduces students to adaptive platform trials, an ambitious, more efficient type of clinical trial that increases access to therapies. The (A) case centers on Dr. Brian Alexander’s efforts to launch an adaptive... View Details

Keywords: Clinical Trials; Drug Trials; Drug Testing; Cancer Trials; Glioblastoma; Platform Trials; Adaptive Trials; Adaptive Platform Trials; Health Testing and Trials; Health Care and Treatment; Financing and Loans; Business Strategy; Health Industry; United States

Working Paper

Rebates in the Pharmaceutical Industry: Evidence from Medicines Sold in Retail Pharmacies in the U.S.

By: Pragya Kakani, Michael Chernew and Amitabh Chandra

Rising list prices are often used to illustrate the burden of prescription drug spending, but payers routinely negotiate rebates from manufacturers that generate differences between list and net prices. List prices are easily available and affect patient cost-sharing,... View Details

Keywords: Pharmaceuticals; Rebates; Health Care and Treatment; Markets; Price; Analysis; Pharmaceutical Industry

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13 Aug 2018
Research & Ideas

Women Heart Patients Have Better Survival Odds with Women Doctors

heart attack. Of those, between 1,500 to 3,000 fewer women may have died if their doctor had been female, Laura Huang, a study co-author and Harvard Business School associate professor, said in an interview. The research mirrors bias... View Details

Keywords: by Rachel Layne; Health

April 1991 (Revised April 1992)
Case

Hospital Sector in 1992

Examines the major issues facing the hospital sector in 1992. The environment surrounding the industry is one of great uncertainty and rapid change, and involves significant public policy questions. Describes recent trends, issues and new types of competitors that... View Details

Keywords: Risk and Uncertainty; Nonprofit Organizations; Competition; Health Care and Treatment; Policy; Change; Health Industry; United States

February 2000 (Revised April 2001)
Case

Boston Medical Group

By: Richard M.J. Bohmer and Bruce L. Hall

Describes the structure of a variable compensation plan for physicians implemented by a Massachusetts medical group practice. Examines issues such as balancing group and individual risk and selection of performance metrics (productivity and patient satisfaction). View Details

Keywords: Customer Satisfaction; Health Care and Treatment; Executive Compensation; Management Practices and Processes; Risk Management; Standards; Risk and Uncertainty; Health Industry

Article

A Collective Biological Processing Algorithm for EKG Signals

By: Mike Horia Teodorescu

We establish and explore an analogy between hunting by packs of agents and signal processing. We present a version of adaptive ‘Hunting Swarm’ algorithm (HSA), apply it to EKG signals, and investigate the influence of the model parameters on the filtering of stationary... View Details

Keywords: Artificial Intelligence; Technological Innovation; Health Care and Treatment

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May 2007 (Revised September 2007)
Case

Cleveland Clinic

By: Frances X. Frei, Amy C. Edmondson, Christine van Keuren and Eliot Sherman

Cleveland Clinic is consistently ranked among the nation's most eminent hospitals, and for decades has been a leader in pioneering cardiac care. This case evaluates the methods, processes, and personnel that the hospital has cultivated over the years in order to... View Details

Keywords: Health Care and Treatment; Medical Specialties; Innovation and Invention; Service Delivery; Expansion; Health Industry; Cleveland

Article

Hospital Disclosure Practices: Results of a National Survey

By: Rae M. Lamb, David M. Studdert, Richard M.J. Bohmer, Donald M. Berwick and Troyan A. Brennan

Keywords: Health Care and Treatment; Practice; Health Industry

August 2017
Case

Infection Control at Massachusetts General Hospital (Abridged)

By: Robert S. Huckman and Nikolaos Trichakis

The case explores the challenges facing Massachusetts General Hospital concerning the adoption of a new infection control policy, which promises to improve operational performance, patient safety, and profitability. The new policy requires coordination between... View Details

Keywords: Safety; Organizational Change and Adaptation; Integration; Health Care and Treatment; Policy; Health Industry; Boston

May 2017
Supplement

Boston Children's Hospital Process Map Video

By: Robert S. Kaplan and Mary Witkowski

The 13 minute video simulates a discussion among orthopedic surgeons and cast room technicians about the processes and resources used when applying long leg casts for patients. The video should be used when teaching Boston Children’s Hospital (Abridged) case, #914-407,... View Details

Keywords: Activity Based Costing; Healthcare Costing; Process Maps; Activity Based Costing and Management; Health Care and Treatment

November 2009 (Revised December 2009)
Case

GTC Biotherapeutics: Developing Medicines in the Milk of Goats

By: Ray A. Goldberg and Sarah Morton

GTC is the first company in the animal world to receive FDA approval of a transgenic pharmaceutical. What are the implications for other firms in plants and animals and their opportunities to produce new medicines in an economical and safe fashion? View Details

Keywords: Health Care and Treatment; Animal-Based Agribusiness; Plant-Based Agribusiness; Science-Based Business; Medical Specialties; Product; Technological Innovation; Health Industry; Health Industry; United States

September 2022
Article

Giving a Buck or Making a Buck? Donations by Pharmaceutical Manufacturers to Independent Patient Assistance Charities

By: Leemore Dafny, Christopher Ody and Teresa Rokos

The federal Anti-Kickback Statute prohibits biopharmaceutical manufacturers from directly covering Medicare enrollees’ out-of-pocket spending for the drugs they manufacture, but manufacturers may donate to independent patient assistance charities and earmark donations... View Details

Keywords: Cost Sharing; Prescription Drugs; Drug Spending; Medicare; Dual Eligibility; Cost; Health Care and Treatment; Philanthropy and Charitable Giving; Pharmaceutical Industry

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September 1976 (Revised October 1991)
Case

Salem Hospital

By: Regina E. Herzlinger

Keywords: Health Care and Treatment; Health Industry

25 Jun 2013
First Look

First Look: June 25

Publications 2006 pub Leviathan Evolving: New Varieties of State Capitalism in Brazil and Beyond By: Musacchio, Aldo, and Sergio G. Lazzarini Abstract—In this book we describe the transformation of state... View Details

Keywords: Anna Secino

November 2012
Supplement

Amylin Pharmaceuticals (B)

By: Richard G. Hamermesh and Carin-Isabel Knoop

Amylin Pharmaceuticals brought two first-in-class diabetes drugs to market, Byetta and Symlin, in 2005, which were sold in over 80 countries with $650.7 million in sales by 2011. However, the company remained unprofitable as sales plateaued. The small pharmaceutical... View Details

Keywords: Pharmaceuticals; Bristol-Myers Squibb; Health Care and Treatment; Pharmaceutical Industry; United States

March 3, 2005
Article

Adopting New Technologies: Turf Battles in Coronary Revascularization

By: Robert S. Huckman and Gary P. Pisano

Keywords: Information Technology; Health Care and Treatment; Health Industry

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December 2006 (Revised August 2008)
Case

Pervasis Therapeutics, Inc.

By: Robert F. Higgins and Virginia Fuller

In May 2005, Steve Bollinger was about to become president and chief operating officer of Pervasis Therapeutics, a small cell therapy start-up in Cambridge, Mass. If proven successful, Pervasis' product, Vascugel, could change the way vascular disease is treated and... View Details

Keywords: Business Startups; Venture Capital; Financial Strategy; Governing Rules, Regulations, and Reforms; Health Care and Treatment; Health Testing and Trials; Health Industry; Cambridge