Publications

12 Oct 2006
First Look

First Look: October 12, 2006

prescriptions for companies, investors, and policymakers seeking ways to improve the industry's performance. According to Pisano, the biotech industry's problems stem from its special character as a science-based business. This character... View Details

Keywords: Sean Silverthorne

17 Feb 2010
First Look

First Look: Feb. 17

Working PapersThe Evolution of Science-Based Business: Innovating How We Innovate Author:Gary P. Pisano An abstract in unavailable at this time. Download the paper: http://www.hbs.edu/research/pdf/10-062.pdf PublicationsTargeted... View Details

Keywords: Martha Lagace

October 2019 (Revised November 2019)
Case

C16 Biosciences: Lab-Grown Palm Oil

By: Jeffrey J. Bussgang and Olivia Hull

Synthetic biology start-up C16 Biosciences wants to solve a big problem: replace palm oil, a major contributor to deforestation and climate change, with a lab-grown substitute. CEO Shara Ticku has ambitious plans to supply her lab-grown palm oil to food manufacturers,... View Details

Keywords: Science-Based Business; Environmental Sustainability; Social Entrepreneurship; Product Development; Product Positioning; Venture Capital; Strategy; Decision Making; Food and Beverage Industry; Consumer Products Industry

October 2019 (Revised December 2019)
Supplement

Extend Fertility: Conceiving the Market for Egg Preservation (B)

By: Debora L. Spar and Olivia Hull

Keywords: Strategy; Information Technology; Business Startups; Entrepreneurship; Innovation Strategy; Technological Innovation; Commercialization; Science-Based Business; Marketing Strategy; Business Plan; Product Marketing; Product Launch; Product Positioning; Mission and Purpose; Personal Development and Career; Social Issues; Integration; Health; Health Industry

July 2013 (Revised November 2021)
Module Note

Exploration vs. Exploitation

By: Willy Shih

This module note introduces James March's concept of exploration and exploitation, and the management challenge of balancing the allocation of resources to the two activities in the firm. The note also touches on the O'Reilly and Tushman paper on the ambidextrous... View Details

15 Oct 2013
First Look

First Look: October 15

designated partners within the larger fluid department. Our multi-method study reveals the design and benefit of minimal team structures (team scaffolds) in fluid work settings. Download working paper: http://ssrn.com/abstract=1987724 Cases & Course Materials... View Details

Keywords: Sean Silverthorne

2008
Chapter

The Evidence Does Not Speak for Itself: Expert Witnesses and the Organization of DNA-Typing Companies

By: Arthur A. Daemmrich

During the past 15 years, new biotechnology companies have promoted DNA typing as a sophisticated criminal and paternity identification technique. Private testing laboratories produce results that link individuals with crime scenes and fathers to their children.... View Details

Keywords: Governing Rules, Regulations, and Reforms; Courts and Trials; Organizational Structure; Practice; Genetics; Science-Based Business; Trust; Commercialization; Vertical Integration

November 2023 (Revised April 2024)
Case

BiomX: Bringing Phage Back to the Stage

By: Paul A. Gompers, Elie Ofek, Orna Dan and Emilie Billaud

In the spring of 2023, and following the favorable results of a trial involving its phage cocktail for treating lung infections among cystic fibrosis (CF) patients, the leadership of BiomX had several critical issues to wrestle with. First, given its precarious... View Details

Keywords: Working Capital; Financing and Loans; Health Testing and Trials; Product Development; Research and Development; Science-Based Business; Commercialization; Biotechnology Industry; Pharmaceutical Industry

August 2023 (Revised March 2024)
Case

Arla Foods: Data-Driven Decarbonization (A)

By: Michael Parzen, Michael W. Toffel, Susan Pinckney and Amram Migdal

The case describes Arla’s history, in particular its climate change mitigation efforts, and how it implemented a price incentive system to motivate individual farms to implement scope 1 greenhouse gas emissions mitigation measures and receive a higher milk price. The... View Details

July 1997 (Revised June 2001)
Case

H.E. Butt Grocery Company: A Leader in ECR Implementation (B) (Abridged)

By: Robert D. Austin and F. Warren McFarlan

H.E. Butt Grocery Co. led the grocery industry in adopting many innovations, including category management, electronic data interchange, and continuous replenishment. They have also moved aggressively and profitably into newer applications such as Scanner-based payment... View Details

Keywords: Information Management; Independent Innovation and Invention; Innovation and Invention; Business Organization; Risk and Uncertainty; Science-Based Business; Cross-Cultural and Cross-Border Issues; Management Analysis, Tools, and Techniques; Risk Management; Electronics Industry; Computer Industry

July 2011 (Revised January 2013)
Case

Digital Microscopy Is Making Me Crazy!

By: Willy Shih

For Carl Zeiss Microimaging, modular hardware and software enabled customers to tailor Zeiss's broad range of microscopy systems hardware and software to meet a wide range of needs from basic scientific research in the biological and medical sciences to clinical... View Details

Keywords: Information Infrastructure; Applications and Software; Corporate Strategy; Disruptive Innovation; Science-Based Business; Management Analysis, Tools, and Techniques; Business Conglomerates; Digital Platforms; Opportunities; Medical Devices and Supplies Industry; Computer Industry

August 2023 (Revised January 2024)
Supplement

Arla Foods: Data-Driven Decarbonization (A)

By: Michael Parzen, Michael W. Toffel, Amram Migdal and Susan Pinckney

Arla implemented a data-based price incentive system to measure, track, and influence climate friendly changes to reduce CO2 emissions across the world’s fourth largest dairy cooperative. View Details

Keywords: Dairy Industry; Business Earnings; Earnings Management; Environmental Accounting; Agribusiness; Animal-Based Agribusiness; Acquisition; Mergers and Acquisitions; Decision Making; Decisions; Voting; Environmental Management; Climate Change; Environmental Regulation; Environmental Sustainability; Green Technology; Pollution; Moral Sensibility; Values and Beliefs; Financial Strategy; Price; Profit; Revenue; Food; Geopolitical Units; Global Strategy; Ownership Type; Cooperative Ownership; Performance Efficiency; Performance Evaluation; Problems and Challenges; Natural Environment; Science-Based Business; Business Strategy; Commercialization; Cooperation; Corporate Strategy; Food and Beverage Industry; Agriculture and Agribusiness Industry; Europe; United Kingdom; European Union; Germany; Denmark; Sweden; Luxembourg; Belgium

February 2014
Case

BGI: Data-driven Research

By: Willy Shih and Sen Chai

BGI has the largest installed gene-sequencing capacity in the world, and to Zhang Gengyun, general manager of the Life Sciences Division, this represented an opportunity to apply his training as a plant breeder and his early career work as a biochemist to improving... View Details

Research Summary

Overview

By: Kyle R. Myers

Professor Myers studies the economics of what determines the rate and direction of innovation. He has examined the reallocation of scientists through the use of targeted research grants at the National Institutes of Health, and is working to further understand how... View Details

28 Feb 2019
Cold Call Podcast

Pursuing Precision Medicine at Intermountain Healthcare

Keywords: Re: Richard G. Hamermesh; Health; Biotechnology; Pharmaceutical

August 1991 (Revised March 1993)
Case

Champion International Corp.: Timber, Trade, and the Northern Spotted Owl

By: Forest L. Reinhardt

Champion's forest products division owns timberlands, sawmills, and plywood mills in the Pacific Northwest. The listing of the northern spotted owl as an endangered species, and restrictions on exports of logs from state-owned lands, have disrupted the stumpage, log... View Details

Keywords: Science-Based Business; Natural Environment; Product Marketing; Governing Rules, Regulations, and Reforms; Government and Politics; Environmental Sustainability; Corporate Strategy; Trade; Decisions; Management Teams; Forest Products Industry; North and Central America

November 2012
Case

CSIRO: The Light Metals Flagship Decision

By: Willy Shih, Margaret P. Pierson and Dawn Lau

This case explores the challenge of investing in basic research as a public good. CSIRO was Australia's leading science and research agency, and it was chartered to enhance national prosperity through R&D. Its Flagships program was designed to align research interests... View Details

17 Jul 2012
First Look

First Look: July 17

Science-Based Business (Abridged) Ananth Raman and Inga MaurerHarvard Business School Case 611-027 Ray Gilmartin faces a dilemma. His company's credibility has been damaged by... View Details

Keywords: Sean Silverthorne

February 2024 (Revised March 2024)
Teaching Note

X: The Foghorn Decision

By: Kyle Myers and Walter Frick

Teaching Note for HBS Case No. 618-060. View Details