Publications

January 2023
Case

Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery

By: Regina Herzlinger and Brian Walker

What should a successful executive (HBS Baker Scholar) assess as her next move as the CEO of a firm with a promising and yet uncertain new drug? Amy Burroughs’ mandate to successfully commercialize Cleave Therapeutics’ drug for a cancer with no current successful... View Details

Keywords: Product Development; Leadership; Health Testing and Trials; Research and Development; Risk and Uncertainty; Financial Condition; Partners and Partnerships; Pharmaceutical Industry

May 2023 (Revised June 2023)
Case

Novartis (A): Reimagining Medicine

By: Ramon Casadesus-Masanell, Claudio Feser, Karolin Frankenberger and David Redaschi

This case unfolds around the first-ever approved personalized cancer treatment, how Novartis wrapped it into a new business model design, and how Novartis scaled it. Novartis — one of the largest pharmaceutical companies in the world — is, among other ventures,... View Details

Keywords: Health Care and Treatment; Business Model; Leadership; Pharmaceutical Industry; Switzerland

May 2023 (Revised June 2023)
Supplement

Novartis (B): Reimagining Medicine

By: Ramon Casadesus-Masanell, Claudio Feser, Karolin Frankenberger and David Redaschi

This case unfolds around the first-ever approved personalized cancer treatment, how Novartis wrapped it into a new business model design, and how Novartis scaled it. Novartis — one of the largest pharmaceutical companies in the world — is, among other ventures,... View Details

Keywords: Health Care and Treatment; Business Model; Production; Business Strategy; Pharmaceutical Industry

2024
Working Paper

Gastrointestinal Endoscopy--Without Cutting In: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins

This case history describes how endoscopy transformed the diagnosis of ulcers, cancerous polyps, and other alimentary canal diseases and enabled “minimally invasive” surgeries to treat such diseases. Specifically, we chronicle how: 1) flexible glass fiber endoscopes... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

SSRN

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17 Dec 2007
Research & Ideas

The Rise of Medical Tourism

Patients with resources can easily go where care is provided. "Historically doctors moved from Africa and India to London and New York to provide care. Now we are basically flipping it around and... View Details

Keywords: by Martha Lagace; Health; Medical Devices & Supplies

05 Jun 2012
First Look

First Look: June 5

system in particular countries are instructive. It also contains exhibits that display comparative performance of the system in terms of cost and quality. It raises the question of how health View Details

Keywords: Sean Silverthorne

August 2020
Case

Sangu Delle

By: Leslie Perlow and Matthew Preble

By 2020, Sangu Delle (MBA 2016) has already made significant progress towards his life-long goal of solving Africa’s myriad and diverse challenges. At 33 years old, he is the founder and chairman of the for-profit Golden Palm Investments Corporation, CEO of Africa... View Details

Keywords: Impact; Impact Investing; Mental Health; Social Capitalism; Entrepreneurship; Investment; Health Care and Treatment; Personal Development and Career; Health Industry; Africa

March 2014
Teaching Note

Oral Rehydration Therapy

By: Nava Ashraf and Natalie Kindred

This Teaching Note accompanies the case "Oral Rehydration Therapy" (911-035). The case highlights the puzzlingly high rate of diarrhea-related child mortality in developing countries despite the existence of a simple, effective treatment: oral rehydration therapy... View Details

Keywords: Health Care and Treatment; Innovation Strategy; Problems and Challenges; Developing Countries and Economies; Technological Innovation; Distribution Channels; Emerging Markets; Consumer Behavior; Performance Consistency; Performance Evaluation; Health Industry; Africa; Asia

December 2010
Case

Oral Rehydration Therapy

By: Nava Ashraf and Claire Qureshi

This case highlights the puzzlingly high rate of diarrhea-related child mortality in developing countries despite the existence of a simple, effective treatment: oral rehydration therapy (ORT). ORT treated extreme dehydration caused by diarrhea, which was a leading... View Details

Keywords: Health Care and Treatment; Innovation Strategy; Problems and Challenges; Developing Countries and Economies; Technological Innovation; Distribution Channels; Emerging Markets; Consumer Behavior; Performance Consistency; Performance Evaluation; Health Industry; Africa; Asia

25 Apr 2000
Research & Ideas

Adjusting the Fit for Government

The role of government in Africa must be to establish an "investor friendly" environment, according to Obiageli Ezekwesili, a panelist at the Africa Business... View Details

Keywords: by Martha Lagace

27 Aug 2013
First Look

First Look: August 27

Factory Models for Cancer Care This case compares and contrasts four different models for delivering cancer care View Details

Keywords: Sean Silverthorne

18 Feb 2015
First Look

First Look: February 18

to deliver high-quality patient care. The orthopaedic surgeon must collaborate in a new way with fellow health-care professionals, providing care by following teaming protocols. Publisher's link:... View Details

Keywords: Sean Silverthorne

Research Summary

Health-care Applications

Active postmarketing drug surveillance. There is substantial interest within the U.S. health community and among health policymakers in developing a surveillance system that scans public health databases in order to proactively detect potential drug safety... View Details

September 2010 (Revised July 2021)
Case

Gone Rural

By: Andre F. Perold

Gone Rural employs 750 women in rural communities across Swaziland to produce handwoven baskets and other hand-crafted items. The women are mostly grandmothers caring for children orphaned as a result of the country's high AIDS-related death rate. The company has a... View Details

Keywords: Social Enterprise; Corporate Social Responsibility and Impact; Growth and Development; Buildings and Facilities; Business Growth and Maturation; Corporate Finance; Business and Shareholder Relations; Swaziland

August 2023
Case

Constellation Pharmaceuticals: Corporate Development at a Novel Therapeutic Company

By: Satish Tadikonda and Brad Prosek

Constellation Pharmaceuticals was a company focused on epigenetic therapies for cancer patients. Despite a promising start and an early deal with a leading biopharma company, the company weathered twin setbacks in the end of a major research collaboration and the... View Details

Keywords: Mergers and Acquisitions; Health Care and Treatment; Organizational Change and Adaptation; Research and Development; Business Strategy; Partners and Partnerships; Goals and Objectives; Pharmaceutical Industry; United States

January 2017 (Revised January 2019)
Case

Shisong Cardiac Center: Kumbo, Cameroon

By: Kevin Schulman and Nelly-Ange Konthcou

Shisong Cardiac Center in Kumbo, Cameroon, is a regional cardiac referral center in central Africa. As the continent transitions from communicable to non-communicable diseases, there is a critical shortage of surgical care required to treat these conditions. This case... View Details

Keywords: Finance; Operations; Health Care and Treatment; Health Industry; Africa

2022
Article

Improving Efficiency and Reducing Costs of MRI-Guided Prostate Brachytherapy Using Time-Driven Activity-Based Costing

By: Nikhil G. Thaker, Rajat J. Kudchadker, James R. Incalcaterra, Tharakeswara K. Bathala, Robert S. Kaplan, Ankit Agarwal, Deborah A. Kuban, Benjamin D. Frank, Prajnan Das, Thomas W. Feeley and Steven J. Frank

Integrated quality improvement (QI) and cost reduction strategies can help increase value in cancer care. We applied standard QI and TDABC methods to improve workflow efficiency and reduce costs for MRI-guided prostate brachytherapy. We constructed process maps,... View Details

Keywords: Brachytherapy; Quality Improvement; Prostate; Time-Driven Activity-Based Costing; Cost Accounting; Health Care and Treatment; Performance Efficiency; Health Industry

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Article

Use of Crowd Innovation to Develop an Artificial Intelligence-Based Solution for Radiation Therapy Targeting

By: Raymond H. Mak, Michael G. Endres, Jin Hyun Paik, Rinat A. Sergeev, Hugo Aerts, Christopher L. Williams, Karim R. Lakhani and Eva C. Guinan

Importance: Radiation therapy (RT) is a critical cancer treatment, but the existing radiation oncologist work force does not meet growing global demand. One key physician task in RT planning involves tumor segmentation for targeting, which requires substantial... View Details

Keywords: Crowdsourcing; AI Algorithms; Health Care and Treatment; Collaborative Innovation and Invention; AI and Machine Learning