Publications

2024
Working Paper

Tamoxifen—Reducing Breast Cancer Risks: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant Datar and Katherine Stebbins

We describe the development of tamoxifen, considered a “gold standard” treatment for millions of breast cancer patients. Specifically, we describe breast cancer treatments before tamoxifen’s development; the initial development of tamoxifen from 1960 to 1973;... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation and Invention; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Governing Rules, Regulations, and Reforms

2024
Working Paper

Laparoscopy—Minimally Invasive Surgery: Case Histories of Transformational Advances

By: Amar Bhidé, Caitlin N. Bowler and Srikant M. Datar

We describe how operations through laparoscopes – tubular instruments inserted into abdominal cavities – revolutionized gynecological and other surgeries inside the abdomen, such as gall bladder removal. Specifically, we chronicle the 1) foundational contributions of... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

2025
Working Paper

Computed Tomography (CT)--Beyond Traditional X-Rays: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins

This case history describes how Computed Tomography (CT) scanners - that combine Xrays and computers to image soft tissues of the brain and other organs -- have become a widely used diagnostic tool. Specifically, we chronicle the 1) initial development of CT... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

01 Feb 2012
What Do You Think?

Is Support for Small Business Misplaced?

investments in research and development, was emphasized by several respondents. Mark Hopkinson remarked that "most big companies rely for their tech pipeline of new products on the innovation that comes from small business, acquiring... View Details

Keywords: by James Heskett

08 Jan 2016
News

Impact Entrepreneurship

Victor Gbolade Osibodu

Keywords: Diversified

Jorge Marín Correa

Keywords: Electricity and Natural Gas

01 Sep 2020
News

Reinvigorating Democracy: A Vote for Change

They also cite Pew Research Center data showing that trust in the federal government has gone from 77 percent in 1964 to 17 percent in 2019. But even in the face of these difficult odds, Gehl and Porter offer a solution—and one that can... View Details

Keywords: Young, Susan

Profile

Dan Vallone

Professional Development office, I found a position with the Office of Innovation & Improvement in the Department of Education in Washington. It’s a relatively small team, but they play a key role in applying evidence-based approaches... View Details

Keywords: Nonprofit / Government; Nonprofit / Government

fall 2007
Article

The Design of Patent Pools: The Determinants of Licensing Rules

By: Josh Lerner, Marcin Strojwas and Jean Tirole

Patent pools are an important but little-studied economic institution. In this paper, we first make a set of predictions about the licensing terms associated with patent pools. The theoretical framework predicts that (a) pools consisting of complementary patents are... View Details

Keywords: Governing Rules, Regulations, and Reforms; Collaborative Innovation and Invention; Patents; Rights

Find at Harvard

2025
Working Paper

Magnetic Resonance Imaging—High Quality and Radiation Free: Case Histories of Transformational Advances

By: Srikant M. Datar, Amar Bhidé and Katherine Stebbins

This case history describes how Magnetic Resource Imaging (MRI) came to complement – and partially replace -- computed tomography (CT) imaging of soft tissue. Specifically, we chronicle 1) the development of foundational techniques and prototypes (through the 1970s);... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

2025
Working Paper

Mammography - Early Detection, Precise Diagnoses: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins

This case history describes how the development of x-ray-based techniques and equipment (“mammography”) led to widespread screening for breast cancer and enabled “minimally invasive” biopsies of breast tumors. Specifically, we chronicle how: 1) new protocols and... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

2025
Working Paper

Antibiotic Treatments for Ulcers--Eradicating H-Pylori Infections: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins

This case history describes how a chance discovery of bacteria that infect stomach linings completely changed how physicians treat ulcers. Specifically, we chronicle how: 1) two Australian physicians brought the bacterial infection to the world’s attention and... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms