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2024
Working Paper

Computed Tomography (CT)--Beyond Traditional X-Rays: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins

This case history describes how Computed Tomography (CT) scanners - that combine Xrays and computers to image soft tissues of the brain and other organs -- have become a widely used diagnostic tool. Specifically, we chronicle the 1) initial development of CT... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

2024
Working Paper

Mammography - Early Detection, Precise Diagnoses: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins

This case history describes how the development of x-ray-based techniques and equipment (“mammography”) led to widespread screening for breast cancer and enabled “minimally invasive” biopsies of breast tumors. Specifically, we chronicle how: 1) new protocols and... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

2024
Working Paper

Prozac—Controversial Blockbuster: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins

This case history describes the development of Prozac, a blockbuster drug that transformed the treatment of depression – and became a cultural phenomenon in the United States. Specifically, we chronicle the: 1) prior treatments for depression and the research that... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

13 Jul 2011
Research & Ideas

Experimental Researcher Helps Improve Health Care in Zambia

get people to use them." In one study exploring the country's high birth rates, 1,031 women were randomly chosen to receive a voucher guaranteeing free and immediate access to a range of modern contraceptives through a private... View Details

Keywords: by Roger Thompson; Health

01 Jul 2013
Research & Ideas

Crowdfunding a Poor Investment?

checks and balances to keep them accountable, including detailed financial reporting, private companies have no such thing. Because of that, the SEC currently allows only accredited investors—meaning those... View Details

Keywords: by Michael Blanding; Financial Services

01 Jun 2014
News

Ask the Expert: Braving an Insecure New World

always outpace static compliance requirements, so trying to meet them amounts to a misallocation of resources, often costly and with little promise of better security. The ever-increasing data gathered by Internet giants such as Google... View Details

Keywords: cybersecurity; Information

2024
Working Paper

Cephalosporins—Fighting Hospital Infections: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant Datar and Katherine Stebbins

This case history describes the development of three generations of cephalosporins – antibiotics that have significantly reduced hospital infections. Specifically, we chronicle how: 1) Early (pre-cephalosporin) antibiotics were developed in the first half of the 20th... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

2024
Working Paper

Chimeric Antigen Receptor T-Cell Therapy—Living Drugs: Case Histories of Transformational Advances

By: Amar Bhidé and Srikant M. Datar

In 2017, the US Food and Drug Administration (FDA) approved an immunotherapeutic treatment, called CAR-T therapy, for two kinds of blood cancers—acute leukemia (ALL) and a lymphoma. We describe 1) how CAR-T works, 2) the foundational advances and discoveries, 3) the... View Details

Keywords: Immunotherapy; Health Care and Treatment; Innovation and Invention; Research and Development; Governing Rules, Regulations, and Reforms

30 Oct 2006
First Look

First Look: October 31, 2006

contingent claims analysis (CCA). We illustrate how to use the CCA approach to model and measure sectoral and national risk exposures, and analyze policies to offset their... View Details

Keywords: Sean Silverthorne

2024
Working Paper

Tamoxifen—Reducing Breast Cancer Risks: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant Datar and Katherine Stebbins

We describe the development of tamoxifen, considered a “gold standard” treatment for millions of breast cancer patients. Specifically, we describe breast cancer treatments before tamoxifen’s development; the initial development of tamoxifen from 1960 to 1973;... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation and Invention; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Governing Rules, Regulations, and Reforms

2024
Working Paper

Antibiotic Treatments for Ulcers--Eradicating H-Pylori Infections: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins

This case history describes how a chance discovery of bacteria that infect stomach linings completely changed how physicians treat ulcers. Specifically, we chronicle how: 1) two Australian physicians brought the bacterial infection to the world’s attention and... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

17 Jan 2007
Op-Ed

Learning from Private-Equity Boards

If Enron had been owned and controlled by a small group of private-equity investors, could the monitoring and control practices of a... View Details

Keywords: by Malcolm Salter; Financial Services

19 Jul 2019
Blog Post

Making a Broader Impact with Multiple Disciplines

The idea that novel engineering techniques could be used for medical purposes fascinated me and I sought to build smart devices for other anatomical and physiological needs. While LEGO provided an easy... View Details

04 Aug 2009
First Look

First Look: August 4

allocation within an economy. The theory predicts that GAAP's principal focus, as shaped by the demand for and supply of financial information, is on the use of the income statement and View Details

Keywords: Martha Lagace

November 2010
Teaching Note

Saudi Arabia: Modern Reform, Enduring Stability. Dubai: Global Economy (TN)

By: Richard H.K. Vietor

Teaching Note for 709042 and 709043. View Details

Keywords: Economy; Governing Rules, Regulations, and Reforms; Globalization; Balance and Stability; Saudi Arabia; Dubai

Purchase

2024
Working Paper

Fecal Microbiota Transplants —Too Simple to be Safe? Case Histories of Transformational Advances

By: Amar Bhide and Srikant M. Datar

By 2013, after many decades of very slow development and adoption, Fecal Microbiota Transplantation procedures were attracting widespread attention. This case history chronicles the: 1) pioneering fecal transplants performed in the 20th century; 2) development of the... View Details

Keywords: Health Care and Treatment; Innovation and Invention; Governing Rules, Regulations, and Reforms