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October 2016 (Revised February 2017)
Teaching Note

Alvogen

By: Daniel Isenberg, William R. Kerr and Alexis Brownell

Alvogen is an Icelandic pharmaceutical company that makes and sells generic drugs. Founder and CEO Robert Wessman is deciding whether to take on private equity investors willing to buy out all shareholders, merge with a large and publicly-traded US pharmaceutical... View Details

Keywords: Biotechnology; Globalization; Entrepreneurship; Biotechnology Industry

September 2023 (Revised April 2024)
Case

Atomwise: Strategic Opportunities in AI for Pharma

By: Satish Tadikonda

Abraham Heifets and his co-founder, Izhar Wallach, had founded Atomwise to develop i) an AI engine to transform drug discovery by creating better medicines faster, and ii) a machine learning-based discovery engine that combined the power of convolutional neural... View Details

Keywords: Business Model; Business Startups; AI and Machine Learning; Science-Based Business; Technological Innovation; Biotechnology Industry; Pharmaceutical Industry

May 2025
Teaching Note

From oneworld to a New World? LATAM’s High-Stakes Alliance Dilemma

By: Juan Alcacer and Valentina Tarzijan

As global alliances evolve and regulatory barriers mount, LATAM Airlines must reassess the strategic logic of partnerships. In 2019, Delta Air Lines proposed a $1.9 billion investment and deeper cooperation via a Joint Business Agreement, prompting LATAM to evaluate... View Details

Keywords: Partners and Partnerships; Governing Rules, Regulations, and Reforms; Competitive Strategy; Decision Choices and Conditions; Air Transportation Industry; Latin America; North America

February 2008 (Revised December 2023)
Case

Digital Music: From MP3 to Streaming

By: Willy Shih

The emergence of the MP3 file-based music format not only disrupted the market for portable audio players, it also impacted the business models of major record labels. Modularity, and the commoditization spillover enabled by modularity in the personal computer... View Details

Keywords: Recording; Digital Devices; Digital Media; Digital Music; Digital; Digital Economics; Consumer Electronics; Customer Value and Value Chain; Disruptive Innovation; Technological Innovation; Information Technology; Music Industry; Technology Industry; Electronics Industry; United States

October 2023
Case

Foodology: Creating a Virtual Restaurant Group in Latin America

By: Rembrand M. Koning, Jorge Tamayo and Jenyfeer Martínez Buitrago

In April 2020, Daniela Izquierdo (HBS, 2019) and Juan Guillermo Azuero (HBS, 2019), awaited the results of Harvard Business School’s Alumni New Venture Competition. Operating since September 2019, Foodology, a Colombian food-tech startup in the cloud kitchen segment,... View Details

Keywords: Business Startups; Business Model; Entrepreneurship; Food and Beverage Industry; Latin America; South America; Colombia

06 Feb 2018
First Look

First Look at New Research and Ideas: February 6, 2018

management of the pace of technological substitution by providing insights on complementarities between technologies and horizontally differentiated human capital Download working paper: https://www.hbs.edu/faculty/Pages/item.aspx?num=53855 View Details

July 1986 (Revised August 1987)
Background Note

Note on Comparative Advantage

By: David B. Yoffie and John J. Coleman

Discusses David Ricardo's theory of comparative advantage and the refinement of his model developed by Eli Heckscher and Bertil Ohlin. Presents several criticisms of the Heckscher-Ohlin theory, including Wassily Leontief's empirical demonstration that the nature of... View Details

Keywords: Business Model; Forecasting and Prediction; Macroeconomics; Trade; Theory

August 2022
Supplement

Sweet Teez Bakery: Projecting the Dough’s Rise Financial Supplement

By: Emily R. McComb, Mel Martin and Amy Klopfenstein

Abstract: In 2021, the HBS Impact Investment Fund student team met with entrepreneur Teresa Maynard, who had applied for a $25,000 impact investment loan. The students thought the former Harvard Data Scientist’s bakery business, Sweet Teez Bakery, showed promise.... View Details

Keywords: Impact Investment; Entrepreneurship; Social Entrepreneurship; Finance; Investment; Goods and Commodities; Financial Reporting; Small Business; Food and Beverage Industry; Massachusetts; United States

27 Oct 2010
Working Paper Summaries

The Intensive Margin of Technology Adoption

Keywords: by Diego Comin & Martí Mestieri

March 2010 (Revised March 2010)
Case

Looking for Opportunity in Adversity: Iqbal Quadir and Grameenphone (A)

By: Bhaskar Chakravorti and David Lane

Iqbal Quadir, a former New York investment banker, set about to bring universal telecommunications to his native Bangladesh. He was convinced that, GSM, the same advanced wireless technology that penetrated developed countries in Europe was also the right solution for... View Details

Keywords: Decisions; Personal Development and Career; Entrepreneurship; Problems and Challenges; Wireless Technology; Telecommunications Industry; Bangladesh

2023
Chapter

Business, Climate Change and the Anthropocene

By: Andrew J. Hoffman and Sukanya Roy

This chapter will assess climate change as a concern for business, both as a stand-alone issue and as part of the broader shift that scientists are calling the Anthropocene. It will begin by examining the extent to which the market – comprised of corporations, the... View Details

Keywords: Climate Change; Problems and Challenges; Mission and Purpose

March 2009
Case

Incept LLC and Confluent Surgical (A)

By: Bhaskar Chakravorti, Toby E. Stuart and James Weber

A venture capitalist must decide whether to invest in a medical technology company that licenses intellectual property from a privately held IP holding company based on a platform technology. Entrepreneurs Amar Sawhney and Fred Khosravi founded Incept LLC to... View Details

Keywords: Business Model; Entrepreneurship; Intellectual Property; Rights; Agreements and Arrangements; Partners and Partnerships; Trust; Medical Devices and Supplies Industry

24 Jan 2024
Op-Ed

Why Boeing’s Problems with the 737 MAX Began More Than 25 Years Ago

older airplane models at the expense of all-new aircraft. Secondly, in 2001 Condit moved Boeing’s headquarters from its original home in Seattle to Chicago—all to gain $60 million in state and local tax credits over 20 years. With none of... View Details

Keywords: by Bill George; Air Transportation; Transportation; Aerospace

Research Summary

Overview

The research activity of Stefano Denicolai regards the management of innovation and technology. His recent works investigate if and how the investment in intangible assets (IA) - especially knowledge assets, such as patents or copyright - impacts on the firm... View Details

Keywords: Innovation Management; International Entrepreneurship; Intangible Assets; Open Innovation; Innovation and Management; Entrepreneurship; Competitive Strategy; Technology Industry; Biotechnology Industry; Web Services Industry; Tourism Industry

14 Oct 2021
In Practice

Reunited and It Feels (Not) So Good: Tips for Managing a Rocky Return

masks. We recently asked Harvard Business School professors whose research and expertise traverse topics related to remote work what advice they would offer managers and executives actively seeking to navigate these points of friction.... View Details

Keywords: by Kristen Senz

09 Oct 2001
Research & Ideas

Driven: How Human Nature Shapes Organizations

to a well-known and admired model of industrial organization—General Motors. We will also compare the theoretical model to a much-admired high-technology firm, Hewlett-Packard. Finally we will propose a... View Details

Keywords: by Paul Lawrence & Nitin Nohria

May 2025
Supplement

On (B): The Cyclon Spins On

By: Ramon Casadesus-Masanell, Karolin Frankenberger, Sascha Mader and Karen Elterman

A follow-up to the On case (723-430), this short case explores how the performance athletic shoe company On expanded its Cyclon subscription and recycling program through 2024, adding two new shoe models to the subscription and a one-time-purchase recyclable T-shirt. View Details

February 2008 (Revised September 2008)
Case

Apple Inc., 2008

By: David B. Yoffie and Michael Slind

In January 2007, three decades after its incorporation, Apple Computer shed the second word in its name and became Apple Inc. With that move, the company signaled a fundamental shift away from its historic status as a vendor of the Macintosh personal computer (PC)... View Details

Keywords: Business Model; Leadership; Industry Growth; Corporate Strategy; Information Infrastructure; Internet and the Web; Consumer Products Industry; Electronics Industry; Technology Industry