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- All HBS Web (655)
- Faculty Publications (147)
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- 27 Mar 2018
- First Look
First Look at New Research, March 27, 2018
Abstract—Current academic and policy debates focus on the impact of tort reforms on physicians’ behavior and medical costs. This paper examines whether these reforms also affect incentives to develop new technologies. We develop a... View Details
Keywords: Sean Silverthorne
- February 2024
- Article
Representation and Extrapolation: Evidence from Clinical Trials
By: Marcella Alsan, Maya Durvasula, Harsh Gupta, Joshua Schwartzstein and Heidi L. Williams
This article examines the consequences and causes of low enrollment of Black patients in clinical
trials. We develop a simple model of similarity-based extrapolation that predicts that evidence is
more relevant for decision-making by physicians and patients when it... View Details
Keywords: Representation; Racial Disparity; Health Testing and Trials; Race; Equality and Inequality; Innovation and Invention; Pharmaceutical Industry
Alsan, Marcella, Maya Durvasula, Harsh Gupta, Joshua Schwartzstein, and Heidi L. Williams. "Representation and Extrapolation: Evidence from Clinical Trials." Quarterly Journal of Economics 139, no. 1 (February 2024): 575–635.
- Article
The Relationship Between Workplace Stressors and Mortality and Health Costs in the United States
By: Joel Goh, Jeffrey Pfeffer and Stefanos A. Zenios
Even though epidemiological evidence links specific workplace stressors to health outcomes, the aggregate contribution of these factors to overall mortality and health spending in the United States is not known. In this paper, we build a model to estimate the excess... View Details
Goh, Joel, Jeffrey Pfeffer, and Stefanos A. Zenios. "The Relationship Between Workplace Stressors and Mortality and Health Costs in the United States." Management Science 62, no. 2 (February 2016): 608–628.
- April 2024
- Article
A Machine Learning Algorithm Predicting Risk of Dilating VUR among Infants with Hydronephrosis Using UTD Classification
By: Hsin-Hsiao Scott Wang, Michael Lingzhi Li, Dylan Cahill, John Panagides, Tanya Logvinenko, Jeanne Chow and Caleb Nelson
Backgrounds: Urinary Tract Dilation (UTD) classification has been designed to be a more objective grading system to evaluate antenatal and post-natal UTD. Due to unclear association between UTD classifications to specific anomalies such as vesico-ureteral reflux (VUR),... View Details
Wang, Hsin-Hsiao Scott, Michael Lingzhi Li, Dylan Cahill, John Panagides, Tanya Logvinenko, Jeanne Chow, and Caleb Nelson. "A Machine Learning Algorithm Predicting Risk of Dilating VUR among Infants with Hydronephrosis Using UTD Classification." Journal of Pediatric Urology 20, no. 2 (April 2024): 271–278.
- July–August 2024
- Article
The Middle Path to Innovation
By: Regina E. Herzlinger, Duke Rohlen, Ben Creo and Will Kynes
Too many companies are failing to innovate. One reason, say the authors, is the polarized approach companies take to innovation. At one end of the spectrum, corporate R&D efforts tend to focus on product refreshes and incremental line upgrades that generate modest... View Details
Herzlinger, Regina E., Duke Rohlen, Ben Creo, and Will Kynes. "The Middle Path to Innovation." Harvard Business Review 102, no. 4 (July–August 2024): 134–145.
- September 2016
- Supplement
Health Leads: Reaching for Impact (B)
By: V. Kasturi Rangan and Sarah Appleby
The (B) case documents the development of a strategy to achieve system-level impact in a rapidly changing healthcare landscape for a nonprofit focused on addressing patients' basic social needs through healthcare institutions. Founded in 1996 with a volunteer-staffed... View Details
Keywords: Scaling Social Impact; Scaling Social Enterprise; Health Care Delivery; Health Care Outcomes; Nonprofit Scaling; Nonprofit; Social Enterprise; Social Entrepreneurship; Health Care and Treatment; Nonprofit Organizations; Growth and Development Strategy; Health Industry; United States
Rangan, V. Kasturi, and Sarah Appleby. "Health Leads: Reaching for Impact (B)." Harvard Business School Supplement 517-023, September 2016.
- Article
How Not to Cut Health Care Costs
By: Robert S. Kaplan and Derek A. Haas
Health care providers in much of the world are trying to respond to the tremendous pressure to reduce costs—but evidence suggests that many of their attempts are counterproductive, raising costs and sometimes decreasing the quality of care. Using evidence from field... View Details
Kaplan, Robert S., and Derek A. Haas. "How Not to Cut Health Care Costs." Harvard Business Review 92, no. 11 (November 2014): 116–122.
- March 2015
- Case
Transforming Care at UnityPoint Health – Fort Dodge
By: Amy C. Edmondson, Ashley-Kay Fryer and Morten T. Hansen
This case details the transformation of a health care delivery system, UnityPoint Health – Fort Dodge, into a Pioneer Accountable Care Organization (ACO) after the passage of health reform in the United States. The case explores in detail how the hospital CEO and staff... View Details
Keywords: ACO; Health Care; Health Care Industry; Health Reform; Change Leadership; Change Management; Coordination; Health Care and Treatment; Leading Change; Health Industry; United States
Edmondson, Amy C., Ashley-Kay Fryer, and Morten T. Hansen. "Transforming Care at UnityPoint Health – Fort Dodge." Harvard Business School Case 615-052, March 2015.
- September 2016
- Case
Health Leads: Reaching for Impact (A)
By: V. Kasturi Rangan and Sarah Appleby
Explores strategies to achieve system-level impact for a nonprofit focused on addressing patients' basic social needs through healthcare institutions. Founded in 1996 with a volunteer-staffed help desk at Boston Medical Center connecting low-income patients with basic... View Details
Keywords: Scaling Social Impact; Nonprofit; Healthcare; Health Care Outcomes; Health Care Reform; Health Care Delivery; Scaling Social Enterprise; Social Enterprise; Health; Nonprofit Organizations; Health Care and Treatment; Health Industry; United States
Rangan, V. Kasturi, and Sarah Appleby. "Health Leads: Reaching for Impact (A)." Harvard Business School Case 517-022, September 2016.
- March 2010 (Revised October 2011)
- Case
Highland District County Hospital: Gastroenterology Care in Sweden
By: Michael E. Porter, Jennifer F Baron and Martin Rejler
Sweden's Highland District County Hospital, similar to a community hospital in the US, undertook a major restructuring to integrate care delivery for medical conditions served by the Department of Medicine. Each subspecialty within the Department would form a single,... View Details
Porter, Michael E., Jennifer F Baron, and Martin Rejler. "Highland District County Hospital: Gastroenterology Care in Sweden." Harvard Business School Case 710-469, March 2010. (Revised October 2011.)
- March 2023 (Revised June 2025)
- Case
Close Concerns: Diabetes Research and Advocacy
By: Regina E. Herzlinger and Brian L. Walker
Diagnosed with diabetes at the age of 18, Kelly Close understood the importance of balancing consistency and iteration. This principle had also informed her professional work, which started with a rapid promotion from financial analyst at Goldman Sachs to an analyst... View Details
Keywords: Diabetes; Health; Health Care; Health Care And Treatment; Health Care Outcomes; Health Care Industry; Knowledge Dissemination; Outcome or Result; Equality and Inequality; Business Model; Entrepreneurship
Herzlinger, Regina E., and Brian L. Walker. "Close Concerns: Diabetes Research and Advocacy." Harvard Business School Case 323-047, March 2023. (Revised June 2025.)
- April 2004 (Revised June 2004)
- Case
Entrepreneurship Goes Global: ResMed's Gamble
By: Christopher A. Bartlett, Andrew N. McLean and Meg Glinska
On the basis of its innovative medical device for treating sleep apnea, CEO Peter Farrell has made Australian-born ResMed a successful global company. But the company is struggling to implement a strategy to expand the device from its focused core market to a much... View Details
Keywords: Business Model; Globalization; Innovation and Management; Management; Marketing Channels; Production; Expansion; Medical Devices and Supplies Industry
Bartlett, Christopher A., Andrew N. McLean, and Meg Glinska. "Entrepreneurship Goes Global: ResMed's Gamble." Harvard Business School Case 304-051, April 2004. (Revised June 2004.)
- 14 Nov 2017
- First Look
New Research and Ideas: November 14, 2017
through three examples: the design of medical residency matching programs, a scrip system to allocate food donations to food banks, and the recent "Incentive Auction" that reallocated wireless spectrum from television broadcasters to... View Details
Keywords: Carmen Nobel
- 30 Mar 2010
- First Look
First Look: March 30
people believe the risk decreases (negative recency) but at the same time exhibit more cautious behavior (positive recency). The rest of the difference is consistent with two well established mechanisms: judgment error and the use of small samples in choice.... View Details
Keywords: Sean Silverthorne
- 2019
- Working Paper
Soul and Machine (Learning)
By: Davide Proserpio, John R. Hauser, Xiao Liu, Tomomichi Amano, Alex Burnap, Tong Guo, Dokyun Lee, Randall Lewis, Kanishka Misra, Eric Schwarz, Artem Timoshenko, Lilei Xu and Hema Yoganarasimhan
Machine learning is bringing us self-driving cars, improved medical diagnostics, and machine translation, but can it improve marketing decisions? It can. Machine learning models predict extremely well, are scalable to “big data,” and are a natural fit to rich media... View Details
Proserpio, Davide, John R. Hauser, Xiao Liu, Tomomichi Amano, Alex Burnap, Tong Guo, Dokyun Lee, Randall Lewis, Kanishka Misra, Eric Schwarz, Artem Timoshenko, Lilei Xu, and Hema Yoganarasimhan. "Soul and Machine (Learning)." Harvard Business School Working Paper, No. 20-036, September 2019.
- 28 Feb 2017
- First Look
First Look at New Research, February 28
interactions to remote medical scribes, thus freeing doctors from the burden of having to manually input information into an electronic medical record (EMR) and giving them additional time to focus on... View Details
Keywords: Sean Silverthorne
- January–February 2023
- Article
Data-Driven COVID-19 Vaccine Development for Janssen
By: Dimitris Bertsimas, Michael Lingzhi Li, Xinggang Liu, Jennings Xu and Najat Khan
The COVID-19 pandemic has spurred extensive vaccine research worldwide. One crucial part of vaccine development is the phase III clinical trial that assesses the vaccine for safety and efficacy in the prevention of COVID-19. In this work, we enumerate the first... View Details
Keywords: COVID-19; Health Testing and Trials; Forecasting and Prediction; AI and Machine Learning; Research; Pharmaceutical Industry
Bertsimas, Dimitris, Michael Lingzhi Li, Xinggang Liu, Jennings Xu, and Najat Khan. "Data-Driven COVID-19 Vaccine Development for Janssen." INFORMS Journal on Applied Analytics 53, no. 1 (January–February 2023): 70–84.
- March 2009
- Case
Incept LLC and Confluent Surgical (A)
By: Bhaskar Chakravorti, Toby E. Stuart and James Weber
A venture capitalist must decide whether to invest in a medical technology company that licenses intellectual property from a privately held IP holding company based on a platform technology. Entrepreneurs Amar Sawhney and Fred Khosravi founded Incept LLC to... View Details
Keywords: Business Model; Entrepreneurship; Intellectual Property; Rights; Agreements and Arrangements; Partners and Partnerships; Trust; Medical Devices and Supplies Industry
Chakravorti, Bhaskar, Toby E. Stuart, and James Weber. "Incept LLC and Confluent Surgical (A)." Harvard Business School Case 809-062, March 2009.
- 15 Jan 2019
- First Look
New Research and Ideas, January 15, 2019
forthcoming American Journal of Therapeutics Food and Drug Administration Guidance Documents and New Medical Devices: The Case of Breast Prostheses By: Weitzman, Rachel E., Ariel Dora Stern, and Daniel B. Kramer Abstract—No abstract... View Details
Keywords: Dina Gerdeman
- Article
Behavioral Hazard in Health Insurance
By: Katherine Baicker, Sendhil Mullainathan and Joshua Schwartzstein
A fundamental implication of standard moral hazard models is overuse of low-value medical care because copays are lower than costs. In these models, the demand curve alone can be used to make welfare statements, a fact relied on by much empirical work. There is ample... View Details
Baicker, Katherine, Sendhil Mullainathan, and Joshua Schwartzstein. "Behavioral Hazard in Health Insurance." Quarterly Journal of Economics 130, no. 4 (November 2015): 1623–1667. (Online Appendix.)