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      • July 2013 (Revised November 2021)
      • Module Note

      Exploration vs. Exploitation

      By: Willy Shih
      This module note introduces James March's concept of exploration and exploitation, and the management challenge of balancing the allocation of resources to the two activities in the firm. The note also touches on the O'Reilly and Tushman paper on the ambidextrous... View Details
      Keywords: Exploration And Exploitation; Exploitation; Research; Scientific Research; Product Commercialization; Innovation and Invention; Innovation and Management; Innovation Leadership; Innovation Strategy; Technological Innovation; Knowledge Acquisition; Growth and Development Strategy; Resource Allocation; Strategic Planning; Research and Development; Science-Based Business; Corporate Strategy; Knowledge Sharing; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry; United States
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      Shih, Willy. "Exploration vs. Exploitation." Harvard Business School Module Note 614-004, July 2013. (Revised November 2021.)
      • Article

      Experiments in Open Innovation at Harvard Medical School

      By: Eva C. Guinan, Kevin J. Boudreau and Karim R. Lakhani
      Harvard Medical School seems an unlikely organization to open up its innovation process. By most measures, the more than 20,000 faculty, research staff and graduate students affiliated with Harvard Medical School are already world class and at the top of the medical... View Details
      Keywords: Health Disorders; Collaborative Innovation and Invention; Boston
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      Guinan, Eva C., Kevin J. Boudreau, and Karim R. Lakhani. "Experiments in Open Innovation at Harvard Medical School." Art. 3. MIT Sloan Management Review 54, no. 3 (Spring 2013): 45–52.
      • Article

      Beyond Magic Bullets: True Innovation in Health Care

      By: Vaibhav A. Narayan, Marco Mohwinckel, Gary Pisano, Michael Yang and Husseini Manji
      The molecular medicine revolution—based on advances in fields such as genomics and network modeling in the decade since the human genome sequence was completed—has changed the way we think about, study, and approach the development of novel therapies. However, these... View Details
      Keywords: Integration; Business Model; Organizational Structure; Health Care and Treatment; Innovation and Invention; Pharmaceutical Industry
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      Narayan, Vaibhav A., Marco Mohwinckel, Gary Pisano, Michael Yang, and Husseini Manji. "Beyond Magic Bullets: True Innovation in Health Care." Nature Reviews: Drug Discovery 12, no. 2 (February 2013): 85–86.
      • October 2012
      • Case

      Designing a Culture of Collaboration at Lake Nona Medical City

      By: Amy C. Edmondson, Sydney Ribot and Tiona Zuzul
      Describes Lake Nona, a 7,000-acre residential and research cluster in central Florida, and its process and innovation culture, and Lake Nona Institute, the organization behind the planning and governance of this new eco-friendly community. Emphasis is placed on the... View Details
      Keywords: Collaboration; Innovation; Health Care; Real Estate; Entrepreneurship; Collaborative Innovation and Invention; Governance; Real Estate Industry; Florida
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      Edmondson, Amy C., Sydney Ribot, and Tiona Zuzul. "Designing a Culture of Collaboration at Lake Nona Medical City." Harvard Business School Case 613-022, October 2012.
      • September 2012
      • Supplement

      Intraoperative Radiotherapy for Breast Cancer (B)

      By: Willy Shih
      The intraoperative radiotherapy (IORT) business at Carl Zeiss Meditec had struggled with growth since the time of the (A) case. Though the unit had grown revenues in excess of 50% and had exceeded its EBIT target, it faced several key strategic choices. Should it... View Details
      Keywords: Radiotherapy; Breast Cancer; Brachytherapy; Therapeutic Radiation; Oncology; Oncology Treatment Systems; Elekta AB; Varian Medical Systems; Xoft; Electronic Brachytherapy; Intraoperative Radiotherapy; Disruptive Innovation; Health Care and Treatment; Entrepreneurship; Technological Innovation; Growth and Development Strategy; Health Industry; Germany
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      Shih, Willy. "Intraoperative Radiotherapy for Breast Cancer (B)." Harvard Business School Supplement 613-040, September 2012.
      • August 2012 (Revised August 2014)
      • Case

      Cancer Treatment Centers of America® (A)

      By: Regina E. Herzlinger and Natalie Kindred
      Cancer Treatment Centers of America (CTCA), a U.S. network of four privately owned oncology focused factory hospitals, was weighing options for growth. CTCA was entirely cancer focused and specialized in treating patients with complex and advanced-stage cancers, who... View Details
      Keywords: Cancer; Cancer Treatment; Health Care; Healthcare; Accountability; Outcomes; Outcomes Measurement; Outcomes Reporting; Hub And Spoke Cancer Care; Hub And Spoke; Hub-and-spoke; Focused Factory; Mission and Purpose; Private Ownership; For-Profit Firms; Health Disorders; Medical Specialties; Policy; Business Model; Expansion; Decision Choices and Conditions; Advertising; Health Care and Treatment; Innovation and Invention; Health Industry; United States
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      Herzlinger, Regina E., and Natalie Kindred. "Cancer Treatment Centers of America® (A)." Harvard Business School Case 313-012, August 2012. (Revised August 2014.)
      • June 2012
      • Case

      Innovating at AT&T: Partnering to Lead the Broadband Revolution

      By: Lynda M. Applegate, Phillip Andrews and Kerry Herman
      In 2010, the U.S. retail market value for next-generation non-handset wirelessly-enabled devices was just over $1 billion. By 2011 it had grown 1,141% to $13.2 billion and was forecast to reach $24.7 billion in 2015. At the same time, user demand for data was surging... View Details
      Keywords: Innovation & Entrepreneurship; Team Leadership; Emerging Technologies; Business Models; Business To Business; Corporate Vision; Growth Strategy; Corporate Culture; Innovation and Invention; Corporate Entrepreneurship; Partners and Partnerships; Leadership; Mobile and Wireless Technology; Growth and Development Strategy; Globalized Firms and Management; Business Model; Technology Industry; United States
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      Applegate, Lynda M., Phillip Andrews, and Kerry Herman. "Innovating at AT&T: Partnering to Lead the Broadband Revolution." Harvard Business School Case 812-124, June 2012.
      • March 2012 (Revised April 2013)
      • Case

      Schön Klinik: Eating Disorder Care

      By: Michael E. Porter, Emma Stanton, Jessica A. Hohman and Caleb Stowell
      The Schön Klinik is a private, for-profit German hospital group trying to establish itself as a premium health care provider in a competitive German market. The case details Schön Klinik's founding, its early focus on measurement and improvement, and the design and... View Details
      Keywords: Health Care Quality; Outcomes; Quality Improvement; Strategy And Performance Measurement; Integration; Measurement and Metrics; Competition; Health Disorders; Health Care and Treatment; Outcome or Result; Performance Evaluation; Business Processes; Health Industry; Germany
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      Porter, Michael E., Emma Stanton, Jessica A. Hohman, and Caleb Stowell. "Schön Klinik: Eating Disorder Care." Harvard Business School Case 712-475, March 2012. (Revised April 2013.)
      • December 2011 (Revised December 2011)
      • Case

      Cancer Treatment Centers of America: Scaling the Mother Standard of Care

      By: Rosabeth Moss Kanter and Matthew Bird
      The CEO of a private and growing national network of specialty care hospitals focusing on advanced-stage and complex cancer treatments reflected on the firm's past phase of growth before meeting with the company's Chairman and founder to discuss how to further scale... View Details
      Keywords: Health Care and Treatment; Business Growth and Maturation; Medical Specialties; Service Delivery; Innovation and Invention; Health Industry
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      Kanter, Rosabeth Moss, and Matthew Bird. "Cancer Treatment Centers of America: Scaling the Mother Standard of Care." Harvard Business School Case 312-073, December 2011. (Revised December 2011.)
      • November 2011 (Revised August 2012)
      • Case

      Healthymagination at GE Healthcare Systems

      By: Vineet Kumar and V. Kasturi Rangan
      Jeff Immelt, the CEO of GE, introduced a new innovation strategy named "healthymagination" in 2009. With cost, quality, and access as its three pillars, healthymagination ensures a strong focus for new product introduction efforts all around GE. But will this focus... View Details
      Keywords: Innovation and Invention; Product Marketing; Marketing Strategy; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry
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      Kumar, Vineet, and V. Kasturi Rangan. "Healthymagination at GE Healthcare Systems." Harvard Business School Case 512-039, November 2011. (Revised August 2012.)
      • July 2011 (Revised January 2013)
      • Case

      Digital Microscopy Is Making Me Crazy!

      By: Willy Shih
      For Carl Zeiss Microimaging, modular hardware and software enabled customers to tailor Zeiss's broad range of microscopy systems hardware and software to meet a wide range of needs from basic scientific research in the biological and medical sciences to clinical... View Details
      Keywords: Information Infrastructure; Applications and Software; Corporate Strategy; Disruptive Innovation; Science-Based Business; Management Analysis, Tools, and Techniques; Business Conglomerates; Digital Platforms; Opportunities; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry
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      Shih, Willy. "Digital Microscopy Is Making Me Crazy!" Harvard Business School Case 612-002, July 2011. (Revised January 2013.)
      • November 2009 (Revised December 2009)
      • Case

      GTC Biotherapeutics: Developing Medicines in the Milk of Goats

      By: Ray A. Goldberg and Sarah Morton
      GTC is the first company in the animal world to receive FDA approval of a transgenic pharmaceutical. What are the implications for other firms in plants and animals and their opportunities to produce new medicines in an economical and safe fashion? View Details
      Keywords: Health Care and Treatment; Animal-Based Agribusiness; Plant-Based Agribusiness; Science-Based Business; Medical Specialties; Product; Technological Innovation; Health Industry; Pharmaceutical Industry; United States
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      Goldberg, Ray A., and Sarah Morton. "GTC Biotherapeutics: Developing Medicines in the Milk of Goats." Harvard Business School Case 910-403, November 2009. (Revised December 2009.)
      • October 2009 (Revised August 2014)
      • Case

      Tengion: Bringing Regenerative Medicine to Life

      By: Elie Ofek and Polly Ross Ribatt
      Tengion is a young biotech company that is at the frontier of regenerative medicine—a nascent field that seeks to promote the creation of new cells and tissue to repair or replace tissue or organ function lost due to age, disease, damage, or congenital defects. In late... View Details
      Keywords: Decision Choices and Conditions; Financial Crisis; Entrepreneurship; Health Care and Treatment; Technological Innovation; Product Launch; Product Development; Research and Development; Biotechnology Industry; United States
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      Ofek, Elie, and Polly Ross Ribatt. "Tengion: Bringing Regenerative Medicine to Life." Harvard Business School Case 510-031, October 2009. (Revised August 2014.)
      • August 2009 (Revised June 2015)
      • Case

      MINTing Innovation at NewYork-Presbyterian (A)

      By: Richard G. Hamermesh and David Kiron
      Several top surgeons at NewYork-Presbyterian Hospital (NYP) are receiving financial and administrative support to advance their surgical device inventions through the earliest stages of commercialization. View Details
      Keywords: Health Care; Innovation & Entrepreneurship; Hospital; Entrepreneurship; Financing and Loans; Investment; Health Care and Treatment; Innovation and Invention; Intellectual Property; Commercialization; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry; New York (state, US)
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      Hamermesh, Richard G., and David Kiron. "MINTing Innovation at NewYork-Presbyterian (A)." Harvard Business School Case 810-004, August 2009. (Revised June 2015.)
      • January 2009 (Revised February 2009)
      • Case

      Pitney Bowes: Employer Health Strategy

      By: Michael E. Porter and Jennifer F Baron
      Pitney Bowes, a Fortune 500 mail and document management firm, offered its first health plans in the years following World War II. Over the ensuing decades, Pitney Bowes adapted its approach to employee health amid rising health care costs, shifting employer attitudes... View Details
      Keywords: Cost; Insurance; Policy; Health Care and Treatment; Compensation and Benefits; Employees; Corporate Strategy
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      Porter, Michael E., and Jennifer F Baron. "Pitney Bowes: Employer Health Strategy." Harvard Business School Case 709-458, January 2009. (Revised February 2009.)
      • December 2008 (Revised April 2010)
      • Case

      Proteus Biomedical: Making Pigs Fly

      By: Richard G. Hamermesh, Lauren Barley and Ginger Graham
      Proteus is a healthcare start-up that has developed technology to embed electronics for computing and sensing in existing medical devices and drugs. The technology could potentially change the basis of competition in the pharmaceutical industry. The company is... View Details
      Keywords: Business Startups; Entrepreneurship; Technological Innovation; Rights; Negotiation Deal; Business Strategy; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry
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      Hamermesh, Richard G., Lauren Barley, and Ginger Graham. "Proteus Biomedical: Making Pigs Fly." Harvard Business School Case 809-051, December 2008. (Revised April 2010.)
      • November 2007
      • Case

      Center for Integration of Medicine and Innovative Technology (CIMIT)

      By: H. Kent Bowen and Courtney Purrington
      Translating innovative ideas form the clinician to the patient remains a major problem in the field of medicine. Dr. John Parrish and colleagues created an organization (CIMIT) that brings the technical, financial, and administrative resources to these innovative... View Details
      Keywords: Financing and Loans; Innovation and Invention; Technological Innovation; Resource Allocation; Alliances; Research and Development; Health Industry; Service Industry
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      Bowen, H. Kent, and Courtney Purrington. "Center for Integration of Medicine and Innovative Technology (CIMIT)." Harvard Business School Case 608-036, November 2007.
      • May 2007 (Revised September 2007)
      • Case

      Cleveland Clinic

      By: Frances X. Frei, Amy C. Edmondson, Christine van Keuren and Eliot Sherman
      Cleveland Clinic is consistently ranked among the nation's most eminent hospitals, and for decades has been a leader in pioneering cardiac care. This case evaluates the methods, processes, and personnel that the hospital has cultivated over the years in order to... View Details
      Keywords: Health Care and Treatment; Medical Specialties; Innovation and Invention; Service Delivery; Expansion; Health Industry; Cleveland
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      Frei, Frances X., Amy C. Edmondson, Christine van Keuren, and Eliot Sherman. "Cleveland Clinic." Harvard Business School Case 607-143, May 2007. (Revised September 2007.)
      • September 2006 (Revised April 2007)
      • Case

      Medtronic Vision 2010

      By: Lynda M. Applegate
      Describes the company's year-long efforts to transition from a medical device company selling products to physicians for use with patients suffering chronic end-stage disease, to a medical technology company providing life-long solutions for people with chronic... View Details
      Keywords: Business Plan; Transition; Decision Choices and Conditions; Corporate Entrepreneurship; Financial Management; Financing and Loans; Health Care and Treatment; Innovation and Invention; Strategic Planning; Health Industry
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      Applegate, Lynda M. "Medtronic Vision 2010." Harvard Business School Case 807-051, September 2006. (Revised April 2007.)
      • April 2006
      • Case

      Medical Innovation Beyond MedStar: Mobilizing for National Impact

      By: Rosabeth M. Kanter, Ryan Raffaelli and Michelle Heskett
      Dr. Craig Feied, director of MedStar Health's Medical Informatics programs, wanted his innovations to influence national health care. Since joining Washington Hospital Center's Emergency Department in 1995 with Dr. Mark Smith, their information system had become the... View Details
      Keywords: Collaborative Innovation and Invention; Innovation Strategy; Technological Innovation; Policy; Government and Politics; Innovation and Management; Projects; Corporate Social Responsibility and Impact; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry; Washington (state, US)
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      Kanter, Rosabeth M., Ryan Raffaelli, and Michelle Heskett. "Medical Innovation Beyond MedStar: Mobilizing for National Impact." Harvard Business School Case 306-096, April 2006.
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