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  • All HBS Web  (2,058)
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  • 2024
  • Working Paper

Mammography - Early Detection, Precise Diagnoses: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how the development of x-ray-based techniques and equipment (“mammography”) led to widespread screening for breast cancer and enabled “minimally invasive” biopsies of breast tumors. Specifically, we chronicle how: 1) new protocols and... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
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Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Mammography - Early Detection, Precise Diagnoses: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-002, July 2019. (Revised May 2024.)
  • 02 Dec 2015
  • What Do You Think?

What Will It Take to Achieve Gender Equality in Leadership?

he said, “The very act of trying to attain gender equality portends to assume that is a positive goal. My concern is not equality but quality. Man or woman, we as individuals and organizations need to rip away all the barriers that lie... View Details
Keywords: by James Heskett
  • 2024
  • Working Paper

Laparoscopy—Minimally Invasive Surgery: Case Histories of Transformational Advances

By: Amar Bhidé, Caitlin N. Bowler and Srikant M. Datar
We describe how operations through laparoscopes – tubular instruments inserted into abdominal cavities – revolutionized gynecological and other surgeries inside the abdomen, such as gall bladder removal. Specifically, we chronicle the 1) foundational contributions of... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
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Bhidé, Amar, Caitlin N. Bowler, and Srikant M. Datar. "Laparoscopy—Minimally Invasive Surgery: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-008, July 2019. (Revised May 2024.)
  • 2024
  • Working Paper

Prozac—Controversial Blockbuster: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes the development of Prozac, a blockbuster drug that transformed the treatment of depression – and became a cultural phenomenon in the United States. Specifically, we chronicle the: 1) prior treatments for depression and the research that... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
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Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Prozac—Controversial Blockbuster: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-135, July 2020. (Revised May 2024.)
  • 14 Dec 2009
  • Research & Ideas

Can Entrepreneurs Drive People Movers to Success?

and enlarging the stations, which led to a cost spiral. These days, designers understand the crucial importance of small vehicles to limiting system cost. Another key improvement: Robust computer control is... View Details
Keywords: by Martha Lagace; Transportation
  • 05 Aug 2002
  • Research & Ideas

Are Consumers the Cure for Broken Health Insurance?

If companies are willing to embrace a new model of health coverage—one that places control over costs and care directly in the hands of employees—the competitive forces that spur productivity View Details
Keywords: by Regina E. Herzlinger
  • 13 Jul 2011
  • Research & Ideas

Experimental Researcher Helps Improve Health Care in Zambia

get people to use them." In one study exploring the country's high birth rates, 1,031 women were randomly chosen to receive a voucher guaranteeing free and immediate access to a range of modern contraceptives through a private... View Details
Keywords: by Roger Thompson; Health
  • 2024
  • Working Paper

Antibiotic Treatments for Ulcers--Eradicating H-Pylori Infections: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how a chance discovery of bacteria that infect stomach linings completely changed how physicians treat ulcers. Specifically, we chronicle how: 1) two Australian physicians brought the bacterial infection to the world’s attention and... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
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Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Antibiotic Treatments for Ulcers--Eradicating H-Pylori Infections: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-006, July 2019. (Revised May 2024.)
  • February 2024
  • Teaching Note

Fusion Industry Association: Igniting the Future of Clean Energy

By: Kyle Myers, Joshua Lev Krieger, Walter Frick and Jim Matheson
Teaching Note for HBS Case No. 624-064. This Teaching Note explores the Fusion Industry Association's efforts to advance commercial fusion energy, highlighting challenges in innovation, regulation, market structure, and financing within the emerging technology sector... View Details
Keywords: Financing and Loans; Governing Rules, Regulations, and Reforms; Technological Innovation; Industry Growth; Energy Industry
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Myers, Kyle, Joshua Lev Krieger, Walter Frick, and Jim Matheson. "Fusion Industry Association: Igniting the Future of Clean Energy." Harvard Business School Teaching Note 624-067, February 2024.
  • November 2010
  • Teaching Note

Saudi Arabia: Modern Reform, Enduring Stability. Dubai: Global Economy (TN)

By: Richard H.K. Vietor
Teaching Note for 709042 and 709043. View Details
Keywords: Economy; Governing Rules, Regulations, and Reforms; Globalization; Balance and Stability; Saudi Arabia; Dubai
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Vietor, Richard H.K. "Saudi Arabia: Modern Reform, Enduring Stability. Dubai: Global Economy (TN)." Harvard Business School Teaching Note 711-039, November 2010.
  • 2024
  • Working Paper

Chimeric Antigen Receptor T-Cell Therapy—Living Drugs: Case Histories of Transformational Advances

By: Amar Bhidé and Srikant M. Datar
In 2017, the US Food and Drug Administration (FDA) approved an immunotherapeutic treatment, called CAR-T therapy, for two kinds of blood cancers—acute leukemia (ALL) and a lymphoma. We describe 1) how CAR-T works, 2) the foundational advances and discoveries, 3) the... View Details
Keywords: Immunotherapy; Health Care and Treatment; Innovation and Invention; Research and Development; Governing Rules, Regulations, and Reforms
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Bhidé, Amar, and Srikant M. Datar. "Chimeric Antigen Receptor T-Cell Therapy—Living Drugs: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 21-035, August 2020. (Revised May 2024.)
  • 10 Apr 2006
  • Research & Ideas

Lessons from the Browser Wars

between 1995 and 1999. Understanding the complex interaction between the two technologies and how a second mover was able to unseat the incumbent market champion will help View Details
Keywords: by Sara Grant; Computer; Consumer Products; Technology
  • fall 2007
  • Article

The Design of Patent Pools: The Determinants of Licensing Rules

By: Josh Lerner, Marcin Strojwas and Jean Tirole
Patent pools are an important but little-studied economic institution. In this paper, we first make a set of predictions about the licensing terms associated with patent pools. The theoretical framework predicts that (a) pools consisting of complementary patents are... View Details
Keywords: Governing Rules, Regulations, and Reforms; Collaborative Innovation and Invention; Patents; Rights
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Lerner, Josh, Marcin Strojwas, and Jean Tirole. "The Design of Patent Pools: The Determinants of Licensing Rules." RAND Journal of Economics 38, no. 3 (fall 2007): 610–625. (Earlier version distributed as National Bureau of Economic Research Working Paper No. 9680.)
  • 01 Jul 2013
  • Research & Ideas

Crowdfunding a Poor Investment?

checks and balances to keep them accountable, including detailed financial reporting, private companies have no such thing. Because of that, the SEC currently allows only accredited investors—meaning those... View Details
Keywords: by Michael Blanding; Financial Services
  • 16 Jul 2024
  • Op-Ed

Corporate Boards Are Failing in Their No. 1 Duty

with Azure, acquiring LinkedIn in social media and Activision/Blizzard in gaming, and investing in OpenAI to gain control of ChatGPT. Equally important, he transformed the... View Details
Keywords: by Bill George
  • 07 Dec 2016
  • HBS Case

Why Millennials Flock to Fintech for Personal Investing

diversification of assets, managed through a portfolio of exchange-traded funds (ETF’s) that track market indexes. “It’s a great way to invest cheaply in a diversified basket of stocks, bonds, and other securities,” says Viceira. If... View Details
Keywords: by Michael Blanding; Financial Services
  • 2024
  • Working Paper

Fecal Microbiota Transplants —Too Simple to be Safe? Case Histories of Transformational Advances

By: Amar Bhide and Srikant M. Datar
By 2013, after many decades of very slow development and adoption, Fecal Microbiota Transplantation procedures were attracting widespread attention. This case history chronicles the: 1) pioneering fecal transplants performed in the 20th century; 2) development of the... View Details
Keywords: Health Care and Treatment; Innovation and Invention; Governing Rules, Regulations, and Reforms
Citation
SSRN
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Bhide, Amar, and Srikant M. Datar. "Fecal Microbiota Transplants —Too Simple to be Safe? Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 21-132, June 2021. (Revised May 2024.)
  • 13 Aug 2014
  • Lessons from the Classroom

Managing the Family Business: Entrepreneurs Needed for Long-Run Success

risk-taking, resourceful attitude of an entrepreneur. Entrepreneurs are good at identifying commercial opportunities and getting new products and services off the ground, even when they don't View Details
Keywords: by Michael J. Roberts
  • 02 May 2011
  • Research & Ideas

Casino Payoff: Hands-Off Management Works Best

researchers and practitioners alike: What is the proper balance to be struck by a business between encouraging autonomy so that employees can ignore red tape to serve the customer quickly View Details
Keywords: by Dennis Fisher; Entertainment & Recreation
  • 02 Apr 2015
  • Research & Ideas

Digital Initiative Summit: Who Has the Power in the Music Industry?

The music industry likes power. Power chords, power ballads, even Towers of Power. The balance of power in the industry, however, has been completely upset with the advent and rapid proliferation of digital... View Details
Keywords: Re: Felix Oberholzer-Gee; Music
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