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- All HBS Web (1,072)
- Faculty Publications (815)
- 2025
- Working Paper
Prozac—Controversial Blockbuster: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes the development of Prozac, a blockbuster drug that transformed
the treatment of depression – and became a cultural phenomenon in the United States. Specifically, we
chronicle the: 1) prior treatments for depression and the research that... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Prozac—Controversial Blockbuster: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-135, July 2020. (Revised January 2025.)
- September 2019 (Revised January 2020)
- Case
Gun Safety in America: Three Leaders Propose Innovative Solutions
By: Rosabeth Moss Kanter and Joseph Paul
Gun violence was a significant problem in America. Three Harvard Advanced Leadership Initiative Fellows Christy Wood, Russell Sternlicht, and Gareth Glaser each decided to do something about gun safety. They each used their professional and leadership experience to... View Details
Keywords: Gun Violence; Guns; Advanced Leadership; Advanced Leadership Initiative; Innovation; Innovation & Entrepreneurship; Social Change; Social Responsibility; Leadership; Change Management; Experience and Expertise; Social Entrepreneurship; Values and Beliefs; Policy; Governing Rules, Regulations, and Reforms; Leading Change; Non-Governmental Organizations; Social Issues; Innovation and Invention; Corporate Social Responsibility and Impact; United States
Kanter, Rosabeth Moss, and Joseph Paul. "Gun Safety in America: Three Leaders Propose Innovative Solutions." Harvard Business School Case 320-004, September 2019. (Revised January 2020.)
- 07 Jul 2014
- Research & Ideas
Banning Big-box Stores Can Hurt Local Retailers
were centrally determined, their actual implementation was delegated to local planning authorities. "This setup gave me the opportunity to look at the variations between areas with and without View Details
- October 2007
- Teaching Note
Rovna Dan: The Flat Tax in Slovakia (TN)
By: Laura Alfaro, Rafael M. Di Tella and Renee Kim
Teaching Note to 707043. View Details
- 01 Jun 2013
- News
Education Innovation
populated, in part, by HBS alumni. Doug Lemov (MBA 2004) is pushing to "reteach" teachers, equipping practitioners with real-world skills to improve learning ("5 Bright Ideas"). Scott Given (MBA 2010) and his fellow charter school View Details
- June 2010 (Revised December 2010)
- Case
Hôpital de Pontoise
By: Richard M.J. Bohmer, Daniela Beyersdorfer and Simon Harrow
In 2010, Andre Razafindranaly, managing director of a large French public hospital, considers which organizational structure will help them adjust to the changing health sector environment. The move from global budget to activity-based funding has led his and many... View Details
Keywords: Activity Based Costing and Management; Governance Controls; Governing Rules, Regulations, and Reforms; Health Care and Treatment; Leading Change; Service Delivery; Organizational Change and Adaptation; Organizational Structure; Health Industry; France
Bohmer, Richard M.J., Daniela Beyersdorfer, and Simon Harrow. "Hôpital de Pontoise." Harvard Business School Case 610-100, June 2010. (Revised December 2010.)
- 2025
- Working Paper
Mammography - Early Detection, Precise Diagnoses: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how the development of x-ray-based techniques and equipment (“mammography”) led to widespread screening for breast cancer and enabled “minimally invasive” biopsies of breast tumors. Specifically, we chronicle how: 1) new protocols and... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Mammography - Early Detection, Precise Diagnoses: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-002, July 2019. (Revised January 2025.)
- 2010
- Chapter
The Many Faces of Nonprofit Accountability
By: Alnoor Ebrahim
Calls for greater accountability are not new. Leaders of organizations, be they nonprofit, business, or government, face a constant stream of demands from various constituents demanding accountable behavior. But what does it mean to be accountable? By and large,... View Details
Keywords: Crime and Corruption; Corporate Accountability; Governing Rules, Regulations, and Reforms; Taxation; Leadership; Management; Nonprofit Organizations; Behavior; Trust
Ebrahim, Alnoor. "The Many Faces of Nonprofit Accountability." Chap. 4 in The Jossey-Bass Handbook of Nonprofit Leadership and Management. 3rd ed. Edited by David O. Renz, 110–121. San Francisco: Jossey-Bass, 2010.
- September 2019
- Teaching Note
Gun Safety in America: Three Leaders Propose Innovative Solutions
By: Rosabeth Moss Kanter and Joseph Paul
This is a teaching note to the original case: Gun violence was a significant problem in America. Three Harvard Advanced Leadership Initiative Fellows Christy Wood, Russell Sternlicht, and Gareth Glaser each decided to do something about gun safety. They each used... View Details
Keywords: Gun Violence; Guns; Advanced Leadership; Advanced Leadership Initiative; Innovation; Innovation & Entrepreneurship; Social Change; Social Responsibility; Leadership; Change Management; Experience and Expertise; Social Entrepreneurship; Values and Beliefs; Policy; Governing Rules, Regulations, and Reforms; Leading Change; Non-Governmental Organizations; Social Issues; Corporate Social Responsibility and Impact; United States
- May 2007
- Case
Free the Grapes--Direct-to-Consumer Shipping in the Wine Industry
By: Felix Oberholzer-Gee, Dennis A. Yao, Patricia Wu and Libby Cantrill
While wine tourism in the United States was booming, the majority of consumers who tasted a Cabernet Sauvignon in one of Napa Valley's tasting rooms were not permitted to ship the wine directly to their home. In 2002, direct-to-consumer shipping was either banned or... View Details
Keywords: Business Conglomerates; Governing Rules, Regulations, and Reforms; Lawsuits and Litigation; Agreements and Arrangements; Business and Government Relations; Corporate Strategy; Food and Beverage Industry; United States
Oberholzer-Gee, Felix, Dennis A. Yao, Patricia Wu, and Libby Cantrill. "Free the Grapes--Direct-to-Consumer Shipping in the Wine Industry." Harvard Business School Case 707-472, May 2007.
- September 2000
- Case
MBA In Jeopardy (A)
By: Lynn S. Paine, Gagan Gupta and Phani K. Nagarjuna
The Community Standards Panel of Harvard Business School must determine whether two students have violated the school's community standards, and if so, what sanction would be appropriate. Concerns allegations of plagiarism. In a second-year elective course, two... View Details
Keywords: Moral Sensibility; Business Education; Learning; Cross-Cultural and Cross-Border Issues; Governing Rules, Regulations, and Reforms; Education Industry
Paine, Lynn S., Gagan Gupta, and Phani K. Nagarjuna. "MBA In Jeopardy (A)." Harvard Business School Case 301-033, September 2000.
- January 27, 2020
- Article
Food-Stamp Work Requirements Just Look Cruel
The rule doesn’t help beneficiaries find the steady employment that doesn’t exist. View Details
Kominers, Scott Duke. "Food-Stamp Work Requirements Just Look Cruel." Bloomberg Opinion (January 27, 2020).
- 2010
- Working Paper
The Many Faces of Nonprofit Accountability
By: Alnoor Ebrahim
What does it mean for a nonprofit organization to be accountable? Nonprofit leaders tend to pay attention to accountability once a problem of trust arises—a scandal in the sector or in their own organization, questions from citizens or donors who want to know if their... View Details
Keywords: Corporate Accountability; Corporate Disclosure; Governing Rules, Regulations, and Reforms; Leadership; Mission and Purpose; Performance Evaluation; Nonprofit Organizations; Business Strategy
Ebrahim, Alnoor. "The Many Faces of Nonprofit Accountability." Harvard Business School Working Paper, No. 10-069, February 2010.
- 2008
- Working Paper
Hiring Cheerleaders: Board Appointments of 'Independent' Directors
By: Lauren Cohen, Andrea Frazzini and Christopher J. Malloy
We test the hypothesis that firms appoint independent directors who are overly sympathetic to management, while still technically independent according to regulatory definitions. We explore a subset of independent directors for whom we have detailed, micro-level data... View Details
Keywords: Competency and Skills; Governing Rules, Regulations, and Reforms; Governing and Advisory Boards; Managerial Roles; Prejudice and Bias
Cohen, Lauren, Andrea Frazzini, and Christopher J. Malloy. "Hiring Cheerleaders: Board Appointments of 'Independent' Directors." NBER Working Paper Series, No. 14232, August 2008.
- 2024
- Working Paper
Cephalosporins—Fighting Hospital Infections: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant Datar and Katherine Stebbins
This case history describes the development of three generations of cephalosporins – antibiotics that have significantly reduced hospital infections. Specifically, we chronicle how: 1) Early (pre-cephalosporin) antibiotics were developed in the first half of the 20th... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant Datar, and Katherine Stebbins. "Cephalosporins—Fighting Hospital Infections: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-133, July 2020. (Revised May 2024.)
- January 2009 (Revised July 2009)
- Case
Targanta Therapeutics: Hitting a Moving Target
By: Arthur A. Daemmrich
This case explores regulatory, product testing, and business strategy at Targanta Therapeutics, a biotech company preparing its first new drug application to the FDA. In October 2007, Mark Leuchtenberger, president and CEO of Targanta—which has just held a successful... View Details
Keywords: Decision Choices and Conditions; Entrepreneurship; Governing Rules, Regulations, and Reforms; Health Testing and Trials; Product Development; Business and Government Relations; Business Strategy; Biotechnology Industry; Pharmaceutical Industry
Daemmrich, Arthur A. "Targanta Therapeutics: Hitting a Moving Target." Harvard Business School Case 709-002, January 2009. (Revised July 2009.)
- September 2008 (Revised April 2009)
- Supplement
Kevin Sharer at Amgen: Sustaining the High-Growth Company (B)
By: William W. George
Kevin Sharer, CEO of Amgen, is assessing the challenges he has faced as a major product came under regulatory scrutiny. View Details
Keywords: Governing Rules, Regulations, and Reforms; Leadership; Product Development; Biotechnology Industry
George, William W. "Kevin Sharer at Amgen: Sustaining the High-Growth Company (B)." Harvard Business School Supplement 409-037, September 2008. (Revised April 2009.)
- Article
Recent Advances in the Empirics of Organizational Economics
By: Nicholas Bloom, Raffaella Sadun and John Van Reenen
We present a survey of recent contributions in empirical organizational economics, focusing on management practices and decentralization. Productivity dispersion between firms and countries has motivated the improved measurement of firm organization across industries... View Details
Keywords: Economics; Management Practices and Processes; Performance Productivity; Geographic Location; Motivation and Incentives; Factories, Labs, and Plants; Competition; Human Capital; Markets; Governing Rules, Regulations, and Reforms; Multinational Firms and Management; India; Brazil; United States
Bloom, Nicholas, Raffaella Sadun, and John Van Reenen. "Recent Advances in the Empirics of Organizational Economics." Annual Review of Economics 2 (2010): 105–137.
- July 2010 (Revised December 2011)
- Case
Controlling Hot Money
By: Robert C. Pozen
The manager of the Japan Equities Fund is faced with an increase in "hot money" moving quickly in and out of the Fund. This short-term trading is an attempt to take advantage of the difference between the closing times of the Tokyo and New York Stock Exchanges. The CFO... View Details
Keywords: Stocks; International Finance; Investment Funds; Governing Rules, Regulations, and Reforms; Market Timing; Market Transactions; Financial Services Industry; New York (city, NY)
Pozen, Robert C. "Controlling Hot Money." Harvard Business School Case 311-022, July 2010. (Revised December 2011.)
- 1993
- Chapter
Deposit Insurance Reform: A Functional Approach
By: Robert C. Merton and Zvi Bodie
Keywords: Banks and Banking; Insurance; Governing Rules, Regulations, and Reforms; Government and Politics; Insurance Industry; Banking Industry
Merton, Robert C., and Zvi Bodie. "Deposit Insurance Reform: A Functional Approach." In Carnegie-Rochester Conference Series on Public Policy. Vol. 38, edited by A. Meltzer and C. Plosser. Amsterdam: Elsevier, 1993.