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- January 2024 (Revised April 2024)
- Case
Target Malaria: Editing Mosquitoes through Gene Drives
By: Shikhar Ghosh and Shweta Bagai
Target Malaria, a non-profit research consortium, is exploring the application of CRISPR-Cas9 gene editing technology to combat malaria in Sub-Saharan Africa. Its approach uses gene drives, a revolutionary tool, to suppress the population of malaria-carrying... View Details
- January 2024
- Case
National Football League and Private 5G
By: Andy Wu, Grant Son and Shuoyu Chen
On September 9, 2021, the National Football League (NFL) designated Verizon as its official 5G partner in a 10-year deal, committed to enhance the experience for NFL teams, players, and fans in stadiums. NFL Commissioner Roger Goodell said, “Verizon will help us... View Details
- December 2023 (Revised March 2024)
- Case
Manufacturing Moderna's Future
By: Satish Tadikonda and William Marks
In 2019, Moderna faced long odds of survival having failed to develop a successful clinical program out of the vast platform technology they had built around mRNA. Nearly overnight, the company skyrocketed to success with a vaccine for COVID-19, leading to an extremely... View Details
- 2023
- Working Paper
Money, Time, and Grant Design
By: Kyle Myers and Wei Yang Tham
The design of research grants has been hypothesized to be a useful tool for
influencing researchers and their science. We test this by conducting two thought
experiments in a nationally representative survey of academic researchers. First,
we offer participants a... View Details
- 2023
- Article
Balancing Risk and Reward: An Automated Phased Release Strategy
By: Yufan Li, Jialiang Mao and Iavor Bojinov
Phased releases are a common strategy in the technology industry for gradually releasing new products or updates through a sequence of A/B tests in which the number of treated units gradually grows until full deployment or deprecation. Performing phased releases in a... View Details
- December 2023
- Article
Self-Orienting in Human and Machine Learning
By: Julian De Freitas, Ahmet Uğuralp, Zeliha Uğuralp, Laurie Paul, Joshua B. Tenenbaum and T. Ullman
A current proposal for a computational notion of self is a representation of one’s body in a specific time and place, which includes the recognition of that representation as the agent. This turns self-representation into a process of self-orientation, a challenging... View Details
- November 2023 (Revised April 2024)
- Case
BiomX: Bringing Phage Back to the Stage
By: Paul A. Gompers, Elie Ofek, Orna Dan and Emilie Billaud
In the spring of 2023, and following the favorable results of a trial involving its phage cocktail for treating lung infections among cystic fibrosis (CF) patients, the leadership of BiomX had several critical issues to wrestle with. First, given its precarious... View Details
- 2023
- Book
How the Harvard Business School Changed the Way We View Organizations
By: Jay W. Lorsch
The story of the field of organizational behavior (which overlaps considerably with the origin story of Harvard Business School) and how it created the “medical model” of systems thinking—anchored in the practices of listening, observing, testing, and only then... View Details
Keywords: Organizational Behavior; Systems Thinking; Medical Model; Organizations; Behavior; System; History
- November 2023 (Revised April 2024)
- Case
Khanmigo: Revolutionizing Learning with GenAI
By: William A. Sahlman, Allison M. Ciechanover and Emily Grandjean
Already a leader in the edtech space since its 2008 launch, Khan Academy was now one of the first edtech organizations to embrace generative artificial intelligence ("genAI"). In March 2023, Khan Academy began beta testing Khanmigo, a genAI “guide” and tutor built with... View Details
- November–December 2023
- Article
Network Centralization and Collective Adaptability to a Shifting Environment
By: Ethan S. Bernstein, Jesse C. Shore and Alice J. Jang
We study the connection between communication network structure and an organization’s collective adaptability to a shifting environment. Research has shown that network centralization—the degree to which communication flows disproportionately through one or more... View Details
- 2023
- Working Paper
The Buy-In Effect: When Increasing Initial Effort Motivates Behavioral Follow-Through
By: Holly Dykstra, Shibeal O'Flaherty and A.V. Whillans
Behavioral interventions often focus on reducing friction to encourage behavior change. In
contrast, we provide evidence that adding friction can promote long-term behavior change when
behaviors involve repeated costly efforts over longer time horizons. In... View Details
- October 2023 (Revised February 2024)
- Technical Note
Design and Evaluation of Targeted Interventions
By: Eva Ascarza and Ta-Wei (David) Huang
Targeted interventions serve as a pivotal tool in business strategy, streamlining decisions for enhanced efficiency and effectiveness. This note delves into two central facets of such interventions: first, the design of potent decision guidelines, or targeting... View Details
- October 2023 (Revised April 2024)
- Case
FARM Rio: Bringing a Brazilian Fashion Brand to the World
By: Isamar Troncoso and Jill Avery
FARM Rio, a twenty-six year old Brazilian fashion brand, had recently put down roots in the U.S. The brand, known for its bold, colorful, nature-inspired tropical prints, was testing the waters in Europe to assess if and how the brand should further expand globally.... View Details
- 2023
- Working Paper
Trusting Talent: Cross-Country Differences in Hiring
By: Letian Zhang and Shinan Wang
This article argues that a society’s social trust influences employers’ hiring strategies. In selecting workers, employers could either focus on applicants’ potential and select on foundational skills (e.g., social skills, math skills) or focus on their readiness and... View Details
- September 2023
- Supplement
Design and Evaluation of Targeted Interventions
By: Eva Ascarza
Targeted interventions serve as a pivotal tool in business strategy, streamlining decisions for enhanced efficiency and effectiveness. This note delves into two central facets of such interventions: first, the design of potent decision guidelines, or targeting... View Details
- September–October 2023
- Article
Prospective Evaluation of the Cost of Performing Breast Imaging Examinations Using Time-Driven Activity-Based Costing Method: A Single Center Study
By: Aamir Ali, Jordana Phillips, Damir Ljuboja, Syed S. Shehab, Etta D. Pisano, Robert S. Kaplan and Ammar Sarwar
We use time-driven activity-based costing (TDABC) to measure the cost of performing breast imaging using different modalities: full-field digital mammography (FFDM), digital breast tomosynthesis (DBT), contrast-enhanced mammography (CEM), US and MRI exams, and... View Details
- September 2023
- Article
The Changing Role of Managers
By: Letian Zhang
This study argues that the increase in middle management in recent decades was
accompanied by a major shift in managerial roles. Increased task complexity and a
new management philosophy have reduced the need for direct supervision but generated
a much greater... View Details
- September 2023
- Article
The Dynamics of Team Learning: Harmony and Rhythm in Teamwork Arrangements for Innovation
By: Jean-François Harvey, Johnathan R. Cromwell, Kevin J. Johnson and Amy C. Edmondson
Innovation teams must navigate inherent tensions between different learning activities to produce high levels of performance. Yet, we know little about how teams combine these activities—notably reflexive, experimental, vicarious, and contextual learning—most... View Details
- Article
Update on E-liability Accounting
By: Robert Kaplan, Karthik Ramanna and Piyush Jha
Since publication of the original E-liability carbon accounting paper (HBR, Nov 2021), we created the E-liability Institute to help companies, governments, and nonprofits implement the method. The Institute’s mission is to test and validate the method, and develop... View Details
- August 2023 (Revised May 2024)
- Case
Dicerna Pharmaceuticals: Decision Making in Clinical Trial Design and Operations
By: Satish Tadikonda and Amanda McEwen
The success or failure of Dicerna Pharmaceuticals (Dicerna) as an emerging pharmaceutical company would likely hinge on its lead drug candidate Nedosiran and the company’s ability to see it successfully through clinical development. Ralf Rosskamp, Chief Medical... View Details