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      • 2022
      • Working Paper

      Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation

      By: Amitabh Chandra, Jennifer Kao, Kathleen Miller and Ariel D. Stern
      Regulators of new products confront a tradeoff between speeding a new product to market and collecting additional product quality information. The FDA’s Breakthrough Therapy Designation (BTD) provides an opportunity to understand if a regulator can use new policy to... View Details
      Keywords: Research and Development; Governing Rules, Regulations, and Reforms; Product Development
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      Chandra, Amitabh, Jennifer Kao, Kathleen Miller, and Ariel D. Stern. "Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation." NBER Working Paper Series, No. 30712, December 2022.
      • Winter 2022
      • Article

      Vaccines and the COVID-19 Pandemic: Lessons from Failure and Success

      By: Scott Duke Kominers and Alex Tabarrok
      The losses from the global COVID-19 pandemic have been staggering—trillions in economic costs, on top of significant losses of life, health, and well-being. The world made significant and successful investments in vaccines to mitigate the pandemic, yet there were... View Details
      Keywords: COVID-19; Vaccination; Market Design; Health Pandemics; Loss; Outcome or Result; Opportunities; Crisis Management
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      Kominers, Scott Duke, and Alex Tabarrok. "Vaccines and the COVID-19 Pandemic: Lessons from Failure and Success." Oxford Review of Economic Policy 38, no. 4 (Winter 2022): 719–741.
      • November 2022
      • Case

      The Battle Among Channels for Marketing Pharmaceuticals: UpScript, Pharmacy Benefit Managers, and Direct-to-Consumer Sales

      By: Regina E. Herzlinger and Tiffany Farrell
      Can an online, direct-to-consumer pharmacy both improve the quality and speed of care for patients who need branded drugs and stabilize profits for pharmaceutical manufacturers? UpScript, after years spent achieving legal and regulatory compliance and simultaneous... View Details
      Keywords: DTC; Internet and the Web; Marketing Channels; Customer Value and Value Chain; Governing Rules, Regulations, and Reforms; Competitive Strategy; Service Delivery; Growth and Development Strategy; Pharmaceutical Industry; Health Industry; Retail Industry
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      Herzlinger, Regina E., and Tiffany Farrell. "The Battle Among Channels for Marketing Pharmaceuticals: UpScript, Pharmacy Benefit Managers, and Direct-to-Consumer Sales." Harvard Business School Case 323-031, November 2022.
      • October 2022
      • Case

      EducationSuperHighway 2.0

      By: William A. Sahlman, Allison M. Ciechanover and Emily Grandjean
      In 2012, Evan Marwell launched EducationSuperHighway (ESH) to address a major problem: though most public K-12 schools in the US had access to the Internet, only roughly 30% had true broadband access that would enable every student to have high speed connectivity. ... View Details
      Keywords: Nonprofit Organizations; Social Entrepreneurship; Social Issues; Leading Change; Early Childhood Education; Infrastructure; Internet and the Web; Telecommunications Industry; Education Industry; Technology Industry; United States; San Francisco
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      Sahlman, William A., Allison M. Ciechanover, and Emily Grandjean. "EducationSuperHighway 2.0." Harvard Business School Case 823-060, October 2022.
      • 2024
      • Working Paper

      Adjusting Prices in the Long-tail: The Role of Competitive Monitoring

      By: Ayelet Israeli and Eric Anderson
      Most e-commerce retailers offer a long-tail of very low demand products. Individually, these items may have low sales but collectively they are critical to the overall e-commerce business model. Because of their minimal sales, pricing is a constant challenge. The... View Details
      Keywords: Algorithmic Pricing; Ecommerce; Price Monitoring; Price; Competition; Retail Industry
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      Israeli, Ayelet, and Eric Anderson. "Adjusting Prices in the Long-tail: The Role of Competitive Monitoring." Working Paper, June 2024.
      • August 2022 (Revised November 2022)
      • Case

      Altos Ventures (A)

      By: Jo Tango and Alys Ferragamo
      In December 2012, Altos Ventures General Partners Han Kim, Anthony Lee, and Ho Nam met to discuss the future of the firm. Altos had already adjusted its strategy multiple times. It began as a U.S.-focused venture capital investor whose first two funds were backed by a... View Details
      Keywords: Strategic Planning; Venture Capital; Investment Portfolio; Partners and Partnerships
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      Tango, Jo, and Alys Ferragamo. "Altos Ventures (A)." Harvard Business School Case 823-035, August 2022. (Revised November 2022.)
      • July 28, 2022
      • Article

      DAO Governance Attacks, and How to Avoid Them

      By: Pranav Garimidi, Scott Duke Kominers and Tim Roughgarden
      Many web3 projects embrace permissionless voting using a fungible and tradable native token. Permissionless voting can offer many benefits, from lowering barriers to entry to increasing competition. Token holders can use their tokens to vote on a range of issues—from... View Details
      Keywords: Crypto Economy; Cryptocurrency; Governance; Voting; Decentralized Autonomous Organizations; Organizational Structure; Digital Platforms
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      Garimidi, Pranav, Scott Duke Kominers, and Tim Roughgarden. "DAO Governance Attacks, and How to Avoid Them." a16zcrypto.com (July 28, 2022).
      • June 10, 2022
      • Article

      Does Your Company’s Culture Reinforce Its Strategy and Purpose?

      By: Hubert Joly
      Good strategy has traditionally been seen as the key to business success. More recently, purpose has become an essential element of doing business. But something else is missing: culture, or the essential elements of how an organization and its employees behave, as... View Details
      Keywords: Success; Mission and Purpose; Organizational Culture; Corporate Strategy
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      Joly, Hubert. "Does Your Company’s Culture Reinforce Its Strategy and Purpose?" Harvard Business Review (website) (June 10, 2022).
      • June 2022
      • Case

      Business Implications from Regulating Carbon Emissions in the EU

      By: George Serafeim and Benjamin Maletta
      In the beginning of the 21st century, the European Union (the EU) had led the global fight against climate change with a wide array of policy measures. The EU’s primary approach to climate policy had been taxation via the European Union Emissions Trading System (EU... View Details
      Keywords: Regulation; Carbon Emissions; Trade; Sustainability; Decarbonization; Performance; Climate Change; Analysis; Strategy; Taxation; Policy; Environmental Regulation; Industry Structures; European Union
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      Serafeim, George, and Benjamin Maletta. "Business Implications from Regulating Carbon Emissions in the EU." Harvard Business School Case 122-106, June 2022.
      • June 2022
      • Article

      The Use and Misuse of Patent Data: Issues for Finance and Beyond

      By: Josh Lerner and Amit Seru
      Patents and citations are powerful tools for understanding innovation increasingly used in financial economics (and management research more broadly). Biases may result, however, from the interactions between the truncation of patents and citations and the changing... View Details
      Keywords: Patents; Analytics and Data Science; Corporate Finance; Research
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      Lerner, Josh, and Amit Seru. "The Use and Misuse of Patent Data: Issues for Finance and Beyond." Review of Financial Studies 35, no. 6 (June 2022): 2667–2704.
      • 2022
      • Book

      Democratize Work: The Case for Reorganizing the Economy

      By: Isabelle Ferreras, Julie Battilana and Dominique Méda
      What happens to a society—and a planet—when capitalism outgrows democracy? The tensions between democracy and capitalism are longstanding, and they have been laid bare by the social effects of COVID-19. The narrative of “essential workers” has provided thin cover for... View Details
      Keywords: Democratic Capitalism; Essential Workers; Sustainability; Equality and Inequality; Climate Change; Social Issues
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      Ferreras, Isabelle, Julie Battilana, and Dominique Méda, eds. Democratize Work: The Case for Reorganizing the Economy. Chicago: University of Chicago Press, 2022.
      • April 2022
      • Article

      Going Out or Opting Out? Capital, Political Vulnerability, and the State in China's Outward Investment

      By: Meg Rithmire
      How do state-business relations interact with outward investment in authoritarian regimes? This paper examines this question in the context of China’s rapid transformation into a major capital exporter. While most political economy scholarship focuses on firms’... View Details
      Keywords: Outward Investment; Capital Controls; Corruption; Foreign Direct Investment; Political Economy; State-owned Enterprises; Investment; Global Range; Capital; Globalization; Policy; Government and Politics; China
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      Rithmire, Meg. "Going Out or Opting Out? Capital, Political Vulnerability, and the State in China's Outward Investment." Comparative Politics 54, no. 3 (April 2022): 477–499.
      • 2022
      • Working Paper

      THEMIS: A Framework for Cost-Benefit Analysis of COVID-19 Non-Pharmaceutical Interventions

      By: Dimitris Bertsimas, Michael Lingzhi Li and Saksham Soni
      Since December 2019, the world has been ravaged by the COVID-19 pandemic, with over 150 million confirmed cases and 3 million confirmed deaths worldwide. To combat the spread of COVID-19, governments have issued unprecedented non-pharmaceutical interventions (NPIs),... View Details
      Keywords: COVID-19; Health Pandemics; Policy; Framework; Cost vs Benefits; Outcome or Result; United States; Germany; Brazil; Singapore; Spain
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      Bertsimas, Dimitris, Michael Lingzhi Li, and Saksham Soni. "THEMIS: A Framework for Cost-Benefit Analysis of COVID-19 Non-Pharmaceutical Interventions." Working Paper, April 2022.
      • March 31, 2022
      • Article

      Two Approaches to Capping Health Care Prices

      By: Michael E. Chernew, Maximilian J. Pany and Leemore S. Dafny
      High health care prices for the privately-insured contribute to high premiums, which put downward pressure on wages, and induce employers to reduce benefit generosity and charge employees more for coverage. As the average annual premium for family coverage currently... View Details
      Keywords: Price Caps; Health Care and Treatment; Price
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      Chernew, Michael E., Maximilian J. Pany, and Leemore S. Dafny. "Two Approaches to Capping Health Care Prices." Health Affairs Forefront (March 31, 2022).
      • March 2022 (Revised April 2022)
      • Teaching Note

      Group Functions at the Maersk Group

      By: David J. Collis
      In 2014, seven years after he was appointed CEO of the Danish shipping and oil conglomerate A.P. Møller Maersk (the Maersk Group), Nils Andersen was reexamining the size and role of corporate headquarters in the company he had reshaped as a "premium conglomerate."... View Details
      Keywords: Maersk; Business Units; Conglomerates; Decentralization; Core Business; Value Added; Synergy; Headquarters; Shipping; Petroleum; Oil And Gas; Drilling; Corporate Strategy; Business Conglomerates; Business Divisions; Transportation Industry; Shipping Industry; Denmark
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      Collis, David J. "Group Functions at the Maersk Group." Harvard Business School Teaching Note 722-417, March 2022. (Revised April 2022.)
      • March 2022 (Revised November 2023)
      • Case

      Doubling Down: Elon Musk's Big Bets in 2022

      By: David Yoffie and Daniel Fisher
      2021 was a banner year for Elon Musk. CEO of the electric vehicle manufacturer Tesla, the aerospace manufacturer SpaceX, and a few smaller startups, Musk became the richest person on Earth after Tesla reached a market capitalization of $1 trillion and SpaceX a private... View Details
      Keywords: Innovation and Management; Competitive Advantage; Competitive Strategy; Information Infrastructure; Applications and Software; Transportation; Strategic Planning; Leadership Style; Leading Change; Goals and Objectives; Aerospace Industry; Auto Industry; Battery Industry; United States; Europe; China
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      Yoffie, David, and Daniel Fisher. "Doubling Down: Elon Musk's Big Bets in 2022." Harvard Business School Case 722-439, March 2022. (Revised November 2023.)
      • March 2022 (Revised May 2022)
      • Case

      Winning Business at Russell Reynolds (A)

      By: Ethan Bernstein and Cara Mazzucco
      In an effort to make compensation drive collaboration, Russell Reynolds Associates’ (RRA) CEO Clarke Murphy sought to re-engineer the bonus system for his executive search consultants in 2016. As his HR analytics guru, Kelly Smith, points out, that risks upsetting–and... View Details
      Keywords: Compensation; Collaboration; Executive Search Firms; Consulting Firms; Compensation and Benefits; Restructuring; Human Resources; Human Capital; Management Practices and Processes; Organizational Culture; Organizational Change and Adaptation; Social and Collaborative Networks; Recruitment; Selection and Staffing; Talent and Talent Management; Consulting Industry; Employment Industry; Asia; Europe; Latin America; Middle East; North and Central America; South America; Oceania
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      Bernstein, Ethan, and Cara Mazzucco. "Winning Business at Russell Reynolds (A)." Harvard Business School Case 422-045, March 2022. (Revised May 2022.)
      • March 2022
      • Supplement

      Winning Business at Russell Reynolds (B)

      By: Ethan Bernstein and Cara Mazzucco
      In an effort to make compensation drive collaboration, Russell Reynolds Associates’ (RRA) CEO Clarke Murphy sought to re-engineer the bonus system for his executive search consultants in 2016. As his HR analytics guru, Kelly Smith, points out, that risks upsetting–and... View Details
      Keywords: Compensation; Collaboration; Executive Search Firms; Consulting Firms; Compensation and Benefits; Restructuring; Human Resources; Human Capital; Management Practices and Processes; Organizational Culture; Organizational Change and Adaptation; Social and Collaborative Networks; Recruitment; Selection and Staffing; Talent and Talent Management; Consulting Industry; Employment Industry; Asia; Europe; Latin America; Middle East; North and Central America; South America; Oceania
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      Bernstein, Ethan, and Cara Mazzucco. "Winning Business at Russell Reynolds (B)." Harvard Business School Supplement 422-046, March 2022.
      • March 2022
      • Article

      Assessing the Impact of the COVID-19 Pandemic on Clinician Ambulatory Electronic Health Record Use

      By: A Jay Holmgren, Lance Downing, Mitchell Tang, Christopher Sharp, Christopher Longhurst and Robert S. Huckman
      Objective: The COVID-19 pandemic changed clinician electronic health record (EHR) work in a multitude of ways. To evaluate how, we measure ambulatory clinician EHR use in the United States throughout the COVID-19 pandemic.

      Materials and Methods: We use EHR... View Details
      Keywords: Health Care; Electronic Health Records; Productivity; COVID-19 Pandemic; Health Care and Treatment; Health Pandemics; Information Technology; Performance Productivity; United States
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      Holmgren, A Jay, Lance Downing, Mitchell Tang, Christopher Sharp, Christopher Longhurst, and Robert S. Huckman. "Assessing the Impact of the COVID-19 Pandemic on Clinician Ambulatory Electronic Health Record Use." Journal of the American Medical Informatics Association 29, no. 3 (March 2022): 453–460.
      • 2022
      • Chapter

      Immigration Policy Levers for U.S. Innovation and Startups

      By: William R. Kerr and Sari Pekkala Kerr
      Immigrants account for about a quarter of US invention and entrepreneurship despite a policy environment that is not well suited for these purposes. This chapter reviews the U.S. immigration policy environment that governs how skilled migrants move to America for... View Details
      Keywords: High-tech; H1-B; Immigration; Entrepreneurship; Innovation and Invention; Business Startups; Venture Capital
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      Kerr, William R., and Sari Pekkala Kerr. "Immigration Policy Levers for U.S. Innovation and Startups." In Innovation and Public Policy, edited by Austan D. Goolsbee and Benjamin F. Jones. Chicago: University of Chicago Press, 2022.
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