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  • 2009
  • Working Paper

Where Is the Pharmacy to the World? International Regulatory Variation and Pharmaceutical Industry Location

By: Arthur Daemmrich
A consumer-oriented model for drug development and use has attracted attention in recent years as an alternative to the much-maligned approach of mass-marketing blockbuster drugs. In a parallel development, patients and disease-based organizations have assumed greater... View Details
Keywords: Governing Rules, Regulations, and Reforms; Health Disorders; Health Testing and Trials; Power and Influence; Competitive Strategy; Pharmaceutical Industry; European Union; Germany; United States
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  • Research Summary

Clinical Trials as a setting for Health Policy and Management Research

The clinical trial marketplace is in flux. A decade ago, pharmaceutical firms almost exclusively conducted the study of their novel drug compounds within major academic medical centers. But today, industry-sponsored clinical trials are increasingly using community... View Details
  • January 2020
  • Article

The Market Reacts Quickly: Changes in Paclitaxel Vascular Device Purchasing Within the Ascension Healthcare System

By: Peter P. Monteleone, Subhash Banerjee, Priya Kothapalli, Ariel Dora Stern, Daniel Fehder, Ron Ginor, Dominic Vollmar, Edward T. A. Fry and Mark J. Pirwitz
Background. A meta-analysis of trials in endovascular therapy suggested an increased mortality associated with treatment exposure to paclitaxel. Multiple publications and corrections of prior data were performed, and the United States Food and Drug Administration has... View Details
Keywords: Medical Devices; Health Testing and Trials; Analysis; Sales
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  • September 2020
  • Case

Minerva 2020: Clinical Trials

By: John R. Wells and Benjamin Weinstock
In March 2020, Dr. Cynthia Bamdad, founder and CEO of Minerva Biotechnologies Inc. (Minerva), was reviewing the first results of human clinical trials for the company’s novel CAR-T drug therapeutic, one of the first ever to target solid cancer tumors. The results... View Details
Keywords: Biotechnology; Strategic Decision Making; Entrepreneurship; Health Testing and Trials; Decision Choices and Conditions; Strategy
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  • January–February 2023
  • Article

Data-Driven COVID-19 Vaccine Development for Janssen

By: Dimitris Bertsimas, Michael Lingzhi Li, Xinggang Liu, Jennings Xu and Najat Khan
The COVID-19 pandemic has spurred extensive vaccine research worldwide. One crucial part of vaccine development is the phase III clinical trial that assesses the vaccine for safety and efficacy in the prevention of COVID-19. In this work, we enumerate the first... View Details
Keywords: COVID-19; Health Testing and Trials; Forecasting and Prediction; AI and Machine Learning; Research; Pharmaceutical Industry
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  • 02 Mar 2007
  • What Do You Think?

What Is the Government’s Role in US Health Care?

avoidance on the part of physicians, a litigious society, and inadequate protection from it for physicians (Rowland Freeman), "defensive" medicine leading to unnecessary tests and treatments, an insurance system that is costly and... View Details
Keywords: by Jim Heskett; Health
  • 21 Feb 2018
  • Research & Ideas

When a Competitor Abandons the Market, Should You Advance or Retreat?

test results, changing market conditions, deteriorating financials of the host company, or escalating project costs. Krieger chose to focus on drug development, in part, because in the United States... View Details
Keywords: by Rachel Layne; Pharmaceutical; Health
  • 19 Dec 2017
  • First Look

New Research and Ideas, December 19, 2017

Abstract—No abstract available. Publisher's link: https://www.hbs.edu/faculty/Pages/item.aspx?num=53633 Characterizing the Drug Development Pipeline for Precision Medicines By: Chandra, Amitabh, Craig Garthwaite, and Ariel Dora Stern... View Details
Keywords: Carmen Nobel
  • 11 May 2010
  • First Look

First Look: May 11

can induce a controlling shareholder to list equity. Higher valuations support listings associated with greater agency costs. We test the predictions that follow from this idea on a sample of publicly listed corporate subsidiaries in... View Details
Keywords: Martha Lagace
  • Article

Use of Connected Digital Products in Clinical Research Following the COVID-19 Pandemic: A Comprehensive Analysis of Clinical Trials

By: Caroline Marra, William J. Gordon and Ariel Dora Stern
Objectives: In an effort to mitigate COVID-19 related challenges for clinical research, the U.S. Food and Drug Administration (FDA) issued new guidance for the conduct of ‘virtual’ clinical trials in late March 2020. This study documents trends in the use of... View Details
Keywords: Connected Digital Products; Telehealth; Remote Monitoring; Health Testing and Trials; Research; Governing Rules, Regulations, and Reforms; Information Technology
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  • 16 Dec 2014
  • First Look

First Look: December 16

share the same ethnic, educational, or career background are more likely to syndicate with each other. This homophily reduces the probability of investment success, and the detrimental effect is most prominent for early-stage investments. A variety of View Details
Keywords: Sean Silverthorne
  • 13 Jan 2009
  • First Look

First Look: January 13, 2009

and regulation of clinical trials, managerial challenges related to pharmaceutical product testing, and current debates regarding prescription drug safety. Since clinical testing takes between five and seven... View Details
Keywords: Martha Lagace
  • 21 Sep 2022
  • Research & Ideas

You Don’t Have to Quit Your Job to Find More Meaning in Life

overpriced drugs (moral condition) or drove patients into debt by increasing prices (immoral condition). Only 19 percent of participants said Ariana’s life was meaningful when she drove patients into debt by increasing prices. By... View Details
Keywords: by Shalene Gupta
  • 28 Oct 2014
  • First Look

First Look: October 28

between following a prosocial norm and self-regulation. We tested 433 children between 6 and 13 years of age in two variations of the Dictator Game (DG). Children were asked what they should or would give in the game and then played an... View Details
Keywords: Carmen Nobel
  • 13 Jul 2020
  • Research & Ideas

Merck CEO Ken Frazier Discusses a COVID Cure, Racism, and Why Leaders Need to Walk the Talk

idea of reliable and safe and tested on humans, on people. Frazier: Yes. On large numbers of people. Neeley: On large numbers of people. Frazier: Yes. There are a lot of examples of vaccines in the past that have stimulated the immune... View Details
Keywords: by Staff; Pharmaceutical
  • 20 Oct 2011
  • Research & Ideas

Getting the Marketing Mix Right

individual-level choice behavior to be recovered from the data," according to the researchers. The team tested the new model by looking at the marketing of prescription drugs, namely, statins, used to lower cholesterol levels in... View Details
Keywords: by Dina Gerdeman
  • 01 Jun 2015
  • Research & Ideas

The Surprising Benefits of Oversharing

to Answer. When John and colleagues tested these various conditions, they found that participants were much more likely to choose a dating partner who answered all the questions, rather than someone who chose not to answer. Surprisingly,... View Details
Keywords: by Michael Blanding
  • 17 Sep 2021
  • Research & Ideas

The Trial of Elizabeth Holmes: Visionary, Criminal, or Both?

Ramesh Balwani, had long known that Theranos’ home blood test didn’t work, but misled investors to keep money flowing in. Holmes and Balwani are accused of defrauding patients, doctors, and investors of over $700 million. At its peak in... View Details
Keywords: by Christina Pazzanese, Harvard Gazette; Biotechnology; Technology; Medical Devices & Supplies
  • 08 Feb 2000
  • Research & Ideas

Building Effective R&D Capabilities Abroad

to commercialize its R&D more effectively in foreign markets. Until then, Eli Lilly had operated one home-base-augmenting laboratory site abroad and some small sites in industrialized countries for clinical testing and View Details
Keywords: by Walter Kuemmerle
  • 19 Sep 2016
  • Research & Ideas

Why Isn't Business Research More Relevant to Business Practitioners?

disciplines, where academic research is leading to the development of a second skin that could improve drug delivery or alerting farmers and scientists on how to reduce nitrous oxide emissions from agricultural farming. Harvard Business... View Details
Keywords: by Carmen Nobel; Education

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