Publications

April 1993 (Revised November 1994)
Case

Pablo Valenzuela, vice president of R&D at Chiron Corp., faces several choices for how to allocate scarce resources across several promising projects. These choices will determine Chiron's position in several emerging biotechnology and diagnostic markets, including... View Details

Keywords: Health Testing and Trials; Research and Development; Failure; Business Strategy; Joint Ventures; Strategic Planning; Opportunities; Product Development; Biotechnology Industry; California

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01 Jun 2013
News

Coach for Life

his Authentic Leadership Development elective, Hurley hit the court for some impromptu coaching and informal hoops with section intramural teams. He later joined members of the HBS community at a March... View Details

Keywords: Elementary and Secondary Schools; Elementary and Secondary Schools

January 2009 (Revised July 2009)
Case

Targanta Therapeutics: Hitting a Moving Target

By: Arthur A. Daemmrich

This case explores regulatory, product testing, and business strategy at Targanta Therapeutics, a biotech company preparing its first new drug application to the FDA. In October 2007, Mark Leuchtenberger, president and CEO of Targanta—which has just held a successful... View Details

Keywords: Decision Choices and Conditions; Entrepreneurship; Governing Rules, Regulations, and Reforms; Health Testing and Trials; Product Development; Business and Government Relations; Business Strategy; Biotechnology Industry; Pharmaceutical Industry

February 2008 (Revised August 2008)
Case

EXACT Sciences Corp.: Commercializing a Diagnostic Test

By: Regina E. Herzlinger

This case addresses the challenges of commercializing molecular diagnostics. Along the way, it explains the technology, payment system, and the measures used to assess the value of a diagnostic test. View Details

Keywords: Health Testing and Trials; Genetics; Science-Based Business; Commercialization; Biotechnology Industry

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April 2024
Article

A Machine Learning Algorithm Predicting Risk of Dilating VUR among Infants with Hydronephrosis Using UTD Classification

By: Hsin-Hsiao Scott Wang, Michael Lingzhi Li, Dylan Cahill, John Panagides, Tanya Logvinenko, Jeanne Chow and Caleb Nelson

Backgrounds: Urinary Tract Dilation (UTD) classification has been designed to be a more objective grading system to evaluate antenatal and post-natal UTD. Due to unclear association between UTD classifications to specific anomalies such as vesico-ureteral reflux (VUR),... View Details

Keywords: Health Disorders; Health Testing and Trials; AI and Machine Learning; Health Industry

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October 2020
Teaching Plan

Merck: COVID-19 Vaccines

By: Willy C. Shih

COVID-19 infections were still climbing across the U.S. and many other parts of the world in September 2020, and it seemed that every time Ken Frazier, the CEO of Merck & Co. consented to an interview in recent months he always seemed to hear the same question,... View Details

Keywords: Vaccines; Health Pandemics; Health Testing and Trials; Innovation and Management; Innovation Strategy; Research and Development; Business Strategy; Pharmaceutical Industry; United States

01 Feb 2011
First Look

First Look: Feb. 1

Bonding Stick? A Natural Experiment Involving the Supreme Court and Cross-Listed Firms Authors:Amir N. Licht, Xi Li, and Jordan I. Siegel Abstract Using a natural experiment to... View Details

01 Dec 2010
News

Chaotic Funding Derails Research

time to consider the devastating implications of this chaotic funding environment. And to do that, one needs to understand how a modern research lab operates. A typical lab has twenty to forty people, led by a senior researcher (the... View Details

Keywords: William Sahlman; Science funding; stem cell research; Colleges, Universities, and Professional Schools; Colleges, Universities, and Professional Schools

December 2023 (Revised March 2024)
Case

Manufacturing Moderna's Future

By: Satish Tadikonda and William Marks

In 2019, Moderna faced long odds of survival having failed to develop a successful clinical program out of the vast platform technology they had built around mRNA. Nearly overnight, the company skyrocketed to success with a vaccine for COVID-19, leading to an extremely... View Details

Keywords: Health Pandemics; Health Testing and Trials; Technological Innovation; Product Development; Production; Science-Based Business; Biotechnology Industry

14 Apr 2021
Research & Ideas

The High Cost of the Slow COVID Vaccine Rollout

dollars in value, Kominers and his co-authors reported in Market Design to Accelerate COVID-19 Vaccine Supply in the March 12 issue of Science. “The value of being able to produce vaccines at scale the minute they clear View Details

Keywords: by Michael Blanding; Health

June 2016
Teaching Plan

Terrapin Laboratory

By: Joseph B. Fuller and Andrew Otazo

This teaching plan accompanies the case "Terrapin Laboratory," HBS No. 315-098. That case describes the formation and rapid growth of a drug testing company. The company needs to decide whether to enter the painkiller testing market, in addition to growing its drug... View Details

Keywords: Business Growth; Entrepreneurial Management; Growth Strategy; Market Entry; Venture Capital; Market Entry and Exit; Entrepreneurship; Health Testing and Trials; Growth and Development Strategy; Pharmaceutical Industry

30 Jan 2012
Research & Ideas

Measuring the Efficacy of the World’s Managers

larger number of organizations. The researchers have also started to work on management experiments, modeled on the randomized control trials adopted in the medical field. This experimental approach is much more costly View Details

Keywords: by Carmen Nobel

05 May 2003
Research & Ideas

What It Takes to Restore Trust in Business

raised the issue of restitution for investors who had been defrauded and subjected to misrepresentations. "We have apparently decided that the issues of restitution ... should primarily be left to the View Details

Keywords: by Martha Lagace; Financial Services

15 Dec 2024
News

After Ozempic

Alzheimer’s disease in a phase 2 trial. Other trials are examining the extent to which GLP-1s can curb cravings for alcohol, nicotine, opioids, and even psychostimulants—or whether it could help eliminate... View Details

Keywords: Jen McFarland Flint; Illustrations by Pete Ryan; Ambulatory Health Care Services; Health, Social Assistance

October 2006 (Revised August 2007)
Case

Calloway Laboratory: Pee for Profit

By: Richard G. Hamermesh and David Kiron

Describes the formation and rapid growth of a drug-testing company. The company needs to decide whether to enter the painkiller testing market, in addition to growing its drug treatment center business. View Details

Keywords: For-Profit Firms; Health Care and Treatment; Health Testing and Trials; Growth and Development Strategy; Market Entry and Exit; Health Industry

March 2015 (Revised September 2016)
Case

Terrapin Laboratory

By: Richard G. Hamermesh and Joseph B. Fuller

Describes the formation and rapid growth of a drug testing company. The company needs to decide whether to enter the painkiller testing market, in addition to growing its drug treatment center business. The associated teaching materials provide students the opportunity... View Details

Keywords: Business Growth; Entrepreneurial Management; Entrepreneurship; Growth Strategy; Market Entry; Venture Capital; Growth Management; Expansion; Financing and Loans; Health Care and Treatment; Health Testing and Trials; Business Startups; Pharmaceutical Industry; Health Industry