Publications

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September–October 2020
Article

The Past, Present, and (Near) Future of Gene Therapy and Gene Editing

By: Julia Pian, Amitabh Chandra and Ariel Dora Stern

Emerging gene therapy and gene-editing technologies will have a growing impact on patient lives and health-care delivery. We analyzed a decade of data on clinical trials and venture capital investments to understand the likely trajectory of genetically focused... View Details

Keywords: Gene Therapy; Gene Editing; Impact; Health Care and Treatment; Technological Innovation; Health Testing and Trials; Venture Capital; Change

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October 1999 (Revised April 2003)
Case

International Investor, The: Islamic Finance and the Equate Project

By: Benjamin C. Esty and Mathew M Millett

Equate Petrochemical Co. (Equate) is a joint venture between Union Carbide Corp. and Petrochemical Industries Co. (PIC) for the construction of a $2 billion petrochemical plant in Kuwait. The sponsors began construction in August 1994, using a bridge loan, and are in... View Details

Keywords: International Finance; Project Finance; Religion; Investment; Finance; Mining Industry; Energy Industry; Kuwait

July 2018
Teaching Note

Cumplo.com

By: Frank V. Cespedes

Teaching Note for HBS No. 818-039. Teaching Note for HBS No. 818-039. Cumplo is a Chilean-based fin-tech startup that provides investors and small businesses with opportunities to access loans and investments in ways distinct from traditional financial institutions in... View Details

Keywords: Fintech; Alternative Finance; Crowdfunding; Crowdlending; Marketing Strategy; Growth and Development Strategy; Social Entrepreneurship; Expansion; Financial Services Industry; Latin America; South America; Chile

June 2018 (Revised October 2018)
Teaching Note

Valuing Snap After the IPO Quiet Period (A), (B), and (C)

By: Marco Di Maggio and Benjamin C. Esty

Teaching Note for HBS Nos. 218-095, 218-096, and 218-116. View Details

June 1975 (Revised September 2004)
Case

Angus Cartwright III

By: Kenneth J. Hatten, William J. Poorvu, Howard H. Stevenson, Arthur I. Segel and John H. Vogel, Jr.

Judy and John DeRight, looking to diversify their investment portfolios, have retained Angus Cartwright, Jr. to identify prospective real estate acquisitions. Mr. Cartwright has four potential properties that he feels merit an in-depth financial analysis. The case... View Details

Keywords: Acquisition; Cash Flow; Investment Return; Investment Portfolio; Taxation; Balanced Scorecard; Valuation

March 2020
Case

SRS and the Defense Innovation Unit: Rethinking Procurement

By: Paul A. Gompers and David Lane

SRS and the Defense Innovation Unit (DIU) follows the process by which SRS, a lean maker of remotely-operated submersible vehicles, navigates the DIU’s acquisition process. Set up in 2015 to speed the U.S. military’s access to promising commercial technologies, the DIU... View Details

Keywords: Procurement; Defense Innovation Unit; Business Startups; Acquisition; Technological Innovation; Investment; Commercialization; United States

November 2018
Case

David Hysong and SHEPHERD Therapeutics

By: Ananth Raman, John Masko and Aldo Sesia

In 2016, David Hysong, at age 27, found out he had a rare, incurable cancer. Rather than wait around to die, Hysong, a recent graduate of Harvard Divinity School, decided to launch a biotechnology company called Shepherd Therapeutics to development treatments for his... View Details

Keywords: Cancer; Therapeutics; Drugs; Health Care and Treatment; Business Startups; Product Development; Financing and Loans; Growth and Development Strategy; Problems and Challenges

22 Mar 2024
Research & Ideas

Open Source Software: The $9 Trillion Resource Companies Take for Granted

Like: The Network Effect: Why Companies Should Care About Employees’ LinkedIn Connections How to Get Companies to Make Investments That Benefit Everyone How to Make AI 'Forget' All the Private Data It Shouldn't Have Feedback or ideas to... View Details

Keywords: by Rachel Layne; Computer; Information Technology; Technology

August 2010 (Revised January 2013)
Supplement

Urban Water Partners (B)

By: Karthik Ramanna, George Serafeim and Aldo Sesia

The case explores a new business venture to bring clean water to residents of Dar es Salaam, Tanzania, who otherwise cannot afford it. Management has enough money to get their company through August 2010, but needs more capital thereafter. An HBS alumnus is interested... View Details

Keywords: Human Needs; Accrual Accounting; Financial Statements; Health Industry; Utilities Industry; Dar es Salaam

07 May 2025
Video

Climate Rising: Advancing the Circular Economy with Lauren Rodriguez of Closed Loop Partners

February 2015
Case

Founder Field Day

By: Matthew Rhodes-Kropf, Ramana Nanda and Nathaniel Burbank

Branded as the "Millennial firm for Millennials," Mike Rothenberg founded Rothenberg Ventures (RV) in 2012 while earning his MBA at the Harvard Business School (HBS). Over the following 24 months, Rothenberg raised $20 million and built a venture capital firm that made... View Details

Keywords: Finance; Startups; Seed-investing; Micro-VC; Venture Capital; Business Startups; San Francisco; New York (city, NY)

Profile

Henry McCance

unacceptable,” as he puts it, that so little progress had been made to treat a dreaded disease identified more than a century ago and now afflicting five million people in the United States. Friend and fellow venture capital investor... View Details

Keywords: Venture Capital / Private Equity; Venture Capital / Private Equity; Venture Capital / Private Equity

2021
Working Paper

The Dance Between Government and Private Investors: Public Entrepreneurial Finance around the Globe

By: Jessica Bai, Shai Bernstein, Abhishek Dev and Josh Lerner

This paper examines the interaction between governments and private capital investors when financing early-stage ventures. We first provide a simple conceptual framework to explore when collaboration between governments and private investors is likely to emerge. Using... View Details

Keywords: Public Entrepreneurship; Subsidy; Industrial Policy; Entrepreneurship; Public Sector; Financing and Loans; Venture Capital; Global Range

SSRN

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August 2022
Case

Meaningful Gigs

By: Brian Trelstad and Rachel Philbin

In October 2020, just a year after founding their company Meaningful Gigs, founders Ronnie Kwesi Coleman and Stephanie Nachemja-Burton prepared for a vital investment meeting with Rethink Education. They had already reached $400,000 in annually recurring revenue (ARR)... View Details

Keywords: Venture Capital; Growth and Development Strategy; Revenue; Education Industry; Technology Industry; Africa; United States

September 2000 (Revised April 2011)
Background Note

Note on the Private Equity Fundraising

By: Josh Lerner, G. Felda Hardymon and Ann Leamon

Provides an overview of raising venture capital and private equity funds. View Details

Keywords: Venture Capital; Private Equity; Investment Funds