Publications

Find at Harvard

Register to Read

2018
Chapter

The Orphan Drug Act at 35: Observations and an Outlook for the Twenty-First Century

By: Nicholas Bagley, Benjamin Berger, Amitabh Chandra, Craig Garthwaite and Ariel Dora Stern

On the 35th anniversary of the adoption of the Orphan Drug Act (ODA), we describe the enormous changes in the markets for therapies for rare diseases that have emerged over recent decades. The most prominent example is the fact that the profit-maximizing price of new... View Details

Keywords: Health Care and Treatment; Laws and Statutes; Research and Development; Investment; Markets; Monopoly

Find at Harvard

Register to Read

July 2000 (Revised November 2001)
Case

Catalyst Medical Solutions

By: Amy C. Edmondson, Richard M.J. Bohmer and Naomi Atkins

Faced with a drop in the NASDAQ, four eHealth entrepreneurs must decide between two distribution strategies for their new company's technology. The team, comprised of three full-time resident physicians and an MBA, has developed software to enable electronic... View Details

Keywords: Product Development; Health Care and Treatment; Distribution; Strategy; Venture Capital; Applications and Software; Partners and Partnerships; Borrowing and Debt; Information Technology Industry; Service Industry

Find at Harvard

26 Nov 2001
Research & Ideas

Women Entrepreneurs Use Springboard for Funding

What do a health food manufacturer, an infectious-diseases specialist and a content-management expert have in common? Answer: All are women, all are entrepreneurs. And by virtue of being women and entrepreneurs they share one... View Details

Keywords: by Martha Lagace

December 2010
Teaching Note

Roche's Acquisition of Genentech (TN)

By: Bo Becker and Carliss Y. Baldwin

Teaching Note for 210-040. View Details

Keywords: Mergers and Acquisitions; Stock Shares; Opportunities; Strategy; Organizational Culture; Value; Negotiation Tactics; Health Industry; Health Industry

December 2012 (Revised November 2014)
Case

W.R. Grace & Co.: Dealing with Asbestos Torts

By: Stuart C. Gilson and Sarah L. Abbott

A manufacturer of building products and specialty chemicals, W. R. Grace & Co. filed for Chapter 11 bankruptcy in 2001 in response to a flood of lawsuits alleging that its products contained asbestos, and had caused hundreds of thousands of people to contract... View Details

Keywords: Bankruptcy Reorganization; Business Failures; Environmental Regulations; Class Action Lawsuits; Natural Environment; Valuation; Health Disorders; Capital Structure; Restructuring; Lawsuits and Litigation; Chemicals; Crisis Management; Insolvency and Bankruptcy; Legal Liability; Construction Industry; Chemical Industry; United States

18 Dec 2018
First Look

New Research and Ideas, December 18, 2018

R&D-intensive firms react to negative shocks to their existing products? We explore this question using detailed project-level data from drug development firms. Using FDA Public Health Advisories as an exogenous and idiosyncratic... View Details

Keywords: Dina Gerdeman

February 2025
Article

Sale of Private Equity–Owned Physician Practices and Physician Turnover

By: Victoria Berquist, Lev Klarnet and Leemore Dafny

Private equity (PE) ownership of physician practices is increasing, with owners targeting sales, or exits, in 3 to 7 years. Little is known about the association of exit with physician retention and subsequent employment. Using panel data over the period 2014-2020, we... View Details

Keywords: Private Equity; Retention; Health Industry

Register to Read

August 2012 (Revised August 2024)
Case

ABC Pharmaceuticals

By: Regina E. Herzlinger and Erik R. Sparks

This case asks students to price a new drug that is in Stage II of its clinical trials. It contains detailed estimates of the time required and costs for all the steps needed to commercialize a drug in the U.S. Students will learn virtually all the steps required to... View Details

Keywords: Drug Development; Price; Product; Product Launch; Health Industry; Health Industry; Health Industry

February 2021
Supplement

HNA Group: Global Excellence with Chinese Characteristics (C)

By: William C. Kirby, Billy Chan and John P. McHugh

July 2017 was supposed to be a triumphant month for HNA Group. The latest Fortune Global 500 list showed the company had again skyrocketed in its ranking to no. 170, an improvement of over 200 positions from the year prior. Yet earlier that same July, the mysterious... View Details

Keywords: Conglomerate; Airline Industry; Coronavirus; Financial Risk; Debt; Bankruptcy; Global Strategy; Restructuring; Health Pandemics; Financial Markets; Organizational Change and Adaptation; Financial Condition; Globalized Firms and Management; Business and Government Relations; Air Transportation Industry; Financial Services Industry; China

January 2002
Case

Price-Fixing Vignettes

By: Guhan Subramanian and Michelle Kalka

This case escribes the antitrust prosecutions in the United States and abroad of the international bulk vitamins cartel. Both the civil and criminal fines were historically high, and it was the first time the United States prosecuted foreign nationals for U.S. criminal... View Details

Keywords: Price; Lawsuits and Litigation; Governance Compliance; Auctions; Laws and Statutes; Monopoly; Globalized Markets and Industries; Health Industry; Health Industry; United States

25 Apr 2017
First Look

First Look at New Research, April 25

entrepreneurs from the investor can create frictions that might inhibit the funding of good projects. It has largely abstracted away from the fact that a startup typically does not have just one investor but rather several VCs that come together in a syndicate to View Details

Keywords: Sean Silverthorne

December 2004 (Revised April 2006)
Case

Nestle and Alcon--The Value of a Listing

By: Mihir A. Desai, Vincent Dessain and Anders Sjoman

In response to a perceived undervaluation by the capital markets, Nestle is considering divesting a part of its ophthalmology subsidiary, Alcon, and must decide on a listing location. In the process, students are challenged to wrestle with the valuation of a... View Details

Keywords: Business Conglomerates; International Finance; Corporate Entrepreneurship; Markets; Taxation; Business Subsidiaries; Valuation; Health Industry; Health Industry; Europe; United States

February 2011 (Revised June 2011)
Case

Hardina Smythe and the Healthcare Investment Conundrum

By: Matthew Rhodes-Kropf, Ann Leamon and Lisa Strope

Hardina Smythe, a recent MBA graduate, has just joined a top-tier venture capital firm in the difficult environment of late 2010. Her first assignment is to evaluate three different deals and make recommendations to the partners. Each potential investment has strengths... View Details

Keywords: Venture Capital; Asset Management; Private Equity; Entrepreneurship; Investment; Health Care and Treatment; Innovation and Invention; Financial Services Industry

20 Mar 2000
Research & Ideas

No Place Like Home: America’s Housing Crisis and Its Impact on Business

imbalance. (photo: Webb Chappell) With the federal government's involvement diminishing, nonprofit organizations that specialize in public-private financing for housing and holistic community development have come to the fore. Laurie J.... View Details

Keywords: by Garry Emmons; Construction; Real Estate

14 Apr 2015
First Look

First Look: April 14

Applied Corporate Finance When One Size Doesn't Fit All: Evolving Directions in the Research and Practice of Enterprise Risk Management By: Mikes, Anette, and Robert S. Kaplan Abstract—Enterprise risk management (ERM) has become a crucial... View Details

Keywords: Sean Silverthorne

Article

Spending Variation Among ACOs in the Medicare Shared Savings Program

By: Michael Anne Kyle, J. Michael McWilliams, Mary Beth Landrum, Bruce E. Landon, Paul Trompke, David J. Nyweide and Michael E. Chernew

OBJECTIVES: Understanding variation in spending across organizations, rather than across geographic areas, is important because care is delivered by organizations and interventions increasingly focus on organizations. Accountable care organizations (ACOs) are... View Details

Keywords: Medicare; Accountable Care Organizations; ACOs; Health Care and Treatment; Spending; Analysis