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February 2016 (Revised September 2017)
Case

Neurotrack and the Alzheimer's Puzzle

By: Richard G. Hamermesh, Liz Kind and Carin-Isabel Knoop

Elli Kaplan founded Neurotrack in 2012 with a breakthrough noninvasive cognitive diagnostics test that will detect Alzheimer's disease in its earliest pre-symptomatic stages. While the company has gained great traction in the three years since it was started, with no... View Details

Keywords: Alzheimer's Disease; Diagnostics; Healthcare; Entrepreneurship; Health Disorders; Science-Based Business; Business Model; Medical Devices and Supplies Industry; United States

2015
Case

Advanced Leadership Pathways: Torsten Thiele and the Global Ocean Trust

By: Rosabeth Moss Kanter and Brian Hoffstein

Following a successful career in finance, Torsten Thiele devoted himself full-time to the challenging cause of ocean conservation and stewardship. In August 2015, Thiele had already come a long way in spearheading initiatives towards the protection of the ocean: from... View Details

Keywords: Environment; Natural Environment; Environmental Sustainability; Pollutants; Science-Based Business; Climate Change; Social Enterprise; Leadership

November 2014
Teaching Note

Houston We Have a Problem: NASA and Open Innovation (A) and (B)

By: Michael L. Tushman, Hila Lifshitz-Assaf and Kerry Herman

Keywords: Leading Change; Innovation Leadership; Science-Based Business

February 2014
Case

BGI: Data-driven Research

By: Willy Shih and Sen Chai

BGI has the largest installed gene-sequencing capacity in the world, and to Zhang Gengyun, general manager of the Life Sciences Division, this represented an opportunity to apply his training as a plant breeder and his early career work as a biochemist to improving... View Details

September 2013 (Revised November 2015)
Case

Living Proof: Are We a Technology Company or a Beauty Company?

Jon Flint came up with the idea of a science-based beauty company while talking with his hairdresser about the problems with typical hair and skin care products. Together with a small team that included Professor Robert Langer of MIT, he committed to assemble a team... View Details

July 2013 (Revised November 2021)
Module Note

Exploration vs. Exploitation

This module note introduces James March's concept of exploration and exploitation, and the management challenge of balancing the allocation of resources to the two activities in the firm. The note also touches on the O'Reilly and Tushman paper on the ambidextrous... View Details

July 2013
Case

Novozymes: Establishing the Cellulosic Ethanol Value Chain

By: Willy Shih and Sen Chai

As the world's largest producer of industrial enzymes, Novozymes had invested heavily for many years to bio-engineer enzymes that could break down cellulose into fermentable sugar. In 2010, the company had launched what it thought would become a breakthrough product... View Details

January 2013
Case

Cabot Corporation: The Fuel Cell Decision (A)

By: Willy Shih and Ying Zhou

Managers at Cabot Corporation are faced with deciding the future of its fuel cell program. The (A) case recounts the view of the business manager and the technical project lead, and the (B) case describes the perspective of a senior manager who is the head of the New... View Details

January 2013
Supplement

Cabot Corporation: The Fuel Cell Decision (B)

By: Willy Shih and Ying Zhou

Managers at Cabot Corporation are faced with deciding the future of its fuel cell program. The (A) case recounts the view of the business manager and the technical project lead, and the (B) case describes the perspective of a senior manager who is the head of the New... View Details

January 2013 (Revised September 2013)
Case

Royal DSM: Fighting Hidden Hunger

By: Rebecca Henderson, Noah Fisher and Mary Shelman

In 2007 Royal DSM, a leading life science and materials company, entered a partnership with the World Food Programme (WFP) to combat hidden hunger around the world by providing micronutrient solutions. The case investigates the unexpectedly large impact the partnership... View Details

Keywords: Conflict of Interests; Human Needs; Partners and Partnerships; Global Range; Nutrition; Science-Based Business; Non-Governmental Organizations; Service Industry; Health Industry

2014
Working Paper

Bridging Science and Technology Through Academic-Industry Partnerships

By: Sen Chai and Willy C. Shih

Scientific research and its translation into commercialized technology is a driver of wealth creation and economic growth. Partnerships to foster the translational processes from public research organizations, such as universities and hospitals, to private firms are a... View Details

Keywords: Innovation; Firm Performance; Public-private Partnership Funding; Translational Research; Small And Medium Enterprises; Partners and Partnerships; Public Sector; Private Sector; Performance; Science-Based Business; Innovation and Invention

November 2012
Case

CSIRO: The Light Metals Flagship Decision

By: Willy Shih, Margaret P. Pierson and Dawn Lau

This case explores the challenge of investing in basic research as a public good. CSIRO was Australia's leading science and research agency, and it was chartered to enhance national prosperity through R&D. Its Flagships program was designed to align research interests... View Details

April 2012 (Revised May 2012)
Case

Merck: Operating Science-Based Business

By: Ananth Raman, Inga Maurer and William Schmidt

Merck is known for its commitment to investing in basic R&D. Are Merck's long-term investments justifiable when the firm faces extreme earnings pressure? View Details

Keywords: Science-Based Business; Management; Research and Development; Business and Shareholder Relations; Operations; Pharmaceutical Industry; United States

July 2011 (Revised January 2013)
Case

Digital Microscopy Is Making Me Crazy!

For Carl Zeiss Microimaging, modular hardware and software enabled customers to tailor Zeiss's broad range of microscopy systems hardware and software to meet a wide range of needs from basic scientific research in the biological and medical sciences to clinical... View Details

Keywords: Information Infrastructure; Applications and Software; Corporate Strategy; Disruptive Innovation; Science-Based Business; Management Analysis, Tools, and Techniques; Business Conglomerates; Digital Platforms; Opportunities; Medical Devices and Supplies Industry; Computer Industry

June 2011 (Revised October 2013)
Case

Gene Patents (A)

By: Richard Hamermesh, David Kiron and Phillip Andrews

In March 2010, U.S. District Court Judge Robert Sweet overturned 30 years of legal precedent and ruled that unaltered human genes could not be patented. This case reviews patent law and how it relates to our increasing knowledge of the Human Genome. The case issues... View Details

Keywords: Courts and Trials; Patents; Genetics; Judgments; Science-Based Business; Biotechnology Industry; United States

September 2010
Case

Merck: Investing in Science-Based Business (Abridged)

By: Ananth Raman and Inga Katharina Maurer

Ray Gilmartin faces a dilemma. His company's credibility has been damaged by the recent withdrawal of Vioxx, a multi-billion dollar drug. Moreover, the withdrawal of Vioxx would imply that Merck would fail to meet analysts' earnings expectations for 2005 unless... View Details

Keywords: Factories, Labs, and Plants; Cost Management; Production; Research and Development

June 2010 (Revised May 2017)
Teaching Note

Sydney IVF: Stem Cell Research

By: Robert Simons and Kathryn Rosenberg

Teaching Note for 109017. View Details

Keywords: Strategy And Execution; Management Control Systems; Levers Of Control; Strategy; Risk Management; Decisions; Cooperative Ownership; Product Development; Moral Sensibility; Governing Rules, Regulations, and Reforms; Expansion; Science-Based Business; Research; Management Practices and Processes; Business Subsidiaries; Biotechnology Industry; Sydney

Article

The Evolution of Science-Based Business: Innovating How We Innovate

By: Gary P. Pisano

Science has long been connected to innovation and to business. As early as the late 19th century, chemical companies, realizing the commercial potential of science, created the first industrial research laboratories. During much of the 20th century, large-scale... View Details

Keywords: Entrepreneurship; Governance; Innovation and Management; Risk Management; Research and Development; Science-Based Business; Commercialization

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December 2009 (Revised April 2012)
Case

Neoprene

By: Tom Nicholas and Felipe Tamega Fernandes

In 1931, during one of the worst economic crises in U.S. history, Du Pont announced the discovery of an innovative rubber synthetic product—neoprene. Yet at the time of the announcement, Du Pont did not have any neoprene to sell. Manufacturing facilities were still... View Details

Keywords: Financial Crisis; Business History; Innovation and Invention; Product Development; Risk and Uncertainty; Science-Based Business; Commercialization; Chemical Industry; United States

November 2009 (Revised December 2009)
Case

GTC Biotherapeutics: Developing Medicines in the Milk of Goats

By: Ray A. Goldberg and Sarah Morton

GTC is the first company in the animal world to receive FDA approval of a transgenic pharmaceutical. What are the implications for other firms in plants and animals and their opportunities to produce new medicines in an economical and safe fashion? View Details

Keywords: Health Care and Treatment; Animal-Based Agribusiness; Plant-Based Agribusiness; Science-Based Business; Medical Specialties; Product; Technological Innovation; Health Industry; Pharmaceutical Industry; United States

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