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  • 2024
  • Working Paper

Cephalosporins—Fighting Hospital Infections: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant Datar and Katherine Stebbins
This case history describes the development of three generations of cephalosporins – antibiotics that have significantly reduced hospital infections. Specifically, we chronicle how: 1) Early (pre-cephalosporin) antibiotics were developed in the first half of the 20th... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
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  • 2024
  • Working Paper

Tamoxifen—Reducing Breast Cancer Risks: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant Datar and Katherine Stebbins
We describe the development of tamoxifen, considered a “gold standard” treatment for millions of breast cancer patients. Specifically, we describe breast cancer treatments before tamoxifen’s development; the initial development of tamoxifen from 1960 to 1973;... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation and Invention; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Governing Rules, Regulations, and Reforms
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  • 2024
  • Working Paper

Laparoscopy—Minimally Invasive Surgery: Case Histories of Transformational Advances

By: Amar Bhidé, Caitlin N. Bowler and Srikant M. Datar
We describe how operations through laparoscopes – tubular instruments inserted into abdominal cavities – revolutionized gynecological and other surgeries inside the abdomen, such as gall bladder removal. Specifically, we chronicle the 1) foundational contributions of... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
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  • 2024
  • Working Paper

Computed Tomography (CT)--Beyond Traditional X-Rays: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how Computed Tomography (CT) scanners - that combine Xrays and computers to image soft tissues of the brain and other organs -- have become a widely used diagnostic tool. Specifically, we chronicle the 1) initial development of CT... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
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  • November 2022
  • Case

The Battle Among Channels for Marketing Pharmaceuticals: UpScript, Pharmacy Benefit Managers, and Direct-to-Consumer Sales

By: Regina E. Herzlinger and Tiffany Farrell
Can an online, direct-to-consumer pharmacy both improve the quality and speed of care for patients who need branded drugs and stabilize profits for pharmaceutical manufacturers? UpScript, after years spent achieving legal and regulatory compliance and simultaneous... View Details
Keywords: DTC; Internet and the Web; Marketing Channels; Customer Value and Value Chain; Governing Rules, Regulations, and Reforms; Competitive Strategy; Service Delivery; Growth and Development Strategy; Health Industry; Health Industry; Health Industry
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  • 14 Nov 2019
  • Book

Lifting the Lid on Turkey's Hidden Business History

in health and education, including founding Koç University in 1992, now one of the most prestigious universities in the country. Silverthorne: In what ways is Turkish business history distinctive and in what ways does it share... View Details
Keywords: by Sean Silverthorne
  • March 1999
  • Case

Merck & Co., Inc.: Corporate Strategy, Organization and Culture (A)

By: Michael Beer and Perry Fagan
In the early 1990s, Merck faced a series of challenges because of significant changes in its competitive and regulatory environment (e.g., growth in power of pharmaceutical buyers like managed care organizations led to price pressures and President Clinton's review of... View Details
Keywords: Organizational Change and Adaptation; Business or Company Management; Organizational Culture; Problems and Challenges; Management Practices and Processes; Competitive Strategy; Management Teams; Health Care and Treatment; Governing Rules, Regulations, and Reforms; Situation or Environment; Alignment; Pharmaceutical Industry; United States
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  • 19 Oct 2015
  • Research & Ideas

Business Research that Makes for Smarter Public Policy

Safety and Health Administration (OSHA), to participate in a workshop with academics who study government regulation and industry compliance. The event featured a series of presentations by scholars sharing their research findings and... View Details
Keywords: by Michael Blanding
  • 18 Feb 2009
  • First Look

First Look: February 18, 2009

marketing of stylish, lower-tech bicycles. The company's future hangs in the balance. Purchase this case: http://harvardbusinessonline.hbsp.harvard.edu/ b01/en/common/item_detail.jhtml?id=609042 KPMG (B): Risk and Reform Harvard Business... View Details
Keywords: Martha Lagace
  • 05 Mar 2019
  • First Look

New Research and Ideas, March 5, 2019

company. Digitizing Disclosure: The Case of Restaurant Hygiene Scores By: Dai, Weijia (Daisy), and Michael Luca Abstract— Collaborating with Yelp and the city of San Francisco, we revisit a canonical example of quality disclosure by... View Details
Keywords: Dina Gerdeman
  • 03 Apr 2018
  • First Look

New Research and Ideas, April 3, 2018

leads to a 14% increase in the likelihood of exit for a 3.5-star restaurant (which is the median rating on Yelp) but has no discernible impact for a 5-star restaurant (on a 1 to 5 star scale). Our analysis also highlights how digital data... View Details
Keywords: Sean Silverthorne
  • 05 Jul 2011
  • First Look

First Look: July 5

e-books eroded publishers' profitable print formats. E-readers like Kindle, as well as Apple's iPad, that invigorated the digital book market are discussed. Also includes a general overview of book publishing including the K-12 and... View Details
Keywords: Sean Silverthorne
  • 10 Oct 2007
  • First Look

First Look: First Look: October 10

by 7.5 percent relative to private firms. We interpret this as evidence of investor belief of policy irreversibility, where reforms may reach a stage beyond which future regimes have difficulty reversing those policies. Further analysis... View Details
Keywords: Martha Lagace
  • 10 Jan 2017
  • First Look

First Look at New Research: January 10, 2017

https://cb.hbsp.harvard.edu/cbmp/product/517016-PDF-ENG Harvard Business School Case 817-028 Innovating Beyond Ochsner The Ochsner Health System has developed a proprietary software tool designed to treat hypertension. Built into the... View Details
Keywords: Sean Silverthorne
  • 14 Jan 2014
  • First Look

First Look: January 14

following question: how can data and analytic tools be used to create new value? The authors have explored that question with many clients. In their work, they've seen IT create new value in five patterns: using data from sensors in objects to improve offerings (think... View Details
Keywords: Sean Silverthorne
  • 02 Nov 2010
  • First Look

First Look: November 2, 2010

data and then thinking about the potential complementarities of strategies from a portfolio construction context. Purchase this case:http://cb.hbsp.harvard.edu/cb/product/211025-PDF-ENG News in the Digital World: Who Pays? Stephen P.... View Details
Keywords: Sean Silverthorne
  • 18 Dec 2018
  • First Look

New Research and Ideas, December 18, 2018

R&D-intensive firms react to negative shocks to their existing products? We explore this question using detailed project-level data from drug development firms. Using FDA Public Health Advisories as an exogenous and idiosyncratic... View Details
Keywords: Dina Gerdeman
  • 17 Apr 2007
  • First Look

First Look: April 17, 2007

http://www.hbsp.harvard.edu/b01/en/common/item_detail.jhtml?id=107060 International Capital Markets and Sovereign Debt: Crisis Avoidance and Resolution Harvard Business School Note 707-018 Successive economic crises of the 1990s and early 2000s intensified focus on... View Details
Keywords: Martha Lagace
  • 09 Dec 2008
  • First Look

First Look: December 9, 2008

economists—had foreseen. The crisis raises questions about how competently financial institutions, such as mutual funds, managed their global capital investments. It raises questions about how effective the International Monetary Fund's package of View Details
Keywords: Martha Lagace
  • 27 Feb 2007
  • First Look

First Look: February 27, 2007

letter from the Recording Industry Association of America, Inc. (RIAA) asking him to shut down eDonkey, MetaMachine's popular file-sharing system. In September 2005, more than 30 million users relied on eDonkey to share digital files,... View Details
Keywords: Martha Lagace

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