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  • August 1995 (Revised June 1997)
  • Case

Hillcrest Research Associates, Inc.

Hillcrest designs and administers testing procedures for drugs to determine whether they pass FDA specifications. As the company grows, it encounters problems with information technology and with the clinical research associates, who feel pressured to report more... View Details
Keywords: Growth Management; Information Technology; Health Testing and Trials; Pharmaceutical Industry
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Barnes, Louis B. "Hillcrest Research Associates, Inc." Harvard Business School Case 496-021, August 1995. (Revised June 1997.)
  • 10 Sep 2001
  • Research & Ideas

The Negotiator’s Secret: More Than Merely Effective

Review excerpt below, Professor James K. Sebenius describes number six on the list, "Failing to correct for skewed vision." Negotiators are often too confident of their own position and too quick to demonize the other side, he... View Details
Keywords: by James K. Sebenius
  • 20 Aug 2001
  • Research & Ideas

Making an Ally of Uncle Sam

Goals for influencing government should flow directly from the analytic frameworks that companies use to develop business strategies. As Michael Porter noted in Competitive Strategy, "No structural analysis is complete without a diagnosis of how present View Details
Keywords: by Michael Watkins, Mickey Edwards & Usha Thakrar
  • 2009
  • Case

Innovamedica: Innovation in an Emerging Market

By: Roberto Charvel, Fernando Fabre and T. Putimahtama
Innovamedica was a medical start up with several state of the art devices such as a silicon substitute heart and other inventions. However, the founding scientist was struggling in attracting talent and fundraising and that had an impact on growth. View Details
Keywords: Biotech; Entrepreneurial Finance; Entrepreneurship; Start-up; Emergent Countries; Business Startups; Talent and Talent Management; Design; Corporate Entrepreneurship; Private Equity; Health Testing and Trials; Innovation and Invention; Managerial Roles; Biotechnology Industry; Latin America; North and Central America
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Charvel, Roberto, Fernando Fabre, and T. Putimahtama. "Innovamedica: Innovation in an Emerging Market." Instituto Panamericano de Alta Dirección de Empresa (IPADE) Case (P)DGe-440, 2009.
  • 02 Sep 2010
  • What Do You Think?

How Transparent Should Boards Be?

his way. In John Caddell's words, "The CEO made mistakes. The board did as well-the hired the wrong guy Both need to take their medicine So, the answer is: pay the man now. Move on." In Guishan Longani's words, " avoid the public View Details
Keywords: by Jim Heskett
  • June 2008 (Revised July 2008)
  • Case

The Miami Project to Cure Paralysis

By: Robert Steven Kaplan, Christopher Marquis and Brent Kazan
Marc Buoniconti is the co-founder of the Miami Project to Cure Paralysis, a nonprofit medical research organization. The project was founded in 1985 by Marc and his father Nick, a former Hall of Fame football player, when Marc suffered a spinal cord injury. In 2007,... View Details
Keywords: Investment; Philanthropy and Charitable Giving; Health Testing and Trials; Leadership; Growth and Development Strategy; Mission and Purpose; Research and Development; Nonprofit Organizations; Health Industry; Miami
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Kaplan, Robert Steven, Christopher Marquis, and Brent Kazan. "The Miami Project to Cure Paralysis." Harvard Business School Case 408-003, June 2008. (Revised July 2008.)
  • 08 May 2020
  • In Practice

Nonprofits Hurt by COVID-19 Must Hoard Cash to Hold On

address the problem at scale. The collective interplay is refined through trial and error over a long period of time. All this goes through the window in a crisis like the one we now face. There is no time... View Details
Keywords: by Danielle Kost
  • November 2007
  • Case

Antegren: A Beacon of Hope

By: Joshua D. Margolis, Thomas J. DeLong and Terence Heymann
The CEO of Biogen Idec faces a set of difficult decisions regarding a promising drug for Multiple Sclerosis that is headed for early approval by the FDA. The first in a series focuses on operational decisions triggered by the drive for early approval. Sparks discussion... View Details
Keywords: Demand and Consumers; Leadership; Ethics; Corporate Social Responsibility and Impact; Decision Choices and Conditions; Crisis Management; Health Testing and Trials; Biotechnology Industry; Pharmaceutical Industry
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Margolis, Joshua D., Thomas J. DeLong, and Terence Heymann. "Antegren: A Beacon of Hope." Harvard Business School Case 408-025, November 2007.
  • 11 Jul 2012
  • Research & Ideas

Book Excerpt: ’The Future of Boards’

Editor's note: The credit crisis and subsequent recession has thrown many financial and business institutions into, if not chaos, then at least a sense that the landscape underneath has shifted... View Details
Keywords: by Jay Lorsch
  • April 2009 (Revised May 2010)
  • Case

Partners In Health: HIV Care in Rwanda

By: Michael E. Porter, Scott S. Lee, Joseph Rhatigan and Jim Yong Kim
In 2005, Partners in Health (PIH) was invited by the Rwandan Ministry of Health to assume responsibility for the management of public health care in two rural districts in Eastern Rwanda and create an HIV treatment program at these sites. PIH successfully implemented a... View Details
Keywords: Developing Countries and Economies; Health Care and Treatment; Health Testing and Trials; Medical Specialties; Service Delivery; Nonprofit Organizations; Expansion; Health Industry; Rwanda
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Porter, Michael E., Scott S. Lee, Joseph Rhatigan, and Jim Yong Kim. "Partners In Health: HIV Care in Rwanda." Harvard Business School Case 709-474, April 2009. (Revised May 2010.)
  • 25 Mar 2013
  • Research & Ideas

How Chapter 11 Saved the US Economy

the airline to work with the court to restructure and unload a significant amount of its debt, giving an iconic company "a second bite of the apple," says Gilson. An unabashed advocate of Chapter... View Details
Keywords: by Kim Girard; Financial Services
  • July 2021 (Revised July 2022)
  • Case

Brigham & Women's Hospital: Using Patient Reported Outcomes to Improve Breast Cancer Care

By: Robert S. Kaplan, Navraj S. Nagra and Syed S. Shehab
Dr. Andrea Pusic, breast cancer reconstruction surgeon, wants to extend outcomes measurement beyond traditional surgical metrics of infections, complications, and survival rates. The case describes her development of a new mobile phone app, which collects patients’... View Details
Keywords: Health Care and Treatment; Outcome or Result; Cost Management; Activity Based Costing and Management; Mobile and Wireless Technology; Health Testing and Trials; Surveys; Health Industry; Boston
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Kaplan, Robert S., Navraj S. Nagra, and Syed S. Shehab. "Brigham & Women's Hospital: Using Patient Reported Outcomes to Improve Breast Cancer Care." Harvard Business School Case 122-010, July 2021. (Revised July 2022.)
  • February 2022 (Revised November 2022)
  • Case

Nuritas

By: Mitchell Weiss, Satish Tadikonda, Vincent Dessain and Emer Moloney
Nora Khaldi had built a technology “to unlock the power of nature” in the service of extending human lifespan and improving health, and now in April 2020 was debating telling her Board of Directors she wanted to put on ice some of her discoveries. Nuritas, the company... View Details
Keywords: Cash Burn; Cash Flow Analysis; Pharmaceutical Companies; Founder; Artificial Intelligence; AI; Entrepreneurship; Health Testing and Trials; Health Care and Treatment; Decision Making; Market Entry and Exit; AI and Machine Learning; Pharmaceutical Industry
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Weiss, Mitchell, Satish Tadikonda, Vincent Dessain, and Emer Moloney. "Nuritas." Harvard Business School Case 822-080, February 2022. (Revised November 2022.)
  • December 2006 (Revised August 2008)
  • Case

Pervasis Therapeutics, Inc.

By: Robert F. Higgins and Virginia Fuller
In May 2005, Steve Bollinger was about to become president and chief operating officer of Pervasis Therapeutics, a small cell therapy start-up in Cambridge, Mass. If proven successful, Pervasis' product, Vascugel, could change the way vascular disease is treated and... View Details
Keywords: Business Startups; Venture Capital; Financial Strategy; Governing Rules, Regulations, and Reforms; Health Care and Treatment; Health Testing and Trials; Health Industry; Cambridge
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Higgins, Robert F., and Virginia Fuller. "Pervasis Therapeutics, Inc." Harvard Business School Case 807-026, December 2006. (Revised August 2008.)
  • September 1991 (Revised August 1994)
  • Background Note

Note on Pharmaceutical Industry Regulation

By: Willis M. Emmons III
Traces the evolution of U.S. regulatory policy towards the pharmaceutical industry over the course of the twentieth century. A major theme is the steady shift away from a policy of 'let the buyer beware' to the creation of a complex and time-consuming review process,... View Details
Keywords: Safety; Industry Growth; Marketing; Research and Development; Health Testing and Trials; Economics; Pharmaceutical Industry; United States
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Emmons, Willis M., III. "Note on Pharmaceutical Industry Regulation." Harvard Business School Background Note 792-002, September 1991. (Revised August 1994.)
  • October 2020
  • Teaching Plan

Merck: COVID-19 Vaccines

By: Willy C. Shih
COVID-19 infections were still climbing across the U.S. and many other parts of the world in September 2020, and it seemed that every time Ken Frazier, the CEO of Merck & Co. consented to an interview in recent months he always seemed to hear the same question,... View Details
Keywords: Vaccines; Health Pandemics; Health Testing and Trials; Innovation and Management; Innovation Strategy; Research and Development; Business Strategy; Pharmaceutical Industry; United States
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Shih, Willy C. "Merck: COVID-19 Vaccines." Harvard Business School Teaching Plan 621-067, October 2020.
  • April 2024
  • Article

A Machine Learning Algorithm Predicting Risk of Dilating VUR among Infants with Hydronephrosis Using UTD Classification

By: Hsin-Hsiao Scott Wang, Michael Lingzhi Li, Dylan Cahill, John Panagides, Tanya Logvinenko, Jeanne Chow and Caleb Nelson
Backgrounds: Urinary Tract Dilation (UTD) classification has been designed to be a more objective grading system to evaluate antenatal and post-natal UTD. Due to unclear association between UTD classifications to specific anomalies such as vesico-ureteral reflux (VUR),... View Details
Keywords: Health Disorders; Health Testing and Trials; AI and Machine Learning; Health Industry
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Wang, Hsin-Hsiao Scott, Michael Lingzhi Li, Dylan Cahill, John Panagides, Tanya Logvinenko, Jeanne Chow, and Caleb Nelson. "A Machine Learning Algorithm Predicting Risk of Dilating VUR among Infants with Hydronephrosis Using UTD Classification." Journal of Pediatric Urology 20, no. 2 (April 2024): 271–278.
  • 30 Jan 2012
  • Research & Ideas

Measuring the Efficacy of the World’s Managers

larger number of organizations. The researchers have also started to work on management experiments, modeled on the randomized control trials adopted in the medical field. This experimental approach is much more costly View Details
Keywords: by Carmen Nobel
  • 26 Feb 2007
  • Research & Ideas

The Power of the Noncompete Clause

have rejected Microsoft's claims, Microsoft and Google settled out of court regarding Google's hiring Microsoft executive Kai-Fu Lee to head Google China. And the following... View Details
Keywords: by Martha Lagace
  • February 2008 (Revised August 2008)
  • Case

EXACT Sciences Corp.: Commercializing a Diagnostic Test

By: Regina E. Herzlinger
This case addresses the challenges of commercializing molecular diagnostics. Along the way, it explains the technology, payment system, and the measures used to assess the value of a diagnostic test. View Details
Keywords: Health Testing and Trials; Genetics; Science-Based Business; Commercialization; Biotechnology Industry
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Herzlinger, Regina E. "EXACT Sciences Corp.: Commercializing a Diagnostic Test." Harvard Business School Case 308-090, February 2008. (Revised August 2008.)
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