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  • 2018
  • Chapter

The Orphan Drug Act at 35: Observations and an Outlook for the Twenty-First Century

By: Nicholas Bagley, Benjamin Berger, Amitabh Chandra, Craig Garthwaite and Ariel Dora Stern
On the 35th anniversary of the adoption of the Orphan Drug Act (ODA), we describe the enormous changes in the markets for therapies for rare diseases that have emerged over recent decades. The most prominent example is the fact that the profit-maximizing price of new... View Details
Keywords: Health Care and Treatment; Laws and Statutes; Research and Development; Investment; Markets; Monopoly
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Bagley, Nicholas, Benjamin Berger, Amitabh Chandra, Craig Garthwaite, and Ariel Dora Stern. "The Orphan Drug Act at 35: Observations and an Outlook for the Twenty-First Century." Chap. 4 in Innovation Policy and the Economy, Volume 19, edited by Josh Lerner and Scott Stern, 97–137. University of Chicago Press, 2018.
  • 26 Jun 2000
  • Research & Ideas

What’s an Internet Business Model? Ask a Health Care Professional

business: customers, products, value propositions, the capabilities and advantages any player brings that will allow the plans to meet success. And while businesses have always used a "platform" of technology of one kind or another to... View Details
Keywords: by Martha Lagace; Health

    Suraj Srinivasan

    Suraj Srinivasan is the Philip J. Stomberg Professor of Business Administration, a member of the Accounting and Management faculty unit, and chair of the View Details

    Keywords: accounting industry; financial services
    • 15 Oct 2013
    • First Look

    First Look: October 15

    innovation, our results also help to explain why technological development was still robust following one of the largest shocks in the history of the U.S. banking system. Working Papers Team Scaffolds: How Minimal Team Structures Enable... View Details
    Keywords: Sean Silverthorne
    • May 2009 (Revised October 2009)
    • Case

    Verne Global: Building a Green Data Center in Iceland

    Verne Global, a pioneering startup created to build the first large-scale data center in Iceland, faces critical challenges regarding its green strategy. Verne Co-Founder Isaac Kato is tasked with evaluating how the company can most successfully market and sell the... View Details
    Keywords: Buildings and Facilities; Business Startups; Marketing Strategy; Product Marketing; Sales; Environmental Sustainability; Pollutants; Green Technology Industry; Green Technology Industry; Iceland
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    Steenburgh, Thomas J., and Nnamdi Daniel Okike. "Verne Global: Building a Green Data Center in Iceland." Harvard Business School Case 509-063, May 2009. (Revised October 2009.)
    • October 2003 (Revised January 2004)
    • Case

    ITC eChoupal Initiative, The

    Soybean farmers in India have traditionally sold their product through ineffective and frequently dishonest physical marketplaces (mandi). Farmers are generally poor and often illiterate and are forced to be "price-takers" after an arduous journey to the mandi. They... View Details
    Keywords: Plant-Based Agribusiness; Fairness; Internet and the Web; Supply Chain Management; Emerging Markets; Agriculture and Agribusiness Industry; India
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    Upton, David M., and Virginia Fuller. "ITC eChoupal Initiative, The." Harvard Business School Case 604-016, October 2003. (Revised January 2004.)
    • Program

    Strategic Marketing for Driving Growth

    Summary Strategic agility and an unyielding focus on growth are essential for the success of any organization, especially when new technologies such as generative AI are profoundly changing how businesses acquire, engage, and retain... View Details
    • January 2013 (Revised October 2015)
    • Case

    Pittsburgh

    By: Eric Werker, Meg Rithmire, Benjamin Kennedy and Andrew Knauer
    The case narrates the development of Pittsburgh from the 1940s to 2012. It analyzes the collapse of the steel industry in the early 1980s, the city's subsequent decline, and the city's later re-emergence as a hub for higher education, the tech sector, and the... View Details
    Keywords: Google; Population; City Growth; Shale; PNC; Tom Murphy; Luke Ravenstahl; Public-private Partnership; Tax Increment Financing; Brownfields; Renaissance; Industry Clusters; Industry Growth; City; Business and Government Relations; Taxation; Philanthropy and Charitable Giving; Nonprofit Organizations; Higher Education; Technology Industry; Technology Industry; Technology Industry; Technology Industry; Pittsburgh
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    Werker, Eric, Meg Rithmire, Benjamin Kennedy, and Andrew Knauer. "Pittsburgh." Harvard Business School Case 713-035, January 2013. (Revised October 2015.)
    • 2020
    • Working Paper

    The Evolutionary Nature of Breakthrough Innovation: Re-Evaluating the Exploration vs. Exploitation Dichotomy

    By: Dominika K. Sarnecka and Gary P. Pisano
    Over the past few decades, a consensus has emerged that breakthrough innovations emerge from exploration of novel terrain while more routine innovations are the product of exploitation. In this paper, we revisit this explore versus exploit dichotomy with an analysis... View Details
    Keywords: Breakthrough Innovation; Exploration And Exploitation; Innovation and Invention; Technological Innovation
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    Sarnecka, Dominika K., and Gary P. Pisano. "The Evolutionary Nature of Breakthrough Innovation: Re-Evaluating the Exploration vs. Exploitation Dichotomy." Harvard Business School Working Paper, No. 21-071, December 2020.
    • May 2017 (Revised July 2017)
    • Supplement

    Aadhaar: From Voluntary to Mandatory

    By: Tarun Khanna, Anjali Raina and Rachna Chawla
    Approximately 1.1 billion residents of India (99% of the population) had a unique biometric identity—Aadhaar—by 2017. In six years, the Unique Identification Authority of India (UIDAI) had achieved an unprecedented milestone in emerging and developed markets. The... View Details
    Keywords: Entrepreneurship; Business and Government Relations; Emerging Markets; Information; Information Technology; Organizational Design; Infrastructure; Identity; Projects; Information Management; Government and Politics; Digital Platforms; Internet and the Web; Transformation; Society; Welfare; Social Issues; Private Sector; Public Sector; Information Technology Industry; Asia; India; New Delhi
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    Khanna, Tarun, Anjali Raina, and Rachna Chawla. "Aadhaar: From Voluntary to Mandatory." Harvard Business School Supplement 717-512, May 2017. (Revised July 2017.)
    • 2000
    • Book

    Merchants to Multinationals

    By: Geoffrey Jones
    This book examines the evolution of multinational trading companies from the eighteenth century to the present day. During the Industrial Revolution, British merchants established overseas branches which became major trade intermediaries, and later engaged in foreign... View Details
    Keywords: Competency and Skills; Trade; Foreign Direct Investment; Multinational Firms and Management; Corporate Governance; Growth and Development; Human Resources; Information Management; Relationships; Corporate Strategy; Africa; Asia; Latin America
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    Jones, Geoffrey. Merchants to Multinationals. Oxford: Oxford University Press, 2000. (Winner of Newcomen-Harvard Book Award Given once every three years to the best work in the field of business history published in the United States.)
    • 17 Jan 2017
    • First Look

    First Look at New Research: January 17

    R. Abstract—This study tests the importance of Ricardian technology differences for international trade. The empirical analysis has three comparative advantages: including emerging and advanced economies,... View Details
    Keywords: Sean Silverthorne
    • 16 Apr 2001
    • Research & Ideas

    Angels Face the Innovator’s Dilemma

    or high potential markets that are $10 billion in size in any given year." The bigger the company becomes, he pointed out, the more important it is that the company lays out a very deliberate strategy. Yet the disruptive technologies... View Details
    Keywords: by Martha Lagace; Financial Services
    • April 1994 (Revised October 2002)
    • Case

    Frito-Lay, Inc.: A Strategic Transition (1990-1992)

    By: Lynda M. Applegate
    Describes the changes in structure, management systems, people, and processes instituted by the company. Provides students with an opportunity to explore the nature of "IT-enabled" organizational change and the process through which it is implemented. Also enables a... View Details
    Keywords: Organizational Change and Adaptation; Information Technology; Business Strategy; Food and Beverage Industry
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    Applegate, Lynda M. "Frito-Lay, Inc.: A Strategic Transition (1990-1992)." Harvard Business School Case 194-109, April 1994. (Revised October 2002.)
    • December 1996 (Revised July 2002)
    • Background Note

    Note on Marketing and the Internet

    By: John A. Deighton, Alison Berkley and John Barabino
    The World Wide Web is new, a comprehensive marketing environment. It is a medium for direct marketing, for retailing and distribution, for the delivery of service and product elements, for marketing research, and even for posting and testing prices. This note explores... View Details
    Keywords: Marketing; Internet and the Web; Digital Marketing
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    Deighton, John A., Alison Berkley, and John Barabino. "Note on Marketing and the Internet." Harvard Business School Background Note 597-037, December 1996. (Revised July 2002.)
    • November 2000
    • Exercise

    Atlantis-Biovent Negotiation: Confidential Instructions for Atlantis

    By: Michael A. Wheeler
    This two-party exercise illustrates bidding strategy in the context of settling a large insurance claim. Specifically, the claimant (Biovent) and the insurer (Atlantis) are asked to submit confidential offers to a dispute resolution Web site that will determine whether... View Details
    Keywords: Insurance; Bids and Bidding; Digital Platforms; Negotiation Process; Conflict and Resolution; Strategy; Internet and the Web
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    Wheeler, Michael A. "Atlantis-Biovent Negotiation: Confidential Instructions for Atlantis." Harvard Business School Exercise 801-262, November 2000.
    • 12 Jul 2010
    • Research & Ideas

    Rocket Science Retailing: A Practical Guide

    within stores. Align incentives within your organization and in the supply chain. Use technology judiciously and pay attention to emerging new technologies, whose value might still not be apparent. Explain... View Details
    Keywords: by Martha Lagace; Retail; Auto
    • April 2005 (Revised February 2007)
    • Case

    American Outsourcing

    By: Richard H.K. Vietor and Alexander Veytsman
    Covers the phenomenon of outsourcing jobs from the United States. Reviews the evolution of Mexico's Maquiladoras, manufacturing special economic areas in China, and information technology and service-sourcing in India. Also reviews exports/imports, exchange rates,... View Details
    Keywords: Job Cuts and Outsourcing; Employment; Emerging Markets; Wages; Trade; United States; Mexico; China; India
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    Vietor, Richard H.K., and Alexander Veytsman. "American Outsourcing." Harvard Business School Case 705-037, April 2005. (Revised February 2007.)
    • Web

    Placement - Doctoral

    Disintermediation, and Platform-Based Strategies Advisors: Feng Zhu , Shane M. Greenstein , and Marco Iansiti Raha Imanirad Technology & Operations Management, 2020 Placement: York University, Schulich School of Business Dissertation:... View Details
    • Program

    Mergers and Acquisitions

    your company is private or public, or looking to buy or to sell, you will emerge with new ability to broker powerful deals and create shareholder value. Key Benefits Completing a successful merger or acquisition is a multifaceted project... View Details
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