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  • All HBS Web  (1,401)
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    • News  (333)
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  • Working Paper

Rebates in the Pharmaceutical Industry: Evidence from Medicines Sold in Retail Pharmacies in the U.S.

By: Pragya Kakani, Michael Chernew and Amitabh Chandra
Rising list prices are often used to illustrate the burden of prescription drug spending, but payers routinely negotiate rebates from manufacturers that generate differences between list and net prices. List prices are easily available and affect patient cost-sharing,... View Details
Keywords: Pharmaceuticals; Rebates; Health Care and Treatment; Markets; Price; Analysis; Pharmaceutical Industry
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Kakani, Pragya, Michael Chernew, and Amitabh Chandra. "Rebates in the Pharmaceutical Industry: Evidence from Medicines Sold in Retail Pharmacies in the U.S." NBER Working Paper Series, No. 26846, March 2020.
  • February 2018
  • Article

Development and Feasibility of Bundled Payments for the Multidisciplinary Treatment of Head and Neck Cancer: A Pilot Program

By: Tracy Spinks, Alexis Guzman, Beth M. Beadle, Seohyun Lee, Ron Walters, Jim Incalcaterra, Ehab Hanna, Amy Hessel, Randal Weber, Sandra Denney, Lee Newcomer and Thomas W. Feeley
Purpose: Despite growing interest in bundled payments to reduce the costs of care, this payment method remains largely untested in cancer. This 3-year pilot tested the feasibility of a 1-year bundled payment for the multidisciplinary treatment of head and neck... View Details
Keywords: Health Care and Treatment; Cost Management
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Spinks, Tracy, Alexis Guzman, Beth M. Beadle, Seohyun Lee, Ron Walters, Jim Incalcaterra, Ehab Hanna, Amy Hessel, Randal Weber, Sandra Denney, Lee Newcomer, and Thomas W. Feeley. "Development and Feasibility of Bundled Payments for the Multidisciplinary Treatment of Head and Neck Cancer: A Pilot Program." Journal of Oncology Practice 14, no. 2 (February 2018): e103–e121.
  • February 2025
  • Article

Innovations in Evaluating Ambulatory Costs of Cystic Fibrosis Care: A Comparative Study Across Multidisciplinary Care Centers in Ireland and the United States

By: Emma Brady, Ryan C. Perkins, Kate Cullen, Gregory S. Sawicki, Robert S. Kaplan and Gerardine Doyle
Lead clinicians at two large pediatric cystic fibrosis (CF) centers in the United States and Ireland measured and compared their ambulatory care costs. The clinicians selected three strata of patients (0–11 months, 1–5 years, and 6–17 years of age). Process maps were... View Details
Keywords: Health Care and Treatment; Cost; Service Delivery; Resource Allocation; Health Industry
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Brady, Emma, Ryan C. Perkins, Kate Cullen, Gregory S. Sawicki, Robert S. Kaplan, and Gerardine Doyle. "Innovations in Evaluating Ambulatory Costs of Cystic Fibrosis Care: A Comparative Study Across Multidisciplinary Care Centers in Ireland and the United States." NEJM Catalyst Innovations in Care Delivery 6, no. 2 (February 2025).
  • July 2009
  • Teaching Note

The Miami Project to Cure Paralysis (TN)

By: Robert Steven Kaplan, Christopher Marquis and Ben Creo
Teaching Note for [408003]. View Details
Keywords: Nonprofit Organizations; Research; Health Care and Treatment; Medical Specialties; Financing and Loans; Leadership; Strategy; Problems and Challenges; Health Testing and Trials; Miami
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Kaplan, Robert Steven, Christopher Marquis, and Ben Creo. "The Miami Project to Cure Paralysis (TN)." Harvard Business School Teaching Note 410-005, July 2009.
  • August 2022 (Revised January 2025)
  • Case

NOW PT (A): Should We Invest?

By: George A Riedel, Amy Klopfenstein and Mel Martin
In fall 2021, a team of students from the HBS Impact Investing Fund considered Neurologic Optimal Wellness Physical Therapy (NOW PT) for a potential investment. Dr. Banks, the founder of NOW PT, drove to visit patients. She sought an investment from the fund to open a... View Details
Keywords: Entrepreneurship; Social Entrepreneurship; Finance; Investment; Health; Health Care and Treatment; Medical Specialties; Buildings and Facilities; Health Industry; Health Industry; North and Central America; United States; Massachusetts
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Riedel, George A., Amy Klopfenstein, and Mel Martin. "NOW PT (A): Should We Invest?" Harvard Business School Case 323-009, August 2022. (Revised January 2025.)
  • February 2023
  • Article

A Different Framework to Achieve Universal Coverage in the U.S.

By: Katherine Baicker, Amitabh Chandra and Mark Shepard
This JAMA Forum discusses alternative ways to achieve universal coverage in the US such as administrative simplification in the Affordable Care Act plans to increase enrollment, having a basic policy that would be available to everyone, and options for supplemental... View Details
Keywords: Health Care and Treatment; Government Legislation; Insurance; Cost; United States
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Baicker, Katherine, Amitabh Chandra, and Mark Shepard. "A Different Framework to Achieve Universal Coverage in the U.S." e230187. JAMA Health Forum 4, no. 2 (February 2023).
  • October 2005 (Revised September 2006)
  • Case

DentalCorp

By: Richard G. Hamermesh and Ricardo Reisen de Pinho
DentalCorp is the fifth largest provider of dental insurance in Brazil and has tripled its sales in the past two years. Whether to expand to Chile or to continue expansion in Brazil is the major strategic choice facing the company at the end of 2004. View Details
Keywords: International Finance; Expansion; Entrepreneurship; Health Care and Treatment; Global Strategy; Health Industry; Health Industry; Brazil; Chile
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Hamermesh, Richard G., and Ricardo Reisen de Pinho. "DentalCorp." Harvard Business School Case 806-023, October 2005. (Revised September 2006.)
  • October 2024
  • Supplement

NOW PT (B)

By: George A Riedel, Allison J. Wigen and Dave Habeeb
Pre-Abstract: Instructors should consider the timing of making videos available to students, as they may reveal key case details.

Abstract: In fall 2021, a team of students from the HBS Impact Investing Fund considered Neurologic Optimal Wellness Physical... View Details
Keywords: Health Care and Treatment; Medical Specialties; Business Model; Investment; Health Industry; United States
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Riedel, George A., Allison J. Wigen, and Dave Habeeb. "NOW PT (B)." Harvard Business School Multimedia/Video Supplement 325-702, October 2024.
  • December 2021
  • Case

Grace Capital

By: Sara Fleiss, Robin Greenwood, Eren Kuzucu and Denise Han
In March 2020, the global pandemic was delivering a dose of volatility to the U.S. economy. Catherine Faddis, the CIO of Grace Capital, a Boston-based long-only equity manager, analyzed movements in her portfolio while eyeing previously shelved opportunities to invest... View Details
Keywords: Preferred Stock; COVID-19 Pandemic; Economy; Health Pandemics; Volatility; Entrepreneurship; Finance; Investment; Strategy; Decision Making; Investment Portfolio; Financial Services Industry; United States
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Fleiss, Sara, Robin Greenwood, Eren Kuzucu, and Denise Han. "Grace Capital." Harvard Business School Case 222-052, December 2021.
  • September 2022
  • Article

Giving a Buck or Making a Buck? Donations by Pharmaceutical Manufacturers to Independent Patient Assistance Charities

By: Leemore Dafny, Christopher Ody and Teresa Rokos
The federal Anti-Kickback Statute prohibits biopharmaceutical manufacturers from directly covering Medicare enrollees’ out-of-pocket spending for the drugs they manufacture, but manufacturers may donate to independent patient assistance charities and earmark donations... View Details
Keywords: Cost Sharing; Prescription Drugs; Drug Spending; Medicare; Dual Eligibility; Cost; Health Care and Treatment; Philanthropy and Charitable Giving; Pharmaceutical Industry
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Dafny, Leemore, Christopher Ody, and Teresa Rokos. "Giving a Buck or Making a Buck? Donations by Pharmaceutical Manufacturers to Independent Patient Assistance Charities." Health Affairs 41, no. 9 (September 2022).
  • September–October 2020
  • Article

The Past, Present, and (Near) Future of Gene Therapy and Gene Editing

By: Julia Pian, Amitabh Chandra and Ariel Dora Stern
Emerging gene therapy and gene-editing technologies will have a growing impact on patient lives and health-care delivery. We analyzed a decade of data on clinical trials and venture capital investments to understand the likely trajectory of genetically focused... View Details
Keywords: Gene Therapy; Gene Editing; Impact; Health Care and Treatment; Technological Innovation; Health Testing and Trials; Venture Capital; Change
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Pian, Julia, Amitabh Chandra, and Ariel Dora Stern. "The Past, Present, and (Near) Future of Gene Therapy and Gene Editing." NEJM Catalyst Innovations in Care Delivery 1, no. 5 (September–October 2020).
  • January 2011 (Revised January 2012)
  • Supplement

The Case of the Unidentified Healthcare Companies2010 (CW)

By: Richard M.J. Bohmer, Ethan S Bernstein, Margarita Krivitski and Srinidhi Reddy
This case presents financial statements and selected rations for 14 unidentified healthcare organizations and asks that each set of financial information be matched with one of the following healthcare companies: a biotechnology firm, a community nursing company, a... View Details
Keywords: Financial Statements; Financial Management; Health Care and Treatment; Health Industry; Health Industry
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Bohmer, Richard M.J., Ethan S. Bernstein, Margarita Krivitski, and Srinidhi Reddy. "The Case of the Unidentified Healthcare Companies2010 (CW)." Harvard Business School Spreadsheet Supplement 611-701, January 2011. (Revised January 2012.)
  • 08 Sep 2015
  • First Look

September 8, 2015

that exists at the top of organizational hierarchies. Publisher's link: https://www.hbs.edu/faculty/Pages/item.aspx?num=49601 forthcoming Management Science Financing Risk and Innovation By: Nanda, Ramana, and Matthew Rhodes-Kropf... View Details
Keywords: Carmen Nobel
  • February 2006 (Revised February 2009)
  • Case

AIDS in Brazil

By: Rohit Deshpande and Ricardo Reisen de Pinho
Abbott Labs has reached an impasse with the Brazilian government in negotiations over the pricing of a new anti-AIDS drug, Kaletra. The Brazilian government threatens compulsory licensing unless Abbott drastically reduces the price of Kaletra. View Details
Keywords: Price; Government and Politics; Health Care and Treatment; Health Disorders; Rights; Negotiation; Business and Government Relations; Pharmaceutical Industry; Brazil
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Deshpande, Rohit, and Ricardo Reisen de Pinho. "AIDS in Brazil." Harvard Business School Case 506-062, February 2006. (Revised February 2009.)
  • August 2025
  • Article

Revenue Collapses and the Consumption of Small Business Owners in the COVID-19 Pandemic

By: Olivia S. Kim, Jonathan A. Parker and Antoinette Schoar
Using financial account data linking small businesses to their owner households, we examine how business owners’ consumption responded to changes in business revenues during the COVID-19 crisis. In the first two months following the National Emergency, business... View Details
Keywords: Revenue; Small Business; Health Pandemics; Spending; Consumer Behavior
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Kim, Olivia S., Jonathan A. Parker, and Antoinette Schoar. "Revenue Collapses and the Consumption of Small Business Owners in the COVID-19 Pandemic." Art. 104079. Journal of Financial Economics 170 (August 2025).
  • November 2005 (Revised November 2005)
  • Case

Massachusetts General Hospital and the Enbrel Royalty

By: David S. Scharfstein and Darren R. Smart
Massachusetts General Hospital is considering selling its royalty interest in Enbrel, Amgen's blockbuster drug for the treatment of rheumatoid arthritis. In assessing whether to sell, and at what price, the hospital must determine its value to a potential buyer as well... View Details
Keywords: Valuation; Price; Investment Return; Capital; Value; Revenue; Health Care and Treatment; Health Industry; Health Industry; Massachusetts
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Scharfstein, David S., and Darren R. Smart. "Massachusetts General Hospital and the Enbrel Royalty." Harvard Business School Case 206-075, November 2005. (Revised November 2005.)
  • March 2017
  • Article

Variation in the Cost of Care for Primary Total Knee Arthroplasties

By: Derek A. Haas and Robert S. Kaplan
The study examined the cost variation across 29 high-volume U.S. hospitals for delivering a primary total knee arthroplasty without major complicating conditions. Hospital and physician personnel costs were calculated using time-driven activity-based costing.... View Details
Keywords: Cost Management; Performance Productivity; Health Care and Treatment; Health Industry
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Haas, Derek A., and Robert S. Kaplan. "Variation in the Cost of Care for Primary Total Knee Arthroplasties." Arthroplasty Today 3, no. 1 (March 2017): 33–37.
  • December 2009 (Revised March 2025)
  • Case

Phreesia: The Patient Intake Company

By: Regina E. Herzlinger, Sunaina Yarlagadda and Brian L. Walker
How should the co-founders of an organization that provides patient sign-in and billing services scale their company after five years of successfully targeting small private physician practices? Phreesia had deployed a direct mail and sales force strategy that resulted... View Details
Keywords: Advertising; Social Entrepreneurship; Revenue; Health Care and Treatment; Health Industry
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Herzlinger, Regina E., Sunaina Yarlagadda, and Brian L. Walker. "Phreesia: The Patient Intake Company." Harvard Business School Case 310-066, December 2009. (Revised March 2025.)
  • March 2011
  • Teaching Note

PrimedicProviding Primary Care in Mexico (TN)

By: Richard G. Hamermesh
Teaching Note for 811040. View Details
Keywords: Business Startups; Health Care and Treatment; Venture Capital; Financing and Loans; Business Model; Medical Devices and Supplies Industry; Mexico
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Hamermesh, Richard G. "PrimedicProviding Primary Care in Mexico (TN)." Harvard Business School Teaching Note 811-074, March 2011.
  • April 1, 2024
  • Other Article

Paying For AI In Healthcare: Setting The Right Precedent Amidst Growing Use

By: Mitchell Tang, Kaylee Wilson and Ateev Mehrotra
Keywords: Health Care and Treatment; AI and Machine Learning; Cost
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Tang, Mitchell, Kaylee Wilson, and Ateev Mehrotra. "Paying For AI In Healthcare: Setting The Right Precedent Amidst Growing Use." Health Affairs Forefront (April 1, 2024).
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