Publications

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August 1996 (Revised May 1997)
Case

Delta & Pine Land: Measuring the Value of Transgenic Cotton

By: Ray A. Goldberg and Charlotte A. Tasker

Discusses the joint venture between two companies with different capabilities: 1) technology provider and 2) transportation agent. Discusses how to capture value from joint venture and biotechnology: 1) who are winners and who are losers; 2) how much value can/should... View Details

Keywords: Agribusiness; Joint Ventures; Marketing Strategy; Supply Chain Management; Performance Consistency; Information Technology; Transportation; Valuation; Biotechnology Industry

November 1995 (Revised February 1996)
Case

Monsanto Company: The Coming of Age of Bio-Technology

By: Ray A. Goldberg and Thomas N. Urban Jr

Monsanto has one product, Roundup, accounting for 30% of company net income and is going off patent. How should the company position itself and its products in the future? View Details

Keywords: Patents; Product Positioning; Strategic Planning; System Shocks; Biotechnology Industry

November 1978 (Revised October 1989)
Case

Amicon Corp. (B)

Details the negotiation between Amicon and three potential licensees, Jackson, Maynard-Smith and Behrstein. View Details

Keywords: Technology; Patents; Negotiation Process; Negotiation Participants; Health Care and Treatment; Biotechnology Industry

May 2015
Case

Transforming Alkermes into a Global Biopharmaceutical Company

By: C. Fritz Foley and Nicholas Haas

In the summer of 2011, Jim Frates, CFO of Alkermes faced choices about how to finance the acquisition of Dublin, Ireland-based Elan Drug Technologies (EDT)—a deal that was expected to close in the fall. The case describes the history of Alkermes, provides information... View Details

Keywords: Financing; Debt; Merger; CFO; Financial Management; Biotechnology Industry; Biotechnology Industry; United States; Europe

April 2011
Teaching Note

Office of Technology Transfer - Shanghai Institutes for Biological Sciences (TN)

By: Willy Shih and Sen Chai

Teaching Note for 611057. View Details

Keywords: Patents; Rights; Infrastructure; Multinational Firms and Management; Research and Development; Complexity; Commercialization; Technology Adoption; Motivation and Incentives; Biotechnology Industry; Biotechnology Industry; Shanghai

March 2011 (Revised February 2012)
Case

Innovation and Growth at Actelion Ltd.

By: Gary P. Pisano, Daniela Beyersdorfer and Ruth Dittrich

In late 2010, Jean-Paul Clozel, CEO of the Swiss biotech pharmaceuticals firm Actelion, looks back on a successful decade. The small venture that he had started with a few of his scientist colleagues in the late 1990s to discover novel medicine in a research-driven... View Details

Keywords: Business Model; Talent and Talent Management; Innovation and Management; Leadership; Growth and Development Strategy; Product Development; Organizational Culture; Research and Development; Biotechnology Industry; Biotechnology Industry; Switzerland

February 2009
Case

Avid Radiopharmaceuticals: The Venture Debt Question

By: Matthew Rhodes-Kropf and Ann Leamon

The CEO of a promising biotech company must decide how to respond to the macro-economic slump of late 2008. He had planned to pursue an aggressive schedule, moving the firm's Alzheimer's and Parkinson's disease imaging compounds through clinical trials and into the... View Details

Keywords: Financial Crisis; Entrepreneurship; Borrowing and Debt; Venture Capital; Financial Management; Investment; Health Testing and Trials; Expansion; Biotechnology Industry; Biotechnology Industry

January 2009 (Revised July 2009)
Case

Targanta Therapeutics: Hitting a Moving Target

By: Arthur A. Daemmrich

This case explores regulatory, product testing, and business strategy at Targanta Therapeutics, a biotech company preparing its first new drug application to the FDA. In October 2007, Mark Leuchtenberger, president and CEO of Targanta—which has just held a successful... View Details

Keywords: Decision Choices and Conditions; Entrepreneurship; Governing Rules, Regulations, and Reforms; Health Testing and Trials; Product Development; Business and Government Relations; Business Strategy; Biotechnology Industry; Biotechnology Industry

September 2008
Teaching Note

Chi Mei Optoelectronics (TN)

By: Willy C. Shih

Teaching Note for [608-123]. View Details

Keywords: Diversification; Information Technology; Market Entry and Exit; Standards; Industry Clusters; Supply Chain; Production; Experience and Expertise; Biotechnology Industry; Biotechnology Industry; Taiwan; Asia; Korean Peninsula; China

September 2007 (Revised May 2009)
Case

Syndexa and Technology Transfer at Harvard University

By: Richard G. Hamermesh and David Kiron

Gokhan Hotamisligil is a star researcher at Harvard School of Public Health who has made groundbreaking discoveries linking fat cells, inflammation, and diabetes. He now wants to form a company to commercialize these discoveries. At the same time, Isaac Kohlberg, the... View Details

Keywords: Business Startups; Higher Education; Entrepreneurship; Innovation and Invention; Intellectual Property; Rights; Agreements and Arrangements; Science-Based Business; Commercialization; Biotechnology Industry; Biotechnology Industry

November 2006 (Revised March 2008)
Case

The Harvard Stem Cell Institute

By: William A. Sahlman

Describes a set of issues confronting the leaders of the Harvard Stem Cell Institute, an innovative cross-university effort to accelerate scientific discovery and translation in the domain of stem cells. Covers a wide range of topics, including understanding how... View Details

Keywords: Talent and Talent Management; Higher Education; Entrepreneurship; Collaborative Innovation and Invention; Intellectual Property; Research and Development; Genetics; Biotechnology Industry; Biotechnology Industry; Massachusetts

November 2005 (Revised November 2005)
Case

Massachusetts General Hospital and the Enbrel Royalty

By: David S. Scharfstein and Darren R. Smart

Massachusetts General Hospital is considering selling its royalty interest in Enbrel, Amgen's blockbuster drug for the treatment of rheumatoid arthritis. In assessing whether to sell, and at what price, the hospital must determine its value to a potential buyer as well... View Details

Keywords: Valuation; Price; Investment Return; Capital; Value; Revenue; Health Care and Treatment; Biotechnology Industry; Biotechnology Industry; Massachusetts

March 2005 (Revised August 2005)
Case

Procurement at Betapharm Corp. (A)

Presents a move by Betapharm to centralize procurement and e-sourcing and the many control and incentive issues that arose subsequently. View Details

Keywords: Motivation and Incentives; Governance Controls; Supply Chain Management; Biotechnology Industry; Biotechnology Industry

June 2003 (Revised March 2008)
Case

Schering-Plough and Genome Therapeutics: Discovering an Asthma Gene

By: Regina E. Herzlinger and Marc Aquino

Personalized medicine requires the identification of mutated genes. Schering-Plough's search for the one related to asthma requires finding families with the disease. Examines the industry that helps conduct such research, including contract research organizations. View Details

Keywords: Health Disorders; Research and Development; Genetics; Biotechnology Industry; Biotechnology Industry

November 1998 (Revised October 1999)
Case

E.I. du Pont de Nemours and Company (A)

Du Pont's chief executive must decide what steps to take as his company expands from commodity and specialized chemicals into biotechnology. View Details

Keywords: Technology; Leading Change; Expansion; Biotechnology Industry; Biotechnology Industry

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September 1997 (Revised October 1997)
Case

Bayer AG (A)

By: John A. Quelch

Bayer's senior executives convene in Germany to consider submitting a $1 billion bid that would recover the Bayer brand name and trademark cross in North America, both of which were confiscated by the U.S. government after World War I. The group also sets out to assess... View Details

Keywords: Management Teams; Brands and Branding; War; Communication; Trademarks; Acquisition; Government and Politics; Biotechnology Industry; Biotechnology Industry; Germany; North America; United States

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01 Dec 1996
News

Entrepreneurship at HBS

direct marketing, consumer products, and consulting. Following Professor Georges F. Doriot's lead, our graduates have had a major impact on the venture capital industry, which in turn financed a revolution in semiconductors, personal computers, communications, and... View Details

September 2008 (Revised July 2012)
Case

Khosla Ventures: Biofuels Strategy

By: Joseph B. Lassiter III, William A. Sahlman and Alison Berkley Wagonfeld

By 2008, a number of the firm's early cleantech investments were showing promise, and the companies were starting to need significantly more money to create the massive scale required in the energy sector. As Khosla thought about the hundreds of millions of dollars... View Details

Keywords: Entrepreneurial Marketing; Entrepreneurial Finance; New Product Development; Partnerships; Entrepreneurial Management; Venture Capital; Strategy; Partners and Partnerships; Renewable Energy; Entrepreneurship; Investment Funds; Environmental Sustainability; Product Development; Biotechnology Industry; Biotechnology Industry