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      • October 2022 (Revised June 2025)
      • Case

      Lyra Health: Transforming Mental Health

      By: Rembrand Koning and Nicole Keller
      In January 2022, Lyra Health was deciding between several different alternatives to grow the business. Founded in 2015, Lyra Health, was a digital mental health platform that combined technology with human therapists and coaches to deliver high quality mental health... View Details
      Keywords: Mental Health; Health Care and Treatment; Corporate Entrepreneurship; Customer Value and Value Chain; Growth and Development Strategy; Expansion; Health Industry; Technology Industry; San Francisco
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      Koning, Rembrand, and Nicole Keller. "Lyra Health: Transforming Mental Health." Harvard Business School Case 723-365, October 2022. (Revised June 2025.)
      • October 21, 2022
      • Article

      Climate Regulations Are About to Disrupt Global Shipping

      By: Willy C. Shih
      Ships that transport goods across oceans are collectively a major generator of greenhouse gases. Rules from the International Maritime Organization and the European Union aimed at curbing these emission promise to make transoceanic and regional shipping more expensive... View Details
      Keywords: Shipping; Decarbonization; Environmental Regulation; Supply Chain; Disruption; Shipping Industry; Atlantic Ocean; Oceania; Asia; Europe; North and Central America
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      Shih, Willy C. "Climate Regulations Are About to Disrupt Global Shipping." Harvard Business Review Digital Articles (October 21, 2022).
      • October 2022
      • Case

      Afrigen Biologics: Vaccines for the Global South

      By: Debora L. Spar and Julia Comeau
      The majority of vaccines used on the continent of Africa (99%) are produced offshore. This makes African nations reliant on the West for major health care needs, a problem which was exacerbated by the COVID-19 pandemic. Afrigen Biologics (in partnership with the WHO)... View Details
      Keywords: Vaccination; Vaccine; mRNA; COVID; COVID-19; Inequity; Hub-and-spoke; Health Care and Treatment; Health Pandemics; Production; Social Issues; Business and Government Relations; South Africa; Africa
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      Spar, Debora L., and Julia Comeau. "Afrigen Biologics: Vaccines for the Global South." Harvard Business School Case 323-030, October 2022.
      • October 2022 (Revised July 2025)
      • Case

      Driving Decarbonization at BMW

      By: Shirley Lu, George Serafeim and Michael W. Toffel
      The case describes BMW’s electrification and decarbonization strategy, and how the company measured carbon emissions throughout the life cycle of its vehicles and used tools like carbon abatement cost curves to evaluate decarbonization opportunities. In mid-2022,... View Details
      Keywords: Decarbonization; Climate Change; Environment; Sustainability; Carbon Accounting; Carbon; Carbon Abatement; Electric Vehicles; Automobiles; Transportation; Environmental Accounting; Environmental Management; Environmental Sustainability; Accounting; Strategy; Technological Innovation; Supply Chain; Business and Stakeholder Relations; Transportation Industry; Auto Industry; Battery Industry; Germany; China; United States; Europe
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      Lu, Shirley, George Serafeim, and Michael W. Toffel. "Driving Decarbonization at BMW." Harvard Business School Case 123-008, October 2022. (Revised July 2025.)
      • October 2022
      • Case

      EducationSuperHighway 2.0

      By: William A. Sahlman, Allison M. Ciechanover and Emily Grandjean
      In 2012, Evan Marwell launched EducationSuperHighway (ESH) to address a major problem: though most public K-12 schools in the US had access to the Internet, only roughly 30% had true broadband access that would enable every student to have high speed connectivity. ... View Details
      Keywords: Nonprofit Organizations; Social Entrepreneurship; Social Issues; Leading Change; Early Childhood Education; Infrastructure; Internet and the Web; Telecommunications Industry; Education Industry; Technology Industry; United States; San Francisco
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      Sahlman, William A., Allison M. Ciechanover, and Emily Grandjean. "EducationSuperHighway 2.0." Harvard Business School Case 823-060, October 2022.
      • October 2022
      • Case

      Beam Dental (A)

      By: Rembrand Koning and Alicia Dadlani
      In May 2014, Alex Frommeyer, cofounder and CEO of Kentucky-based Beam Dental, a seed-stage startup that developed connected toothbrushes that tracked brushing habits, needed to decide which strategy to pitch to a venture capital firm. The first pitch deck played to the... View Details
      Keywords: Business Startups; Business Strategy; Entrepreneurship; Financing and Loans; Presentations; Product Development; Insurance Industry; United States; Kentucky; Ohio
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      Koning, Rembrand, and Alicia Dadlani. "Beam Dental (A)." Harvard Business School Case 723-355, October 2022.
      • October 2022 (Revised November 2023)
      • Case

      Framebridge (A): Reimagining Custom Framing

      By: Rembrand Koning and Alicia Dadlani
      In December 2018, Susan Tynan, founder and CEO of Framebridge, a four-year-old venture-backed startup that sold online custom framing, formulated plans for the future. Her vision was to revolutionize the $4 billion industry by making custom framing easy, transparent,... View Details
      Keywords: Business Startups; Business Strategy; Entrepreneurship; Operations; Consumer Products Industry; United States; District of Columbia; Kentucky
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      Koning, Rembrand, and Alicia Dadlani. "Framebridge (A): Reimagining Custom Framing." Harvard Business School Case 723-352, October 2022. (Revised November 2023.)
      • October 2022
      • Supplement

      Framebridge (B): A New Approach

      By: Rembrand Koning and Alicia Dadlani
      In 2022, after revamping operations and expanding retail stores, Framebridge founder and CEO Susan Tynan is optimistic for the future but realizes changing market dynamics. New competitors are entering the market, and margin pressures remained. This case is part two of... View Details
      Keywords: Business Startups; Business Strategy; Entrepreneurship; Operations; Market Entry and Exit; Consumer Products Industry; United States; District of Columbia; Kentucky
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      Koning, Rembrand, and Alicia Dadlani. "Framebridge (B): A New Approach." Harvard Business School Supplement 723-353, October 2022.
      • 2022
      • Book

      Tutorials in Operations Research: Emerging and Impactful Topics in Operations

      By: Mabel Chou, Hise O. Gibson and Bradley Staats
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      Chou, Mabel, Hise O. Gibson, and Bradley Staats, eds. Tutorials in Operations Research: Emerging and Impactful Topics in Operations. Catonsville, MD, USA: Institute for Operations Research and the Management Sciences (INFORMS), 2022.
      • September 2022
      • Technical Note

      Addressing Social Determinants of Health in the American Landscape

      By: Susanna Gallani and Jacob Riegler
      Social determinants of health (SDOH) have gained significant attention in recent years. A growing body of research shows that a person’s health is influenced by a large number of non-genetic factors, most of which operate outside the realm of health care and are... View Details
      Keywords: Socioeconomic Determinants Of Health; Social Determinants Of Health; Population Health; Health; Health Care and Treatment; Social Issues; Health Industry; Insurance Industry; Medical Devices and Supplies Industry; United States
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      Gallani, Susanna, and Jacob Riegler. "Addressing Social Determinants of Health in the American Landscape." Harvard Business School Technical Note 123-023, September 2022.
      • September 2022 (Revised May 2024)
      • Case

      Navya: Steering toward a Driverless Future

      By: Julian De Freitas, Elie Ofek, Shaun Ingledew and Tonia Labruyere
      In 2022, Sophie Desormière arrived at French roboshuttle producer Navya, tasked with charting a new course in a challenging sector. The company, which had recently listed on the Paris Stock Exchange, was burning through cash reserves and needed to transform the promise... View Details
      Keywords: Autonomous Vehicles; Market Entry and Exit; Opportunities; Governing Rules, Regulations, and Reforms; Consumer Behavior; Business Model; Auto Industry; Transportation Industry; France; United States
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      De Freitas, Julian, Elie Ofek, Shaun Ingledew, and Tonia Labruyere. "Navya: Steering toward a Driverless Future." Harvard Business School Case 523-046, September 2022. (Revised May 2024.)
      • September 2022 (Revised September 2024)
      • Case

      Esas Group: Investing Together, Staying Together

      By: Christina R. Wing and Alpana Thapar
      This case opens in June 2022, after Esas Group, one of Turkey’s largest family-owned investment firms, implements a series of changes to professionalize the business and help transition family members from operators to responsible investors. In December 2019, the Group... View Details
      Keywords: Family Business; Transition; Business or Company Management; Organizational Structure; Governing and Advisory Boards; Governance; Financial Services Industry; Turkey
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      Wing, Christina R., and Alpana Thapar. "Esas Group: Investing Together, Staying Together." Harvard Business School Case 623-027, September 2022. (Revised September 2024.)
      • September 2022 (Revised November 2022)
      • Case

      The Uyghur Forced Labor Prevention Act: Trade and Genocide in U.S.-China Relations

      By: Jeremy Friedman and David Lane
      On June 21, 2022, the Uyghur Forced Labor Prevention Act (UFLPA) went into effect, requiring companies to prove that goods imported from the People’s Republic of China were not made with forced labor. The bill was a reaction to reports of products being made with... View Details
      Keywords: Ethics; Multinational Firms and Management; Globalized Markets and Industries; Governing Rules, Regulations, and Reforms; Policy; Government Legislation; International Relations; Labor; Wages; Law Enforcement; Law; Rights; Operations; Supply Chain Management; Business and Government Relations; Agriculture and Agribusiness Industry; Manufacturing Industry; Mining Industry; China; United States
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      Friedman, Jeremy, and David Lane. "The Uyghur Forced Labor Prevention Act: Trade and Genocide in U.S.-China Relations." Harvard Business School Case 723-001, September 2022. (Revised November 2022.)
      • August 2022 (Revised March 2025)
      • Case

      Wasabi Technologies (A)

      By: N. Louis Shipley and Mel Martin
      After launching a successful hot cloud storage company, Founder and CEO David Friend is ready to scale the venture rapidly. Wasabi Technologies had focused primarily on direct sales, but an opportunity to pivot to channel sales was on the horizon. The company’s major... View Details
      Keywords: Direct Sales; Channel Sales; Information Management; Sales; Product Development; Growth and Development Strategy; Business Divisions; Information Technology Industry; United States
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      Shipley, N. Louis, and Mel Martin. "Wasabi Technologies (A)." Harvard Business School Case 823-021, August 2022. (Revised March 2025.)
      • August 2022
      • Case

      Air Wars: Deregulating the U.S. Airline Industry

      By: Tom Nicholas and James Weber
      In the early decades of the twentieth century, the U.S. government assisted in the development of an airline industry by subsidizing the delivery of mail and allowing mail carriers to also fly passengers. Because the government awarded mail routes to the lowest... View Details
      Keywords: Government Regulation; Deregulation; Change Management; Economics; Entrepreneurship; Financial Management; Business History; Human Resources; Compensation and Benefits; Labor; Labor Unions; Leading Change; Leadership Style; Crisis Management; Industry Structures; Operations; Strategy; Adaptation; Competition; Air Transportation; Air Transportation Industry; United States
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      Nicholas, Tom, and James Weber. "Air Wars: Deregulating the U.S. Airline Industry." Harvard Business School Case 823-033, August 2022.
      • August 2022 (Revised May 2025)
      • Case

      Fresh Food Generation

      By: Brian Trelstad, Amy Klopfenstein and Mel Martin
      This case highlights one of five BIPOC entrepreneurs in the Boston area as part of the HBS Impact Investment Fund. In fall 2021, a team of HBS students reviewed the financial statements of Fresh Food Generation (FFG), a Dorchester, Massachusetts-based food service... View Details
      Keywords: Impact Investing; Investment; Entrepreneurial Finance; Entrepreneurship; Race; Food and Beverage Industry; Boston
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      Trelstad, Brian, Amy Klopfenstein, and Mel Martin. "Fresh Food Generation." Harvard Business School Case 323-010, August 2022. (Revised May 2025.)
      • August 2022 (Revised October 2022)
      • Case

      Sian Flowers: Fresher by Sea?

      By: Willy C. Shih, Michael W. Toffel and Pippa Tubman Armerding
      The setting for this case is the Sian Flowers, a company headquartered in Kitengela, Kenya that exports roses to predominantly Europe. Because cut flowers have a limited shelf life and consumers want them to retain their appearance for as long as possible, Sian or its... View Details
      Keywords: Supply Chain; Supply Chains; Sustainability; Sustainable Agriculture; Sustainability Reporting; Carbon Emissions; Supply Chain Management; Quality; Ship Transportation; Cost Management; Agriculture and Agribusiness Industry; Africa; Kenya; Netherlands; Europe
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      Shih, Willy C., Michael W. Toffel, and Pippa Tubman Armerding. "Sian Flowers: Fresher by Sea?" Harvard Business School Case 623-008, August 2022. (Revised October 2022.)
      • August 1, 2022
      • Article

      The Supply Chain, Explained

      By: Willy C. Shih
      Why have supply chains been such a mess? For starters, there are a lot more layers than you think. This article describes some common features of supply chains that help the reader to understand how things could have gone so far off track during the pandemic. View Details
      Keywords: COVID-19 Pandemic; Supply Chain; Manufacturing Industry; United States
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      Shih, Willy C. "The Supply Chain, Explained." Wall Street Journal (August 1, 2022). (Online Edition, July 22, 2022.)
      • July 2022 (Revised February 2025)
      • Case

      A Soul and a Service: North Carolina Mutual Life Insurance

      By: Tom Nicholas and John Masko
      The North Carolina Mutual and Provident Association (the Mutual) was founded in 1898 as a for-profit entity selling life insurance catering to the Black community. The Mutual was entering a field crowded with established White-owned competitors that largely refused to... View Details
      Keywords: Black Entrepreneurs; Insurance; History; Race; Prejudice and Bias; Entrepreneurship; Decision Choices and Conditions; Growth and Development Strategy; Insurance Industry; United States
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      Nicholas, Tom, and John Masko. "A Soul and a Service: North Carolina Mutual Life Insurance." Harvard Business School Case 823-032, July 2022. (Revised February 2025.)
      • July 2022 (Revised September 2022)
      • Case

      Birla Carbon Egypt: Building Soft Power in a Foreign Country

      By: Jeremy Friedman and Malini Sen
      Birla Carbon, a flagship business of the nearly $60-billion global conglomerate and India-headquartered Aditya Birla Group (ABG), is one of the world's top manufacturers and suppliers of high-quality carbon black. The largest among its 16 manufacturing plants is Birla... View Details
      Keywords: Acquisition; Family Business; Disruption; Transformation; Diversity; Trade; Energy; Values and Beliefs; Cross-Cultural and Cross-Border Issues; Global Strategy; Government and Politics; Private Ownership; Civil Society or Community; Risk and Uncertainty; Value Creation; Industrial Products Industry; Rubber Industry; Egypt; Africa; India; Asia; Atlanta; United States
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      Friedman, Jeremy, and Malini Sen. "Birla Carbon Egypt: Building Soft Power in a Foreign Country." Harvard Business School Case 723-003, July 2022. (Revised September 2022.)
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