Publications

2024
Working Paper

Dusting Off the Old Ones: Drug Licensing to Startups, Innovation Success and Efficiency

By: Mosab Hammoudeh, Joshua Lev Krieger and Jiajie Xu

This paper investigates whether moving R&D from incumbents to startups can increase innovation. Using comprehensive drug development data, we examine the outcomes of drug projects licensed from large firms to startups. We find that these projects licensed to startups... View Details

Keywords: Product Development; Innovation and Invention; Business Startups; Research and Development; Performance Efficiency; Pharmaceutical Industry

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Article

The Career Effects of Scandal: Evidence from Scientific Retractions

By: Pierre Azoulay, Alessandro Bonatti and Joshua Lev Krieger

We investigate how the scientific community's perception of a scientist's prior work changes when one of his articles is retracted. Relative to non-retracted control authors, faculty members who experience a retraction see the citation rate to their earlier,... View Details

Keywords: Reputation; Perception; Status and Position; Outcome or Result

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2024
Working Paper

Charting (and Updating) the Path: A Bayesian Perspective on Entrepreneurial Learning

By: Joshua L. Krieger

This chapter explores two distinct modes of entrepreneurial learning: assessing venture viability and choosing between alternative development paths. It introduces a framework for decomposing venture viability into technological feasibility, commercial potential and... View Details

Keywords: Decision Making; Entrepreneurship; Growth and Development Strategy; Learning

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January 2022
Case

Tomorrow.io Goes to Space

By: Joshua Lev Krieger, Abhishek Nagaraj and James Barnett

This case study explores the evolution of Tomorrow.io, a weather forecasting technology company, as it pivoted toward building and launching space-based weather radar satellites. This strategic shift was driven by the company's ambition to overcome data limitations in... View Details

Keywords: Communication; Competency and Skills; Engineering; Globalization; Innovation and Invention; Performance; Information Technology; Aerospace Industry

September 2020 (Revised January 2021)
Case

Catalys Pacific

By: Joshua Lev Krieger

In 2019, BT Slingsby founds Catalys Pacific, the first biotech “venture creation” fund in Tokyo. After convincing some of the biggest Japanese pharmaceutical firms to invest, BT hopes the fund can make a big splash and transform biotechnology innovation in Japan. After... View Details

Keywords: Pharmaceutical Companies; Biotech; Health Care; Entrepreneur; Innovation; International Business; Entrepreneurial Finance; Entrepreneurship; Finance; Innovation Strategy; Venture Capital; Strategy; Cross-Cultural and Cross-Border Issues; Pharmaceutical Industry; Biotechnology Industry; Tokyo

November 2017
Case

The 'Wonder Drug' That Killed Babies

By: Joshua Lev Krieger, Tom Nicholas and Matthew Preble

In the early 1960s, a popular drug taken by patients worldwide for a range of maladies was found to cause severe birth defects and other health problems in babies born to mothers who had taken it during a certain stage of fetal development. As many as 10,000 children... View Details

Keywords: Regulation; Business and Government Relations; Business and Community Relations; Business and Stakeholder Relations; Product Marketing; Corporate Social Responsibility and Impact; Business History; Health; Government Legislation; Corporate Accountability; Ethics; Governing Rules, Regulations, and Reforms; Pharmaceutical Industry; Public Administration Industry; United States; United Kingdom; Australia; Germany; Europe

January 2022 (Revised March 2022)
Teaching Note

Catalys Pacific

By: Joshua Lev Krieger

Teaching Note for HBS Case No. 821-035. View Details

May 2021
Article

Private and Social Returns to R&D: Drug Development and Demographics

By: Efraim Benmelech, Janice Eberly, Dimitris Papanikolaou and Joshua Krieger

Investment in intangible capital such as R&D has increased dramatically since the 1990s. However, productivity growth remains sluggish in recent years. One potential reason is that a significant share of the increase in intangible investment is geared toward consumer... View Details

Keywords: Drug Development; Research and Development; Investment Return; Demographics; Pharmaceutical Industry

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September 2024
Article

Standing on the Shoulders of Science

By: Joshua Lev Krieger, Monika Schnitzer and Martin Watzinger

Today’s innovations rely on scientific discoveries of the past, yet only some corporate R&D builds directly on scientific output. In this paper, we analyze U.S. patents to investigate how firms generate value by building on prior art “closer” to science. We show... View Details

Keywords: Patent Novelty; Value Capture; Science; Patents; Valuation; Research and Development

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January 2024
Case

Fusion Industry Association: Igniting the Future of Clean Energy

By: Joshua Lev Krieger, Jim Matheson, Kyle R. Myers and Henry Tao

Fusion energy is evolving from a scientific idea to a commercial possibility, drawing large investments and regulatory discussions; how should the FIA navigate this evolution?

The Fusion Industry Association (FIA) is at the forefront of transforming fusion... View Details

Keywords: Science-Based Business; Engineering; Venture Capital; Entrepreneurship; Government and Politics; Government Legislation; Industry Clusters; Industry Growth; Industry Structures; Technological Innovation; Energy Industry; United States

August 2024 (Revised November 2024)
Case

Commonwealth Fusion Systems: Born at Scale

By: Joshua Lev Krieger, Jim Matheson, Kyle Myers, Gunnar Trumbull and Richard Vietor

This case study chronicles the journey of Commonwealth Fusion Systems (CFS) on its ambitious mission to commercialize fusion energy and become the world’s leading provider of fusion power plants. Emerging from a “special arrangement” with MIT's Plasma Science and... View Details

Keywords: Nuclear Energy; Innovation; Entrepreneurship; Entrepreneurial Finance; Energy Generation; Commercialization; Science-Based Business; Technological Innovation; Market Entry and Exit; Energy Industry

Web

Tough Tech Ventures - Course Catalog

HBS Course Catalog Tough Tech Ventures Course Number 1727 Associate Professor Joshua Lev Krieger Senior Lecturer Jim Matheson Spring; Q3Q4; 3.0 credits Paper Course Overview... View Details

August 2022
Teaching Note

In-Q-Tel: Innovation On A Mission

By: Josh Lerner and Joshua Lev Krieger

Teaching Note for HBS Case No. 823-031. View Details

February 2025
Case

Fly, Fix, Fly at True Anomaly

By: Joshua Lev Krieger, Jim Matheson, Fiona Murray and David Allen

How should companies learn from failure? Founded by four U.S. Space Force warfighters, the tough tech startup True Anomaly wanted to compete with major defense contractors to supply the U.S. Department of Defense with satellites and software that could help protect... View Details

Keywords: Business Startups; Engineering; National Security; Digital Platforms; Failure; Problems and Challenges; Business and Government Relations; War; Aerospace Industry; United States; Colorado