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    • All HBS Web  (2,040)
      • Faculty Publications  (327)

      Systemic InnovationRemove Systemic Innovation →

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      • April 2024 (Revised November 2024)
      • Case

      Moderna: Pioneering a People Platform to Accelerate Science Innovation

      By: Tatiana Sandino, Emil Dy and Samuel Grad
      Moderna was founded in 2010 to explore how messenger ribonucleic acid (mRNA) could be used to create breakthrough medicines by encoding instructions for the body to create antibodies. When Stéphane Bancel (HBS 2000) took over in 2011, he bet on the potential of this... View Details
      Keywords: Disruptive Innovation; Talent and Talent Management; Selection and Staffing; AI and Machine Learning; Digital Strategy; Innovation and Management; Leadership Development; Management Practices and Processes; Management Systems; Organizational Culture; Performance Evaluation; Alignment; Employee Relationship Management; Science-Based Business; Expansion; Pharmaceutical Industry; Biotechnology Industry; United States
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      Sandino, Tatiana, Emil Dy, and Samuel Grad. "Moderna: Pioneering a People Platform to Accelerate Science Innovation." Harvard Business School Case 124-091, April 2024. (Revised November 2024.)
      • 2024
      • Working Paper

      Appropriate Entrepreneurship? The Rise of China and the Developing World

      By: Josh Lerner, Junxi Liu, Jacob Moscona and David Yang
      Global innovation and entrepreneurship has traditionally been dominated by a handful of high-income countries, especially the US. This paper investigates the international consequences of the rise of a new hub for innovation, focusing on the dramatic growth of... View Details
      Keywords: Entrepreneurship; Venture Capital; Emerging Markets; Economic Growth; China
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      Lerner, Josh, Junxi Liu, Jacob Moscona, and David Yang. "Appropriate Entrepreneurship? The Rise of China and the Developing World." Harvard Business School Working Paper, No. 24-061, March 2024.
      • March 2024 (Revised May 2025)
      • Case

      Governing OpenAI (A)

      By: Lynn S. Paine, Suraj Srinivasan and Will Hurwitz
      In late November 2023, OpenAI’s new board of directors took stock of the situation. The company, which sought to develop artificial general intelligence (AGI)—computer systems with capabilities exceeding human abilities—was looking to regain its footing after a chaotic... View Details
      Keywords: Artificial Intelligence; Board Of Directors; Board Decisions; Board Dynamics; Corporate Boards; Governance Changes; Governance Structure; Leadership Change; Legal Aspects Of Business; Nonprofit Governance; Strategy And Execution; Technological Change; AI and Machine Learning; Corporate Governance; Leadership; Management; Mission and Purpose; Technological Innovation; Governing Rules, Regulations, and Reforms; Governing and Advisory Boards; Resignation and Termination; Ethics; Nonprofit Organizations; Open Source Distribution; Partners and Partnerships; Technology Industry; San Francisco; United States
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      Paine, Lynn S., Suraj Srinivasan, and Will Hurwitz. "Governing OpenAI (A)." Harvard Business School Case 324-103, March 2024. (Revised May 2025.)
      • February 2024 (Revised December 2024)
      • Case

      Best Buy Health: Enabling Care at Home

      By: Robert S. Huckman, Rosabeth Moss Kanter, Antonio Moreno, Bradley Staats and Sarah Mehta
      This case explores retailer Best Buy’s decision to enter health care. Best Buy Health aims to enable care at home across three prongs: consumer health, active aging, and virtual care. A key pillar of Best Buy Health's strategy is leveraging the Geek Squad—the company's... View Details
      Keywords: Business Ventures; Health Care and Treatment; Innovation and Invention; Business Strategy; Market Entry and Exit; Service Delivery; Service Operations; Electronics Industry; Health Industry; Retail Industry; United States; Minnesota
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      Huckman, Robert S., Rosabeth Moss Kanter, Antonio Moreno, Bradley Staats, and Sarah Mehta. "Best Buy Health: Enabling Care at Home." Harvard Business School Case 624-009, February 2024. (Revised December 2024.)
      • February 2024
      • Article

      Representation and Extrapolation: Evidence from Clinical Trials

      By: Marcella Alsan, Maya Durvasula, Harsh Gupta, Joshua Schwartzstein and Heidi L. Williams
      This article examines the consequences and causes of low enrollment of Black patients in clinical trials. We develop a simple model of similarity-based extrapolation that predicts that evidence is more relevant for decision-making by physicians and patients when it... View Details
      Keywords: Representation; Racial Disparity; Health Testing and Trials; Race; Equality and Inequality; Innovation and Invention; Pharmaceutical Industry
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      Alsan, Marcella, Maya Durvasula, Harsh Gupta, Joshua Schwartzstein, and Heidi L. Williams. "Representation and Extrapolation: Evidence from Clinical Trials." Quarterly Journal of Economics 139, no. 1 (February 2024): 575–635.
      • January 2024 (Revised August 2024)
      • Case

      Essex County Community Foundation: Pivot to Systems Philanthropy

      By: V. Kasturi Rangan, Brian Trelstad and Courtney Han
      2023 marked five years of the Essex County Community Foundation (ECCF)’s “systems philanthropy” approach to grantmaking. Located in northeastern Massachusetts, the community foundation served 800,000 residents across 34 cities and towns that varied widely by... View Details
      Keywords: Philanthropy and Charitable Giving; Reputation; Civil Society or Community; Social Issues; Alignment; Nonprofit Organizations; Business and Stakeholder Relations; Collaborative Innovation and Invention; Leading Change; Massachusetts
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      Rangan, V. Kasturi, Brian Trelstad, and Courtney Han. "Essex County Community Foundation: Pivot to Systems Philanthropy." Harvard Business School Case 524-066, January 2024. (Revised August 2024.)
      • 2024
      • Book

      The Everything Token: How NFTs and Web3 Will Transform the Way We Buy, Sell, and Create

      By: Steve Kaczynski and Scott Duke Kominers
      We demystify the coming digital revolution, showing how NFTs will transform our online and offline interactions.

      NFTs aren’t just pictures on the internet, or a fad that has come and gone. Rather, they’re a new technology for creating digital assets and... View Details
      Keywords: Economic Systems; Microeconomics; Entrepreneurship; Cultural Entrepreneurship; Information Technology; Innovation and Invention; Innovation Strategy; Digital Platforms; Digital Strategy; Digital Transformation; Internet and the Web; Technology Adoption; Marketing; Marketing Strategy; Product Marketing; Product Positioning; Markets; E-commerce; Market Design; Value; Customer Value and Value Chain; Collaborative Innovation and Invention; Innovation and Management; Organizational Structure; Customer Ownership; Ownership; Advertising Industry; Communications Industry; Computer Industry; Consumer Products Industry; Fashion Industry; Information Technology Industry; Media and Broadcasting Industry; Technology Industry; Web Services Industry
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      Kaczynski, Steve, and Scott Duke Kominers. The Everything Token: How NFTs and Web3 Will Transform the Way We Buy, Sell, and Create. Portfolio/Penguin, 2024.
      • December 2023
      • Case

      TikTok: The Algorithm Will See You Now

      By: Shikhar Ghosh and Shweta Bagai
      In a world where attention is a scarce commodity, this case explores the meteoric rise of TikTok—an app that transformed from a niche platform for teens into the most visited domain by 2021—surpassing even Google. Its algorithm was a sophisticated mechanism for... View Details
      Keywords: Social Media; Applications and Software; Disruptive Innovation; Business and Government Relations; International Relations; Cybersecurity; Culture; Technology Industry; China; United States; India
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      Ghosh, Shikhar, and Shweta Bagai. "TikTok: The Algorithm Will See You Now." Harvard Business School Case 824-125, December 2023.
      • December 2023 (Revised January 2025)
      • Case

      Research In Motion: Launching and Scaling the World's First Smartphone Empire (A)

      By: Tatiana Sandino and Samuel Grad
      In 2005, Research In Motion’s (RIM) BlackBerry smartphone was a sensation. After its launch in 1999, the groundbreaking BlackBerry had captured the hearts and minds of corporate America through its secure wireless email service. The device was so addictive and... View Details
      Keywords: Business Growth and Maturation; Decision Choices and Conditions; Mobile and Wireless Technology; Innovation and Management; Technological Innovation; Business or Company Management; Management Style; Product Development; Managerial Roles; Growth and Development Strategy; Technology Industry; United States; Canada
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      Sandino, Tatiana, and Samuel Grad. "Research In Motion: Launching and Scaling the World's First Smartphone Empire (A)." Harvard Business School Case 124-023, December 2023. (Revised January 2025.)
      • November 2023
      • Case

      Open Source Machine Learning at Google

      By: Shane Greenstein, Martin Wattenberg, Fernanda B. Viégas, Daniel Yue and James Barnett
      Set in early 2023, the case exposes students to the challenges of managing open source software at Google. The case focuses on the challenges for Alex Spinelli, Vice President of Product Management for Core Machine Learning. He must set priorities for Google’s efforts... View Details
      Keywords: Decision Choices and Conditions; Technological Innovation; Open Source Distribution; Strategy; AI and Machine Learning; Applications and Software; Technology Industry; United States
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      Greenstein, Shane, Martin Wattenberg, Fernanda B. Viégas, Daniel Yue, and James Barnett. "Open Source Machine Learning at Google." Harvard Business School Case 624-015, November 2023.
      • 2023
      • Working Paper

      Coordinated R&D Programs and the Creation of New Industries

      By: Daniel P. Gross and Maria P. Roche
      Complex systems technologies—including “deep tech”—are prone to numerous frictions that stymie commercial development. Yet technologies with these features underpin some of the most valuable industries of the past century. We examine how large, mission-oriented... View Details
      Keywords: Research and Development; Policy; Business and Government Relations; Technological Innovation; Collaborative Innovation and Invention
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      Gross, Daniel P., and Maria P. Roche. "Coordinated R&D Programs and the Creation of New Industries." Harvard Business School Working Paper, No. 24-027, April 2023. (Revised October 2024.)
      • October 2023 (Revised March 2024)
      • Case

      KOKO Networks: Bridging Energy Transition and Affordability with Carbon Financing

      By: George Serafeim, Siko Sikochi and Namrata Arora
      The problem was massive: two million hectares of African forests were lost annually to charcoal production for cooking, an area equivalent to 13 times Greater London, resulting in one billion tons of carbon emissions yearly. At the same time, an estimated 700,000... View Details
      Keywords: Clean Tech; Digital; Carbon Credits; Carbon Offsetting; Africa; Emerging Markets; Energy; Climate Change; Entrepreneurship; Energy Sources; Environmental Sustainability; Health; Market Design; Business Startups; Transition; Environmental Regulation; Policy; Energy Industry; Consumer Products Industry; Africa; Kenya; Rwanda
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      Serafeim, George, Siko Sikochi, and Namrata Arora. "KOKO Networks: Bridging Energy Transition and Affordability with Carbon Financing." Harvard Business School Case 124-022, October 2023. (Revised March 2024.)
      • October 2023
      • Case

      Fixie and Conversational AI Sidekicks

      By: Jeffrey J. Bussgang and Carin-Isabel Knoop
      In March 2023, Fixie Co-Founder and Chief Architect Matt Welsh and co-founders had the kind of meeting no founders want to have. The president of leading artificial intelligence (AI) research and deployment firm OpenAI, which had catapulted into fame with its ChatGPT... View Details
      Keywords: Large Language Model; Entrepreneurship; Decision Choices and Conditions; AI and Machine Learning; Technological Innovation; Competitive Strategy; Technology Industry; United States
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      Bussgang, Jeffrey J., and Carin-Isabel Knoop. "Fixie and Conversational AI Sidekicks." Harvard Business School Case 824-037, October 2023.
      • September 2023 (Revised September 2023)
      • Teaching Note

      Roche: Innovation and Access to Healthcare

      By: George Serafeim
      Teaching Note for HBS Case No. 123-075. In May 2022, Roche Group, one of the largest healthcare companies in the world, hosted its first investor event focused exclusively on its efforts to impact access to healthcare. While Roche had recently set an ambitious goal to... View Details
      Keywords: ESG; Access To Care; Healthcare; Healthcare Access; Innovation; Social Impact; Affordable; Health Care and Treatment; Innovation and Invention; Product Development; Resource Allocation; Corporate Social Responsibility and Impact; Health Industry
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      Serafeim, George. "Roche: Innovation and Access to Healthcare." Harvard Business School Teaching Note 124-028, September 2023. (Revised September 2023.)
      • September 2023
      • Case

      FoodCloud: Tackling Food Insecurity and Climate Change in One Bite

      By: Brian Trelstad and Emer Moloney
      In 2013, Aoibheann O’Brien and Iseult Ward founded FoodCloud, a non-profit social enterprise that aimed to address food waste and food insecurity issues. Through its technology platform, Foodiverse, FoodCloud connected surplus food from retailers with community groups... View Details
      Keywords: Nonprofit Organizations; Expansion; Technological Innovation; Environmental Sustainability; Social Issues; Growth and Development Strategy; Green Technology Industry; Agriculture and Agribusiness Industry; Food and Beverage Industry; Republic of Ireland; Europe
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      Trelstad, Brian, and Emer Moloney. "FoodCloud: Tackling Food Insecurity and Climate Change in One Bite." Harvard Business School Case 324-031, September 2023.
      • September 2023
      • Teaching Note

      Apple’s iPhone Revolution: Pioneering the Circular Economy

      By: George Serafeim
      Teaching Note for HBS Case 123-089. The case describes the Trade-In system for iPhones that allow iPhones to be refurbished and reused or to be recycled. The case provides information for the students to analyze the financial attractiveness of the Trade-In system and... View Details
      Keywords: Iphone; Smartphone; Technology; Business Model Innovation; Carbon Emissions; Recycling; Business Model; Product Design; Climate Change; Environmental Sustainability; Green Technology; Technology Industry
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      Serafeim, George. "Apple’s iPhone Revolution: Pioneering the Circular Economy." Harvard Business School Teaching Note 124-026, September 2023.
      • September 2023 (Revised January 2024)
      • Case

      RightHand Robotics: Choosing the First Market

      By: Thomas R. Eisenmann and Stacy Straaberg
      In early 2015, RightHand Robotics’s (RHR) leadership faced a set of decisions in commercializing the startup’s robotic picking solution. RHR’s central product was the RightPick integrated robotic picking system which featured a robotic arm, a three-fingered robotic... View Details
      Keywords: Business Startups; Market Entry and Exit; Product; Research and Development; Business Strategy; Commercialization; Information Infrastructure; Technological Innovation; Manufacturing Industry; Technology Industry; United States; Massachusetts
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      Eisenmann, Thomas R., and Stacy Straaberg. "RightHand Robotics: Choosing the First Market." Harvard Business School Case 824-006, September 2023. (Revised January 2024.)
      • August 2023
      • Article

      Explaining Machine Learning Models with Interactive Natural Language Conversations Using TalkToModel

      By: Dylan Slack, Satyapriya Krishna, Himabindu Lakkaraju and Sameer Singh
      Practitioners increasingly use machine learning (ML) models, yet models have become more complex and harder to understand. To understand complex models, researchers have proposed techniques to explain model predictions. However, practitioners struggle to use... View Details
      Keywords: AI and Machine Learning; Technological Innovation; Technology Adoption
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      Slack, Dylan, Satyapriya Krishna, Himabindu Lakkaraju, and Sameer Singh. "Explaining Machine Learning Models with Interactive Natural Language Conversations Using TalkToModel." Nature Machine Intelligence 5, no. 8 (August 2023): 873–883.
      • June 2023 (Revised June 2023)
      • Supplement

      Roche: Innovation and Access to Healthcare

      By: George Serafeim
      In May 2022, Roche Group, one of the largest healthcare companies in the world, hosted its first investor event focused exclusively on its efforts to impact access to healthcare. While Roche had recently set an ambitious goal to double the number of patients that had... View Details
      Keywords: ESG (Environmental, Social, Governance) Performance; Sustainable Finance; Growth Strategy And Execution; Sustainability Targets; Impact Evaluation; Healthcare Access; Healthcare Innovation; Healthcare Systems; Healthcare Operations; Finance; Strategy; Health Testing and Trials; Health Care and Treatment; Growth Management; Measurement and Metrics; Innovation Strategy; Corporate Social Responsibility and Impact; Health Industry; Pharmaceutical Industry; Switzerland; North America; Europe; Asia; Latin America; Africa
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      Serafeim, George. "Roche: Innovation and Access to Healthcare." Harvard Business School Multimedia/Video Supplement 123-713, June 2023. (Revised June 2023.)
      • April 2023 (Revised September 2023)
      • Case

      Levels: The Remote, Asynchronous, Deep Work Management System

      By: Joseph B. Fuller and George Gonzalez
      Levels is a highly innovative startup in the health care space. They intend to revolutionize health by linking behavior—eating, exercise, sleeping, etc.—to changes in metabolism. They believe metabolic health can be managed through careful monitoring of changes in... View Details
      Keywords: Applications and Software; Business Startups; Organizational Culture; Management Style; Technology Industry; United States
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      Fuller, Joseph B., and George Gonzalez. "Levels: The Remote, Asynchronous, Deep Work Management System." Harvard Business School Case 323-069, April 2023. (Revised September 2023.)
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