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Article

Lessons From Hollywood: A New Approach To Funding R&D

By: Gary P. Pisano and Andrew W. Lo

Companies find it increasingly difficult to justify long-term, risky R&D investments—particularly in science-based fields such as biotechnology, advanced materials, and energy. We argue in this article that the traditional venture model has limits for such investments... View Details

Keywords: Financial Innovation; Financial Strategy; Project Management; R＆D; Start-up; Innovation Strategy; Business Model; Research and Development; Financial Management; Risk Management; Strategy

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September 2022
Article

Find and Replace: R&D Investment Following the Erosion of Existing Products

By: Joshua L. Krieger, Xuelin Li and Richard T. Thakor

How do innovative firms react when existing products experience negative shocks? We explore this question with detailed project-level data from drug development firms. Using FDA Public Health Advisories as idiosyncratic negative shocks to approved drugs, we first... View Details

Keywords: R＆D Investments; Drug Development; Product Shocks; M＆A; Biopharmaceutical Industry; FDA; System Shocks; Research and Development; Investment; Decision Making; Pharmaceutical Industry

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January 2021
Case

Takeda Pharmaceutical Company Limited (A)

By: David J. Collis, Nobuo Sato and Akiko Kanno

This case follows Christophe Weber, President and CEO of Takeda Pharmaceutical Company Limited, a leading pharmaceutical company headquartered in Tokyo, Japan, as Takeda considers acquiring Shire Plc, a biotech company based in Ireland. The acquisition would turn... View Details

Keywords: Pharmaceutical Companies; Pharmaceuticals; Biotech; Biotechnology; M＆A; Mergers ＆ Acquisitions; R＆D; Talent Management; Mergers and Acquisitions; Globalization; Management; Global Strategy; Talent and Talent Management; Pharmaceutical Industry; Biotechnology Industry; Japan; Asia

2017
Working Paper

Innovation, Reallocation and Growth

By: Daron Acemoglu, Ufuk Akcigit, Harun Alp, Nicholas Bloom and William R. Kerr

We build a model of firm-level innovation, productivity growth, and reallocation featuring endogenous entry and exit. A new and central economic force is the selection between high- and low-type firms, which differ in terms of their innovative capacity. We estimate the... View Details

Keywords: Entry; Growth; Industrial Policy; Innovation; R＆D; Reallocation; Selection; Business Ventures; Resource Allocation; Performance Productivity; Policy; Research and Development; Innovation and Invention; Growth and Development; United States

October 2015
Article

Managing the Performance Tradeoffs from Partner Integration: Implications of Contract Choice in R&D Projects

By: Alan MacCormack and Anant Mishra

Formal contracts represent an important governance instrument with which firms exercise control of and compensate partners in R&D projects. The specific type of contract used, however, can vary significantly across projects. In some, firms govern partnering... View Details

Keywords: ＂＂Partner Integration; Contract Choice; R＆D Project Management; Relational Contracts; Partnering Performance; Research and Development; Projects; Partners and Partnerships; Performance; Contracts

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November 2012
Teaching Plan

The Langer Lab: Commercializing Science (TP)

By: Vicki L. Sato and Annelena Lobb

The Langer Lab at the Massachusetts Institute of Technology (MIT) was a unique operation. Its head, Robert Langer, had always focused on selecting ideas to research that would have the greatest positive impact for humanity, and he encouraged an unusual... View Details

Keywords: Computers; Industry Evolution; Entrepreneurship; Intellectual Capital; R＆D; Technology Transfer; Patents; Research and Development; Massachusetts

Summer 2018
Article

Scale versus Scope in the Diffusion of New Technology: Evidence from the Farm Tractor

By: Daniel P. Gross

Although tractors are now used in nearly every agricultural field operation and in the production of nearly all crops, they first developed with much more limited application. Early diffusion was accordingly rapid in these narrower applications but limited in scope... View Details

Keywords: Technology Diffusion; Spatial Technology Diffusion; Farm Tractors; R＆D; General-purpose Technologies; Technology Adoption; Agribusiness; Transportation; Research and Development; Agriculture and Agribusiness Industry; United States

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January 2021
Supplement

Takeda Pharmaceutical Company Limited (B)

By: David J. Collis, Nobuo Sato and Akiko Kanno

This case is a follow up to HBS Case No. 721-373, Takeda Pharmaceutical Company Limited (A). Following the events of the previous case, Takeda reached an agreement to acquire Ireland-based Shire Plc. The case follows some of the achievements and challenges Takeda and... View Details

Keywords: Pharmaceutical Companies; Pharmaceuticals; M＆A; Mergers ＆ Acquisitions; Biotech; Biotechnology; R＆D; Talent Management; Mergers and Acquisitions; Globalization; Global Strategy; Talent and Talent Management; Strategy; Biotechnology Industry; Pharmaceutical Industry; Japan; Asia

February 2022
Article

Taxation and Innovation in the 20th Century

By: Ufuk Akcigit, John Grigsby, Tom Nicholas and Stefanie Stantcheva

This paper studies the effect of corporate and personal taxes on innovation in the United States over the twentieth century. We build a panel of the universe of inventors who patent since 1920, and a historical state-level corporate tax database with corporate tax... View Details

Keywords: Innovation; Income Taxes; Corporate Taxation; Firms; Inventors; State Taxation; Business Taxation; R＆D Tax Credits; Taxation; Innovation and Invention; History; United States

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January 2015
Article

Collaboration in Multi-Partner R&D Projects: The Impact of Partnering Scale and Scope

By: Anant Mishra, Aravind Chandrasekaran and Alan MacCormack

How can firms design collaboration structures for effective performance in R&D projects that involve multiple partners? To address this question, we examine the theoretical underpinnings of collaboration structures in multi-partner R&D projects—i.e., the scale and the... View Details

Keywords: Multi-Partner R＆D Projects; Empirical Research; New Development; Collaboration Structures; Partnering Scale And Scope; Partners and Partnerships; Infrastructure; Performance Capacity; Research and Development; Collaborative Innovation and Invention

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April 2012
Case

Bella Healthcare India

By: Dorothy Leonard and Sunru Yong

Bella Healthcare India was originally established in Bangalore as a low-cost manufacturing facility for a U.S.-based cardiology equipment developer. Under country manager Joseph Cherian it evolved considerably, developing its own research and development capabilities.... View Details

November 2012
Case

CSIRO: The Light Metals Flagship Decision

By: Willy Shih, Margaret P. Pierson and Dawn Lau

This case explores the challenge of investing in basic research as a public good. CSIRO was Australia's leading science and research agency, and it was chartered to enhance national prosperity through R&D. Its Flagships program was designed to align research interests... View Details

2020
Working Paper

Short-Termism, Shareholder Payouts, and Investment in the EU

By: Jesse M. Fried and Charles C.Y. Wang

Investor-driven “short-termism” is said to harm EU public firms' ability to invest for the long term, prompting calls for the EU to better insulate managers from shareholder pressure. But the evidence offered—in the form of rising levels of repurchases and dividends—is... View Details

Keywords: Short-termism; Quarterly Capitalism; EU; Dividends; Equity Issuances; Equity Compensastion; Capital Flows; Capital Distribution; R＆D; Innovation; Investment; Corporate Governance; Investment Return; Acquisition; European Union

2020
Working Paper

Inventing the Endless Frontier: The Effects of the World War II Research Effort on Post-War Innovation

By: Daniel P. Gross and Bhaven N. Sampat

During World War II, the U.S. government launched an unprecedented effort to mobilize science for war: a newly-established Office of Scientific Research and Development (OSRD) entered thousands of R&D contracts with industrial and academic contractors, spending one to... View Details

Keywords: World War II; Vannevar Bush; OSRD; Mission-oriented R＆D; Direction Of Innovation; Geography Of Innovation; Technology Clusters; U.S. Innovation System; Innovation and Invention; Research and Development; Problems and Challenges; War; History; Government Administration; United States

Article

Trends and Predictors of Biomedical Research Quality, 1990–2015: A Meta-Research Study

By: Maryaline Catillon

Keywords: Biomedical Research; R＆D; Innovation; Technology; Drug Trials; RCT; Health; Healthcare; Health Care And Treatment; Health Care Policy; Innovation and Invention; Innovation Strategy; Research and Development; Technological Innovation; Health Industry; Pharmaceutical Industry

June 2012
Case

Microsoft IT India

By: Willy C. Shih, Margaret Pierson, Alexander Down, William Gustave Jair-Shemuel Jurist, Diego Medicina and Helen Wang

Raj Biyani faced tough challenges managing Microsoft IT India: leading a remote development organization in which key decisions were made in Redmond, and managing an organization that was perceived as less strategic than its sister Microsoft India Development Center... View Details

Keywords: Organizational Development; Cross-functional Management; Foreign Subsidiaries; Strategy Alignment; Organizational Behavior; Indian Software Development; Global Distributed R＆D; Software Industry; Organizational Structure; Research and Development; Operations; Leadership; Globalized Firms and Management; Business Subsidiaries; Information Technology; Applications and Software; Technology Industry; India

Summer 2021
Article

The World Management Survey at 18: lessons and the way forward

By: Daniela Scur, Raffaella Sadun, John Van Reenen, Renata Lemos and Nicholas Bloom

Understanding how differences in management ‘best practices’ affect organizational outcomes has been a focus of both theoretical and empirical work in the fields of management, sociology, economics, and public policy. The World Management Survey (WMS) project was born... View Details

Keywords: Firm Objectives, Organization, And Behavior; Business Economics; Choice Of Technology; Management Of Technological Innovation And R＆D; Technological Change: Choices And Consequences; Management Practices and Processes

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November 2012
Article

The Organization of Firms Across Countries

By: Nicholas Bloom, Raffaella Sadun and John Van Reenen

We argue that social capital as proxied by trust increases aggregate productivity by affecting the organization of firms. To do this we collect new data on the decentralization of investment, hiring, production, and sales decisions from Corporate Headquarters to local... View Details

Keywords: Decentralization; Social Capital; Theory Of The Firm; Firm Objectives, Organization, And Behavior; Business Economics; Management Of Technological Innovation And R＆D; Technological Change: Choices And Consequences; Diffusion Processes; Organizational Structure; Performance Productivity; Trust; Technology Adoption; Multinational Firms and Management

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2022
Working Paper

Multinationals and Varieties of Capitalism: When U.S. Giants Stepped into the Swiss Coordinated Labor Market in the 1950s

By: Sabine Pitteloud

This working paper investigates unintended consequences of U.S. FDI in Switzerland in the 1950s-1960s: the increased competition that U.S. firms generated within the national labor market and the challenge their hiring practices constituted for the institutional... View Details

Keywords: Multinationals; Capitalism; Business ＆ Government Relations; Foreign Direct Investment; Immigration Policy; History; Switzerland; Americanization; R＆D; Labor History; Labor Market Institutions; Tax Havens; ＂USA,＂; Business Interest Association; Lobbying; Labor and Management Relations; Business History; Multinational Firms and Management

December 2016 (Revised December 2018)
Case

From Start-Up to Grown-Up Nation: The Future of the Israeli Innovation Ecosystem

By: Elie Ofek and Margot Eiran

In June 2016, Benjamin (Bibi) Netanyahu, Prime Minister of Israel, wrestled with how to sustain Israel’s strong innovation track record and the country’s reputation as the “startup nation.” Despite the economic miracle the country had wrought since its founding, he... View Details

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