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  • August 2020
  • Article

A History of Prescription Drug Monitoring Programs in the United States: Political Appeal and Public Health Efficacy

By: A Jay Holmgren, Alyssa Botelho and Allan M Brandt
Prescription drug monitoring programs (PDMPs) have become a widely embraced policy to address the US opioid crisis. Despite mixed scientific evidence on their effectiveness at improving health and reducing overdose deaths, 49 states and Washington, DC have adopted... View Details
Keywords: Health Disorders; Information Technology; Programs; Technology Adoption; History; Government and Politics; Policy; United States
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  • November 2021 (Revised May 2022)
  • Case

West Virginia: Finding the Right Path Forward

By: Matthew C. Weinzierl, Christine Keung and Reggie Smith
Once at the center of the American economy, the state of West Virginia had seen decades of decline as its coal industry fell on hard times. With beautiful but challenging topography, a proud but shrinking population, and a new scourge of the opioid epidemic, the... View Details
Keywords: Population Health; Geographic Location; Economic Slowdown and Stagnation; Problems and Challenges; Social Issues; West Virginia
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  • November 2021
  • Article

Gaussian Process Subset Scanning for Anomalous Pattern Detection in Non-iid Data

By: William Herlands, Edward McFowland III, Andrew Gordon Wilson and Daniel B. Neill
Identifying anomalous patterns in real-world data is essential for understanding where, when, and how systems deviate from their expected dynamics. Yet methods that separately consider the anomalousness of each individual data point have low detection power for subtle,... View Details
Keywords: Pattern Detection; Subset Scanning; Gaussian Processes; Mathematical Methods
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  • January 19, 2024
  • Article

Value-Based Health Care Can Transform the Treatment of Patients with Substance Use Disorder

By: Robert S. Kaplan and Sarah E. Wakeman
U.S. overdose deaths currently exceed 100,000 per year. New facilities, known as bridge clinics, are broadening access to high-quality care by offering outpatient substance use disorder (SUD) treatment with few access barriers. But many of the critical services offered... View Details
Keywords: Health Care and Treatment; Cost; Adoption
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  • 2022
  • Book

Complicit: How We Enable the Unethical and How to Stop

By: Max H. Bazerman
It is easy to condemn obvious wrongdoers such as Elizabeth Holmes, Adam Neumann, Harvey Weinstein, and the Sackler family. But we rarely think about the many people who supported their unethical or criminal behavior. In each case there was a supporting cast of... View Details
Keywords: Complicity; Enabling; Ethics; Behavior; Personal Characteristics; Society
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    Hacking Heroin

    “Hacking Heroin” was the first hackathon that Annie Rittgers, founder of Cincinnati-based consultancy firm 17a, had organized or even attended. “There will continue to be a lot of preventable overdose deaths and wasted potential if the opioid crisis continues... View Details
    • Web

    Capstone | MBA

    medicine, microbiomes, opioid use disorder, organoid systems for drug development, oncology, psychedelics, women’s health, and many more. Recent Capstone Projects iPSC-Derived NK Cells – Changing Cancer’s Fate Richard Nixon declared a war... View Details

      Complicit: How We Enable the Unethical and How to Stop

      It is easy to condemn obvious wrongdoers such as Elizabeth Holmes, Adam Neumann, Harvey Weinstein, and the Sackler family. But we rarely think about the many people who supported their unethical or criminal behavior. In each case there was a supporting cast of... View Details
      • Web

      Faculty & Advisors | MBA

      directors of the Biomedical Science Careers Program, an organization dedicated to supporting underrepresented students to pursue a career in STEM, and RIZE Massachusetts, a nonprofit foundation focused on ending the opioid epidemic. She... View Details
      • 30 Apr 2024
      • Book

      When Managers Set Unrealistic Expectations, Employees Cut Ethical Corners

      at Wells Fargo (2016), bribery at Odebrecht (2016), sexual harassment at Uber (2017), misuse of personal data at Facebook (2018), airliner safety at Boeing (2019), fraudulent financial reporting at Wirecard (2020), opioid marketing at... View Details
      Keywords: by Dina Gerdeman
      • 15 Nov 2022
      • Book

      Stop Ignoring Bad Behavior: 6 Tips for Better Ethics at Work

      In 1995, Purdue Pharma began selling a powerful and addictive opioid drug called OxyContin. The company was aware that the drug, which was marketed to doctors as a safe way to manage chronic pain, was a potent narcotic that could quickly... View Details
      Keywords: by Pamela Reynolds
      • 16 Nov 2021
      • HBS Case

      How a Company Made Employees So Miserable, They Killed Themselves

      purpose, and in turn put workers at a greater risk for depression, opioid addiction, and even suicide, Whillans says. “It’s important for managers to realize the psychological threat that workers are facing as they come up against ageism... View Details
      Keywords: by Michael Blanding
      • 20 Apr 2021
      • Book

      A Simple Question That Can Guide Companies to Epic Success

      Imagine a full airplane, most passengers will have paid a different price (and fees!). That’s great for the airline, but it is all just value capture, there is zero value created through the price discrimination. McKinsey’s work in the View Details
      Keywords: by Danielle Kost
      • 01 Jun 2018
      • News

      The Long Run

      trajectory of overdose deaths from prescription drugs and heroin. According to the Centers for Disease Control and Prevention, the US death rate from opioid overdose has increased over 400 percent since 1999; the picture is even grimmer... View Details
      Keywords: Julia Hanna; photographed by Melissa Golden
      • 20 Jan 2017
      • News

      Beating Pain with Brain Power

      teaching medical professionals how to help patients avoid opioid addiction by using hypnotic strategies to reduce the need for pain medications. “My work with Comfort Talk, which is the name of my company, in using hypnotic techniques for... View Details
      • 13 Mar 2025
      • Blog Post

      Advancing Health Care Innovation and Impact with Anita Gupta (GMP 29, 2020)

      lasting impact in health care. As a physician anesthesiologist and pharmacist, I had spent years advocating for access to care, navigating complex health care systems, and working on policies to address the opioid crisis. But I knew that... View Details
      • 02 Aug 2018
      • News

      Can Marketing Help Halt the Heroin Epidemic?

      destroying individuals and families. In recent years, as the opioid crisis swept the country, the organization shifted to a broader focus, re-branded as the Georgia Prevention Project. Now Langford wants to stem the spread of View Details
      • 01 Dec 2017
      • News

      Pencils Up: Taking Note of New Courses

      and overall outcomes. Projects will include improving New York’s system to match middle school students to their preferred school and prompting doctors to respond more effectively to the opioid crisis, among others. View Details
      Keywords: Julia Hanna
      • 01 Dec 2022
      • News

      Road to Recovery

      in 2016, with Gastfriend as CEO and his father as chief medical officer. A 2014 study estimated that 12.5 million Americans had substance use disorders, and that number was rising, largely due to opioid use. In addition to the human toll,... View Details
      Keywords: April White; Ambulatory Health Care Services; Health, Social Assistance
      • 01 Jun 2017
      • News

      Turning Point: Addiction’s Impact

      needed for the most important problems of our time.” The opioid epidemic is devastating our country and undermining our economic competitiveness, from the streets to the C-suites. It is a scourge whose complexities span the geopolitical... View Details
      Keywords: Melissa Weiksnar (MBA 1982)