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    • News  (163)
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  • All HBS Web  (940)
    • News  (163)
    • Research  (701)
    • Multimedia  (3)
  • Faculty Publications  (265)
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  • February 2021
  • Case

Digital Manufacturing at Amgen

By: Shane Greenstein, Kyle R. Myers and Sarah Mehta
This case discusses efforts made by biotechnology (biotech) company Amgen to introduce digital technologies into its manufacturing processes. Doing so is complicated by the fact that the process for manufacturing biologics—or therapeutics made from living cells—is... View Details
Keywords: Digital Technologies; Change; Change Management; Decision Making; Cost vs Benefits; Decisions; Information; Analytics and Data Science; Innovation and Invention; Innovation and Management; Innovation Leadership; Innovation Strategy; Technological Innovation; Jobs and Positions; Knowledge; Leadership; Organizational Culture; Science; Strategy; Information Technology; Technology Adoption; Biotechnology Industry; Pharmaceutical Industry; United States; California; Puerto Rico; Rhode Island
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Greenstein, Shane, Kyle R. Myers, and Sarah Mehta. "Digital Manufacturing at Amgen." Harvard Business School Case 621-008, February 2021.
  • 17 Oct 2012
  • Research & Ideas

America Needs a Manufacturing Renaissance

have even decided to buy their R&D from suppliers in Asia as well. (For instance, most laptop computers are designed and manufactured by a small handful of Taiwanese companies.) In the short term, such outsourcing could dramatically... View Details
Keywords: by Gary P. Pisano & Willy C. Shih; Manufacturing
  • March 1994 (Revised November 1994)
  • Case

Komatsu Ltd. (A): Target Costing System

Komatsu, a leading manufacturer of construction equipment, seeks to expand aggressively through the 1990s. Key to its competitiveness is a strict adherence to target costs throughout the product development process. Komatsu conducts several design-for-manufacturability... View Details
Keywords: Cost; Machinery and Machining; Expansion; Product Development; Manufacturing Industry
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Cooper, Robin. "Komatsu Ltd. (A): Target Costing System." Harvard Business School Case 194-037, March 1994. (Revised November 1994.)
  • September 2022
  • Article

Giving a Buck or Making a Buck? Donations by Pharmaceutical Manufacturers to Independent Patient Assistance Charities

By: Leemore Dafny, Christopher Ody and Teresa Rokos
The federal Anti-Kickback Statute prohibits biopharmaceutical manufacturers from directly covering Medicare enrollees’ out-of-pocket spending for the drugs they manufacture, but manufacturers may donate to independent patient assistance charities and earmark donations... View Details
Keywords: Cost Sharing; Prescription Drugs; Drug Spending; Medicare; Dual Eligibility; Cost; Health Care and Treatment; Philanthropy and Charitable Giving; Pharmaceutical Industry
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Dafny, Leemore, Christopher Ody, and Teresa Rokos. "Giving a Buck or Making a Buck? Donations by Pharmaceutical Manufacturers to Independent Patient Assistance Charities." Health Affairs 41, no. 9 (September 2022).
  • October 1993 (Revised November 1994)
  • Case

Michigan Manufacturing Corp.: The Pontiac Plant--1988

By: Clayton M. Christensen
Michigan Manufacturing is a broad-line maker of components for the automotive industry. It has developed a network of nine plants as its product line has grown. Newer, higher-volume products tend to be made in newer, focused, high-volume plants, while older product... View Details
Keywords: Cost Accounting; Factories, Labs, and Plants; Profit; Brands and Branding; Mission and Purpose; Networks; Manufacturing Industry; Manufacturing Industry
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Christensen, Clayton M. "Michigan Manufacturing Corp.: The Pontiac Plant--1988." Harvard Business School Case 694-051, October 1993. (Revised November 1994.)
  • January 2009 (Revised October 2012)
  • Case

Semiconductor Manufacturing International Corporation: 'Reverse BOT'

By: Willy Shih
Semiconductor Manufacturing International Corporation (SMIC) is executing a strategy that leverages the desires of municipalities in China to build clusters of high technology companies. By partnering with those cities to build new semiconductor fabs that SMIC would... View Details
Keywords: Growth and Development Strategy; Industry Clusters; Infrastructure; State Ownership; Business and Community Relations; Semiconductor Industry; China
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Shih, Willy. "Semiconductor Manufacturing International Corporation: 'Reverse BOT'." Harvard Business School Case 609-062, January 2009. (Revised October 2012.)
  • December 1991 (Revised October 1998)
  • Case

Eli Lilly and Co.: Manufacturing Process Technology Strategy--1991

By: Gary P. Pisano, Steven C. Wheelwright and Jonathan West
Outlines the evolution of Lilly's corporate manufacturing strategy over the past decade. The corporate vice president of manufacturing must decide on the next phase of Lilly's strategy for the early 1990s, as well as to what extent and what role process development... View Details
Keywords: Cost vs Benefits; Management Practices and Processes; Industry Structures; Product Development; Production; Research and Development; Competitive Advantage; Corporate Strategy; Manufacturing Industry
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Pisano, Gary P., Steven C. Wheelwright, and Jonathan West. "Eli Lilly and Co.: Manufacturing Process Technology Strategy--1991." Harvard Business School Case 692-056, December 1991. (Revised October 1998.)
  • May 2024
  • Article

True Costs of Uterine Artery Embolization: Time-Driven Activity-Based Costing in Interventional Radiology Over a 3-Year Period

By: Julia C. Bulman, Nicole H. Kim, Robert S. Kaplan, Sarah Schroeppel DeBacker, Olga R. Brook and Ammar Sarwar
The study used time-driven activity-based costing (TDABC) to estimate the costs to perform uterine artery embolization (UAE). Utilization times for patients undergoing outpatient UAE for fibroids or adenomyosis were captured from electronic health record timestamps and... View Details
Keywords: Cost Accounting; Health Care and Treatment; Health Industry
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Bulman, Julia C., Nicole H. Kim, Robert S. Kaplan, Sarah Schroeppel DeBacker, Olga R. Brook, and Ammar Sarwar. "True Costs of Uterine Artery Embolization: Time-Driven Activity-Based Costing in Interventional Radiology Over a 3-Year Period." Journal of the American College of Radiology 21, no. 5 (May 2024): 721–728.
  • 20 Jul 2015
  • Research & Ideas

Globalization Hasn’t Killed the Manufacturing Cluster

economy, and factor cost differentials, like labor costs, became more important, Pisano says. That's why there was a huge outflow of unskilled apparel manufacturing from the United States. "There's nothing... View Details
Keywords: by Roberta Holland; Manufacturing; Manufacturing; Manufacturing
  • November 1994
  • Case

Hewlett-Packard: French Manufacturing Operations

By: Robin Cooper, Patricia Bost and Robert S. Kaplan
Keywords: Activity Based Costing and Management; Cost Accounting; France
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Cooper, Robin, Patricia Bost, and Robert S. Kaplan. "Hewlett-Packard: French Manufacturing Operations." Harvard Business School Case 195-120, November 1994.
  • May 1993
  • Case

Kaufmann Manufacturing Company (A)

By: Julie H. Hertenstein and William J. Bruns Jr.
A management team at Kaufmann is studying the latest year's operations and sales, which seem to have led to very confusing financial results. Sales exceeded forecast and production for the first six months, however Kaufmann reported a loss. Yet, when sales were below... View Details
Keywords: Budgets and Budgeting; Earnings Management; Cost Accounting; Financial Reporting; Cost vs Benefits; Capital Budgeting; Cost Management; Profit; Outcome or Result
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Hertenstein, Julie H., and William J. Bruns Jr. "Kaufmann Manufacturing Company (A)." Harvard Business School Case 193-159, May 1993.
  • 2025
  • Working Paper

Markups and Cost Pass-through Along the Supply Chain

By: Santiago Alvarez-Blaser, Alberto Cavallo, Alexander MacKay and Paolo Mengano
We study markups and pricing strategies along the supply chain. Our unique dataset combines detailed price and cost information from a large global manufacturer with matched retail prices collected online for the period July 2018 through June 2023. We show that total... View Details
Keywords: Markups; Pricing; Price; Supply Chain; Inflation and Deflation; Cost
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Alvarez-Blaser, Santiago, Alberto Cavallo, Alexander MacKay, and Paolo Mengano. "Markups and Cost Pass-through Along the Supply Chain." Harvard Business School Working Paper, No. 25-009, August 2024. (Revised February 2025.)
  • May 1987 (Revised October 1996)
  • Case

Murray Ohio Manufacturing Co.

By: Krishna G. Palepu
After a record year in 1983, Murray Ohio's earnings declined in 1984. The company was faced with competition from cheap imports and was experiencing declining margins. Students are asked to analyze the company's 1984 financial statements and predict whether there is... View Details
Keywords: Financial Statements; Financial Reporting; Business Divisions; Cost Management; Spending; Decision Making; Change Management; Problems and Challenges; Management Systems; Manufacturing Industry
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Palepu, Krishna G. "Murray Ohio Manufacturing Co." Harvard Business School Case 187-178, May 1987. (Revised October 1996.)
  • 2012
  • Working Paper

Is India's Manufacturing Sector Moving Away from Cities?

By: Ejaz Ghani, Arti Grover Goswami and William R. Kerr
This paper investigates the urbanization of the Indian manufacturing sector by combining enterprise data from formal and informal sectors. We find that plants in the formal sector are moving away from urban and into rural locations, while the informal sector is moving... View Details
Keywords: Urban Development; Policy; Factories, Labs, and Plants; Geographic Location; Education; Infrastructure; Manufacturing Industry; India
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Ghani, Ejaz, Arti Grover Goswami, and William R. Kerr. "Is India's Manufacturing Sector Moving Away from Cities?" Harvard Business School Working Paper, No. 12-090, April 2012.
  • September 2002
  • Case

Align Technology, Inc.: Matching Manufacturing Capacity to Sales Demand

By: H. Kent Bowen and Jonathan P Groberg
Align Technology is a four-year-old medical products company that has invented a new product requiring new manufacturing processes. Demand for the new product has grown more slowly than initial forecasts predicted, and the cost structure is preventing the company from... View Details
Keywords: Health Care and Treatment; Collaborative Innovation and Invention; Problems and Challenges; Product; Forecasting and Prediction; Marketing Strategy; Sales; Demand and Consumers; Production; Health Industry
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Bowen, H. Kent, and Jonathan P Groberg. "Align Technology, Inc.: Matching Manufacturing Capacity to Sales Demand." Harvard Business School Case 603-058, September 2002.
  • December 1994
  • Case

Hewlett-Packard: Boeblingen Manufacturing Operation (BMO)

By: Patricia Bost, Robin Cooper and Robert S. Kaplan
Keywords: Cost Accounting
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Bost, Patricia, Robin Cooper, and Robert S. Kaplan. "Hewlett-Packard: Boeblingen Manufacturing Operation (BMO)." Harvard Business School Case 195-183, December 1994.
  • August 1994 (Revised May 2001)
  • Case

ITT Automotive: Global Manufacturing Strategy (1994)

By: Gary P. Pisano and Sharon L. Rossi
ITT Automotive is in the process of developing a new-generation antilock brake system (ABS), designated the MK-20. The case focuses on the level of automation to be used in the production of this new system, and whether all plants should use the same process... View Details
Keywords: Information Technology; Innovation Strategy; Production; Product Development; Globalized Firms and Management; Performance Productivity; Manufacturing Industry; Manufacturing Industry; Belgium; Germany; United States
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Pisano, Gary P., and Sharon L. Rossi. "ITT Automotive: Global Manufacturing Strategy (1994)." Harvard Business School Case 695-002, August 1994. (Revised May 2001.)
  • 19 Apr 2012
  • Working Paper Summaries

Is India’s Manufacturing Sector Moving Away from Cities?

Keywords: by Ejaz Ghani, Arti Grover Goswami & William R. Kerr; Manufacturing
  • May 1997
  • Case

Toyota Motor Corporation: Target Costing System

Explores Toyota's target costing system, considered to be the most advanced such system of any major Japanese manufacturer. Specifically, describes Toyota's process of setting rigorous cost-reduction goals and the steps taken to achieve them. View Details
Keywords: Cost Management; Manufacturing Industry; Manufacturing Industry; Japan
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Cooper, Robin, and Takao Tanaka. "Toyota Motor Corporation: Target Costing System." Harvard Business School Case 197-031, May 1997.
  • October 2003
  • Case

Taiwan Semiconductor Manufacturing Company: Building a Platform for Distributed Innovation

By: Marco Iansiti and Marcin Strojwas
Surging costs of building a state-of-the-art fabrication facility were pushing firms to outsource manufacturing while advanced technologies were requiring a tighter coupling between design and manufacturing. Explores the development of strategy in this environment.... View Details
Keywords: Strategy; Business Model; Networks; Product Design; Production; Decisions; Customer Relationship Management; Supply Chain Management
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Iansiti, Marco, and Marcin Strojwas. "Taiwan Semiconductor Manufacturing Company: Building a Platform for Distributed Innovation." Harvard Business School Case 604-044, October 2003.
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