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  • 28 Mar 2023
  • Research & Ideas

The FDA’s Speedy Drug Approvals Are Safe: A Win-Win for Patients and Pharma Innovation

“The findings of our study suggest that regulatory innovation can support more efficient drug development—in particular, in settings where we have unmet medical needs. ” In the first comprehensive analysis of its kind, Harvard Business... View Details
Keywords: by Kasandra Brabaw; Pharmaceutical
  • October 2007 (Revised July 2013)
  • Case

Vertex Pharmaceuticals and the Cystic Fibrosis Foundation: Venture Philanthropy Funding for Biotech

By: Robert F. Higgins, Sophie LaMontagne and Brent Kazan
In 2001, Vertex Pharmaceuticals Incorporated acquired the San Diego-based biotech company, Aurora Biosciences. The combination of Vertex's and Aurora's technologies would improve the flow of novel drug candidates into development. However, several questions related to... View Details
Keywords: Philanthropy; Philanthropy Funding; Innovation; Funding Model; Venture Capital; Partners and Partnerships; Financing and Loans; Investment Funds; Acquisition; Philanthropy and Charitable Giving; Biotechnology Industry; Pharmaceutical Industry; San Diego
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Higgins, Robert F., Sophie LaMontagne, and Brent Kazan. "Vertex Pharmaceuticals and the Cystic Fibrosis Foundation: Venture Philanthropy Funding for Biotech." Harvard Business School Case 808-005, October 2007. (Revised July 2013.)
  • Research Summary

Overview

By: Peter Tufano
Tufano’s research has focused on financial innovation and financial engineering—and for more than two decades, household finance. While he continues to study these topics, his current primary research is on the role of business in addressing climate change. With... View Details
Keywords: Financial Innovation; Financial Engineering; Household Finance; Leadership Transitions
  • March 2015 (Revised June 2015)
  • Case

Medalogix

By: Richard G. Hamermesh and Matthew G. Preble
This case examines an exciting new approach to health care that will help care providers identify when hospice services are the appropriate type of care for patients. The company, Medalogix, already has a product on the market that uses a proprietary algorithm to... View Details
Keywords: Health Care; Health Care Entrepreneurship; Health Care Services; Implementing Strategy; Dissemination; Innovation; Market Selection; Health; Health Care and Treatment; Analytics and Data Science; Marketing Strategy; Innovation and Management; Innovation Strategy; Health Industry; United States
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Hamermesh, Richard G., and Matthew G. Preble. "Medalogix." Harvard Business School Case 815-116, March 2015. (Revised June 2015.)
  • Fall 2024
  • Article

The Three Traps That Stymie Reinvention: Organizational Identity, Architecture, and Collaboration Can Be Either Assets or Liabilities to Pursuing Growth in New Sectors

By: Ryan Raffaelli
In more than a decade of researching innovation, I have observed how organizations respond to new opportunities, technological changes, or unexpected market shifts that threaten to upend their current business model. This process, which I call reinvention, may occur... View Details
Keywords: Innovation And Strategy; Change Leadership; Collaboration; Architecture; Transformation; Disruption; Leading Change; Innovation Strategy; Identity; Organizational Culture; Organizational Structure
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Raffaelli, Ryan. "The Three Traps That Stymie Reinvention: Organizational Identity, Architecture, and Collaboration Can Be Either Assets or Liabilities to Pursuing Growth in New Sectors." MIT Sloan Management Review 66, no. 1 (Fall 2024): 46–52. (Cover story.)
  • 2019
  • Working Paper

The Consequences of Invention Secrecy: Evidence from the USPTO Patent Secrecy Program in World War II

By: Daniel P. Gross
This paper studies the effects of the USPTO's patent secrecy program in World War II, under which over 11,000 U.S. patent applications were issued secrecy orders that halted examination and prohibited inventors from disclosing their inventions or filing in foreign... View Details
Keywords: Invention Secrecy; Invention Disclosure; Trade Secrecy; Secrecy Orders; Cummulative Innovation; Wold War 2; Patents; National Security; History; Innovation and Invention; Outcome or Result; Intellectual Property; Policy; Commercialization; United States
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Gross, Daniel P. "The Consequences of Invention Secrecy: Evidence from the USPTO Patent Secrecy Program in World War II." Harvard Business School Working Paper, No. 19-090, May 2019. (Revised May 2019. NBER Working Paper Series, No. 25545, May 2019)
  • May 2006
  • Case

Esterline Technologies: Lean Manufacturing

By: Richard L. Nolan, Karen A. Brown and Subodha Kumar
Raises the issue of the appropriate role of IT in lean manufacturing. Most large manufacturing companies have implemented ERP IT systems to support lean manufacturing practices. The Kerry plant of Esterline Technologies attempted an ERP implementation and then... View Details
Keywords: Decisions; Technological Innovation; Management Analysis, Tools, and Techniques; Management Systems; Production; Information Technology; Technology Adoption; Manufacturing Industry
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Nolan, Richard L., Karen A. Brown, and Subodha Kumar. "Esterline Technologies: Lean Manufacturing." Harvard Business School Case 906-417, May 2006.
  • Teaching Interest

Overview

By: Regina E. Herzlinger
Course Requirements

Students are required to prepare a business plan, which employs the framework of this course, to explore an entrepreneurial opportunity in health care, and to evaluate their classmates' plans.

Career Focus

For... View Details
Keywords: Healthcare; Healthcare Industry; Healthcare Innovation; Healthcare Costs; Healthcare Operations; Healthcare Organizations; Healthcare Startups; Healthcare Technology; Healthcare Ventures
  • August 1997 (Revised September 1997)
  • Case

Imedia Corporation: The Pricing Decision

Efi Arazi, the president of a start-up called Imedia, must determine an appropriate pricing strategy for an innovation that will change the basis of competition in the cable TV industry. View Details
Keywords: Technology; Price; Entrepreneurship; Telecommunications Industry
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Kosnik, Thomas J., and Doron Kempel. "Imedia Corporation: The Pricing Decision." Harvard Business School Case 598-005, August 1997. (Revised September 1997.)
  • March 2008
  • Case

Cambrian House

By: Peter A. Coles, Karim R. Lakhani and Andrew P. McAfee
Cambrian House builds internet-based products and services by relying entirely on its user community for all aspects of its innovation and new product development process. Users suggest ideas for new products and services and also participate in a monthly voting... View Details
Keywords: Decision Choices and Conditions; Voting; Technological Innovation; Knowledge Management; Marketing Strategy; Open Source Distribution; Product Development; Strategic Planning; Business and Community Relations; Internet
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Coles, Peter A., Karim R. Lakhani, and Andrew P. McAfee. "Cambrian House." Harvard Business School Case 608-016, March 2008.
  • Article

How to Capture Value from Innovation: Shaping Intellectual Property and Industry Architecture

By: Gary P. Pisano and David J. Teece
Capturing value from innovation requires innovators to figure out how to blunt inroads into the profit stream by imitators, customers, suppliers, and other providers of complementary products and services. In making strategic decisions around technology... View Details
Keywords: Technological Innovation; Intellectual Property; Knowledge Management; Knowledge Sharing; Industry Structures; Standards; Commercialization; Value
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Pisano, Gary P., and David J. Teece. "How to Capture Value from Innovation: Shaping Intellectual Property and Industry Architecture." Special Issue on Leading Through Innovation (50th Anniversary Issue). California Management Review 50, no. 1 (Fall 2007): 278–296.
  • October 2017 (Revised August 2018)
  • Case

HTC and Virtual Reality

By: David B. Yoffie, Andy Wu and Allison M. Ciechanover
In fall 2017, HTC CEO and Chairperson Cher Wang was driving the company to focus on virtual reality (VR). HTC's first VR product, VIVE, released in spring 2016, was applauded for its superior immersive room-scale capabilities. However, early adoption of VR beyond... View Details
Keywords: Virtual Reality; Strategy; Competition; Information Technology; Innovation and Management; Consumer Behavior; Customer Relationship Management; Technology Industry
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Yoffie, David B., Andy Wu, and Allison M. Ciechanover. "HTC and Virtual Reality." Harvard Business School Case 718-421, October 2017. (Revised August 2018.)
  • April 2012
  • Article

Local R&D Strategies and Multi-location Firms: The Role of Internal Linkages

By: Juan Alcacer and Minyuan Zhao
This study looks at the role of firms' internal linkages in highly competitive technology clusters, where much of the world's R&D takes place. The leading players in these clusters are multilocation firms that organize and integrate knowledge across sites worldwide.... View Details
Keywords: Multinational Firms and Management; Technological Innovation; Knowledge Use and Leverage; Management Analysis, Tools, and Techniques; Research and Development; Risk and Uncertainty; Competition; Competitive Advantage; Technology
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Alcacer, Juan, and Minyuan Zhao. "Local R&D Strategies and Multi-location Firms: The Role of Internal Linkages." Management Science 58, no. 4 (April 2012): 734–753.
  • July 2010 (Revised September 2011)
  • Background Note

Hiring Professionals in China: A Practitioner's Guide

By: Heidi K. Gardner
This note outlines how leading professional service firms operating in China revise their standard hiring practices to fit local challenges and customs. Based on interviews with professionals in a number of established accounting, strategy consulting, and executive... View Details
Keywords: Talent and Talent Management; Globalized Firms and Management; Employees; Selection and Staffing; Service Industry; China
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Gardner, Heidi K. "Hiring Professionals in China: A Practitioner's Guide." Harvard Business School Background Note 411-029, July 2010. (Revised September 2011.)
  • 2010
  • Working Paper

Local R&D Strategies and Multi-location Firms: The Role of Internal Linkages

By: Juan Alcacer and Minyuan Zhao
This study looks at the role of firms' internal linkages in highly competitive technology clusters, where much of the world's R&D takes place. The leading players in these clusters are multi-location firms that organize and integrate knowledge across sites worldwide.... View Details
Keywords: Geographic Location; Collaborative Innovation and Invention; Technological Innovation; Knowledge Use and Leverage; Industry Clusters; Research and Development; Competitive Advantage; Semiconductor Industry
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Alcacer, Juan, and Minyuan Zhao. "Local R&D Strategies and Multi-location Firms: The Role of Internal Linkages." Harvard Business School Working Paper, No. 10-064, February 2010.
  • November 2008
  • Article

Chartering New Territory: Diversification, Legitimacy and Practice Area Creation in Professional Service Firms

By: Heidi Gardner, N. Anand and Timothy Morris
Diversification into innovative domains through new practice area creation is a critical imperative for professional services firms. Using theories of organizational territoriality and corporate charters, we conceptualize professional firms as federations of distinct... View Details
Keywords: Diversification; Lawfulness; Code Law; Management Practices and Processes; Service Operations; Innovation and Invention; Management Analysis, Tools, and Techniques
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Gardner, Heidi, N. Anand, and Timothy Morris. "Chartering New Territory: Diversification, Legitimacy and Practice Area Creation in Professional Service Firms." Special Issue on Professional Service Firms: Where Organization Theory and Organizational Behavior Might Meet, edited by Roy Suddaby, Royston Greenwood, and Celeste Wilderom Journal of Organizational Behavior 29, no. 8 (November 2008).
  • Article

A Blueprint for Pharmacy Benefits Managers to Increase Value

By: William Shrank, Michael E. Porter, Sachin H. Jain and Niteesh K. Choudhary
Pharmacy benefits managers (PBMs) have a unique opportunity to promote public health and generate value in the healthcare system. However, PBMs are largely evaluated on their ability to control costs rather than improve health. PBMs should be evaluated along three... View Details
Keywords: Opportunities; Health; System; Cost Management; Partners and Partnerships; Motivation and Incentives; Value; Innovation and Invention; Performance Effectiveness; Health Industry; Pharmaceutical Industry
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Shrank, William, Michael E. Porter, Sachin H. Jain, and Niteesh K. Choudhary. "A Blueprint for Pharmacy Benefits Managers to Increase Value." American Journal of Managed Care 15, no. 2 (February 2009).
  • 2007
  • Working Paper

Global Competitors as Next-Door Neighbors: Competition and Geographic Concentration in the Semiconductor Industry

By: Minyuan Zhao and Juan Alcacer
Despite the many advantages offered by technology clusters, firms located in them face the risk of losing valuable knowledge to nearby competitors. In this study, we argue that multi-location firms strategically organize their R&D activities to appropriate the value of... View Details
Keywords: Information Technology; Industry Clusters; Innovation and Invention; Geographic Location; Competitive Strategy; Globalization; Semiconductor Industry
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Zhao, Minyuan, and Juan Alcacer. "Global Competitors as Next-Door Neighbors: Competition and Geographic Concentration in the Semiconductor Industry." Michigan Ross School of Business Working Paper, No. 1091, March 2007. (Available at SSRN.)
  • January 2014
  • Case

In a Bind: Peak Sealing Technologies' Product Line Extension Dilemma

By: Robert J. Dolan and Heather Beckham
Peak Sealing Technologies (PST), a manufacturer of premium carton sealing tapes, stresses technological innovation as the company's core value. But when a new regional competitor introduces a less expensive and inferior product, PST is faced with a decision that could... View Details
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Dolan, Robert J., and Heather Beckham. "In a Bind: Peak Sealing Technologies' Product Line Extension Dilemma." Harvard Business School Brief Case 914-533, January 2014.
  • December 2004 (Revised June 2005)
  • Case

Chez Cora

By: David E. Bell, Hal Hogan and Carin-Isabel Knoop
Chez Cora is a chain of breakfast restaurants that successfully expanded from Quebec to Ontario. Is it organized appropriately for more growth? Could the concept work in the United States? If so, how should a migration to the United States be structured? Includes color... View Details
Keywords: Food; Global Strategy; Innovation Strategy; Growth Management; Service Operations; Food and Beverage Industry; Service Industry; Canada; United States
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Bell, David E., Hal Hogan, and Carin-Isabel Knoop. "Chez Cora." Harvard Business School Case 505-054, December 2004. (Revised June 2005.)
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