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  • January 2023
  • Case

Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery

By: Regina Herzlinger and Brian Walker
What should a successful executive (HBS Baker Scholar) assess as her next move as the CEO of a firm with a promising and yet uncertain new drug? Amy Burroughs’ mandate to successfully commercialize Cleave Therapeutics’ drug for a cancer with no current successful... View Details
Keywords: Product Development; Leadership; Health Testing and Trials; Research and Development; Risk and Uncertainty; Financial Condition; Partners and Partnerships; Pharmaceutical Industry
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  • 20 Sep 2011
  • First Look

First Look: September 20

for decades. Purchase this case:http://cb.hbsp.harvard.edu/cb/product/311130-PDF-ENG Intraoperative Radiotherapy for Breast Cancer Willy ShihHarvard Business School Case 612-003 "This trial is going to... View Details
Keywords: Sean Silverthorne
  • September 2020
  • Case

Minerva 2004: Discovery

By: John R. Wells and Benjamin Weinstock
After nearly five years in operation, Doctor Cynthia Bamdad, founder and CEO of Minerva Biotechnologies Corporation (Minerva), was reflecting on the company’s next steps. In a few short years, she and her small team had managed to develop a nanoparticle process for... View Details
Keywords: Entrepreneurship; Financing and Loans; Strategy; Decision Choices and Conditions; Biotechnology Industry
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  • May 2023 (Revised June 2023)
  • Supplement

Novartis (C): Reimagining Medicine

By: Ramon Casadesus-Masanell, Claudio Feser, Karolin Frankenberger and David Redaschi
This case unfolds around the first-ever approved personalized cancer treatment, how Novartis wrapped it into a new business model design, and how Novartis scaled it. Novartis — one of the largest pharmaceutical companies in the world — is, among other ventures,... View Details
Keywords: Health Testing and Trials; Health Care and Treatment; Business Model; Problems and Challenges; Pharmaceutical Industry; Switzerland
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  • 21 Aug 2017
  • Lessons from the Classroom

Companies Love Big Data But Lack the Strategy To Use It Effectively

industry? How will better data collection transform the ways in which we do clinical trials for new cancer drugs? It is both staggering and exciting to imagine how data and analytic capabilities will... View Details
Keywords: by Dina Gerdeman
  • 09 Feb 2010
  • First Look

First Look: Feb. 9

human patients. Doyle believes NovoCure has the potential to become an important company with a major new cancer therapy platform but must complete pivotal (Phase III) clinical trials and receive FDA... View Details
Keywords: Martha Lagace
  • 07 Aug 2000
  • Research & Ideas

The Business of Biotech

the anatomical—basis of the disease." Genzyme, which currently has drugs in clinical trials for melanoma and breast cancer, hopes to have its first products on the market as early as 2004. "I think we're going to see more people... View Details
Keywords: by Julia Hanna; Biotechnology; Health; Technology
  • 10 Oct 2017
  • First Look

First Look at New Research and Ideas, October 10, 2017

Foundation, was preparing to launch a new type of clinical trial—an adaptive platform trial—to study potential therapies for glioblastoma (GBM), an aggressive form of brain cancer. Alexander believed that the standard way in which new View Details
Keywords: Sean Silverthorne
  • 07 Oct 2014
  • First Look

First Look: October 7

the Multiple Myeloma Research Foundation What do you do when your rising professional career is cut short by an unexpected cancer diagnosis? Kathy Giusti shifted careers, built a new organization that transformed how View Details
Keywords: Sean Silverthorne
  • 14 Dec 2020
  • Research & Ideas

What Does December's Drug-Approval Dash Mean for COVID-19 Vaccines?

aspects of the drug trial and approval process, including allowing time for potential issues to materialize. When you see an FDA emergency approval for a COVID-19 vaccine, don't interpret this as a normal “FDA approval.” I understand that... View Details
Keywords: by Danielle Kost; Pharmaceutical; Health
  • 11 Dec 2012
  • First Look

First Look: Dec. 11

memoir, Decoded. Droga5 wrestles with two disparate challenges: developing a campaign for the book's launch and finding a way to drive trial for Bing, Microsoft's new search engine. Droga5's innovative solution is to kill two birds with... View Details
Keywords: Sean Silverthorne
  • 21 Feb 2017
  • First Look

First Look at New Research: February 21

Systematic Approach to Discussing Active Surveillance with Patients with Low-risk Prostate Cancer By: Ehdaie, Behfar, Melissa Assel, Nicole Benfante, Deepak Malhotra, and Andrew Vickers Abstract—A systematic approach to counseling—using... View Details
Keywords: Carmen Nobel
  • 18 Dec 2018
  • First Look

New Research and Ideas, December 18, 2018

firms face little competition, even after the end of formal periods of patent protection and market exclusivity. Additionally, the evolving technologies of drug development—in particular, the increasingly common use of auxiliary endpoints in clinical View Details
Keywords: Dina Gerdeman

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