Breakthrough Innovation - Publications - Faculty & Research

2022
Working Paper

Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation

By: Amitabh Chandra, Jennifer Kao, Kathleen Miller and Ariel D. Stern

Regulators of new products confront a tradeoff between speeding a new product to market and collecting additional product quality information. The FDA’s Breakthrough Therapy Designation (BTD) provides an opportunity to understand if a regulator can use new policy to... View Details

Keywords: Research and Development; Governing Rules, Regulations, and Reforms; Product Development

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2001
Chapter

Creating Breakthroughs at 3M

By: E. von Hippel, S. Thomke and M. Sonnack

Keywords: Innovation and Invention; Innovation and Management

Citation

24 Aug 2017
Video

Building Businesses around Breakthrough Science

25 Jan 2021
Working Paper Summaries

The Evolutionary Nature of Breakthrough Innovation: Re-Evaluating the Exploration vs. Exploitation Dichotomy

Keywords: by Dominika K. Sarnecka and Gary P. Pisano

03 Feb 2014
News

Eyes on Medical Breakthroughs

KRAUSS It's the lessons she's learned from life, not just as a businesswoman and a physician, that have allowed Dr. Marlene Krauss to see opportunities other venture investors missed. HBS taught Krauss (MBA 1967) how to lead and how to communicate—but also that, as a... View Details

Keywords: Ralph Ranalli; Management; Ambulatory Health Care Services; Health, Social Assistance

Forthcoming
Article

Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation

By: Amitabh Chandra, Jennifer Kao, Kathleen L. Miller and Ariel Dora Stern

Regulators of new products confront a tradeoff between speeding a product to market and collecting additional product quality information. The FDA's Breakthrough Therapy Designation (BTD) provides an opportunity to understand if regulators can use new policy to... View Details

Keywords: Innovation and Invention; Governing Rules, Regulations, and Reforms; Government Administration; Research and Development; Pharmaceutical Industry

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05 Jul 2006
Research & Ideas

The Accidental Innovator

innovation processes. If you think that most breakthrough inventions—blockbuster drugs, say—are arrived at through careful, scientific, deductive process, without accident being much involved, then you'd... View Details

Keywords: by Sarah Jane Gilbert

05 Dec 2013
Op-Ed

Encourage Breakthrough Health Care by Competing on Products Rather Than Patents

they should open target data and compete on solutions—compounds and molecules addressing the targets. I agree. If we're going to get the breakthrough products we want at a development cost we can afford, we have to figure out the best... View Details

Keywords: by Richard G. Hamermesh; Biotechnology; Health

May 2010
Column

Block-by-Blockbuster Innovation

By: Rosabeth Moss Kanter

Executives often find themselves debating the merits of incremental innovations versus game-changers, but that's a false dichotomy, says HBR columnist Rosabeth Moss Kanter. Even if a company is lucky enough to come up with the next Kindle, Swiffer, or smartphone,... View Details

Keywords: Innovation and Management; Resource Allocation; Product; Business Processes; Risk and Uncertainty

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01 Aug 2011
News

Innovators act the part

Research Summary

Reverse Innovation

VG and Chris Trimble reveal a bold discovery with far-reaching implications in REVERSE INNOVATION: Create Far From Home, Win Everywhere (Harvard Business Review Press; April 10, 2012;... View Details

Research Summary

Design Driven Innovation

By: Roberto Verganti

Firms, managers and scholars have often balanced between two approaches to innovation: user centered (where incremental innovation is pulled by the market) and technology push (where innovation comes from breakthrough development in technologies). However there is a... View Details

19 Aug 2019
Blog Post

Investing in Breakthrough Technologies to Lead the Energy Transition

contributing to this effort by facilitating multi-million-dollar transactions that brings new energy technologies to Shell. During my internship, I have had the opportunity to work on three M&A deals in the new energy space. These companies have developed View Details

Keywords: Manufacturing; Technology

24 Oct 2017
News

The Board’s New Innovation Imperative

20 Oct 2021
News

Drive Innovation with Better Decision-Making

23 Sep 2020
News

The Next Big Breakthrough in AI Will Be Around Language

Keywords: Artificial intelligence

January 2009 (Revised May 2009)
Case

Innovation at Mahindra & Mahindra (A)

By: Stefan H. Thomke and Briana Doerr Luthra

Describes the Mahindra & Mahindra Group's approach to innovation. The Group is among the top industrial houses in India and its managing director Anand Mahindra has put innovation at the core of its growth strategy. Emphasis is placed on managing the balance between... View Details

Keywords: Innovation and Management; Growth and Development Strategy; Problems and Challenges; Marketing; Business Processes; Product; Innovation Strategy; Organizational Design; Demand and Consumers; Auto Industry; Agriculture and Agribusiness Industry; India

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Disruptive Innovation

works and determine when to invest in core versus disruptive business models. As you gain insight into the ways that evolving industries, technologies, and competitive forces can affect your business, you will be better prepared to harness innovation, lead View Details

Article

Dismantling Knowledge Boundaries at NASA: The Critical Role of Professional Identity in Open Innovation

By: Hila Lifshitz - Assaf

Using a longitudinal in-depth field study at NASA, I investigate how the open, or peer-production, innovation model affects R&D professionals, their work, and the locus of innovation. R&D professionals are known for keeping their knowledge work within clearly defined... View Details