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  • September–October 2020
  • Article

The Past, Present, and (Near) Future of Gene Therapy and Gene Editing

By: Julia Pian, Amitabh Chandra and Ariel Dora Stern
Emerging gene therapy and gene-editing technologies will have a growing impact on patient lives and health-care delivery. We analyzed a decade of data on clinical trials and venture capital investments to understand the likely trajectory of genetically focused... View Details
Keywords: Gene Therapy; Gene Editing; Impact; Health Care and Treatment; Technological Innovation; Health Testing and Trials; Venture Capital; Change
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  • November 2016
  • Case

QuintilesIMS: Biosimilar Marketing in England

By: John A. Quelch and Emily C. Boudreau
QuintilesIMS was a leading healthcare consulting firm best known for its data and information offerings as well as its market research and management consulting services for life science companies. By 2015, the company was expanding beyond the biopharmaceutical... View Details
Keywords: Health; Pharmaceutical Industry; Biotech; Marketing; Health Care and Treatment; Biotechnology Industry; England
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  • 2013
  • Working Paper

Visualizing and Measuring Enterprise Architecture: An Exploratory BioPharma Case

By: Robert Lagerstrom, Carliss Baldwin, Alan MacCormack and David Dreyfus
We test a method that was designed and used previously to reveal the hidden internal architectural structure of software systems. The focus of this paper is to test if it can also uncover new facts about the components and their relationships in an enterprise... View Details
Keywords: Complexity; Applications and Software; Product Design; Pharmaceutical Industry
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  • 09 Apr 2014
  • Working Paper Summaries

Visualizing and Measuring Software Portfolio Architectures: A Flexibility Analysis

Keywords: by Robert Lagerstrom, Carliss Y. Baldwin, Alan MacCormack & David Dreyfus; Video Game; Web Services
  • September 2022
  • Article

Giving a Buck or Making a Buck? Donations by Pharmaceutical Manufacturers to Independent Patient Assistance Charities

By: Leemore Dafny, Christopher Ody and Teresa Rokos
The federal Anti-Kickback Statute prohibits biopharmaceutical manufacturers from directly covering Medicare enrollees’ out-of-pocket spending for the drugs they manufacture, but manufacturers may donate to independent patient assistance charities and earmark donations... View Details
Keywords: Cost Sharing; Prescription Drugs; Drug Spending; Medicare; Dual Eligibility; Cost; Health Care and Treatment; Philanthropy and Charitable Giving; Pharmaceutical Industry
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  • 27 Sep 2011
  • First Look

First Look: September 27

which the ACA was passed and develops estimates of its likely impact on the biopharmaceutical industry. Universal insurance, either through a government-run system or by mandated purchase of private insurance, has been controversial in... View Details
Keywords: Sean Silverthorne
  • October 2024
  • Case

Parexel: Scaling Up and Industry Dynamics

By: Regina E. Herzlinger and Ben Creo
Through the lens of biopharmaceutical contract research organization (CRO) PAREXEL, this case traces the evolution of the firm as it reinvents itself in response to the transformation of the CRO sector from a small, secondary cluster of firms into a major player with... View Details
Keywords: Research; Innovation and Invention; Business Model; Transformation; Globalization; Information Technology; Competitive Advantage; Pharmaceutical Industry
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  • August 2023
  • Case

Constellation Pharmaceuticals: Corporate Development at a Novel Therapeutic Company

By: Satish Tadikonda and Brad Prosek
Constellation Pharmaceuticals was a company focused on epigenetic therapies for cancer patients. Despite a promising start and an early deal with a leading biopharma company, the company weathered twin setbacks in the end of a major research collaboration and the... View Details
Keywords: Mergers and Acquisitions; Health Care and Treatment; Organizational Change and Adaptation; Research and Development; Business Strategy; Partners and Partnerships; Goals and Objectives; Pharmaceutical Industry; United States
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  • 2010
  • Working Paper

Boundary Spanning in a For-profit Research Lab: An Exploration of the Interface Between Commerce and Academe

By: Christopher C. Liu and Toby E. Stuart
In innovative industries, private-sector companies increasingly are participants in open communities of science and technology. To participate in the system of exchange in such communities, firms often publicly disclose what would otherwise remain private discoveries.... View Details
Keywords: For-Profit Firms; Higher Education; Information Publishing; Innovation and Invention; Science-Based Business; Social and Collaborative Networks; Boundaries; Biotechnology Industry; Pharmaceutical Industry
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  • 11 Sep 2012
  • Working Paper Summaries

Spatial Organization of Firms: Internal and External Agglomeration Economies and Location Choices Through the Value Chain

Keywords: by Juan Alcácer & Mercedes Delgado
  • 16 Jul 2013
  • Working Paper Summaries

Visualizing and Measuring Enterprise Architecture: An Exploratory BioPharma Case

Keywords: by Robert Lagerstrom, Carliss Baldwin, Alan MacCormack & David Dreyfus
  • 2008
  • Article

Industrial Specialization and Regional Clusters in the Ten New EU Member States

By: Orjan Solvell, Christian H.M. Ketels and Goran Lindqvist
Purpose—The purpose of this paper is to provide an analysis of regional concentration patterns within ten new European Union (EU) member states, EU10, and make comparisons with EU15 and the US economy.
Design/methodology/approach—Industrial... View Details
Keywords: Geographic Location; Policy; Employment; Industry Clusters; Industry Structures; European Union; United States
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  • Research Summary

Clinical Trials as a setting for Health Policy and Management Research

The clinical trial marketplace is in flux. A decade ago, pharmaceutical firms almost exclusively conducted the study of their novel drug compounds within major academic medical centers. But today, industry-sponsored clinical trials are increasingly using community... View Details
  • 28 Jul 2015
  • First Look

First Look: July 28, 2015

Value at IBM (A)." Purchase this case: https://cb.hbsp.harvard.edu/cbmp/product/215059-PDF-ENG Harvard Business School Case 215-079 Transforming Alkermes into a Global Biopharmaceutical Company In the summer of 2011, Jim Frates, CFO... View Details
Keywords: Carmen Nobel
  • 24 Jun 2008
  • First Look

First Look: June 24, 2008

states. In a few cases—IT, biopharmaceuticals and communications equipment—where the total size of the cluster is small, and there is little historical legacy in Eastern Europe, the EU10 exhibits higher geographical concentration than... View Details
Keywords: Martha Lagace
  • 22 Aug 2006
  • First Look

First Look: August 22, 2006

805-067 Molecular Insight has developed a novel biopharmaceutical to detect heart attacks. The company's unique approach to intellectual property protection uses the Hatch Waxman Act and the Orphan Drug Act. The company is struggling to... View Details
Keywords: Martha Lagace
  • 17 Mar 2009
  • First Look

First Look: March 17, 2009

Agreements in Bio-Pharmaceuticals Authors:Juan Alcácer, John Cantwell, and Michelle Gittelman Publication:In Location of Biopharmaceutical Activity, edited by Iain M. Cockburn and Matthew J. Slaughter. NBER, forthcoming. Abstract As the... View Details
Keywords: Martha Lagace
  • 22 Jul 2014
  • First Look

First Look: July 22

Corporate Finance Attracting Long-Term Investors Through Integrated Thinking and Reporting: A Clinical Study of a Biopharmaceutical Company By: Knauer, Andrew, and George Serafeim Abstract—Faced with a large percentage of investors that... View Details
Keywords: Sean Silverthorne
  • 27 Mar 2012
  • First Look

First Look: March 27

case:http://cb.hbsp.harvard.edu/cb/product/912030-PDF-ENG PAREXEL International Corp. (A) Regina E. Herzlinger and Natalie KindredHarvard Business School Case 311-068 Despite severe market turmoil, in 2001, the biopharmaceutical contract... View Details
Keywords: Carmen Nobel
  • 22 Sep 2008
  • Research & Ideas

The Silo Lives! Analyzing Coordination and Communication in Multiunit Companies

electronic communication data, one at a leading biopharmaceuticals company and a second at a global media and professional services firm. One of these follows senior leaders through a period of reorganization, and the other contains... View Details
Keywords: by Sarah Jane Gilbert

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