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  • Article

Lessons From Hollywood: A New Approach To Funding R&D

By: Gary P. Pisano and Andrew W. Lo
Companies find it increasingly difficult to justify long-term, risky R&D investments—particularly in science-based fields such as biotechnology, advanced materials, and energy. We argue in this article that the traditional venture model has limits for such investments... View Details
Keywords: Financial Innovation; Financial Strategy; Project Management; R＆D; Start-up; Innovation Strategy; Business Model; Research and Development; Financial Management; Risk Management; Strategy
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  • 09 Apr 2014
  • Working Paper Summaries

Visualizing and Measuring Software Portfolio Architectures: A Flexibility Analysis

Keywords: by Robert Lagerstrom, Carliss Y. Baldwin, Alan MacCormack & David Dreyfus; Video Game; Web Services
  • November 2016
  • Case

QuintilesIMS: Biosimilar Marketing in England

By: John A. Quelch and Emily C. Boudreau
QuintilesIMS was a leading healthcare consulting firm best known for its data and information offerings as well as its market research and management consulting services for life science companies. By 2015, the company was expanding beyond the biopharmaceutical... View Details
Keywords: Health; Pharmaceutical Industry; Biotech; Marketing; Health Care and Treatment; Biotechnology Industry; England
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  • 2013
  • Working Paper

Visualizing and Measuring Enterprise Architecture: An Exploratory BioPharma Case

By: Robert Lagerstrom, Carliss Baldwin, Alan MacCormack and David Dreyfus
We test a method that was designed and used previously to reveal the hidden internal architectural structure of software systems. The focus of this paper is to test if it can also uncover new facts about the components and their relationships in an enterprise... View Details
Keywords: Complexity; Applications and Software; Product Design; Pharmaceutical Industry
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  • October 2024
  • Case

Parexel: Scaling Up and Industry Dynamics

By: Regina E. Herzlinger and Ben Creo
Through the lens of biopharmaceutical contract research organization (CRO) PAREXEL, this case traces the evolution of the firm as it reinvents itself in response to the transformation of the CRO sector from a small, secondary cluster of firms into a major player with... View Details
Keywords: Research; Innovation and Invention; Business Model; Transformation; Globalization; Information Technology; Competitive Advantage; Pharmaceutical Industry
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  • 11 Sep 2012
  • Working Paper Summaries

Spatial Organization of Firms: Internal and External Agglomeration Economies and Location Choices Through the Value Chain

Keywords: by Juan Alcácer & Mercedes Delgado
  • 2010
  • Working Paper

Boundary Spanning in a For-profit Research Lab: An Exploration of the Interface Between Commerce and Academe

By: Christopher C. Liu and Toby E. Stuart
In innovative industries, private-sector companies increasingly are participants in open communities of science and technology. To participate in the system of exchange in such communities, firms often publicly disclose what would otherwise remain private discoveries.... View Details
Keywords: For-Profit Firms; Higher Education; Information Publishing; Innovation and Invention; Science-Based Business; Social and Collaborative Networks; Boundaries; Biotechnology Industry; Pharmaceutical Industry
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  • August 2023
  • Case

Constellation Pharmaceuticals: Corporate Development at a Novel Therapeutic Company

By: Satish Tadikonda and Brad Prosek
Constellation Pharmaceuticals was a company focused on epigenetic therapies for cancer patients. Despite a promising start and an early deal with a leading biopharma company, the company weathered twin setbacks in the end of a major research collaboration and the... View Details
Keywords: Mergers and Acquisitions; Health Care and Treatment; Organizational Change and Adaptation; Research and Development; Business Strategy; Partners and Partnerships; Goals and Objectives; Pharmaceutical Industry; United States
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  • 27 Sep 2011
  • First Look

First Look: September 27

which the ACA was passed and develops estimates of its likely impact on the biopharmaceutical industry. Universal insurance, either through a government-run system or by mandated purchase of private insurance, has been controversial in... View Details
Keywords: Sean Silverthorne
  • 16 Jul 2013
  • Working Paper Summaries

Visualizing and Measuring Enterprise Architecture: An Exploratory BioPharma Case

Keywords: by Robert Lagerstrom, Carliss Baldwin, Alan MacCormack & David Dreyfus
  • 2008
  • Article

Industrial Specialization and Regional Clusters in the Ten New EU Member States

By: Orjan Solvell, Christian H.M. Ketels and Goran Lindqvist
Purpose—The purpose of this paper is to provide an analysis of regional concentration patterns within ten new European Union (EU) member states, EU10, and make comparisons with EU15 and the US economy.
Design/methodology/approach—Industrial... View Details
Keywords: Geographic Location; Policy; Employment; Industry Clusters; Industry Structures; European Union; United States
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  • Research Summary

Clinical Trials as a setting for Health Policy and Management Research

The clinical trial marketplace is in flux. A decade ago, pharmaceutical firms almost exclusively conducted the study of their novel drug compounds within major academic medical centers. But today, industry-sponsored clinical trials are increasingly using community... View Details
  • 27 Mar 2012
  • First Look

First Look: March 27

case:http://cb.hbsp.harvard.edu/cb/product/912030-PDF-ENG PAREXEL International Corp. (A) Regina E. Herzlinger and Natalie KindredHarvard Business School Case 311-068 Despite severe market turmoil, in 2001, the biopharmaceutical contract... View Details
Keywords: Carmen Nobel
  • 22 Jul 2014
  • First Look

First Look: July 22

Corporate Finance Attracting Long-Term Investors Through Integrated Thinking and Reporting: A Clinical Study of a Biopharmaceutical Company By: Knauer, Andrew, and George Serafeim Abstract—Faced with a large percentage of investors that... View Details
Keywords: Sean Silverthorne
  • 28 Jul 2015
  • First Look

First Look: July 28, 2015

Value at IBM (A)." Purchase this case: https://cb.hbsp.harvard.edu/cbmp/product/215059-PDF-ENG Harvard Business School Case 215-079 Transforming Alkermes into a Global Biopharmaceutical Company In the summer of 2011, Jim Frates, CFO... View Details
Keywords: Carmen Nobel
  • 24 Jun 2008
  • First Look

First Look: June 24, 2008

states. In a few cases—IT, biopharmaceuticals and communications equipment—where the total size of the cluster is small, and there is little historical legacy in Eastern Europe, the EU10 exhibits higher geographical concentration than... View Details
Keywords: Martha Lagace
  • 22 Aug 2006
  • First Look

First Look: August 22, 2006

805-067 Molecular Insight has developed a novel biopharmaceutical to detect heart attacks. The company's unique approach to intellectual property protection uses the Hatch Waxman Act and the Orphan Drug Act. The company is struggling to... View Details
Keywords: Martha Lagace
  • 18 Mar 2014
  • First Look

First Look: March 18

Robert, Carliss Y. Baldwin, Alan MacCormack, and David Dreyfus Abstract—In this paper, we test a method for visualizing and measuring software portfolio architectures and use our measures to predict the costs of architectural change. Our data is drawn from a View Details
Keywords: Sean Silverthorne
  • 11 Sep 2012
  • First Look

First Look: September 11

expansions of biopharmaceutical firms (by both new establishments and employment increase in existing establishments) in the U.S. in 1993-2005. We consider all activities in the value chain and allow location choices to vary by R&D,... View Details
Keywords: Sean Silverthorne
  • 26 Apr 2011
  • Op-Ed

HBS Faculty Comment on Environmental Issues for Earth Day

Chicago press on June 1 in an edited volume entitled Accelerating Innovation: Insights from Multiple Sectors. In detailed histories of agriculture, chemicals, semiconductors, computers, the internet and biopharmaceuticals we asked "what... View Details
Keywords: by Staff; Energy; Utilities

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