Publications

October 2019
Article

Adaptive Platform Trials: Definition, Design, Conduct and Reporting Considerations

By: Derek C. Angus, Brian M. Alexander, Scott Berry, Meredith Buxton, Roger Lewis, Melissa Paoloni, Steven A. R. Webb, Steven Arnold, Anna Barker, Donald A. Berry, Marc J. M. Bonten, Mary Brophy, Christopher Butler, Timothy F. Cloughesy, Lennie P. G. Derde, Laura J. Esserman, Ryan Ferguson, Louis Fiore, Sarah C. Gaffey, J. Michael Gaziano, Kathy Giusti, Herman Goossens, Stephane Heritier, Bradley Hyman, Michael Krams, Kay Larholt, Lisa M. LaVange, Philip Lavori, Andrew W. Lo, Alexander J. London, Victoria Manax, Colin McArthur, Genevieve O’Neill, Giovanni Parmigiani, Jane Perlmutter, Elizabeth A. Petzold, Craig Ritchie, Kathryn M. Rowan, Christopher W. Seymour, Nathan I. Shapiro, Diane M. Simeone, Bradley Smith, Bradley Spellberg, Ariel Dora Stern, Lorenzo Trippa, Mark Trusheim, Kert Viele, Patrick Y. Wen and Janet Woodcock

Researchers, clinicians, policymakers, and patients are increasingly interested in questions about therapeutic interventions that are difficult or costly to answer with traditional, free-standing, parallel-group randomized controlled trials (RCTs). Examples include... View Details

Keywords: Adaptive Platform Trials; Health Testing and Trials

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2017
Working Paper

Economic Uncertainty and Earnings Management

By: Luke C.D. Stein and Charles C.Y. Wang

In the presence of managerial short-termism and asymmetric information about skill and effort provision, firms may opportunistically shift earnings from uncertain to more certain times. We document empirically that when financial markets are less certain about a firm's... View Details

Keywords: Discretionary Accruals; Uncertainty; Implied Volatility; Earnings Response Coefficient; Risk and Uncertainty; Earnings Management; Financial Markets

SSRN

2015
Chapter

Managerial Responsibility and the Purpose of Business: Doing One's Job Well

By: Nien-he Hsieh

Business managers routinely make decisions that significantly affect the lives of others in both positive and negative ways. In the light of these wide-ranging effects, much scholarship has been devoted to specifying the responsibilities of managers of for-profit... View Details

Keywords: Business or Company Management; Goals and Objectives

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June 2015
Case

1996 Welfare Reform in the United States

By: Matthew Weinzierl, Katrina Flanagan and Alastair Su

On August 22, 1996, U.S. President Bill Clinton signed into law the Personal Responsibility and Work Opportunity Reconciliation Act (PRWORA)—a dramatic reform of the American system of economic assistance for the poor that, as its title suggested, attempted to... View Details

Keywords: Welfare State; Public Goods; Moral Hazard; Median Voter Theorem; Poverty; Welfare; Public Administration Industry; United States

Article

Seeking the Roots of Entrepreneurship: Insights from Behavioral Economics

By: Thomas Astebro, Holger Herz, Ramana Nanda and Roberto A. Weber

There is a growing body of evidence that many entrepreneurs seem to enter and persist in entrepreneurship despite earning low risk-adjusted returns. This has lead to attempts to provide explanations—using both standard economic theory and behavioral economics—for why... View Details

Keywords: Entrepreneurship; Personal Characteristics; Attitudes; Behavior

May 2014
Case

Cycle for Survival (A)

By: Das Narayandas, Kerry Herman and Noah Fisher

Katie Kotkins, director of Memorial Sloan Kettering Cancer Center's (MSKCC) Cycle for Survival fundraising event, had to determine the best avenue for continuing the event's success and momentum after its founder, Jennifer (Jen) Goodman Linn (HBS '99) passed away... View Details

Keywords: Not For Profit; Cancer; Partnerships; United States; Fundraising; Nonprofit Organizations; United States

2014
Working Paper

Opting Out of Good Governance

By: C. Fritz Foley, Paul Goldsmith-Pinkham, Jonathan Greenstein and Eric Zwick

Cross-listing on a U.S. exchange does not bond foreign firms to follow the corporate governance rules of that exchange. Hand-collected data show that 80% of cross-listed firms opt out of at least one exchange governance rule, instead committing to observe the rules of... View Details

Keywords: Financial Markets; Globalization; Corporate Governance

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2009
Working Paper

Corporate Misgovernance at the World Bank

By: Ashwin Kaja and Eric D. Werker

We test for evidence of corporate misgovernance at the World Bank. Most major decisions at the World Bank are made by its Board of Executive Directors. However, in any given year the majority of the Bank's member countries do not get a chance to serve on this powerful... View Details

Keywords: Developing Countries and Economies; Banks and Banking; Financing and Loans; International Finance; Corporate Governance; Governing and Advisory Boards

July 2000 (Revised August 2005)
Case

Deaconess-Glover Hospital (A)

Chronicles the initial efforts to teach a health care organization to manage itself according to the principles of the Toyota Production System (TPS). Describes the decision and dilemmas that arose from the implementation experiment. Builds on Bowen and Spear's earlier... View Details

Keywords: Management; Service Delivery; Health Care and Treatment; Health Industry; Massachusetts

23 Jun 2009
First Look

First Look: June 23

relationship, Warren Buffett, arguably the world's most admired and successful investor, has decided to make such a significant investment in Goldman Sachs." He added that the deal "will further bolster our strong capitalization and liquidity position,"... View Details

Keywords: Martha Lagace

February 2000 (Revised August 2000)
Case

Boston.com

By: Thomas R. Eisenmann and Jon K Rust

How aggressively should an incumbent move when developing an online business that threatens its core product? With Internet competitors taking direct aim at the traditional print newspaper business model, the Boston Globe fought back with its own web initiative,... View Details

Keywords: Corporate Entrepreneurship; Decision Making; Change Management; Internet and the Web; Customer Relationship Management; Competitive Strategy; Publishing Industry; Information Technology Industry; United States

21 Sep 2021
News

Readers Ask: How Can I Gain Power and Influence?

Web

Business Finance Course Online | HBS Online

projects Examine how capital markets work and how they affect your business Develop a financial intuition that will give you the confidence to make effective decisions in your career and life Who Will Benefit Early and Mid-Career... View Details

14 Oct 2021
News

Reunited and It Feels (Not) So Good: Tips for Managing a Rocky Return

01 Oct 2001
Research & Ideas

Organizing the Family-Run Business

"paper" board, existing only on paper, or acts as a "rubber stamp," validating whatever decisions the owner makes. During the Sibling Partnership stage, where two or more siblings have voting control of the company,... View Details

April 2010
Case

Metabical: Pricing, Packaging, and Demand Forecasting Recommendations for a New Weight Loss Drug

By: John A. Quelch and Heather Beckham

Metabical is a new weight loss drug from Cambridge Sciences Pharmaceuticals intended for moderately overweight individuals. In anticipation of final FDA approval, the senior director of marketing, Barbara Printup, prepares for the product launch and must make several... View Details

Keywords: Return On Investment; Forecasting; Pricing Policies; Demand Planning; Marketing Strategy; Price; Consumer Behavior; Investment Return; Forecasting and Prediction; Product Launch; Planning; Brands and Branding; Pharmaceutical Industry

April 2019 (Revised February 2025)
Case

Wendell Weeks at Corning Inc.: Extending a History of Life-Changing Innovations (A)

By: Ryan Raffaelli, David G. Fubini and Aldo Sesia

This case examines the leadership challenges associated with maintaining a culture of innovation in established organizations. It asks students to step into the shoes of a leader faced with making several tough decisions about when to invest (or to stop investing) in... View Details

Keywords: Innovation and Invention; Organizational Culture; Innovation Leadership; History; Technological Innovation; Investment; Decision Making