Publications

October 2019
Article

Adaptive Platform Trials: Definition, Design, Conduct and Reporting Considerations

By: Derek C. Angus, Brian M. Alexander, Scott Berry, Meredith Buxton, Roger Lewis, Melissa Paoloni, Steven A. R. Webb, Steven Arnold, Anna Barker, Donald A. Berry, Marc J. M. Bonten, Mary Brophy, Christopher Butler, Timothy F. Cloughesy, Lennie P. G. Derde, Laura J. Esserman, Ryan Ferguson, Louis Fiore, Sarah C. Gaffey, J. Michael Gaziano, Kathy Giusti, Herman Goossens, Stephane Heritier, Bradley Hyman, Michael Krams, Kay Larholt, Lisa M. LaVange, Philip Lavori, Andrew W. Lo, Alexander J. London, Victoria Manax, Colin McArthur, Genevieve O’Neill, Giovanni Parmigiani, Jane Perlmutter, Elizabeth A. Petzold, Craig Ritchie, Kathryn M. Rowan, Christopher W. Seymour, Nathan I. Shapiro, Diane M. Simeone, Bradley Smith, Bradley Spellberg, Ariel Dora Stern, Lorenzo Trippa, Mark Trusheim, Kert Viele, Patrick Y. Wen and Janet Woodcock

Researchers, clinicians, policymakers, and patients are increasingly interested in questions about therapeutic interventions that are difficult or costly to answer with traditional, free-standing, parallel-group randomized controlled trials (RCTs). Examples include... View Details

Keywords: Adaptive Platform Trials; Health Testing and Trials

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06 Dec 2013
News

Prescription: Measure Health Care's Real Costs

26 Mar 2024
Research & Ideas

How Humans Outshine AI in Adapting to Change

that required increasingly more flexible self-orienting. Like a simplified version of a four-player scenario of the classic video game Mario Kart, each game included four “possible selves,” which were indicated by red squares. Yet, only one avatar (also known as the... View Details

Keywords: by Rachel Layne; Technology; Information Technology

February 2014 (Revised May 2014)
Background Note

Flying High, Landing Low: Strengths and Challenges for U.S. Air Transportation

By: Rosabeth Moss Kanter, Aditi Jain and Ai-Ling Jamila Malone

The U.S. air transportation system flies high on some indicators, mostly involving capacity to take to the air, but lands low on others, mostly involving ground facilities and processes. This note provides an overview of the history and current state of air... View Details

23 Nov 2009
Research & Ideas

Management’s Role in Reforming Health Care

knowledge to solving the problems of individual patients—offer enormous potential to help patients and the U.S. health-care system overall, says HBS senior lecturer Richard M.J. Bohmer, a physician and researcher on the intersection of... View Details

Keywords: by Martha Lagace; Health

"One Way to Help Employees Build Emergency Savings" Harvard Business Review (May 2024)

Intentional cooperation between two organizations — BlackRock, a major asset management firm, and national non-profit, Commonwealth — created the conditions for the nation’s largest payroll processor, multiple U.S. employers, retirement record keepers, and others... View Details

2009
Working Paper

Management and the Financial Crisis (We have met the enemy and he is us...)

By: William A. Sahlman

The financial crisis of 2008-9 has revealed that our broad model of corporate governance is broken, independent of the shortcomings in the regulatory system. Managers and boards of directors in scores of systemically important firms failed to protect employees,... View Details

Keywords: Risk Management; Governing and Advisory Boards; Ethics; Corporate Governance; Financial Crisis

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Teaching Interest

Executive Education: Finance for Senior Executives

By: Malcolm P. Baker

Finance for Senior Executives provides the frameworks to strategically use financial resources and position your company for future success. By examining corporate finance from both internal and external perspectives, this HBS Executive Education View Details

December 1992 (Revised March 1997)
Case

Peoria Engine Plant (A)

By: Robert S. Kaplan and Amy P. Hutton

Describes the cost control system used at an automobile engine plant for labor and overhead costs. The finance staff prepares daily, weekly, and monthly variance reports against budgets. Department supervisors, finance staff, and the plant manager discuss the use and... View Details

Keywords: Cost Management; Cost Accounting; Budgets and Budgeting; Earnings Management; Reports; Financial Reporting; Management Analysis, Tools, and Techniques; Performance Improvement; Performance Productivity; Factories, Labs, and Plants; Auto Industry

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November 1989 (Revised April 2018)
Case

Automation Consulting Services

By: Robert Simons and Hilary Weston

Illustrates the management control challenges that are associated with rapid growth and geographic expansion. Situated at an offsite Executive Committee Retreat. The three founding partners of a specialized consulting firm are grappling with several difficult questions... View Details

Keywords: Geographic Location; Governance Controls; Policy; Growth and Development Strategy; Management Teams; Expansion; Consulting Industry

2008
Working Paper

The Architecture of Platforms: A Unified View

By: Carliss Y. Baldwin and C. Jason Woodard

The central role of "platform" products and services in mediating the activities of disaggregated "clusters" or "ecosystems" of firms has been widely recognized. But platforms and the systems in which they are embedded are very diverse. In particular, platforms may... View Details

Keywords: Digital Platforms; Industry Clusters; Infrastructure; Information Infrastructure; Digital Platforms

Keywords: Information Technology; Organizational Change and Adaptation; Organizational Design; Management Analysis, Tools, and Techniques; Organizational Culture; Mobile and Wireless Technology; Performance Productivity; Problems and Challenges; Management Practices and Processes; Business Divisions; Information Management; Information Technology Industry; Telecommunications Industry; United States

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07 Apr 2020
News

What Will U.S. Health Care Look Like After the Pandemic?

February 1991 (Revised February 1992)
Case

Appex Corp.

By: Nitin Nohria

1990 Business Week named Appex Corp. the fastest growing high-technology company in the United States. Appex provided management information systems and intercarrier network services to cellular telephone companies. During its rapid growth, the company went through... View Details

29 Apr 2025
HBS Seminar

Magie Cheng & David Huang

November 2023 (Revised July 2024)
Case

'Care in Every Drop': Ayala Corporation and Manila Water (A)

By: Debora L. Spar, Paul Healy, Tricia Peralta and Julia M. Comeau

Since 1834, eight generations of the Ayala family have used their conglomerate to fund nation-building projects in the Philippines, including investments in tramcars, telecommunications, hospitals, and schools. In 1997, Ayala’s subsidiary, Manila Water, took control of... View Details

Keywords: Family Business; Economic Growth; Social Entrepreneurship; Climate Change; Natural Resources; Crisis Management; Failure; Privatization; Social Issues; Urban Development; Adaptation; Public Opinion; Mission and Purpose; Utilities Industry; Asia; Philippines

13 Mar 2025
HBS Seminar

Sonny Tambe, Wharton

January – February 2011
Article

The Price of Fairness

By: Dimitris Bertsimas, Vivek F. Farias and Nikolaos Trichakis

In this paper we study resource allocation problems that involve multiple self-interested parties or players and a central decision maker. We introduce and study the price of fairness, which is the relative system efficiency loss under a "fair" allocation assuming that... View Details

Keywords: Price; Fairness