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      • 2025
      • Working Paper

      Tamoxifen—Reducing Breast Cancer Risks: Case Histories of Transformational Advances

      By: Amar Bhidé, Srikant Datar and Katherine Stebbins
      We describe the development of tamoxifen, considered a “gold standard” treatment for millions of breast cancer patients. Specifically, we describe breast cancer treatments before tamoxifen’s development; the initial development of tamoxifen from 1960 to 1973;... View Details
      Keywords: Health Care and Treatment; Technological Innovation; Innovation and Invention; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Governing Rules, Regulations, and Reforms
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      Bhidé, Amar, Srikant Datar, and Katherine Stebbins. "Tamoxifen—Reducing Breast Cancer Risks: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-134, July 2020. (Revised January 2025.)
      • June 2020
      • Supplement

      TransDigm in 2017: Congressional Hearing on the DoD Inspector General’s Report (5/15/19)

      By: Benjamin C. Esty
      This video accompanies the case, “TransDigm in 2017: The Beginning of the End or the End of the Beginning?” View Details
      Keywords: Value Capturing; Pricing Strategy; Supplier Power; Buyer Power; Porter's Five Forces; Bargaining Power; Monopoly; Aerospace; Acquisition Strategy; Value Drivers; Ethical Behavior; Regulation; Growth Strategy; Business Ethics; Defense; Procurement; Sustainability; Value Based Health Care; Acquisition; Ethics; Private Equity; Financial Strategy; Growth Management; Performance Evaluation; Business Strategy; Competitive Strategy; Horizontal Integration; Value Creation; Competitive Advantage; Aerospace Industry; Air Transportation Industry; United States
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      Esty, Benjamin C. "TransDigm in 2017: Congressional Hearing on the DoD Inspector General’s Report (5/15/19)." Harvard Business School Multimedia/Video Supplement 720-856, June 2020.
      • Article

      Sustainability, Business, and Health

      By: George Serafeim, Amanda M. Rischbieth and Howard K. Koh
      The coronavirus disease 2019 (COVID-19) pandemic has demonstrated that response demands involvement from every sector of society. As a major example, some businesses have stepped up in ways previously unimaginable. Garment companies have repurposed production to face... View Details
      Keywords: COVID; COVID-19; Sustainability; Health And Wellness; Corporate Social Responsibility; Health Pandemics; Health; Corporate Social Responsibility and Impact; Corporate Accountability; Health Care and Treatment
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      Serafeim, George, Amanda M. Rischbieth, and Howard K. Koh. "Sustainability, Business, and Health." JAMA, the Journal of the American Medical Association 324, no. 2 (July 14, 2020): 147–148.
      • Article

      Are Cost Advantages from a Modern Indian Hospital Transferable to the United States?

      By: R. S. Kaplan, F. Erhun, V.G. Narayanan, B. Mistry and K. Brayton, et al
      We use time-driven activity-based costing to estimate the cost of personnel and space for an elective coronary artery bypass graft (CABG) surgery at two U.S. hospitals, Intermountain and Baylor Heart, and Narayana Health (NH), in India. All three hospitals use modern... View Details
      Keywords: Time-Driven Activity-Based Costing; Health Care and Treatment; Cost; Organizational Structure; Performance Efficiency; India; United States
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      Kaplan, R. S., F. Erhun, V.G. Narayanan, B. Mistry, and K. Brayton, et al. "Are Cost Advantages from a Modern Indian Hospital Transferable to the United States?" American Heart Journal 224 (June 2020): 148–155.
      • June 2020
      • Article

      Overcoming Barriers to Early Disease Intervention

      By: H. Hugo Caicedo, Daniel A. Hashimoto, Julio C. Caicedo, Alex Pentland and Gary P. Pisano
      It is widely acknowledged that earlier intervention in many disease processes leads to better patient outcomes and lower treatment costs. To date, most efforts at early disease intervention have focused on "primary prevention" which focuses on preventing diseases in... View Details
      Keywords: Secondary Prevention; Barriers To Response; Health Disorders; Health Care and Treatment
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      Caicedo, H. Hugo, Daniel A. Hashimoto, Julio C. Caicedo, Alex Pentland, and Gary P. Pisano. "Overcoming Barriers to Early Disease Intervention." Nature Biotechnology 38, no. 6 (June 2020).
      • Article

      The Inpatient Discharge Lounge as a Potential Mechanism to Mitigate Emergency Department Boarding and Crowding

      By: Brian Franklin, Sharif Vakili, Robert S. Huckman, Sarah Hosein, Nicholas Falk, Katherine Cheng, Maria Murray, Sheila Harris, Charles A. Morris and Eric Goralnick
      Delayed access to inpatient beds for admitted patients contributes significantly to emergency department (ED) boarding and crowding, which have been associated with deleterious patient safety effects. To expedite inpatient bed availability, some hospitals have... View Details
      Keywords: Health Care Delivery; Emergency Room; Operations Improvement; Operations Management; Health Care and Treatment; Service Delivery; Operations; Management; Performance Improvement; Service Operations
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      Franklin, Brian, Sharif Vakili, Robert S. Huckman, Sarah Hosein, Nicholas Falk, Katherine Cheng, Maria Murray, Sheila Harris, Charles A. Morris, and Eric Goralnick. "The Inpatient Discharge Lounge as a Potential Mechanism to Mitigate Emergency Department Boarding and Crowding." Annals of Emergency Medicine 75, no. 6 (June 2020): 704–714.
      • Article

      Treatment Of Opioid Use Disorder Among Commercially Insured U.S. Adults, 2008–17

      By: Karen Shen, Eric Barrette and Leemore S. Dafny
      There is abundant literature on efforts to reduce opioid prescriptions and misuse, but comparatively little on the treatment provided to people with opioid use disorder (OUD). Using claims data representing 12–15 million nonelderly adults covered through commercial... View Details
      Keywords: Opioid Treatment; Medication-assisted Treatment; Substance Use Disorder; Private Insurance; Health Disorders; Health Care and Treatment; Insurance; United States
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      Shen, Karen, Eric Barrette, and Leemore S. Dafny. "Treatment Of Opioid Use Disorder Among Commercially Insured U.S. Adults, 2008–17." Health Affairs 39, no. 6 (June 2020): 993–1001.
      • Article

      The Business of Medicine in the Era of COVID-19

      By: David M. Cutler, Sayeh Nikpay and Robert S. Huckman
      This Viewpoint discusses the shifting landscape of health care financing, regulation, and delivery as a result of the coronavirus pandemic, and discusses regulatory and other changes that need to be in place if telehealth and physician practice and hospital mergers... View Details
      Keywords: Health Care; COVID-19; Telemedicine; Business; Health Pandemics; Health Care and Treatment; Change; Competition
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      Cutler, David M., Sayeh Nikpay, and Robert S. Huckman. "The Business of Medicine in the Era of COVID-19." JAMA, the Journal of the American Medical Association 323, no. 20 (May 26, 2020): 2003–2004.
      • May 21, 2020
      • Editorial

      Primary Care Is Hurting: Why Aren't Private Insurers Pitching In?

      By: Leemore S. Dafny and J. Michael McWilliams
      Primary care clinicians are the front line for patients with suspected infection. We rely on them to diagnose, triage, and manage patients with potential or confirmed COVID infections. They are also responsible for keeping non-COVID medical conditions under control... View Details
      Keywords: COVID-19; Primary Care; Health Pandemics; Health Care and Treatment; Financial Condition; Insurance
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      Dafny, Leemore S., and J. Michael McWilliams. "Primary Care Is Hurting: Why Aren't Private Insurers Pitching In?" Health Affairs Blog (May 21, 2020).
      • Article

      Using the Balanced Scorecard for Successful Health Care M&A Integration

      By: Robert S. Kaplan
      The failure of merged organizations to achieve stated goals is commonplace. In health care, the challenge is exacerbated by the industry’s third-party payer system and multiple stakeholders, especially the physicians in the merging entities. This article describes how... View Details
      Keywords: Health Care and Treatment; Mergers and Acquisitions; Integration; Balanced Scorecard
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      Kaplan, Robert S. "Using the Balanced Scorecard for Successful Health Care M&A Integration." NEJM Catalyst (May 21, 2020).
      • May 2020 (Revised March 2022)
      • Case

      The Coronavirus (COVID-19) Pandemic and the Global Economy (A)

      By: Alberto Cavallo and Christian Godwin
      In April 2020, the world struggled to contain the exponential escalation of the coronavirus (COVID-19) pandemic. Dozens of countries had imposed restrictions on travel, work, and social gatherings. A large share of the global population was under lockdowns and... View Details
      Keywords: COVID-19 Pandemic; Demand and Consumers; Supply and Industry; Finance; Central Banking; Financial Markets; International Finance; Globalization; Government and Politics; Health Pandemics; Decision Making; Macroeconomics; Employment; Crisis Management; Supply Chain; Risk and Uncertainty; Financial Services Industry; Financial Services Industry; Financial Services Industry; Financial Services Industry; Financial Services Industry; Financial Services Industry; Financial Services Industry; Financial Services Industry; Financial Services Industry; Financial Services Industry; Financial Services Industry; Financial Services Industry; Financial Services Industry; Financial Services Industry; Financial Services Industry; Asia; China; Europe; Latin America; Africa; United States
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      Cavallo, Alberto, and Christian Godwin. "The Coronavirus (COVID-19) Pandemic and the Global Economy (A)." Harvard Business School Case 720-031, May 2020. (Revised March 2022.)
      • Article

      How to End the Plasma Shortage for Coronavirus Patients

      By: Scott Duke Kominers
      Those who have recovered from the virus will donate more blood if given the right incentives. View Details
      Keywords: COVID-19; Convalescent Plasma; Health Pandemics; Health Care and Treatment; Market Design; Strategy
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      Kominers, Scott Duke. "How to End the Plasma Shortage for Coronavirus Patients." Bloomberg Opinion (May 11, 2020).
      • May 8, 2020
      • Article

      Lead Your Team Into a Post-Pandemic World

      By: Hubert Joly
      The unprecedented COVID-19 pandemic has tested leaders, especially as it relates to how they lead their workers. As the crisis goes on, many that the author has spoken with have begun to frame it around three distinct phases: The Shelter-in-Place Phase, the Re-opening... View Details
      Keywords: COVID-19; Re-opening; Health Pandemics; Leadership; Employees; Communication; Human Needs
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      Joly, Hubert. "Lead Your Team Into a Post-Pandemic World." Harvard Business Review Digital Articles (May 8, 2020).
      • 2020
      • Working Paper

      Paying It Backward and Forward: Expanding Access to Convalescent Plasma Therapy Through Market Design

      By: Scott Duke Kominers, Parag A. Pathak, Tayfun Sönmez and M. Utku Ünver
      COVID-19 convalescent plasma (CCP) therapy is currently a leading treatment for COVID-19. At present, there is a shortage of CCP relative to demand. We develop and analyze a model of centralized CCP allocation that incorporates both donation and distribution. In order... View Details
      Keywords: COVID-19; Convalescent Plasma; Vouchers; Health Pandemics; Health Care and Treatment; Resource Allocation; Market Design
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      Kominers, Scott Duke, Parag A. Pathak, Tayfun Sönmez, and M. Utku Ünver. "Paying It Backward and Forward: Expanding Access to Convalescent Plasma Therapy Through Market Design." Harvard Business School Working Paper, No. 20-116, May 2020. (NBER Working Paper Series, No. 27143, May 2020.)
      • May 2020 (Revised April 2024)
      • Case

      Gavi and COVID-19: Pandemic of the Century

      By: Tarun Khanna and Sid Misra
      Gavi has helped immunize over 760 million children in the world's poorest countries over the past 20 years saving 13 million lives. How should Gavi respond to the need for a vaccine for the worldwide COVID-19 pandemic? View Details
      Keywords: Vaccine; Pandemics; Healthcare; COVID-19; Health Pandemics; Health Care and Treatment; Emerging Markets; Crisis Management; Alliances
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      Khanna, Tarun, and Sid Misra. "Gavi and COVID-19: Pandemic of the Century." Harvard Business School Case 720-451, May 2020. (Revised April 2024.)
      • May 2020
      • Article

      Identifying Sources of Inefficiency in Health Care

      By: Amitabh Chandra and Douglas O. Staiger
      In medicine, the reasons for variation in treatment rates across hospitals serving similar patients are not well understood. Some interpret this variation as unwarranted and push standardization of care as a way of reducing allocative inefficiency. However, an... View Details
      Keywords: Health Care and Treatment; Performance Efficiency; Performance Productivity; Mathematical Methods
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      Chandra, Amitabh, and Douglas O. Staiger. "Identifying Sources of Inefficiency in Health Care." Quarterly Journal of Economics 135, no. 2 (May 2020): 785–843.
      • May–June 2020
      • Article

      The Agenda for the Next Generation of Health Care Information Technology

      By: Thomas W. Feeley, Zachary Landman and Michael E. Porter
      As the diffusion of value-based health care efforts accelerates globally, the need for interoperable information technology systems that support value-based care is essential. Such systems are needed to facilitate dramatic improvements in patient outcomes and... View Details
      Keywords: Value-based Health Care; Health Care and Treatment; Information Technology; Integration; Performance Improvement; Performance Efficiency
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      Feeley, Thomas W., Zachary Landman, and Michael E. Porter. "The Agenda for the Next Generation of Health Care Information Technology." NEJM Catalyst Innovations in Care Delivery 1, no. 3 (May–June 2020).
      • 2020
      • Working Paper

      Spreading the Health: Americans' Estimated and Ideal Distributions of Death and Health(care)

      By: Sorapop Kiatpongsan and Michael I. Norton
      The 2010 Patient Protection and Affordable Care Act intensified debates over the role of government in the distribution of healthcare. A nationally-representative sample of Americans reported their estimated and ideal distributions of healthcare (unmet need for... View Details
      Keywords: Healthcare; Mortality; Inequality; Justice; Equity; Health; Health Care and Treatment; Equality and Inequality; Fairness; Public Opinion; United States
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      Kiatpongsan, Sorapop, and Michael I. Norton. "Spreading the Health: Americans' Estimated and Ideal Distributions of Death and Health(care)." Harvard Business School Working Paper, No. 20-114, April 2020.
      • Article

      Believe in Vaccine Bets Like Bill Gates's

      By: Scott Duke Kominers
      Commitment of public or private funds upfront speeds development, production, and distribution. View Details
      Keywords: Coronavirus; Vaccine; Financing; Health Pandemics; Health Care and Treatment; Product Development; Production; Distribution
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      Kominers, Scott Duke. "Believe in Vaccine Bets Like Bill Gates's." Bloomberg Opinion (April 28, 2020).
      • April 15, 2020
      • Other Article

      Designating Certain Post-Acute Care Facilities As COVID-19 Skilled Care Centers Can Increase Hospital Capacity And Keep Nursing Home Patients Safer

      By: Leemore S. Dafny and Steven S. Lee
      As the number of COVID-19 cases nationwide continues to grow, many hospitals will need to convert acute care beds into intensive care beds and discharge stable patients to post-acute care settings such as nursing homes. In addition, nursing homes unable to care for... View Details
      Keywords: COVID-19; Nursing Homes; Health Pandemics; Health Care and Treatment; Safety; Quality
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      Dafny, Leemore S., and Steven S. Lee. "Designating Certain Post-Acute Care Facilities As COVID-19 Skilled Care Centers Can Increase Hospital Capacity And Keep Nursing Home Patients Safer." Health Affairs Blog (April 15, 2020).
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