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January 2010 (Revised August 2011)
Case

Ganeden Biotech, Inc.

By: Robert C. Pozen, Dale Alan Winger and Matthew Kenneth Ahlers

The CEO of Ganeden Biotech, a small firm with several viable probiotic products but limited resources, must decide what markets to invest in and what intellectual property strategies will best serve its immediate and longer-term business interests. View Details

Keywords: Entrepreneurship; Investment; Intellectual Property; Market Entry and Exit; Business Strategy; Biotechnology Industry

November 2009 (Revised March 2010)
Case

Managing Drugs on the Forefront of Personalized Medicine: The Erbitux and Vectibix Story

By: Richard G. Hamermesh, Raju Kucherlapati and Rachel Gordon

In May 2007, Amgen Inc. (Amgen) received disappointing news from the European Medicines Agency (EMEA) that its drug Vectibix, developed to fight metastatic colorectal cancer, had been rejected. This was especially surprising news given that a similar rival drug had... View Details

Keywords: Entrepreneurship; Governing Rules, Regulations, and Reforms; Health Testing and Trials; Marketing Strategy; Product Positioning; Genetics; Biotechnology Industry; Europe; United States

July 2009
Teaching Note

Targanta Therapeutics: Hitting a Moving Target (TN)

By: Arthur A. Daemmrich

Teaching Note for [709002]. View Details

Keywords: Governing Rules, Regulations, and Reforms; Product Development; Business Strategy; Initial Public Offering; Mergers and Acquisitions; Policy; Selection and Staffing; Health Testing and Trials; Resource Allocation; Biotechnology Industry

May 2004
Teaching Note

Monsanto: Technology Cooperation and Small Holder Farmer Projects (TN)

By: James E. Austin and Diana Barrett

Teaching Note to (9-302-068). View Details

Keywords: Biotechnology Industry

November 2001 (Revised December 2002)
Case

Tracking Stocks at Genzyme (A)

By: Malcolm S. Salter

Genzyme, a tracking stock pioneer, has used its innovative capital structure as a way to frame and grow its R&D-intensive business. Facing the question of how best to integrate a new acquisition into its tracking stock structure, Genzyme's top management is forced to... View Details

Keywords: Integration; Value Creation; Motivation and Incentives; Conflict of Interests; Stocks; Capital Structure; Research and Development; Corporate Governance; Biotechnology Industry

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October 2001
Case

TIGR and ILRI: Solving Problems with Genomics

By: Ray A. Goldberg and James M Beagle

Discusses nonprofit institutional leadership applying advances in genetic science to solve health and animal problems in industrial countries and the developing world. View Details

Keywords: Developing Countries and Economies; Health; Technological Innovation; Leading Change; Emerging Markets; Genetics; Non-Governmental Organizations; Technology Adoption; Biotechnology Industry

October 2001 (Revised June 2002)
Case

Centagenetix (A): Building a Business Model for Genetic Longevity

Describes a start-up company seeking to exploit population genetic data from long-lived, healthy people. The company must address legal, financial, ethical, and personal issues among its team to launch the company. View Details

Keywords: Ethics; Genetics; Business Startups; Biotechnology Industry

April 2001 (Revised January 2003)
Case

Robert Shapiro and Monsanto

Traces Monsanto's efforts to become a global biotech powerhouse under Shapiro's leadership. Examines how his crusade to save the world through genetic modification foundered. View Details

Keywords: Genetics; Supply Chain Management; Alliances; Global Strategy; Cross-Cultural and Cross-Border Issues; Biotechnology Industry

December 2000
Case

Paradigm Genetics: The Industrialization of Genomics

By: Ray A. Goldberg, Carin-Isabel Knoop and Laure Mougeot Stroock

Keywords: Genetics; Biotechnology Industry

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November 1999
Case

Seminis Inc.

By: Ray A. Goldberg, Jonathan West, Carin-Isabel Knoop and David Benedict Pearcy

Seminis became the world leader in vegetable seeds through a series of acquisitions. This case describes the Seminis strategy toward capturing value, biotechnology, and international operations. View Details

Keywords: Business Earnings; Acquisition; Profit; Global Strategy; Corporate Strategy; Valuation; Value Creation; Biotechnology Industry

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August 1996 (Revised May 1997)
Case

Delta & Pine Land: Measuring the Value of Transgenic Cotton

By: Ray A. Goldberg and Charlotte A. Tasker

Discusses the joint venture between two companies with different capabilities: 1) technology provider and 2) transportation agent. Discusses how to capture value from joint venture and biotechnology: 1) who are winners and who are losers; 2) how much value can/should... View Details

Keywords: Agribusiness; Joint Ventures; Marketing Strategy; Supply Chain Management; Performance Consistency; Information Technology; Transportation; Valuation; Biotechnology Industry

November 1995 (Revised February 1996)
Case

Monsanto Company: The Coming of Age of Bio-Technology

By: Ray A. Goldberg and Thomas N. Urban Jr

Monsanto has one product, Roundup, accounting for 30% of company net income and is going off patent. How should the company position itself and its products in the future? View Details

Keywords: Patents; Product Positioning; Strategic Planning; System Shocks; Biotechnology Industry

November 1978 (Revised October 1989)
Case

Amicon Corp. (B)

Details the negotiation between Amicon and three potential licensees, Jackson, Maynard-Smith and Behrstein. View Details

Keywords: Technology; Patents; Negotiation Process; Negotiation Participants; Health Care and Treatment; Biotechnology Industry

July 2014 (Revised January 2017)
Course Overview Note

Building Life Science Businesses Spring Term 2017: Course Outline and Syllabus

By: Richard G. Hamermesh

This Course Outline and Syllabus gives an overview of the Spring 2016 class Building Life Science Businesses.7 View Details

Keywords: Healthcare Ventures; Entrepreneurial Management; Entrepreneurship; Entrepreneurs; Health Care and Treatment; Health Testing and Trials; Medical Specialties; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Asia; North America; Europe

February 2024 (Revised March 2025)
Case

Moving Science: The Rowland Institute at Harvard

By: Maria P. Roche

Set in 2022, this case describes the considerations involved in organizing the physical relocation of the Rowland Institute at Harvard (RIH), a research institute established in 1980 by Edwin H. Land, the founder of the Polaroid Corporation, for the advancement of... View Details

Keywords: Optics; Engineering; Higher Education; Strategy; Science; Buildings and Facilities; Research and Development; Biotechnology Industry; Biotechnology Industry

January 2014 (Revised June 2014)
Supplement

23andMe: Genetic Testing for Consumers (B)

By: John A. Quelch and Margaret L. Rodriguez

Following the FDA's letter in November 2013, which ordered 23andMe to cease sales of its DNA test kits, observers wondered how co-founder and CEO, Anne Wojcicki, would guide the company in the presence of uncertainty. View Details

Keywords: Risk and Uncertainty; Genetics; Crisis Management; Health Care and Treatment; Product Development; Business and Government Relations; Biotechnology Industry; Biotechnology Industry; United States

May 2015
Case

Transforming Alkermes into a Global Biopharmaceutical Company

By: C. Fritz Foley and Nicholas Haas

In the summer of 2011, Jim Frates, CFO of Alkermes faced choices about how to finance the acquisition of Dublin, Ireland-based Elan Drug Technologies (EDT)—a deal that was expected to close in the fall. The case describes the history of Alkermes, provides information... View Details

Keywords: Financing; Debt; Merger; CFO; Financial Management; Biotechnology Industry; Biotechnology Industry; United States; Europe

April 2011
Teaching Note

Office of Technology Transfer - Shanghai Institutes for Biological Sciences (TN)

By: Willy Shih and Sen Chai

Teaching Note for 611057. View Details

Keywords: Patents; Rights; Infrastructure; Multinational Firms and Management; Research and Development; Complexity; Commercialization; Technology Adoption; Motivation and Incentives; Biotechnology Industry; Biotechnology Industry; Shanghai

March 2011 (Revised February 2012)
Case

Innovation and Growth at Actelion Ltd.

By: Gary P. Pisano, Daniela Beyersdorfer and Ruth Dittrich

In late 2010, Jean-Paul Clozel, CEO of the Swiss biotech pharmaceuticals firm Actelion, looks back on a successful decade. The small venture that he had started with a few of his scientist colleagues in the late 1990s to discover novel medicine in a research-driven... View Details

Keywords: Business Model; Talent and Talent Management; Innovation and Management; Leadership; Growth and Development Strategy; Product Development; Organizational Culture; Research and Development; Biotechnology Industry; Biotechnology Industry; Switzerland

February 2009
Case

Avid Radiopharmaceuticals: The Venture Debt Question

By: Matthew Rhodes-Kropf and Ann Leamon

The CEO of a promising biotech company must decide how to respond to the macro-economic slump of late 2008. He had planned to pursue an aggressive schedule, moving the firm's Alzheimer's and Parkinson's disease imaging compounds through clinical trials and into the... View Details

Keywords: Financial Crisis; Entrepreneurship; Borrowing and Debt; Venture Capital; Financial Management; Investment; Health Testing and Trials; Expansion; Biotechnology Industry; Biotechnology Industry

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