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  • All HBS Web  (1,053)
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  • January 2009 (Revised July 2009)
  • Case

Targanta Therapeutics: Hitting a Moving Target

By: Arthur A. Daemmrich
This case explores regulatory, product testing, and business strategy at Targanta Therapeutics, a biotech company preparing its first new drug application to the FDA. In October 2007, Mark Leuchtenberger, president and CEO of Targanta—which has just held a successful... View Details
Keywords: Decision Choices and Conditions; Entrepreneurship; Governing Rules, Regulations, and Reforms; Health Testing and Trials; Product Development; Business and Government Relations; Business Strategy; Biotechnology Industry; Pharmaceutical Industry
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Daemmrich, Arthur A. "Targanta Therapeutics: Hitting a Moving Target." Harvard Business School Case 709-002, January 2009. (Revised July 2009.)
  • 05 Jul 2006
  • Working Paper Summaries

Implementing New Practices: An Empirical Study of Organizational Learning in Hospital Intensive Care Units

Keywords: by Anita L. Tucker, Ingrid M. Nembhard & Amy C. Edmondson; Health
  • October 2024
  • Supplement

NOW PT (B)

By: George A Riedel, Allison J. Wigen and Dave Habeeb
Pre-Abstract: Instructors should consider the timing of making videos available to students, as they may reveal key case details.

Abstract: In fall 2021, a team of students from the HBS Impact Investing Fund considered Neurologic Optimal Wellness Physical... View Details
Keywords: Health Care and Treatment; Medical Specialties; Business Model; Investment; Health Industry; United States
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Riedel, George A., Allison J. Wigen, and Dave Habeeb. "NOW PT (B)." Harvard Business School Multimedia/Video Supplement 325-702, October 2024.
  • October 2024
  • Supplement

NOW PT (A)

By: George A Riedel, Allison J. Wigen and Dave Habeeb
Pre-Abstract: Instructors should consider the timing of making videos available to students, as they may reveal key case details.

Abstract: In fall 2021, a team of students from the HBS Impact Investing Fund considered Neurologic Optimal Wellness Physical... View Details
Keywords: Health Care and Treatment; Medical Specialties; Investment; Business Model; Health Industry; United States
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Riedel, George A., Allison J. Wigen, and Dave Habeeb. "NOW PT (A)." Harvard Business School Multimedia/Video Supplement 325-701, October 2024.
  • December 2021
  • Article

Primary Care Access During the COVID-19 Pandemic: a Simulated Patient Study

By: Michael Anne Kyle, Renuka Tipirneni, Nitya Thakore, Sneha Dave and Ishani Ganguli
Background
Primary care practices have experienced major strains during the COVID-19 pandemic, such that patients newly seeking care may face potential barriers to timely visits.
Objective
To quantify availability and wait times for new patient... View Details
Keywords: COVID-19; Ambulatory Care; Policy/economics; Access; Telemedicine; Health Pandemics; Health Care and Treatment
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Kyle, Michael Anne, Renuka Tipirneni, Nitya Thakore, Sneha Dave, and Ishani Ganguli. "Primary Care Access During the COVID-19 Pandemic: a Simulated Patient Study." Journal of General Internal Medicine 36, no. 12 (December 2021): 3766–3771.
  • 02 Jan 2024
  • Research & Ideas

10 Trends to Watch in 2024

The lightning-fast ascent of generative AI isn’t the only sea change on the horizon for businesses in the new year. The global economy is in flux as war, climate change, trade issues, and infrastructure problems demand attention. Many companies continue to struggle to... View Details
Keywords: by Rachel Layne
  • 16 Dec 2014
  • First Look

First Look: December 16

share the same ethnic, educational, or career background are more likely to syndicate with each other. This homophily reduces the probability of investment success, and the detrimental effect is most prominent for early-stage investments.... View Details
Keywords: Sean Silverthorne
  • 22 Aug 2012
  • Working Paper Summaries

A Randomized Field Study of a Leadership WalkRounds™-Based Intervention

Background: Leadership WalkRounds have been widely adopted as a technique for improving patient safety and safety climate. WalkRounds involve senior managers directly observing frontline work and soliciting... View Details
Keywords: by Anita L. Tucker & Sara J. Singer; Health
  • March 2020 (Revised June 2023)
  • Case

EyeControl: Inspiring Communication

By: Paul A. Gompers and Danielle Golan
Eye-controlled communication device startup EyeControl was founded in Tel Aviv, Israel in 2016 by cofounders with a shared personal connection to locked-in syndrome—a neurological disorder that left sufferers cognitively sound, yet paralyzed, with the exception of eye... View Details
Keywords: Health Disorders; Communication Technology; Business Startups; Expansion; Finance; Decision Making; Social Enterprise; Medical Devices and Supplies Industry
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Gompers, Paul A., and Danielle Golan. "EyeControl: Inspiring Communication." Harvard Business School Case 820-078, March 2020. (Revised June 2023.)
  • August 2017 (Revised July 2018)
  • Case

MannKind Corporation: Take a Deep Breath, This Time Afrezza Will Work

By: Elie Ofek and Amanda Dai
In June 2014, MannKind Corporation announced that after years of development and billions of dollars in expenses, the FDA had finally approved its drug, Afrezza. MannKind would thus be the only company with an inhalable insulin on the market. As an alternative to... View Details
Keywords: Health Care and Treatment; Product Launch; Product Positioning; Marketing Strategy; Adoption; Pharmaceutical Industry
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Ofek, Elie, and Amanda Dai. "MannKind Corporation: Take a Deep Breath, This Time Afrezza Will Work." Harvard Business School Case 518-031, August 2017. (Revised July 2018.)
  • April 2024
  • Article

A Machine Learning Algorithm Predicting Risk of Dilating VUR among Infants with Hydronephrosis Using UTD Classification

By: Hsin-Hsiao Scott Wang, Michael Lingzhi Li, Dylan Cahill, John Panagides, Tanya Logvinenko, Jeanne Chow and Caleb Nelson
Backgrounds: Urinary Tract Dilation (UTD) classification has been designed to be a more objective grading system to evaluate antenatal and post-natal UTD. Due to unclear association between UTD classifications to specific anomalies such as vesico-ureteral reflux (VUR),... View Details
Keywords: Health Disorders; Health Testing and Trials; AI and Machine Learning; Health Industry
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Wang, Hsin-Hsiao Scott, Michael Lingzhi Li, Dylan Cahill, John Panagides, Tanya Logvinenko, Jeanne Chow, and Caleb Nelson. "A Machine Learning Algorithm Predicting Risk of Dilating VUR among Infants with Hydronephrosis Using UTD Classification." Journal of Pediatric Urology 20, no. 2 (April 2024): 271–278.
  • 26 Nov 2013
  • First Look

First Look: November 26

http://www.ajmc.com/publications/issue/2013/2013-1-vol19-n9/Testimonials-Do-Not-Convert-Patients-From-Brand-to-Generic-Medication August 2013 Health Affairs Lessons from England's Health Care Workforce... View Details
Keywords: Sean Silverthorne
  • November 2023
  • Article

Effects of Remote Patient Monitoring Use on Care Outcomes Among Medicare Patients with Hypertension

By: Mitchell Tang, Carter Nakamoto, Ariel Dora Stern, Jose Zubizarreta, Felippe Marcondes, Lori Uscher-Pines, Lee Schwamm and Ateev Mehrotra
Background: Remote patient monitoring (RPM) is a promising tool for improving chronic disease management. Use of RPM for hypertension monitoring is growing rapidly, raising concerns about increased spending. However, the effects of RPM are still... View Details
Keywords: Cost; Health Care and Treatment; Measurement and Metrics
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Tang, Mitchell, Carter Nakamoto, Ariel Dora Stern, Jose Zubizarreta, Felippe Marcondes, Lori Uscher-Pines, Lee Schwamm, and Ateev Mehrotra. "Effects of Remote Patient Monitoring Use on Care Outcomes Among Medicare Patients with Hypertension." Annals of Internal Medicine 176, no. 11 (November 2023): 1465–1475.
  • 17 May 2016
  • First Look

May 17, 2016

2016 New York: Oxford University Press Consumers, Corporations, and Public Health: A Case-Based Approach to Sustainable Business By: John A. Quelch. Abstract—The public health footprint associated with... View Details
Keywords: Sean Silverthorne
  • June 2021
  • Article

From Predictions to Prescriptions: A Data-driven Response to COVID-19

By: Dimitris Bertsimas, Léonard Boussioux, Ryan Cory-Wright, Arthur Delarue, Vassilis Digalakis Jr, Alexander Jacquillat, Driss Lahlou Kitane, Galit Lukin, Michael Lingzhi Li, Luca Mingardi, Omid Nohadani, Agni Orfanoudaki, Theodore Papalexopoulos, Ivan Paskov, Jean Pauphilet, Omar Skali Lami, Bartolomeo Stellato, Hamza Tazi Bouardi, Kimberly Villalobos Carballo, Holly Wiberg and Cynthia Zeng
The COVID-19 pandemic has created unprecedented challenges worldwide. Strained healthcare providers make difficult decisions on patient triage, treatment and care management on a daily basis. Policy makers have imposed social distancing measures to slow the disease, at... View Details
Keywords: COVID-19; Health Pandemics; AI and Machine Learning; Forecasting and Prediction; Analytics and Data Science
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Bertsimas, Dimitris, Léonard Boussioux, Ryan Cory-Wright, Arthur Delarue, Vassilis Digalakis Jr, Alexander Jacquillat, Driss Lahlou Kitane, Galit Lukin, Michael Lingzhi Li, Luca Mingardi, Omid Nohadani, Agni Orfanoudaki, Theodore Papalexopoulos, Ivan Paskov, Jean Pauphilet, Omar Skali Lami, Bartolomeo Stellato, Hamza Tazi Bouardi, Kimberly Villalobos Carballo, Holly Wiberg, and Cynthia Zeng. "From Predictions to Prescriptions: A Data-driven Response to COVID-19." Health Care Management Science 24, no. 2 (June 2021): 253–272.
  • January–February 2024
  • Article

Shared Service Delivery Can Increase Client Engagement: A Study of Shared Medical Appointments

By: Ryan W. Buell, Kamalini Ramdas, Nazlı Sönmez, Kavitha Srinivasan and Rengaraj Venkatesh
Problem Definition: Clients and service providers alike often consider one-on-one service delivery to be ideal, assuming – perhaps unquestioningly – that devoting individualized attention best improves client outcomes. In contrast, in shared service delivery, clients... View Details
Keywords: Health Care and Treatment; Customer Satisfaction; Outcome or Result; Performance Improvement
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Buell, Ryan W., Kamalini Ramdas, Nazlı Sönmez, Kavitha Srinivasan, and Rengaraj Venkatesh. "Shared Service Delivery Can Increase Client Engagement: A Study of Shared Medical Appointments." Manufacturing & Service Operations Management 26, no. 1 (January–February 2024): 154–166.
  • 22 Jul 2014
  • First Look

First Look: July 22

Robert S., and Mary L. Witkowski Abstract—The paper describes the theory and preliminary results for an action research program that explores the implications from better measurements of View Details
Keywords: Sean Silverthorne
  • July 31, 2017
  • Article

A Commitment Contract to Achieve Virologic Suppression in Poorly Adherent Patients with HIV/AIDS

By: Marcella Alsan, John Beshears, Wendy S. Armstrong, James J. Choi, Brigitte C. Madrian, Minh Ly T. Nguyen, Carlos Del Rio, David Laibson and Vincent C. Marconi
Objective: Assess whether a commitment contract informed by behavioral economics leads to persistent virologic suppression among HIV-positive patients with poor antiretroviral therapy (ART) adherence. Design: Single-center pilot randomized clinical trial and a... View Details
Keywords: Adherence; Antiretroviral Therapy; Behavioral Economics; Commitment Contract; Financial Incentives; HIV-1 Virologic Suppression; Health Disorders; Motivation and Incentives
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Alsan, Marcella, John Beshears, Wendy S. Armstrong, James J. Choi, Brigitte C. Madrian, Minh Ly T. Nguyen, Carlos Del Rio, David Laibson, and Vincent C. Marconi. "A Commitment Contract to Achieve Virologic Suppression in Poorly Adherent Patients with HIV/AIDS." AIDS 31, no. 12 (July 31, 2017): 1765–1769.
  • May–June 2018
  • Article

Data Uncertainty in Markov Chains: Application to Cost-Effectiveness Analyses of Medical Innovations

By: Joel Goh, Mohsen Bayati, Stefanos A. Zenios, Sundeep Singh and David Moore
Cost-effectiveness studies of medical innovations often suffer from data inadequacy. When Markov chains are used as a modeling framework for such studies, this data inadequacy can manifest itself as imprecision in the elements of the transition matrix. In this paper,... View Details
Keywords: Markov Chains; Cost Effectiveness; Medical Innovations; Colorectal Cancer; Health Care and Treatment; Cost vs Benefits; Innovation and Invention; Mathematical Methods; Health Industry
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Goh, Joel, Mohsen Bayati, Stefanos A. Zenios, Sundeep Singh, and David Moore. "Data Uncertainty in Markov Chains: Application to Cost-Effectiveness Analyses of Medical Innovations." Operations Research 66, no. 3 (May–June 2018): 697–715. (Winner, 2014 INFORMS Health Applications Society Pierskalla Award & Finalist, 2014 INFORMS George E. Nicholson student paper competition.)
  • 12 Jun 2018
  • Research & Ideas

In a Landscape of 'Me Too' Drug Development, What Spurs Radical Innovation?

their cash reserves have suddenly expanded—they tend to put that extra budget towards more exploratory projects,” says Harvard Business School Assistant Professor Joshua Krieger. He co-authored the study Developing Novel Drugs with Danielle Li, Massachusetts Institute... View Details
Keywords: by Rachel Layne; Health; Health
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