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  • All HBS Web  (2,012)
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    • News  (624)
    • Research  (959)
    • Multimedia  (3)
  • Faculty Publications  (315)
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  • 2001
  • Chapter

Publicly Funded Science and the Productivity of the Pharmaceutical Industry

By: Rebecca Henderson and Ian Cockburn
U.S. taxpayers funded $14.8 billion of health related research last year, four times the amount that was spent in 1970 in real terms. In this paper we evaluate the impact of these huge expenditures on the technological performance of the pharmaceutical industry. While... View Details
Keywords: Public Sector; Science-Based Business; Research and Development; Sovereign Finance; Pharmaceutical Industry
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Henderson, Rebecca, and Ian Cockburn. "Publicly Funded Science and the Productivity of the Pharmaceutical Industry." In Innovation Policy and the Economy, Volume 1, edited by Adam B. Jaffe, Josh Lerner, and Scott Stern, 1–34. MIT Press, 2001.
  • November 2000
  • Case

Wit Capital: Evolution of the Online Investment Bank (B)

Describes the evolution of Wit Capital from its origins as a small brewery to an online investment bank advising both small technology-based companies seeking to raise capital and large companies seeking to acquire Internet companies, as well as offering retail... View Details
Keywords: Internet and the Web; Disruptive Innovation; Service Delivery; Investment Banking; Entrepreneurship
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Hallowell, Roger H., and Charles Ruberto. "Wit Capital: Evolution of the Online Investment Bank (B)." Harvard Business School Case 801-265, November 2000.
  • 25 Jul 2007
  • Lessons from the Classroom

The Evolution of Apple

success as it continues to expand its product line into handheld devices like the iPod and, now, the iPhone? The Apple case originally appeared in 1992 and has been rewritten 5 times since. "The company always looks a little... View Details
Keywords: by Julia Hanna; Computer; Technology
  • September 2012 (Revised April 2013)
  • Case

Digital Microscopy at Carl Zeiss: Managing Disruption

By: Willy Shih
Ulrich Simon, the head of the Microscopy business group at Carl Zeiss AG knew that his unit was facing a disruptive threat, so he chartered a special team to tackle the industrial segment. Given a high degree of autonomy, the project team developed an understanding of... View Details
Keywords: Modularity; High Technology Products; Emergent Strategy; Product Lines; Corporate Strategy; Digital Platforms; Disruptive Innovation; Technology Industry; Germany
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Shih, Willy. "Digital Microscopy at Carl Zeiss: Managing Disruption." Harvard Business School Case 613-039, September 2012. (Revised April 2013.)
  • August 2015
  • Case

Yabbly (A)

By: Shikhar Ghosh and Christopher Payton
In November 2013, with less than 10 months of cash on hand, Tom Leung, the founder and CEO of Yabbly, must decide where to focus his resources. His startup, a question-and-answer application for shopping decisions, had benefited from a strong showing at the SXSW... View Details
Keywords: Startup; Mobile; Online Product Reviews; Consumer Products; Business Model; Business Plan; Business Startups; Entrepreneurship; Innovation Strategy; Mobile and Wireless Technology; Internet and the Web; North America; United States; Washington (state, US); Seattle
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Ghosh, Shikhar, and Christopher Payton. "Yabbly (A)." Harvard Business School Case 816-030, August 2015.
  • 07 Jul 2015
  • First Look

First Look: July 7, 2015

economies. But only a handful of companies have managed to do it successfully until now. In this article, an MIT engineering professor and a Tuck professor of management explain why. After conducting a three-year study of reverse View Details
Keywords: Sean Silverthorne
  • 07 Jun 2023
  • HBS Case

3 Ways to Gain a Competitive Advantage Now: Lessons from Amazon, Chipotle, and Facebook

capabilities that they as a firm can hone, monitor, and manage,” she says. Those capabilities then allow the company to continuously produce innovative products at the same time they are creating more... View Details
Keywords: by Michael Blanding
  • 07 Feb 2017
  • First Look

First Look at New Research: February 7

opportunities to develop skills (“crucible experiences”) and a greater motivation to relocate out of the challenging context. We also find that managers deployed to a challenging context early in their careers continue to experience... View Details
Keywords: Sean Silverthorne
  • April 2025
  • Case

Kleiner Perkins (2019)

By: Jo Tango and Srimayi Mylavarapu
Kleiner Perkins, founded in 1972, quickly rose to prominence as one of Silicon Valley’s leading venture capital firms, earning a reputation for early investments in industry giants like Google, Amazon, and Citrix. However, a bold, strategic pivot to cleantech investing... View Details
Keywords: Venture Capital; Investment Funds; Technological Innovation; Entrepreneurial Finance; Organizational Change and Adaptation; Financial Services Industry
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Tango, Jo, and Srimayi Mylavarapu. "Kleiner Perkins (2019)." Harvard Business School Case 825-193, April 2025.
  • 23 Jun 2009
  • First Look

First Look: June 23

Principles that Matter: Sustaining Software Innovation from the Client to the Web Author:Marco Iansiti Abstract Economic analysis often reviews the role of principles—such as respect for intellectual property rights—in driving innovation.... View Details
Keywords: Martha Lagace
  • 2022
  • Book

Empires of Ideas: Creating the Modern University from Germany to America to China

By: William C. Kirby
The modern university was born in Germany. In the twentieth century, the United States leapfrogged Germany to become the global leader in higher education. Will China challenge its position in the twenty-first?
Today American institutions dominate nearly every... View Details
Keywords: University; Higher Education; History; United States; Germany; China
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Kirby, William C. Empires of Ideas: Creating the Modern University from Germany to America to China. Cambridge, MA: Belknap Press of Harvard University Press, 2022. (Extended Book Reviews at Foreign Policy and Inside Higher Ed.)
  • December 2003 (Revised April 2004)
  • Case

Blockbuster Inc. & Technological Substitution (D): The Threat of Direct Digital Distribution

Examines the emergence of technologies for delivering video content to consumer homes via direct digital distribution and investigates the strategic options facing video rental giant Blockbuster Inc. as it tries to respond to the new technological substitutes. Examines... View Details
Keywords: Organizational Change and Adaptation; Risk and Uncertainty; Decisions; Technological Innovation; Competition; Change Management; Service Industry; Motion Pictures and Video Industry
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Coughlan, Peter J., and Jenny Illes. "Blockbuster Inc. & Technological Substitution (D): The Threat of Direct Digital Distribution." Harvard Business School Case 704-463, December 2003. (Revised April 2004.)
  • 04 Jun 2007
  • Research & Ideas

Is Health Care Making You Better—or Dead?

the needs of human beings, not around the needs of the status quo, didn't happen. Consumer-Driven Health Care was another book that I wrote to help change the demand for health care, to get innovation in the insurance industry. That was... View Details
Keywords: by Sean Silverthorne; Health
  • 18 Jul 2017
  • First Look

First Look at New Research and Ideas, July 18, 2017

this be a Pyrrhic victory? Purchase this case:https://cb.hbsp.harvard.edu/cbmp/product/217062-PDF-ENG Harvard Business School Case 817-107 Edwin Land: The Art and Science of Innovation Throughout the second half of the 20th century,... View Details
Keywords: Sean Silverthorne
  • 03 May 2024
  • Research & Ideas

How Much Does Proximity Influence Startup Innovation? 20 Meters' Worth to Be Exact

COVID-19 pandemic. Four years after the pandemic sent workplaces into lockdown, organizations continue to weigh the benefits of collaboration from time together against the focus gained remotely. “The reality today is, we are unlikely to... View Details
Keywords: by Ben Rand
  • 07 Feb 2022
  • Research & Ideas

Digital Transformation: A New Roadmap for Success

digital transformation an even more urgent need, companies must also morph iteratively to keep up with the speed of emerging technologies. It’s a process of continuous learning and pivoting to adapt to an evolving competitive landscape.... View Details
Keywords: by Linda A. Hill, Ann Le Cam, Sunand Menon, and Emily Tedards
  • December 2003 (Revised April 2004)
  • Case

Blockbuster Inc. & Technological Substitution (B): Confronting New Digital Formats

Investigates how the rise of digital video formats threatens to make videocassette technology obsolete; how this technological substitution might alter the economics and structure of the video rental and retail industries; and how Blockbuster Inc., the industry leader,... View Details
Keywords: Risk and Uncertainty; Decisions; Technological Innovation; Competition; Change Management; Service Industry; Motion Pictures and Video Industry
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Coughlan, Peter J., and Jenny Illes. "Blockbuster Inc. & Technological Substitution (B): Confronting New Digital Formats." Harvard Business School Case 704-407, December 2003. (Revised April 2004.)
  • 31 Jan 2022
  • Research & Ideas

Where Can Digital Transformation Take You? Insights from 1,700 Leaders

is not for the fainthearted. Most of us know how to drive—we have the basics—but we recognize we are ill-prepared to race against world-class competitors. While data and digital technologies were once enablers of efficiency and cost-cutting, today, they’re the engines... View Details
Keywords: by Linda A. Hill, Ann Le Cam, Sunand Menon, and Emily Tedards
  • Research Summary

Sustainability and Integrated Reporting

A sustainable strategy for a company is one that enables it to create value for shareholders over the long term while contributing to a sustainable society. In doing so, it must balance the needs of different types of providers of financial capital (e.g.,... View Details

Keywords: Sustainability; Sustainability Reporting
  • January 2018 (Revised May 2018)
  • Case

AT&T Managing Technological Change and the Future of Telephone Operators in the 20th Century

By: Daniel P. Gross and William R. Kerr
By the 1930s, AT&T dominated the American phone industry, serving 10 million telephones and employing over 100,000 switchboard operators. But beginning in the mid-1910s, the company began changing from manually operated switchboards to mechanical switching systems that... View Details
Keywords: AT&T; Bell Telephone; Phone Lines; Phone Operators; Mechanical Switching; Layoffs; Technological Change; Transition; History; Innovation and Invention; Technological Innovation; Information Technology; Disruption; Change Management; Communications Industry; Telecommunications Industry; United States
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Gross, Daniel P., and William R. Kerr. "AT&T: Managing Technological Change and the Future of Telephone Operators in the 20th Century." Harvard Business School Case 718-486, January 2018. (Revised May 2018.)
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