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      • January 2023
      • Case

      The END Fund: To Eliminate Neglected Tropical Diseases

      By: V. Kasturi Rangan and Courtney Han
      Founded in 2012, the END fund focused on eliminating five Neglected Tropical Diseases that accounted for 80% of the tropical diseases affecting nearly 1.5 billion people worldwide. Its roughly $25 million/year annual budget was fully committed when it got news that the... View Details
      Keywords: Nonprofit Organizations; Health Disorders; Health Care and Treatment; Resource Allocation; Global Range; Decisions; Investment Funds
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      Rangan, V. Kasturi, and Courtney Han. "The END Fund: To Eliminate Neglected Tropical Diseases." Harvard Business School Case 523-063, January 2023.
      • January 2023
      • Case

      Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery

      By: Regina Herzlinger and Brian Walker
      What should a successful executive (HBS Baker Scholar) assess as her next move as the CEO of a firm with a promising and yet uncertain new drug? Amy Burroughs’ mandate to successfully commercialize Cleave Therapeutics’ drug for a cancer with no current successful... View Details
      Keywords: Product Development; Leadership; Health Testing and Trials; Research and Development; Risk and Uncertainty; Financial Condition; Partners and Partnerships; Pharmaceutical Industry
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      Herzlinger, Regina, and Brian Walker. "Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery." Harvard Business School Case 323-045, January 2023.
      • January 2023
      • Case

      Thomas Buberl: Refounding AXA

      By: Hubert Joly, Mihir Desai and Amram Migdal
      In 2022, AXA and its CEO Thomas Buberl faced new types of challenges, including systemic risks such as climate change, geopolitical instability, public health crises, and social tensions caused by economic risks. AXA was one of the world’s largest insurers. Since... View Details
      Keywords: Change; Change Management; Transformation; Transition; Trends; Environmental Management; Climate Change; Ethics; Values and Beliefs; Finance; Insurance; Management; Management Succession; Risk Management; Organizations; Corporate Social Responsibility and Impact; Mission and Purpose; Organizational Change and Adaptation; Planning; Strategic Planning; Risk and Uncertainty; Society; Human Needs; Social Issues; Strategy; Adaptation; Business Strategy; Corporate Strategy; Insurance Industry; Europe; France; Paris
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      Joly, Hubert, Mihir Desai, and Amram Migdal. "Thomas Buberl: Refounding AXA." Harvard Business School Case 523-059, January 2023.
      • 2023
      • Working Paper

      The Subjective Expected Utility Approach and a Framework for Defining Project Risk in Terms of Novelty and Feasibility—A Response to Franzoni and Stephan (2023), ‘Uncertainty and Risk-Taking in Science’

      By: Jacqueline N. Lane
      In their Discussion Paper, Franzoni and Stephan (F&S, 2023) discuss the shortcomings of existing peer review models in shaping the funding of risky science. Their discussion offers a conceptual framework for incorporating risk into peer review models of research... View Details
      Keywords: Risk and Uncertainty; Research; Resource Allocation; Perception
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      Lane, Jacqueline N. "The Subjective Expected Utility Approach and a Framework for Defining Project Risk in Terms of Novelty and Feasibility—A Response to Franzoni and Stephan (2023), ‘Uncertainty and Risk-Taking in Science’." Harvard Business School Working Paper, No. 23-037, January 2023.
      • January–February 2023
      • Article

      Data-Driven COVID-19 Vaccine Development for Janssen

      By: Dimitris Bertsimas, Michael Lingzhi Li, Xinggang Liu, Jennings Xu and Najat Khan
      The COVID-19 pandemic has spurred extensive vaccine research worldwide. One crucial part of vaccine development is the phase III clinical trial that assesses the vaccine for safety and efficacy in the prevention of COVID-19. In this work, we enumerate the first... View Details
      Keywords: COVID-19; Health Testing and Trials; Forecasting and Prediction; AI and Machine Learning; Research; Pharmaceutical Industry
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      Bertsimas, Dimitris, Michael Lingzhi Li, Xinggang Liu, Jennings Xu, and Najat Khan. "Data-Driven COVID-19 Vaccine Development for Janssen." INFORMS Journal on Applied Analytics 53, no. 1 (January–February 2023): 70–84.
      • 2 Mar 2023 - 4 Mar 2023
      • Conference Presentation

      Ethical Risks of Autonomous Products: The Case of Mental Health Crises on AI Companion Applications

      By: Julian De Freitas, K. Uguralp and Z. Oguz
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      De Freitas, Julian, K. Uguralp, and Z. Oguz. "Ethical Risks of Autonomous Products: The Case of Mental Health Crises on AI Companion Applications." Paper presented at the Society for Consumer Psychology Annual Conference, San Juan, PR, March 2–4, 2023.
      • 2023
      • Article

      Experimental Evaluation of Individualized Treatment Rules

      By: Kosuke Imai and Michael Lingzhi Li
      The increasing availability of individual-level data has led to numerous applications of individualized (or personalized) treatment rules (ITRs). Policy makers often wish to empirically evaluate ITRs and compare their relative performance before implementing them in a... View Details
      Keywords: Causal Inference; Heterogeneous Treatment Effects; Precision Medicine; Uplift Modeling; Analytics and Data Science; AI and Machine Learning
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      Imai, Kosuke, and Michael Lingzhi Li. "Experimental Evaluation of Individualized Treatment Rules." Journal of the American Statistical Association 118, no. 541 (2023): 242–256.
      • January 2023
      • Article

      Psychological Safety Comes of Age: Observed Themes in an Established Literature

      By: Amy C. Edmondson and Derrick P. Bransby
      Since its renaissance in the 1990s, psychological safety research has flourished—a boom motivated by recognition of the challenge of navigating uncertainty and change. Today, its theoretical and practical significance is amplified by the increasingly complex and... View Details
      Keywords: Safety; Risk and Uncertainty; Leadership; Working Conditions; Research; Performance; Learning; Organizational Culture
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      Edmondson, Amy C., and Derrick P. Bransby. "Psychological Safety Comes of Age: Observed Themes in an Established Literature." Annual Review of Organizational Psychology and Organizational Behavior 10 (January 2023): 55–78.
      • 2023
      • Working Paper

      The Evolving Academic Field of Climate Finance

      By: Matteo Gasparini and Peter Tufano
      The urgency and the magnitude of climate change will affect every aspect of our economies, societies, and planet. The academic finance research has begun to study the financial implications of global warming, although this body of literature is small. The field has... View Details
      Keywords: Climate Finance; Finance Academia; Greenhouse Gas; Sustainable Finance; Financial Decisions; Educational Finance; Finance; Climate Change; Transition
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      Gasparini, Matteo, and Peter Tufano. "The Evolving Academic Field of Climate Finance." Harvard Business School Working Paper, No. 23-057, January 2023.
      • December 2022
      • Case

      To Feed the Planet: Juan Luciano at ADM

      By: Joshua D. Margolis, David E. Bell, Damien McLoughlin, Stacy Straaberg and James Weber
      In December 2022, Juan Luciano, Chairman and CEO of agribusiness and nutrition giant ADM, considered the next phase of the historic company’s future. Beginning in 2011 when he joined as COO and moving into his tenure as CEO in 2015, Luciano led a transformation of ADM... View Details
      Keywords: Agriculture; Leadership; Agribusiness; Acquisition; Business Units; Customer Focus and Relationships; Customer Value and Value Chain; Forecasting and Prediction; Capital; Cash; Cost of Capital; Cost Management; Profit; Food; Global Range; Innovation Strategy; Leadership Development; Leadership Style; Leading Change; Growth and Development Strategy; Risk Management; Organizational Culture; Organizational Structure; Strategic Planning; Risk and Uncertainty; Adaptation; Business Strategy; Corporate Strategy; Vertical Integration; Value Creation; Transformation; Agriculture and Agribusiness Industry; Agriculture and Agribusiness Industry; United States; Chicago
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      Margolis, Joshua D., David E. Bell, Damien McLoughlin, Stacy Straaberg, and James Weber. "To Feed the Planet: Juan Luciano at ADM." Harvard Business School Case 423-060, December 2022.
      • December 2022
      • Technical Note

      Risks and Opportunities from the Transition to a Low Carbon Economy: A Business Analysis Framework

      By: George Serafeim
      The transition to a low carbon economy introduces many risks and opportunities for businesses. Risks emerge from regulatory actions, such as carbon taxes and cap and trade systems, technological innovation that develop alternatives for customers making existing... View Details
      Keywords: Risk Assessment; Opportunities; Environmental Sustainability; Carbon Footprint; Risk Management; Competitive Dynamics; Business Analysis; Climate Change; Accounting; Finance; Valuation; Business and Shareholder Relations; Technological Innovation; Transition; Product Positioning; Renewable Energy; Analysis
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      Serafeim, George. "Risks and Opportunities from the Transition to a Low Carbon Economy: A Business Analysis Framework." Harvard Business School Technical Note 123-014, December 2022.
      • December 7, 2022
      • Article

      Why Decentralized Crypto Platforms Are Weathering the Crash

      By: Shai Bernstein and Scott Duke Kominers
      In the past year, crypto markets dropped from $2.9 trillion in value to around $800 billion. In the wake of the collapse, crypto lenders and exchanges have been accused of fraud and other wrongdoing. What went wrong? One factor is competition. In theory, competition... View Details
      Keywords: Crypto Economy; Cryptocurrency; Financial Complexity; Financial Crisis; Decentralization; Decentralized Markets; Decentralized Autonomous Organizations; Finance; Market Design; Financial Services Industry
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      Bernstein, Shai, and Scott Duke Kominers. "Why Decentralized Crypto Platforms Are Weathering the Crash." Harvard Business Review Digital Articles (December 7, 2022).
      • December 2022
      • Article

      Does Industry Employment of Active Regulators Weaken Oversight?

      By: Jonas Heese
      I study whether industry employment of active regulators weakens oversight. To examine this question, I exploit that the Financial Reporting Enforcement Panel (FREP), the German capital-market regulator responsible for enforcing public firms’ compliance with accounting... View Details
      Keywords: Conflict-of-interest Policies; Directorships; Enforcement Actions; Industry Employment; Self-regulatory Organizations; Governance Compliance; Governing and Advisory Boards; Policy; Conflict of Interests
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      Heese, Jonas. "Does Industry Employment of Active Regulators Weaken Oversight?" Management Science 68, no. 12 (December 2022): 9198–9218.
      • December 2022
      • Article

      I Don't 'Recall': The Decision to Delay Innovation Launch to Avoid Costly Product Failure

      By: Byungyeon Kim, Oded Koenigsberg and Elie Ofek
      Innovations embody novel features or cutting-edge components aimed at delivering desired customer benefits. Oftentimes, however, we observe the need to recall new products shortly after their introduction. Indeed, a firm may rush an innovation to market in an attempt... View Details
      Keywords: Innovation Management; Innovation And Strategy; Product Development Strategy; Product Introduction; Quality Control; Product Recalls; Game Theory; Market Timing; Innovation Strategy; Product Launch; Product Development
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      Kim, Byungyeon, Oded Koenigsberg, and Elie Ofek. "I Don't 'Recall': The Decision to Delay Innovation Launch to Avoid Costly Product Failure." Management Science 68, no. 12 (December 2022): 8889–8908.
      • 2022
      • Article

      Leadership & Overconfidence

      By: Don A Moore and Max H. Bazerman
      Expressions of confidence can give leaders credibility. In the political realm, they can earn votes and public approval for decisions made in office. Such support is justified when the confidence displayed is truly a sign that a leader (whether a candidate or an... View Details
      Keywords: Personal Characteristics; Leadership; Government Legislation; Political Elections
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      Moore, Don A., and Max H. Bazerman. "Leadership & Overconfidence." Behavioral Science & Policy 8, no. 2 (2022): 59–69.
      • December 2022
      • Article

      Two Representations of Information Structures and Their Comparisons

      By: Jerry R. Green and Nancy L. Stokey
      This paper compares two representations of informativeness. View Details
      Keywords: Decision Choices and Conditions; Risk and Uncertainty; Information; Analysis
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      Green, Jerry R., and Nancy L. Stokey. "Two Representations of Information Structures and Their Comparisons." Decisions in Economics and Finance 45, no. 2 (December 2022): 541–547.
      • November 2022
      • Technical Note

      National Security and Transnational Capitalism

      By: Meg Rithmire
      Though the relationship between national security and transnational commerce had long been interrogated and contested, the 2020s saw the escalation of concerns about insecurity and interdependence. These concerns manifested in a suite of institutional innovations and... View Details
      Keywords: Capitalism; National Security; Globalization
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      Rithmire, Meg. "National Security and Transnational Capitalism." Harvard Business School Technical Note 723-016, November 2022.
      • 2022
      • Article

      Climate Change Vulnerability and Currency Returns

      By: Alex Cheema-Fox, George Serafeim and Hui (Stacie) Wang
      Using measures of physical risk from climate change, we develop a methodology to allocate currency pairs according to a country’s vulnerability and construct portfolios with decreasing vulnerability to physical risk. We show that non-G10 currencies are more vulnerable... View Details
      Keywords: Climate Finance; Vulnerabilities; Currencies; Foreign Exchange; Climate Change; Currency; Natural Disasters
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      Cheema-Fox, Alex, George Serafeim, and Hui (Stacie) Wang. "Climate Change Vulnerability and Currency Returns." Financial Analysts Journal 78, no. 4 (2022): 37–58.
      • November 2022
      • Article

      Opportunity Neglect: An Aversion to Low-probability Gains

      By: Emily Prinsloo, Kate Barasz, Leslie K. John and Michael I. Norton
      Seven preregistered studies (N = 2,890) conducted in the field, lab, and online document opportunity neglect: a tendency to reject opportunities with low probability of success, even when they come with little or no objective cost (e.g., time, money,... View Details
      Keywords: Opportunities; Behavior; Risk and Uncertainty; Success; Perception
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      Prinsloo, Emily, Kate Barasz, Leslie K. John, and Michael I. Norton. "Opportunity Neglect: An Aversion to Low-probability Gains." Psychological Science 33, no. 11 (November 2022): 1857–1866.
      • 2022
      • Working Paper

      The Issuance and Design of Sustainability-linked Loans

      By: Maria Loumioti and George Serafeim
      Sustainability-linked loans (i.e., syndicated loans for which pricing is linked to a sustainability performance indicator) have rapidly evolved into a significant private debt product. We find that sustainability-linked lending has been available mostly to borrowers... View Details
      Keywords: Sustainability; Sustainability Management; Credit Products; Loan Contracts; Loans; Corporate Finance; Credit Risk; Environment; ESG; ESG Ratings; Climate Change; Finance; Borrowing and Debt; Risk and Uncertainty; Credit
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      Loumioti, Maria, and George Serafeim. "The Issuance and Design of Sustainability-linked Loans." Harvard Business School Working Paper, No. 23-027, November 2022.
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