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      • January 2023
      • Case

      Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery

      By: Regina Herzlinger and Brian Walker
      What should a successful executive (HBS Baker Scholar) assess as her next move as the CEO of a firm with a promising and yet uncertain new drug? Amy Burroughs’ mandate to successfully commercialize Cleave Therapeutics’ drug for a cancer with no current successful... View Details
      Keywords: Product Development; Leadership; Health Testing and Trials; Research and Development; Risk and Uncertainty; Financial Condition; Partners and Partnerships; Pharmaceutical Industry
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      Herzlinger, Regina, and Brian Walker. "Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery." Harvard Business School Case 323-045, January 2023.
      • January 2023 (Revised November 2024)
      • Case

      ELCA's Series A

      By: Anke Becker, Raymond Kluender and William R. Kerr
      Vu Phong and Xavier Silva co-founded ELCA to build proprietary software for their technology-enabled language learning tool. Since winning a prestigious venture contest in 2021, their number of registered users grew rapidly, as did the demand for new features like... View Details
      Keywords: Entrepreneurial Finance; Business Startups; Venture Capital; Growth and Development Strategy
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      Becker, Anke, Raymond Kluender, and William R. Kerr. "ELCA's Series A." Harvard Business School Case 823-079, January 2023. (Revised November 2024.)
      • January 2023
      • Case

      Thomas Buberl: Refounding AXA

      By: Hubert Joly, Mihir Desai and Amram Migdal
      In 2022, AXA and its CEO Thomas Buberl faced new types of challenges, including systemic risks such as climate change, geopolitical instability, public health crises, and social tensions caused by economic risks. AXA was one of the world’s largest insurers. Since... View Details
      Keywords: Change; Change Management; Transformation; Transition; Trends; Environmental Management; Climate Change; Ethics; Values and Beliefs; Finance; Insurance; Management; Management Succession; Risk Management; Organizations; Corporate Social Responsibility and Impact; Mission and Purpose; Organizational Change and Adaptation; Planning; Strategic Planning; Risk and Uncertainty; Society; Human Needs; Social Issues; Strategy; Adaptation; Business Strategy; Corporate Strategy; Insurance Industry; Europe; France; Paris
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      Joly, Hubert, Mihir Desai, and Amram Migdal. "Thomas Buberl: Refounding AXA." Harvard Business School Case 523-059, January 2023.
      • 2023
      • Working Paper

      Achieving Universal Health Insurance Coverage in the United States: Addressing Market Failures or Providing a Social Floor?

      By: Katherine Baicker, Amitabh Chandra and Mark Shepard
      The United States spends substantially more on health care than most developed countries, yet leaves a greater share of the population uninsured. We suggest that incremental insurance expansions focused on addressing market failures will propagate inefficiencies and... View Details
      Keywords: Public Sector; Insurance; Health Care and Treatment; Policy; Innovation and Invention
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      Baicker, Katherine, Amitabh Chandra, and Mark Shepard. "Achieving Universal Health Insurance Coverage in the United States: Addressing Market Failures or Providing a Social Floor?" NBER Working Paper Series, No. 30854, January 2023.
      • January–February 2023
      • Article

      Triadic Advocacy Work

      By: Summer R. Jackson and Katherine C. Kellogg
      Scholars of street-level bureaucracy and institutional research focus primarily on the relationships between advocates and their larger bureaucratic and social systems, assuming that advocates have little need to satisfy their beneficiaries. We find otherwise in our... View Details
      Keywords: Occupations And Professions; Ethnography; Power And Politics; Work And Organizations; Advocacy; Public Management; Justice
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      Jackson, Summer R., and Katherine C. Kellogg. "Triadic Advocacy Work." Organization Science 34, no. 1 (January–February 2023): 456–483.
      • December 2022
      • Case

      To Feed the Planet: Juan Luciano at ADM

      By: Joshua D. Margolis, David E. Bell, Damien McLoughlin, Stacy Straaberg and James Weber
      In December 2022, Juan Luciano, Chairman and CEO of agribusiness and nutrition giant ADM, considered the next phase of the historic company’s future. Beginning in 2011 when he joined as COO and moving into his tenure as CEO in 2015, Luciano led a transformation of ADM... View Details
      Keywords: Agriculture; Leadership; Agribusiness; Acquisition; Business Units; Customer Focus and Relationships; Customer Value and Value Chain; Forecasting and Prediction; Capital; Cash; Cost of Capital; Cost Management; Profit; Food; Global Range; Innovation Strategy; Leadership Development; Leadership Style; Leading Change; Growth and Development Strategy; Risk Management; Organizational Culture; Organizational Structure; Strategic Planning; Risk and Uncertainty; Adaptation; Business Strategy; Corporate Strategy; Vertical Integration; Value Creation; Transformation; Agriculture and Agribusiness Industry; Energy Industry; United States; Chicago
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      Margolis, Joshua D., David E. Bell, Damien McLoughlin, Stacy Straaberg, and James Weber. "To Feed the Planet: Juan Luciano at ADM." Harvard Business School Case 423-060, December 2022.
      • December 2022
      • Case

      The Magic of Marks & Spencer Food

      By: David E. Bell, Natalie Kindred and Damien McLoughlin
      Keywords: Brands and Branding; Food; Consumer Behavior; Product Development; Competition; Price; Inflation and Deflation; Trends; Growth and Development; Strategy; Retail Industry; Consumer Products Industry; Food and Beverage Industry; United Kingdom
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      Bell, David E., Natalie Kindred, and Damien McLoughlin. "The Magic of Marks & Spencer Food." Harvard Business School Case 523-080, December 2022.
      • December 2022
      • Technical Note

      Risks and Opportunities from the Transition to a Low Carbon Economy: A Business Analysis Framework

      By: George Serafeim
      The transition to a low carbon economy introduces many risks and opportunities for businesses. Risks emerge from regulatory actions, such as carbon taxes and cap and trade systems, technological innovation that develop alternatives for customers making existing... View Details
      Keywords: Risk Assessment; Opportunities; Environmental Sustainability; Carbon Footprint; Risk Management; Competitive Dynamics; Business Analysis; Climate Change; Accounting; Finance; Valuation; Business and Shareholder Relations; Technological Innovation; Transition; Product Positioning; Renewable Energy; Analysis
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      Serafeim, George. "Risks and Opportunities from the Transition to a Low Carbon Economy: A Business Analysis Framework." Harvard Business School Technical Note 123-014, December 2022.
      • November 2022
      • Case

      Ajax Health: A New Model for Medical Technology Innovation

      By: Regina E. Herzlinger and Ben Creo
      This case teaches key success factors for both startup and established MedTech firms. It examines how to structure a firm to maximize innovation and financial returns with organizational structures that better align the incentives for the different skill sets... View Details
      Keywords: Business Startups; Success; Innovation Strategy; Mergers and Acquisitions; Market Entry and Exit; Financial Strategy; Business Model; Partners and Partnerships; Entrepreneurship; Private Equity; Technology Industry; Medical Devices and Supplies Industry
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      Herzlinger, Regina E., and Ben Creo. "Ajax Health: A New Model for Medical Technology Innovation." Harvard Business School Case 323-043, November 2022.
      • November 2022 (Revised October 2024)
      • Case

      'A Marshall Plan for Africa': James Mwangi and Equity Group Holdings

      By: Caroline M. Elkins, Debora L. Spar, Zeke Gillman and Julia M. Comeau
      Financial Inclusion. Dignity. Trust. These were the core principles driving James Mwangi’s transformation of Equity Building Society, insolvent in 1991, into what is, today, Equity Group Holdings, East and Central Africa’s largest retail banking institution. Raised in... View Details
      Keywords: Income Inequality; Micro Finance; Microcredit; Microfinance; Banks and Banking; Equality and Inequality; Mission and Purpose; Business Model; Social Entrepreneurship; Banking Industry; Financial Services Industry; Africa; Kenya
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      Elkins, Caroline M., Debora L. Spar, Zeke Gillman, and Julia M. Comeau. "'A Marshall Plan for Africa': James Mwangi and Equity Group Holdings." Harvard Business School Case 323-048, November 2022. (Revised October 2024.)
      • November 2022
      • Technical Note

      National Security and Transnational Capitalism

      By: Meg Rithmire
      Though the relationship between national security and transnational commerce had long been interrogated and contested, the 2020s saw the escalation of concerns about insecurity and interdependence. These concerns manifested in a suite of institutional innovations and... View Details
      Keywords: Capitalism; National Security; Globalization
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      Rithmire, Meg. "National Security and Transnational Capitalism." Harvard Business School Technical Note 723-016, November 2022.
      • 2022
      • Article

      Climate Change Vulnerability and Currency Returns

      By: Alex Cheema-Fox, George Serafeim and Hui (Stacie) Wang
      Using measures of physical risk from climate change, we develop a methodology to allocate currency pairs according to a country’s vulnerability and construct portfolios with decreasing vulnerability to physical risk. We show that non-G10 currencies are more vulnerable... View Details
      Keywords: Climate Finance; Vulnerabilities; Currencies; Foreign Exchange; Climate Change; Currency; Natural Disasters
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      Cheema-Fox, Alex, George Serafeim, and Hui (Stacie) Wang. "Climate Change Vulnerability and Currency Returns." Financial Analysts Journal 78, no. 4 (2022): 37–58.
      • October 2022 (Revised January 2023)
      • Case

      Century Bank: Closing Time?

      By: Lauren Cohen, Grace Headinger and Bill Kwon
      Barry Sloane, second-generation Chairman, President, and CEO of his family’s bank, Century Bank, weighed whether to sell to Eastern Bank. As a small regional bank, Century faced a number of challenging trends, such as digitization and market share decline in the coming... View Details
      Keywords: Family Office; Business Exit; Banking; Family; Massachusetts; Boston; United States; Acquisition; Business Exit or Shutdown; Family Business; Family and Family Relationships; Interpersonal Communication; Decision Making; Finance; Banks and Banking; Risk and Uncertainty; Emotions; Banking Industry; Boston; Massachusetts; United States
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      Cohen, Lauren, Grace Headinger, and Bill Kwon. "Century Bank: Closing Time?" Harvard Business School Case 223-040, October 2022. (Revised January 2023.)
      • October 2022
      • Case

      Pricing at Echosec Systems

      By: Elie Ofek, Marco Bertini, Annelena Lobb and Alexis Lefort
      This case follows the evolution of pricing strategy at Echosec Systems, a Canadian open source intelligence firm. The case provides information on pricing as the company grows and diversifies its product offerings. View Details
      Keywords: Marketing Strategy; Product Positioning; Price; Product Development; Information Industry; Canada; United States
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      Ofek, Elie, Marco Bertini, Annelena Lobb, and Alexis Lefort. "Pricing at Echosec Systems." Harvard Business School Case 523-052, October 2022.
      • October 2022 (Revised February 2024)
      • Case

      Masdar City: Aiming for Sustainable and Profitable Real Estate

      By: Boris Vallee and Fares Khrais
      Masdar City broke ground in 2008 and was conceived by the Abu Dhabi government to be an international beacon of innovation in sustainable energy and real estate. It was also to be a profitable investment for the government. At first glance, the two goals pulled in... View Details
      Keywords: Analysis; Business Growth And Maturation; Decisions; Public Sector; Financial Crisis; Construction; Climate Change; Green Technology; Borrowing And Debt; Corporate Finance; Capital; Capital Budgeting; Capital Structure; Cost Of Capital; Equity; REIT; Financial Management; Financial Strategy; Initial Public Offering; Innovation; Growth And Development Strategy; Emerging Markets; Urban Development; Middle East; United Arab Emirates; Sustainable Cities; Green Building; Business and Government Relations; Decision Choices and Conditions; Financing and Loans; Real Estate Industry; Construction Industry; Energy Industry; Green Technology Industry; Abu Dhabi
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      Vallee, Boris, and Fares Khrais. "Masdar City: Aiming for Sustainable and Profitable Real Estate." Harvard Business School Case 223-036, October 2022. (Revised February 2024.)
      • October 2022 (Revised September 2024)
      • Case

      mPharma: Scaling Access to Affordable Primary Care in Africa

      By: Regina E. Herzlinger and Ben Creo
      mPharma hopes to scale up to create the largest pan-African healthcare company ever to provide much-needed primary care in retail pharmacies; a reliable, fairly priced supply of drugs; and micro-insurance for drugs. They must prioritize launching a telemedicine... View Details
      Keywords: Africa; Pharmaceutical Companies; Pharmacy Benefit Manager; Health Care; Health Care And Treatment; Health Care Costs; Health Care Delivery; Health Care Entrepreneurship; Telehealth; Health Equity; Corporate Strategy; Social Entrepreneurship; Equity; Growth and Development Strategy; Expansion; Product Launch; Customer Value and Value Chain; Social Enterprise; Multinational Firms and Management; Pharmaceutical Industry; Health Industry; Africa
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      Herzlinger, Regina E., and Ben Creo. "mPharma: Scaling Access to Affordable Primary Care in Africa." Harvard Business School Case 323-033, October 2022. (Revised September 2024.)
      • October 2022
      • Case

      Beam Dental (A)

      By: Rembrand Koning and Alicia Dadlani
      In May 2014, Alex Frommeyer, cofounder and CEO of Kentucky-based Beam Dental, a seed-stage startup that developed connected toothbrushes that tracked brushing habits, needed to decide which strategy to pitch to a venture capital firm. The first pitch deck played to the... View Details
      Keywords: Business Startups; Business Strategy; Entrepreneurship; Financing and Loans; Presentations; Product Development; Insurance Industry; United States; Kentucky; Ohio
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      Koning, Rembrand, and Alicia Dadlani. "Beam Dental (A)." Harvard Business School Case 723-355, October 2022.
      • Article

      Recovering Investor Expectations from Demand for Index Funds

      By: Mark Egan, Alexander J. MacKay and Hanbin Yang
      We use a revealed-preference approach to estimate investor expectations of stock market returns. Using data on demand for index funds that follow the S&P 500, we develop and estimate a model of investor choice to flexibly recover the time-varying distribution of... View Details
      Keywords: Stock Market Expectations; Demand Estimation; Exchange-traded Funds (ETFs); Demand and Consumers; Investment
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      Egan, Mark, Alexander J. MacKay, and Hanbin Yang. "Recovering Investor Expectations from Demand for Index Funds." Review of Economic Studies 89, no. 5 (October 2022): 2559–2599.
      • September 2022 (Revised June 2025)
      • Case

      York Capital CLOs and WorldStrides International

      By: Victoria Ivashina and William Vrattos
      The case follows the debt restructuring of WorldStrides International, a travel program provider in the education market, after the onset of COVID-19. The pandemic severely impacted the travel industry, creating challenges for many companies like WorldStrides, which... View Details
      Keywords: COVID-19 Pandemic; Debt Restructuring; CLO; Compliance; Debt Securities; Financing and Loans; Decision Making; Travel Industry; Education Industry
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      Ivashina, Victoria, and William Vrattos. "York Capital CLOs and WorldStrides International." Harvard Business School Case 223-034, September 2022. (Revised June 2025.)
      • September 2022
      • Article

      Find and Replace: R&D Investment Following the Erosion of Existing Products

      By: Joshua L. Krieger, Xuelin Li and Richard T. Thakor
      How do innovative firms react when existing products experience negative shocks? We explore this question with detailed project-level data from drug development firms. Using FDA Public Health Advisories as idiosyncratic negative shocks to approved drugs, we first... View Details
      Keywords: R&D Investments; Drug Development; Product Shocks; M&A; Biopharmaceutical Industry; FDA; System Shocks; Research and Development; Investment; Decision Making; Pharmaceutical Industry
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      Krieger, Joshua L., Xuelin Li, and Richard T. Thakor. "Find and Replace: R&D Investment Following the Erosion of Existing Products." Management Science 68, no. 9 (September 2022): 6552–6571.
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