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September–October 2020
Article

The Past, Present, and (Near) Future of Gene Therapy and Gene Editing

By: Julia Pian, Amitabh Chandra and Ariel Dora Stern

Emerging gene therapy and gene-editing technologies will have a growing impact on patient lives and health-care delivery. We analyzed a decade of data on clinical trials and venture capital investments to understand the likely trajectory of genetically focused... View Details

Keywords: Gene Therapy; Gene Editing; Impact; Health Care and Treatment; Technological Innovation; Health Testing and Trials; Venture Capital; Change

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05 Apr 2010
Research & Ideas

HBS Cases: iPads, Kindles, and the Close of a Chapter in Book Publishing

Two days ago, the first buyers of Apple's iPad began putting it through its paces, playing games, navigating the Internet, and downloading electronic books. That groan you heard was from dozens of book... View Details

Keywords: by Julia Hanna; Information; Publishing; Entertainment & Recreation

2016
Working Paper

Markets for Ideas: Prize Structure, Entry Limits, and the Design of Ideation Contests

By: Pavel Kireyev

Contests are a popular mechanism for the procurement of innovation. In marketing, design, and other creative industries, firms use freelance marketplaces to organize contests and obtain high-quality ideas for ads, new products, and even business strategies from... View Details

Keywords: Idea Generation; Crowdsourcing; Contest Design; Structural Estimation; Motivation and Incentives; Competition; Innovation and Invention

01 Dec 2017
News

2017 in Manufacturing: The Supply Chain Goes High Tech

The globalization of manufacturing and the increased dependence on digital technology is transforming the sector and changing its competitive advantage profile. This is a long-term trend, but we are seeing its effects more clearly with... View Details

Keywords: Jerry Jasinowski (AMP 97, 1985), former president and CEO, National Association of Manufacturers

Article

Creating Ecotourism in Costa Rica, 1970–2000

By: Geoffrey Jones and Andrew Spadafora

Between the 1970s and the 2000s, Costa Rica became established as the world’s leading ecotourism destination. This article argues that although Costa Rica benefited from biodiversity and a pleasant climate, the country’s preeminence in ecotourism requires more than a... View Details

Keywords: Ecotourism; Entrepreneurship In Emerging Markets; Sustainable Business And Innovation; Tourism; Green Business; Entrepreneurship; Growth and Development; History; Business History; Tourism Industry; Latin America; Costa Rica

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July 2013 (Revised August 2017)
Case

TaKaDu

By: Elie Ofek and Matthew Preble

In December 2012, Amir Peleg, founder and CEO of TaKaDu, reflected on how to position his young firm for the next fiscal year and beyond. The small Israeli startup had developed an innovative software system that used patented algorithms and statistical analysis to... View Details

December 2003 (Revised April 2004)
Case

Blockbuster Inc. & Technological Substitution (D): The Threat of Direct Digital Distribution

Examines the emergence of technologies for delivering video content to consumer homes via direct digital distribution and investigates the strategic options facing video rental giant Blockbuster Inc. as it tries to respond to the new technological substitutes. Examines... View Details

Keywords: Organizational Change and Adaptation; Risk and Uncertainty; Decisions; Technological Innovation; Competition; Change Management; Service Industry; Motion Pictures and Video Industry

2025
Working Paper

Magnetic Resonance Imaging—High Quality and Radiation Free: Case Histories of Transformational Advances

By: Srikant M. Datar, Amar Bhidé and Katherine Stebbins

This case history describes how Magnetic Resource Imaging (MRI) came to complement – and partially replace -- computed tomography (CT) imaging of soft tissue. Specifically, we chronicle 1) the development of foundational techniques and prototypes (through the 1970s);... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

02 Sep 2014
News

Many of the best ideas for improving health care are quite simple

about what, group experience in adapting to change, the likelihood of integrating information to develop innovative solutions, and the competitive advantage of team... View Details

March 1992 (Revised May 1992)
Teaching Note

Skunkworks at Digital Equipment Corp.: The Tale of XCON, Teaching Note

By: Dorothy A. Leonard

Keywords: Innovation and Invention; Electronics Industry; Computer Industry

March 2017
Case

From mHealth Hackathon to Reality: Diabetes Care

By: Kevin Schulman and Curry Cheek

This case explores the development of a business plan for a mobile health application for diabetes care. The case depicts a student team excited about the opportunity to improve the care of patients with diabetes by contracting an app. They go through a rigorous... View Details

Keywords: Innovation; Mobile Health Technologies; Health Care; Health Care Industry; Behavioral Economics; Applications and Software; Health Care and Treatment; Mobile and Wireless Technology; Innovation and Invention; Health Industry; Telecommunications Industry

05 Oct 2016
What Do You Think?

Can the US Economy Regain the Growth and Prosperity of the Past?

graduates and former students who are exploring innovations such as battery technology, superconductivity, magnetism, and superintelligent computers. My feelings are buoyed when I read about a “second machine age” fueled by digital... View Details

Keywords: by James Heskett

August 2017 (Revised May 2019)
Case

Hilti (A): Fleet Management?

By: Ramon Casadesus-Masanell, Oliver Gassmann and Roman Sauer

This case explores the strategic decision-making process of premium power tools manufacturer Hilti in 1999, when the company was considering implementing a fleet management system in the construction industry. Fleet management would involve a shift from selling power... View Details

September 2020 (Revised June 2021)
Case

Algramo

By: Michael Chu, Monica Silva and Mariana Cal

Founded in 2013 by José Manuel Moller in Chile, Algramo first became known for addressing the “poverty tax” (the surcharge paid by lower income families for staples sold in smaller sizes) through specially-designed dispensers in low-income neighborhood grocery stores... View Details

Keywords: Packaging-as-a-wallet; Plastic Waste; Business At The Base Of The Pyramid; Reusable Packaging; Alliances With FMCGs To Meet ESG Goals; Social Entrepreneurship; Environmental Sustainability; Strategy; Value Creation; Goals and Objectives; Business Model; Consumer Products Industry; Latin America; South America; Chile

June 2025
Article

Integral Outside: The Financial Curb Market, the Electric Telegraph, and the Politics of Pricing in Second Empire France

By: Charlotte Robertson

Financial markets in nineteenth-century France were far more complex than an analysis of the official Bourse or its state-authorized brokers would suggest. Most financial transactions occurred on an illegal yet tacitly tolerated curb market called the coulisse, which... View Details

Keywords: Financial Markets; History; Communication Technology; Knowledge Dissemination; France

2024
Working Paper

Catalysts for Climate Solutions: Corporate Responses to Venture Capital Financing of Climate-tech Startups

By: Shirley Lu, George Serafeim and Simon Xu

We study whether incumbent firms increase their product focus on climate solutions in response to venture capital (VC) financing of climate-tech startups. Using large language models to measure a firm's focus on climate solutions, we find that incumbents in similar... View Details

Keywords: Climate Finance; Climate Change; Technological Innovation; Entrepreneurship; Venture Capital; Private Equity; Environmental Sustainability; Business Startups

March 2016 (Revised April 2017)
Teaching Note

Bridj and the Business of Urban Mobility (A): Introducing a New Model

By: Rosabeth Moss Kanter and Jonathan Cohen

This note is for the purpose of aiding classroom instructors in the use of the Harvard Business School case "Bridj and the Business of Urban Mobility: Introducing a New Model." Instructors may use it to help students understand the challenges that come with disrupting... View Details

February 2001 (Revised January 2004)
Case

Michael Dell: Winning on the Demand Side of the Information Revolution

By: Nancy F. Koehn

Keywords: Entrepreneurship; Leadership; Innovation and Invention; Computer Industry

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23 Oct 2020
News

Two MBA Startups Cited as “Most Disruptive”

Chris Abkarians and Nikhil Agarwal (both MBA 2020) arrived at HBS with an idea driven by necessity. With student loans a hard reality of graduate student life, why not bundle their loans with those of other... View Details

Keywords: disruptive innovation; startups; student loans; entrepreneurship; i-Lab; entrepreneur in residence; Finance

August 2015 (Revised February 2017)
Case

Bridj and the Business of Urban Mobility (A): Developing a New Model

By: Rosabeth Moss Kanter and Daniel Fox

Bridj, a Boston startup that provides Big Data-powered, "pop-up" bus routes that respond to transportation demand, has been in operation for a little over a year and has recently launched service in Washington, D.C., its second market. Despite media acclaim and... View Details

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