Publications

May 2023 (Revised June 2023)
Supplement

Novartis (C): Reimagining Medicine

By: Ramon Casadesus-Masanell, Claudio Feser, Karolin Frankenberger and David Redaschi

This case unfolds around the first-ever approved personalized cancer treatment, how Novartis wrapped it into a new business model design, and how Novartis scaled it. Novartis — one of the largest pharmaceutical companies in the world — is, among other ventures,... View Details

Keywords: Health Testing and Trials; Health Care and Treatment; Business Model; Problems and Challenges; Pharmaceutical Industry; Switzerland

March 2009
Case

Incept LLC and Confluent Surgical (A)

By: Bhaskar Chakravorti, Toby E. Stuart and James Weber

A venture capitalist must decide whether to invest in a medical technology company that licenses intellectual property from a privately held IP holding company based on a platform technology. Entrepreneurs Amar Sawhney and Fred Khosravi founded Incept LLC to... View Details

Keywords: Business Model; Entrepreneurship; Intellectual Property; Rights; Agreements and Arrangements; Partners and Partnerships; Trust; Medical Devices and Supplies Industry

June 1983 (Revised March 1985)
Supplement

EMI and the CT Scanner (B)

By: Christopher A. Bartlett

Describes the development of the first CT Scanner by EMI, a company new to the medical industry, and EMI's entry into the U.S. market. The company's early success is threatened by the entry of a dozen competitors (some very large and experienced), by government... View Details

Keywords: Governing Rules, Regulations, and Reforms; Technological Innovation; Market Entry and Exit; Industry Structures; Product Development; Medical Devices and Supplies Industry

November 2023
Case

The Commons Project in Rwanda—Building Digital Infrastructure for the Global Public Good

By: Álvaro Rodríguez Arregui and Tom Quinn

In September 2022, The Commons Project Foundation (TCP) CEO Zhenya Lindgardt and her team met on a Zoom call to discuss building tools to help Rwandans manage their health data. They believed that helping Africa build digital infrastructure would improve much-needed... View Details

Keywords: Developing Countries and Economies; Capital; Cross-Cultural and Cross-Border Issues; Health Care and Treatment; Information Management; Adaptation; Information Infrastructure; Information Technology Industry; Rwanda; United States

June 2023
Case

Verve Therapeutics: Taking DNA Editing to Heart

By: Shikhar Ghosh and Shweta Bagai

Verve Therapeutics, a public biotech company based in Boston, created a novel approach to addressing cardiovascular disease (CVD) - a leading cause of deaths globally. The company's approach was a single shot treatment to permanently lower cholesterol, thus reducing... View Details

Keywords: AI; Genetic Engineering; Medicine; Health Care and Treatment; Genetics; Innovation Strategy; Business and Stakeholder Relations; Medical Specialties; Innovation and Invention; Entrepreneurship; Biotechnology Industry

23 Mar 2020
Research & Ideas

Product Disasters Can Be Fertile Ground for Innovation

In 2009, a stroke victim at a Los Angeles medical center started losing his hair following a CT brain perfusion scan. After some confusion, doctors determined he had been subject to a radiation overdose—a serious accident that might lead... View Details

Keywords: by Michael Blanding; Medical Devices & Supplies; Medical Devices & Supplies

January–February 2014
Other Article

Barriers to Health Care Innovation: Regina Herzlinger Warns That Innovators Need to Know What Obstacles They Face and How to Overcome Them

By: Regina E. Herzlinger

Health care in the United States and in most other developed countries is ailing, says Regina E. Herzlinger. A chaired professor of business administration specializing in health care at Harvard Business School, Herzlinger says that although the world has witnessed... View Details

Keywords: Healthcare; Healthcare IT; Innovation; Health Care and Treatment; Health; Information Technology; Innovation and Invention; Technology Industry; Technology Industry; United States

Find at Harvard

10 Jul 2000
Research & Ideas

The State of the Markets

indices." Technology is a means to that end. Technology, Efficiency And An Aging Population From a macroeconomic perspective, Seifert pointed out, technologically advanced and efficient capital markets... View Details

Keywords: by James E. Aisner

February 2019 (Revised September 2019)
Case

Theranos: The Unicorn That Wasn't

By: Joseph B. Fuller and John Masko

In 2003, 19-year-old Elizabeth Holmes founded a startup dedicated to making blood testing easier and more affordable. By 2015, her company, Theranos, was worth $9 billion. It boasted a star-studded board and contracts with national pharmacy and supermarket chains... View Details

Keywords: Theranos; Blood; Lab Testing; Fraud; Holmes; Balwani; Shultz; Carreyrou; Securities And Exchange Commission; Food And Drug Administration; FDA; SEC; Health Testing and Trials; Corporate Accountability; Organizational Culture; Misleading and Fraudulent Advertising; Crime and Corruption; Entrepreneurship; Medical Devices and Supplies Industry

11 Jun 2020
In Practice

Are Digital Organizations Better at Overcoming COVID?

chains and people analytics to artificial intelligence-based models and automated biotechnology research, organizations further along the digital curve are responding differently than those still wondering how to evolve. The digital View Details

Keywords: by Danielle Kost

21 Sep 2016
HBS Seminar

Catherine Tucker, MIT Sloan School of Management

September 2019 (Revised August 2020)
Case

Engineering an Inclusive Bioeconomy

By: Tarun Khanna, Raffaella Sadun and Susie L. Ma

In 2019, entrepreneur Juan Carlos Castilla-Rubio was developing a project he hoped could generate and share wealth from the natural resources of the Amazon without destroying those resources. His idea, called Earth Bank of Codes (EBC), would create a library of the... View Details

April 2015
Case

Carolinas HealthCare System: Consumer Analytics

By: John A. Quelch and Margaret L. Rodriguez

In 2014, Dr. Michael Dulin, chief clinical officer for analytics and outcomes research and head of the Dickson Advanced Analytics (DA2) group at Carolinas HealthCare System (CHS), successfully unified all analytics talent and resources into one group over a three year... View Details

Keywords: Consumer Segmentation; Big Data; Management Information Systems; Hospital Management; Health Care and Treatment; Marketing; Segmentation; Analytics and Data Science; Information Management; Information Technology; Health; Health Industry; United States

Gary Pisano is the Harry E. Figgie, Jr. Professor of Business Administration at the Harvard Business School where he has been on the faculty since 1988. From 2018-2023, Pisano was Harvard Business School’s Senior Associate Dean for Faculty Promotion and... View Details

Keywords: biotechnology; electronics; health care; manufacturing; pharmaceuticals

2025
Working Paper

Where Discovery Happens: Research Institutions and Fundamental Knowledge in the Life-Sciences

By: Amitabh Chandra and Connie Xu

Fundamental knowledge in the life sciences has consequential implications for medicine and subsequent medical innovations. Using publications in leading life science journals to measure fundamental knowledge, we document large agglomerations in the institutions where... View Details

Keywords: Research; Innovation and Invention; Science

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Register to Read

September 2022
Case

Proactive for Her

By: Rembrand Koning and Kairavi Dey

Proactive for Her began amid the COVID-19 pandemic, in August 2020 as a digital platform to provide accessible, evidence-based, primary, preventive non-judgmental healthcare services for Indian women, who were often dissuaded from seeking help as premarital sex and... View Details

Keywords: Women's Health; Healthcare; India; Start-up; Telehealth; Digital Platforms; Health Care and Treatment; Customer Focus and Relationships; Business Startups; Health Industry; Asia; South Asia; India